Current Stem Cells News and Events | Page 25

Current Stem Cells News and Events, Stem Cells News Articles.
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Light therapy could replace opioids as main treatment for cancer treatment side effect
A worldwide coalition of researchers and clinicians has agreed that light therapy is among the most effective interventions for the prevention of oral mucositis, painful ulcers in the mouth resulting from cancer therapy. (2019-07-09)

Killing the seeds of cancer: A new finding shows potential in destroying cancer stem cells
When doctors remove a tumor surgically or use targeted therapies, the cancer may appear to be gone. However, evidence suggests a tiny subpopulation of adaptable cancer cells can remain and circulate through the body to seed new metastasis in far-off locations. A collaborative research project The University of Toledo has identified an entirely new class of molecules that shows promise in rooting out and killing those cancer stem cells. (2019-07-08)

Cancer cells will become vulnerable
Researchers from HSE University (The Higher School of Economics) have used machine learning to discover that the two most widespread DNA structures -- stem-loops and quadruplexes -- cause genome mutations that lead to cancer. The results of the study were published in BMC Cancer. (2019-07-08)

Natural antioxidant helps improve immune-based therapies by modulating T-cells
Researchers at the Medical University of South Carolina discovered a way to improve immune-based treatments by modulating T-cells. The advancement can help increase anti-tumor efficiency of T-cell therapy and protect patients from graft-versus-host disease resulting from hematopoietic stem cell transplantation. (2019-07-08)

UCI team pioneers cancer treatment that targets bone metastases while sparing bone
University of California, Irvine researchers have developed and tested on mice a therapeutic treatment that uses engineered stem cells to target and kill cancer bone metastases while preserving the bone. (2019-07-08)

Mechanism behind low cancer occurrence in bats signals potential treatment strategies for humans
Researchers from Duke-NUS Medical School have uncovered a potential mechanism behind cancer suppression in bats that may lead to future therapies for human cancers. The research shows that bat cells accumulate less toxic chemicals than human cells, where these chemicals are moved out of the system mediated by a cell surface pump protein, known as ABCB1, that is more abundant and widely distributed in bat tissue than in humans. (2019-07-03)

World first: Homing instinct applied to stem cells show cells 'home' to cardiac tissue
In a world first, scientists have found a new way to direct stem cells to heart tissue. The findings, led by researchers at the University of Bristol and published in Chemical Science, could radically improve the treatment for cardiovascular disease, which causes more than a quarter of all deaths in the UK (1). (2019-07-03)

Paediatric cancers: Towards more targeted therapy
UCLouvain researcher Anabelle Decottignies has found a possible strategy for killing cancer cells, especially in children, without affecting healthy cells, as reported in the scientific journal Molecular Cell. (2019-07-03)

Immune cells invade aging brains, disrupt new nerve cell formation, Stanford study finds
A study by Stanford University School of Medicine investigators has revealed that immune cells infiltrate the rare newborn nerve-cell nurseries of the aging brain. There's every reason to think those interlopers are up to no good. Experiments in a dish and in living animals indicate they're secreting a substance that chokes off new nerve cell production. (2019-07-03)

Regenerating human retinal ganglion cells in the dish to inform glaucoma treatment
People have a limited ability to regenerate nerves after injury or illness. In glaucoma patients, degeneration of the optic nerve that connects the retina and the brain causes permanent blindness, and there is currently no effective treatment. Now, researchers at the University of Nebraska Medical Center, USA, can induce human retinal ganglion cells, which form the optic nerve, to regenerate nerve fibers in a dish. This study providing a new system for nerve regeneration research. (2019-07-02)

Three-dimensional model illuminates key aspects of early development
Researchers have created a new 3D model of human embryonic tissue that promises to shed light on critical components of development -- including processes that go awry during pregnancy complications. (2019-07-01)

Study finds electronic cigarettes damage brain stem cells
A research team at the University of California, Riverside, has found that electronic cigarettes, often targeted to youth and pregnant women, produce a stress response in neural stem cells, which are critical cells in the brain. (2019-07-01)

Stem cell stimulation improves stroke recovery
Stem cell stimulation shows promise as a potential noninvasive stroke treatment, according to research in mice published in JNeurosci. If extended to humans, this technique could greatly improve patients' quality of life. (2019-07-01)

Glowing brain cells illuminate stroke recovery research
A promising strategy for helping stroke patients recover, transplanting neural progenitor cells to restore lost functions, asks a lot of those cells. To help them to integrate into the brain, the cells get help from 'optochemogenetics.' (2019-07-01)

Helping select the cells with the most potential
Little is known about the mechanisms by which mammalian cells grow and differentiate during the handful of days between fertilization of the egg and implantation of the blastocyst in the uterus. Osaka University researchers have demonstrated that cell competition between neighboring blastocyst cells is dependent upon activation of components of the 'Hippo' tumor-suppression pathway. Such competition ensures that cells with optimum pluripotency are maintained, to maximize chances of normal embryonic development. (2019-06-27)

Researchers grow active mini-brain-networks
Cerebral organoids are artificially grown, 3D tissue cultures that resemble the human brain. Now, researchers from Japan report functional neural networks derived from these organoids in a study publishing June 27, 2019 in the journal Stem Cell Reports. Although the organoids aren't actually 'thinking,' the researchers' new tool -- which detects neural activity using organoids -- could provide a method for understanding human brain function. (2019-06-27)

Growing embryonic tissues on a chip
Researchers at EPFL have developed a method to stimulate human stem cells to organize themselves into ordered layers of different cell types. Published in Nature Methods, the method is based on microfluidics and can help better understand how tissues are formed in the embryo, setting the stage for fabricating functional tissues and organs for drug testing and transplantation. (2019-06-27)

'Can you hear me, now?' A new strategy 'raises the volume' of gut-body communication
A model system enables the study of enteroendocrine cells, one of the most important moderators of communication between the gut and the rest of the body. (2019-06-27)

FEFU scientists likely found way to grow new teeth for patients
A group of histologists and dentists from School of Biomedicine, Far Eastern Federal University (FEFU), teamed up with Russian and Japanese colleagues and found cells that are probably responsible for the formation of human dental tissue. Researchers propose to apply the study outcome within the development of bioengineering techniques in dentistry aimed at growing new dental tissue for patients. A related article is published in the International Journal of Applied and Fundamental Research. (2019-06-27)

'Shooting stars' during cell development impact risk for disease
Fleeting differences in gene expression between individuals that occur at different points in time during cell development may have consequences on the ultimate risk for disease in mature tissues and cell types. (2019-06-27)

A snapshot in time: Study captures fleeting cell differences that can alter disease risk
In cinema and science fiction, one small change in the past can have major, sometimes life-changing effects in the future. Using a series of snapshots, researchers recently captured such so-called 'butterfly effects' in heart muscle cell development, and say this new view into the sequence of gene expression activity may lead to better understanding disease risk. (2019-06-27)

Researchers discriminate between mutations that promote cancer growth and those that don't
Until now, researchers believed recurrent mutations (hotspot mutations) in cancer tumors were the important mutations (driver mutations) that promoted cancer progression. A new University of California, Irvine-led study indicates this is not always true. (2019-06-27)

Functional hair follicles grown from stem cells
Scientists from Sanford Burnham Prebys have created natural-looking hair that grows through the skin using human induced pluripotent stem cells (iPSCs), a major scientific achievement that could revolutionize the hair growth industry. The findings were presented today at the annual meeting of the International Society for Stem Cell Research (ISSCR) and received a Merit Award. A newly formed company, Stemson Therapeutics, has licensed the technology. (2019-06-27)

Widespread disease diabetes: Why do beta cells refuse to release insulin?
One in 11 adults worldwide suffers from diabetes, and the number of diabetes patients is rising rapidly. Diabetes is worldwide one of the most widespread diseases. In the most common form of diabetes, type 2 diabetes, the body cells react increasingly insensitively to the hormone insulin, which is produced by beta cells in the pancreas and is intended to promote the absorption of sugar from the blood into the cells. (2019-06-26)

Reversing t cells' misunderstood rep in responding to a pediatric leukemia
A study of pediatric patients with leukemia demonstrates that they were able to generate T cells against tumor-associated mutations, contradicting previous assumptions that T cells cannot be effectively unleashed on pediatric tumors. (2019-06-26)

Kyushu U researchers unlocking keys to longevity of egg cell supply in mammals
Researchers at Kyushu University have shown that reduced oxygen and mechanical compression are two environmental factors playing a role in creating and maintaining a supply of dormant egg cells in mice to ensure a long period of fertility. These insights into this critical but poorly understood process will further the understanding and development of reproductive biology and medicine. (2019-06-26)

Scientists developing way to help premature babies breathe easier
Researchers suggest a possible cell-based therapy to stimulate lung development in fragile premature infants who suffer from a rare condition called Bronchopulmonary Dysplasia (BPD), which in the most severe cases can lead to lifelong breathing problems and even death. Scientists report in the American Journal of Respiratory and Critical Care Medicine they studied genetic signatures in donated human neonatal lungs by using single-cell RNA sequencing analysis and mouse models of BPD. (2019-06-26)

Blood supply therapy bid boosted by fresh insights into key cells
Therapies to improve recovery after a heart attack could be developed following fresh insights into how key cells are formed. (2019-06-26)

Mice with a human immune system help research into cancer and infections
Researchers from Aarhus University and Aarhus University Hospital have succeeded in using mice with a transplanted human immune system to study functions in the immune system which are otherwise particularly difficult to study. The method could turn out to be important in further research into e.g. cancer, HIV and autoimmune diseases. (2019-06-25)

How gastric stem cells fight bacteria
Stem cells are not only key players in tissue regeneration, they are also capable of taking direct action against bacteria. This is the finding of a study conducted by researchers from Charité - Universitätsmedizin Berlin, which describes what happens during a Helicobacter pylori infection of the human stomach. By actively fighting the colonizing bacteria, gastric stem cells protect themselves against damage that can lead to cancer. Results from this study have been published in Nature Cell Biology. (2019-06-25)

Seizures in Alzheimer's mouse model disrupt adult neurogenesis
Working with animal models of Alzheimer's disease, a team led by researchers at Baylor College of Medicine discovered that seizures that are associated with the disease both in animal models and humans alter the normal dynamics of neurogenesis in adult brains. Administering anti-seizure medication restored neurogenesis and improved performance in a spatial discrimination task. (2019-06-25)

Discovery may help kick-start ageing immune system
The thymus, a vital organ producing the immune system's T cells, is one of the first to diminish in function as we age, resulting in a gradual loss of T cell production and eventually increased susceptibility to infections and cancer. Researchers have identified factors affecting the cells in the thymus that set in motion this loss, paving the way to develop targeted strategies for the recovery of T cells to help combat infections and cancers. (2019-06-25)

Researchers study healthy ALS neurons as way to understand resistance to the disease
Scientists have developed a stem-cell-based modeling system that identifies how some neurons are resistant to ALS -- a breakthrough that offers potential for battling neurodegeneration. (2019-06-25)

Speeding up single-cell genomics research
Time-saving method makes it possible to profile gene regulation in tens of thousands of individual human cells in a single day. Approach combines microfluidics and novel software to scale up single-cell ATAC-seq, which identifies parts of the tightly packaged genome that are more open and accessible to regulatory proteins. Profiling individual cells can clarify how genes function - in which specific cell types, at what time - and whether they play a role in disease. (2019-06-24)

Tapping into the way cells communicate
For the first time, scientists can record cells communicating in real time, opening the floodgates for new developments in cell therapy and other areas within cell biology. (2019-06-24)

Discovery of the cell fate switch from neurons to astrocytes in the developing brain
During mammalian brain development, neural precursor cells first generate neurons and later astrocytes. This cell fate change is a key process generating proper numbers of neurons and astrocytes. Here we discovered that FGF regulates the cell fate switch from neurons to astrocytes in the developing cerebral cortex using mice. FGF is a critical extracellular regulator of the cell fate switch, necessary and sufficient, in the mammalian cerebral cortex. (2019-06-21)

God doesn't play dice -- does cancer?
Colorado study suggests that changes to the tissue ecosystem and not necessarily mutations allows growth of cancer. (2019-06-20)

A chemical approach to imaging cells from the inside
A team of researchers has developed a new technique for mapping cells. The approach, called DNA microscopy, shows how biomolecules such as DNA and RNA are organized in cells and tissues, revealing spatial and molecular information that is not easily accessible through other microscopy methods. DNA microscopy also does not require specialized equipment, enabling large numbers of samples to be processed simultaneously. (2019-06-20)

Treatment for common cause of diarrhea more promising
Researchers at Washington University School of Medicine in St. Louis have figured out how to grow the intestinal parasite Cryptosporidium in the lab, an achievement that will speed efforts to treat or prevent diarrhea caused by the parasite. (2019-06-20)

Processed foods may hold key to rise in autism
University of Central Florida researchers are now a step closer to showing the link between the food pregnant women consume and the effects on a fetus' developing brain. (2019-06-20)

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