Current Telomeres News and Events

Current Telomeres News and Events, Telomeres News Articles.
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Discovery of 'adolescent' skeletal stem cells might someday help prevent osteoporosis
A new study reported in STEM CELLS reveals a unique population of skeletal stem cells (SSCs) that function during the transitional period between rapid bone growth and bone maintenance. (2021-01-13)

A CNIO study links severe COVID-19 disease to short telomeres
The data show that telomeres are shorter in patients suffering more severe COVID-19 pathologies. The researchers propose that one of the consequences of the viral infection is shortening of the telomeres, which, in turn, hampers the regeneration of lung tissue and causes prolonged sequelae in some patients. The study, published in the journal 'Aging', suggests the usefulness of a possible therapy for patients with post-COVID pulmonary injury based on activation of the enzyme telomerase. (2021-01-11)

Aging, diet-induced obesity, and metabolic disease link explored in new research
Unraveling the links among obesity, aging, telomere lengths and metabolic diseases is the subject of the study published today in Nature Metabolism by a collaborative research team at The University of Texas Health Science Center at Houston (UTHealth). (2020-12-14)

Signs of healthy aging found in ergothioneine telomere study
Signs of healthy aging found in ergothioneine telomere in vitro study, published in the Journal of Dietary Supplements, demonstrating Blue California ErgoActive ergothioneine helped to preserve telomere length and reduced the rate of telomere shortening under oxidative stress. The conclusion suggests ergothioneine helps to support healthy aging. (2020-12-10)

Research sheds new light on cause of deadly lung disease
New research could shed light on the mystery cause of a lung disease that is a major killer, and potentially unlock new treatments (2020-12-08)

Telomere shortening protects against cancer
Researchers have found the first evidence that telomere shortening is not just a sign of aging, but a key component of the body's cancer prevention system. (2020-12-01)

Mothers' stress may lead to preterm births, faster aging in children
Why do some people age faster than others? A new UCLA-led study indicates that a mother's stress prior to giving birth may accelerate her child's biological aging later in life. A second UCLA-led study from the same research group found that women suffering from high stress during the months and even years before conception -- defined as feeling overwhelmed and unable to cope -- had shorter pregnancies than other women. (2020-11-30)

Research provides new insights on health effects of long-duration space flight
Among the new findings, the research team found that chronic oxidative stress during spaceflight contributed to the telomere elongation they observed. They also found that astronauts had shorter telomeres after spaceflight than they did before. (2020-11-25)

Researchers uncover the unique way stem cells protect their chromosome ends
Telomeres are specialized structures at the end of chromosomes which protect our DNA and ensure healthy division of cells. According to a new study from researchers at the Francis Crick Institute published in Nature, the mechanisms of telomere protection are surprisingly unique in stem cells. (2020-11-25)

Near-infrared probe decodes telomere dynamics
A new synthetic probe offers a safe and straightforward approach for visualizing chromosome tips in living cells. The probe was designed by scientists at the Institute for Integrated Cell-Material Science (iCeMS) and colleagues at Kyoto University, and could advance research into aging and a wide range of diseases, including cancers. The details were published in the Journal of the American Chemical Society. (2020-11-20)

Tel Aviv University study finds hyperbaric oxygen treatments reverse aging process
A new study from Tel Aviv University (TAU) and the Shamir Medical Center in Israel indicates that hyperbaric oxygen treatments (HBOT) in healthy aging adults can stop the aging of blood cells and reverse the aging process. In the biological sense, the adults' blood cells actually grow younger as the treatments progress. (2020-11-19)

Non-hereditary mutation acts as natural gene therapy in patient with rare disease
Scientists at a research center supported by FAPESP identified a non-inherited mutation in blood cells from a patient with GATA2 deficiency that may have prevented bone marrow failure and other clinical manifestations. (2020-11-17)

Born to be young?
The environment we experience in early-life is known to have major consequences on later-life health and lifespan. A new study led from the University of Turku in Finland using an avian model suggests that increased prenatal exposure to maternal thyroid hormones could have beneficial effects on the 'biological age' at birth. (2020-11-11)

Scientists home in on the mechanism that protects cells from premature aging
A new study by EPFL researchers shows how RNA species called TERRA muster at the tip of chromosomes, where they help to prevent telomere shortening and premature cell aging. (2020-10-14)

Women's expected longevity linked to age at birth of last child
CLEVELAND, Ohio --No one knows for sure how long they will live. A new study, however, suggests that leukocyte telomere length may offer some key insights into a woman's longevity and further demonstrates how maternal age at birth of last child affects telomere length and long-term health. Study results are published online today in Menopause, the journal of The North American Menopause Society (NAMS). (2020-10-07)

Climate crisis ages fish, amphibians and reptiles
Climatic conditions are changing at an unprecedented rate, affecting mainly fish, amphibians and reptiles, ectothermic animals that are unable to generate their own internal heat. With heat waves and rising temperatures, these organisms experience not only increased growth rates and heat stress, but also further ageing. (2020-09-16)

Relaxed through pregnancy
A group of researchers from Charité - Universitätsmedizin Berlin have been able to show that maternal psychological wellbeing during pregnancy has a positive effect on newborn infants. Increased telomere length suggests a reduced rate of cell aging, which could have an effect on children's future health. Results from this study have been published in the American Journal of Psychiatry*. (2020-09-11)

Structure of 'immortality protein' now better understood
A key role in studying the telomerase of Hansenula polymorpha was played by KFU's nuclear magnetic resonance spectrometer. (2020-09-10)

Ultra-processed food consumption is associated with chromosomal changes linked to biological ageing
A new study has shed light on the link between the consumption of ultra-processed foods (UPF) and the shortening of telomeres; sections of chromosomes that can be used as a marker of biological age. The research is being presented at this year's European and International Conference on Obesity (ECOICO 2020), held online this year (1-4 September). (2020-08-31)

NUS researchers develop new system for accurate telomere profiling in less than 3 hours
The novel STAR assay developed by NUS researchers can be used to rapidly determine telomere dysregulation in cancers and age-related diseases in clinical settings. This helps clinicians to make faster diagnosis and plan targeted treatments for patients. (2020-08-25)

Molecular stress indicator not observed in survivors of child sexual abuse
Researchers and medical experts have long known that child sexual abuse has profoundly negative effects on the health of survivors; however, an international team of researchers was not able to find a link between the abuse and telomere length, considered an indicator of cellular aging and health. (2020-08-17)

The CNIO pave the way for a future gene therapy to reverse pulmonary fibrosis associated with ageing
''Our results indicate that a new therapy may be developed to prevent the development of pulmonary fibrosis associated with ageing,'' says CNIO's Maria Blasco, principal investigator of the study * Lung tissue of patients with pulmonary fibrosis does not regenerate because the cells involved in lung generation have damaged telomeres, the ends of the chromosomes. The new study describes a gene therapy that activates the enzyme that repairs telomeres (2020-08-10)

TLK protein inhibition activates the innate immune system
These proteins are a potential therapeutic target for enhancing the effect of some cancer treatments. Inhibition of TLK proteins triggers the Alternative Lengthening of Telomeres pathway, a common process in some of the most aggressive types of cancer, such as glioblastoma. The study, performed by the Genomic Instability and Cancer Laboratory at IRB Barcelona, has been published in the journal Cell Reports. (2020-08-05)

Potential biomarker identified to screen quality of donor's stem cells before harvesting
A new study released in STEM CELLS identifies a potential biomarker for prescreening donors for their MSCs' growth capacity and potency. (2020-06-08)

Tracking cancer's immortality factor
Canadian researchers discover how a key cancer mutation activates telomerase, the 'anti-aging enzyme' that makes tumour cells immortal. (2020-06-03)

Study identifies potential drug treatments for telomere diseases
Capping decades of research, a study in Cell Stem Cell may offer a breakthrough in treating dyskeratosis congenita and other so-called telomere diseases, in which cells age prematurely. Using cells donated by patients, researchers at the Dana-Farber/Boston Children's Cancer and Blood Disorders Center identified several small molecules that appear to rebuild telomere and reverse this cellular aging process. (2020-04-21)

The CNIO discovers that rapamycin has harmful effects when telomeres are short
The CNIO shows that an anti-aging strategy that extends life in normal mice, the treatment with rapamycin, is harmful when mice have short telomeres. The team addresses for the first time the connections between two of the main biochemical processes associated with ageing: the shortening of telomeres and the ability of cells to detect nutrients. The study reveals thus far unknown basic aspects of one of the main molecular pathways, mTOR, involved in cancer and aging. (2020-03-03)

Chemists inhibit a critical gear of cell immortality
Researchers have developed a promising molecular tool that targets and inhibits one of cell immortality's underlying gears: the enzyme telomerase. (2020-03-03)

New study shows the effects of obesity mirror those of aging
In their paper published in the journal Obesity Reviews, researchers argue that obesity should be considered premature aging. They look at how obesity predisposes people to acquiring the kinds of potentially life-altering or life-threatening diseases normally seen in older individuals: compromised genomes, weakened immune systems, decreased cognition, increased chances of developing type 2 diabetes, Alzheimer's disease, cardiovascular disease, cancer and other illnesses. (2020-02-25)

Simple blood test could help predict progression of Parkinson's disease
In order to provide the best medical care for newly diagnosed Parkinson's disease (PD) patients, a method of predicting their cognitive and motor progression, beyond using purely clinical parameters, would have major implications for their management. (2020-02-11)

Traces of immortality in tumor DNA
To gain an infinite lifespan, cancer cells need to maintain the ends of their chromosomes, known as telomeres. They achieve this in various different ways. Scientists from the German Cancer Research Center systematically investigated more than 2,500 tumor genomes of 36 types of cancer to find out how these mechanisms are manifest in changes in the DNA. The study is part of the Pan-Cancer Analysis of Whole Genomes (PCAWG). (2020-02-05)

Researchers uncover the genomics of health
A DNA database of thousands of healthy older Australians is set to change how we determine which genes underpin disease. (2020-01-23)

Drinking 1% rather than 2% milk accounts for 4.5 years of less aging in adults
A new study shows drinking low-fat milk -- both nonfat and 1% milk -- is significantly associated with less aging in adults. Research on 5,834 US adults by Brigham Young University exercise science professor Larry Tucker, Ph.D., found people who drink low-fat (1% and skim) milk experience several years less biological aging than those who drink high-fat (2% and whole) milk. (2020-01-15)

Telomere research at Marshall published in Nature Communications
The findings show a clear genetic link between components of ribosome biogenesis pathway and telomere length, mapping a new direction for understanding and potentially treating human diseases caused by mutations in genes that control both the ribosome and telomere. (2019-12-20)

Possible new treatment strategy against progeria
Progeria is a very rare disease that affects about one in 18 million children and results in premature aging and death in adolescence from complications of cardiovascular disease. In a study on mice and human cells, researchers at Sweden's Karolinska Institute and IFOM, the FIRC Institute of Molecular Oncology in Italy, have identified how antisense oligonucleotide therapies could be used as a new possible treatment option for the disease. The results are published in Nature Communications. (2019-11-18)

Can plants tell us something about longevity?
The oldest living organism on Earth is a plant, Methuselah a bristlecone pine (Pinus longaeva) (pictured below) that is over 5,000 years old. Conversely, animals only live up to a few hundred years. Can we learn something from plants about longevity and stay young forever or even recapture lost youth? (2019-11-18)

Crick researchers unravel protective properties of telomere t-loops
Loops at the ends of telomeres play a vital protective role preventing irretrievable damage to chromosomes, according to new research from the Crick. The study, published in Nature, showed how the winding and unwinding of 't-loops' at the end of telomeres prevents chromosomes from being recognized as DNA damage. The study also uncovered how this process is regulated. (2019-11-13)

Wearable tracker study links insufficient sleep to biological aging and cardiovascular disease risk
Getting a good night's sleep is important and insufficient sleep has been linked to poor health in many studies. Analyzing data collected from wearable trackers, researchers from the SingHealth Duke-NUS Institute of Precision Medicine (PRISM) and the National Heart Centre Singapore (NHCS) recently demonstrated that chronic sleep deprivation is associated with increased cardiovascular disease risk markers and accelerated biological ageing. Their findings have been published in the journal Communications Biology. (2019-11-11)

CNIO researchers obtain the first mice born with hyper-long telomeres
Mice with hyper-long telomeres live, on average, 13% longer and in better health, free from cancer and obesity The study has found for the first time ever a clear relationship between the length of telomeres and insulin and glucose metabolism, which are also crucial in ageing 'This finding opens the interesting hypothesis that genes are not the only thing to consider when it comes to determine species longevity,' indicates Maria Blasco, senior author of the paper. (2019-10-17)

New marker for tumor aggression in neurofibromatosis type 1
Researchers at the Johns Hopkins Kimmel Cancer Center report that their study of tumor samples from people with the rare genetic syndrome neurofibromatosis type 1 (NF1) has uncovered novel molecular clues about which tumors are most likely to be aggressive in those with NF1. According to the researchers, the clues could advance the search for more customized and relevant treatments that spare patients exposure to treatments unlikely to work. (2019-10-16)

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