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Current Telomeres News and Events, Telomeres News Articles.
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Cellular aging is linked to structural changes in the brain
A new study now shows that if telomeres change in their length, that change is also reflected in our brain structure. This association was identified by a team of scientists including Lara Puhlmann and Pascal Vrticka from the MPI CBS in Leipzig together with Elissa Epel from the University of California and Tania Singer from the Social Neuroscience Lab in Berlin as part of the ReSource Project. (2019-09-27)

Gene coding error found in rare, inherited gene cof lung-scarring disorder linked to short telomeres
By combing through the entire genetic sequences of a person with a lung scarring disease and 13 of the person's relatives, Johns Hopkins Medicine researchers say they have found a coding error in a single gene that is likely responsible for a rare form of the disease and the abnormally short protective DNA caps on chromosomes long associated with it. (2019-09-10)

Nobel Laureate, Tom Cech, Ph.D., suggests new way to target third most common oncogene, TERT
Study in PNAS shows that trapping TERT mRNA in the cell nucleus may keep TERT oncogene from being manufactured, silencing the action of TERT in driving cancer. (2019-09-10)

Enzyme known for promoting cancer found to also protect healthy cells
New research from the University of Maryland and the NIH reveals a new role for the enzyme telomerase, which scientists thought was turned off in most normal adult cells, except in cancerous tumors where it promotes unlimited cell division. The researchers discovered that as normal, healthy adult cells approach cell-death, they produce a burst of telomerase that prevents malignancies and softens the final steps in the aging process. (2019-09-02)

Epigenome-wide association study of leukocyte telomere length
In this study, the research team conducted a large-scale epigenome-wide association study of LTL using seven large cohorts the Framingham Heart Study, the Jackson Heart Study, the Womens Health Initiative, the Bogalusa Heart Study, the Lothian Birth Cohorts of 1921 and 1936, and the Longitudinal Study of Aging Danish Twins. Previous studies have explored the association between DNAm and LTL, but these studies were somewhat limited due to moderate sample sizes or the focus on specific regions in the genome. (2019-08-31)

DNA methylation-based estimator of telomere length
Leukocyte DNAm TL is applicable across the entire age spectrum and is more strongly associated with age than measured leukocyte TL. Although both DNAm age and LTL are associated with chronological age, they exhibit only weak correlations with each other after adjusting for age, suggesting the distinct nature of their underlying mechanisms. They also validated the applicability of DNAm TL on a large-scale data set and uncovered associations between age-adjusted DNAm TL with diet and clinical biomarkers. (2019-08-31)

Runaway mitochondria cause telomere damage in cells
Targeted damage to mitochondria produces a 'Chernobyl effect' inside cells, pelting the nucleus with harmful reactive oxygen species and causing chromosomal damage. (2019-08-26)

A single change at telomeres controls the ability of cells to generate a complete organism
Pluripotent cells can give rise to all cells of the body, a power that researchers are eager to control because it opens the door to regenerative medicine and organ culture for transplants. But pluripotency is still a black box for science, controlled by unknown genetic and epigenetic signals. CNIO researchers now uncovers one of those epigenetic signals, after a detective quest that started almost a decade ago. (2019-08-20)

CNIO researchers discover that the rate of telomere shortening predicts species lifespan
Comparison of telomeres of goats, dolphins, gulls, reindeer, vultures, flamingos, elephants, mice and humans reveals that species whose telomeres shorten faster have shorter lives. 'We have found a universal pattern, a phenomenon that explains the lifespans of the species,' says Maria Blasco, senior author of the study. The results are published in the journal Proceedings of the National Academy of Sciences. (2019-07-08)

Paediatric cancers: Towards more targeted therapy
UCLouvain researcher Anabelle Decottignies has found a possible strategy for killing cancer cells, especially in children, without affecting healthy cells, as reported in the scientific journal Molecular Cell. (2019-07-03)

CNIO researchers find effective drug combinations for glioblastoma in mice
Glioblastoma is a brain tumour with very poor prognosis. Patients with glioblastoma usually develop resistance to treatments. Combination therapy could be an effective approach. The study carried out at CNIO provides unexpected and valuable information on cancer biology. It revealed that components in the RAS pathway, which is involved in numerous types of cancer, also participates in telomere maintenance. The study will be published in EMBO Molecular Medicine this week. (2019-06-13)

Telomere length unaffected by smoking
A new study has surprised the medical world, finding that smoking does not shorten the length of telomeres -- a marker at the end of our chromosomes that is widely accepted as an indicator of aging. This suggests that adult telomere length should be considered a static biomarker that changes relatively little during adult life. The authors emphasize that this does not lessen the evidence that smoking is bad for you. (2019-06-05)

Cold-parenting linked to premature aging, increased disease risk in offspring
New research out of Loma Linda University Health suggests that unsupportive parenting styles may have several negative health implications for children, even into their adult years. The study found that the telomeres -- protective caps on the ends of the strands of DNA -- of subjects who considered their mothers' parenting style as 'cold' were on average 25% smaller compared to those who reported having a mother whose parenting style they considered 'warm.' (2019-05-30)

New study reveals an unexpected survival mechanism of a subset of cancer cells
A research group led by Claus M. Azzalin at iMM has discovered that a human enzyme named FANCM is absolutely required for the survival of ALT tumor cells. The results were now published in the open access journal Nature Communications. Future strategies targeting the activity of this molecule in ALT tumor cells can constitute the basis of a novel therapeutic protocol for the treatment of these tumors. (2019-05-28)

Pitt study finds direct oxidative stress damage shortens telomeres
First causal evidence that oxidative stress works directly on telomeres to speed cellular aging. (2019-05-14)

New doctors' DNA ages six times faster than normal in first year
Every summer, tens of thousands of newly minted doctors start the most intense year of their training: the first year of residency, also called the intern year. A new study suggests that the experience will make their DNA age six times faster than normal. And the effect will be largest among those whose training programs demand the longest hours. (2019-05-14)

Environmental pollutants could impact cellular signs of aging
Researchers have linked some environmental pollutants with diseases, a decreased life span and signs of premature aging, such as wrinkles and age spots. But can accelerated aging be detected at the cellular level in healthy people exposed to pollutants? Now, researchers in the ACS journal Environmental Science & Technology report that although pollutant exposure can affect two hallmarks of aging in people (mitochondrial DNA content and telomere length), the results are not so clear-cut. (2019-05-01)

NASA Twins Study offers new insight on how a human's body responds to spaceflight
Colorado State University Professor Susan Bailey, who studies telomeres, or the protective 'caps' on the ends of chromosomes, found that Scott Kelly's telomeres in his white blood cells got longer while in space. Changes in telomere length could mean a person is at risk for accelerated aging or the diseases that come along with getting older. (2019-04-11)

Smoking and pre-eclampsia may cause fertility problems for offspring, study suggests
Low levels of oxygen in the womb -- which can be caused by smoking or conditions such as preeclampsia -- may cause problems with fertility later in life, a study carried out in rats suggests. (2019-03-29)

Stabilizing ends of chromosomes could treat age-related disease
A study has uncovered a new strategy that can potentially treat age-related disease and decline. The report shows that restoring the activity of a class of enzymes called sirtuins with a small compound stabilized telomeres and reduced DNA damage, which in turn improved liver disease in a mouse model. This study suggests that maintaining telomere length might help sustain the regenerative capacity of cells and tissues and improve disease outcome. (2019-03-28)

Sex hormone levels in older men are linked to lower biological age
Older men tend to have lower biological age if they have higher levels of sex hormones, particularly the estradiol form of estrogen, a large new study from Australia finds. The study results will be presented on Sunday at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La., and appear online in the journal Clinical Endocrinology. (2019-03-25)

Getting help with the kids slows down ageing in female birds
Seychelles warblers live and breed in family groups on the tiny island of Cousin. In each group, a dominant female and male reproduce. When helpers assist the with incubation and feeding of chicks, the dominant female breeders age more slowly and live longer, a study by biologists from the University of Groningen and colleagues shows. The results indicate how cooperative breeding -- which also occurs in other species, including humans -- can increase life span. (2019-03-21)

Females live longer when they have help raising offspring
Female birds age more slowly and live longer when they have help raising their offspring, according to new research from the University of Sheffield. (2019-03-21)

What controls the tips of our chromosomes?
The tips of our chromosomes have structures called telomeres that prevent our genetic material from unfolding. When they do not work properly, it can lead to the total erosion of our genetic material and can trigger cancer and age-related diseases. In a study now published in EMBO Journal, a research team from Instituto Gulbenkian de Ciência (IGC; Portugal), led by Jose Escandell and Miguel Godinho Ferreira, discovered a key aspect of the regulation of telomeres. (2019-02-27)

RUDN biochemists found a way to stop the immortality of cancer cells with oligonucleotides
RUDN biochemists found a way to reduce the activity of telomerase (the enzyme of cell immortality) 10 times. (2019-02-11)

In surprising reversal, scientists find a cellular process that stops cancer before it starts
Salk Institute scientists studying the relationship of telomeres to cancer made a surprising discovery: a cellular recycling process called autophagy -- generally thought of as a survival mechanism -- actually promotes the death of cells, thereby preventing cancer initiation. (2019-01-23)

FSU researcher: Unfair treatment by police linked to physiological impacts among black men
In a new study published in the Journal of Health and Social Behavior, FSU researchers found a strong link between unfair treatment by police and telomere length, a biological indicator of psychological stress. (2018-12-18)

New insights into childhood cancer
Peripheral nervous system tumors, known as neuroblastoma, are one of the most common types of childhood tumors. As part of an international research endeavor, researchers from Charité - Universitätsmedizin Berlin have studied the genetic factors behind different tumor subtypes and their prognoses. Their findings enable clinicians to predict the precise clinical course of the disease, and to adapt their treatment regimens accordingly. The study has been published in the prestigious journal Science*. (2018-12-10)

Parrot genome analysis reveals insights into longevity, cognition
Parrots are famously talkative, and a blue-fronted Amazon parrot named Moises -- or at least its genome -- is telling scientists volumes about the longevity and highly developed cognitive abilities that give parrots so much in common with humans. Perhaps someday, it will also provide clues about how parrots learn to vocalize so well. (2018-12-06)

A mechanistic approach to neuroblastoma prognosis and risk
A new study reveals key molecular indicators that could help doctors select the best form of treatment for patients with neuroblastoma -- the most common type of cancer in infants. (2018-12-06)

Without Dna2, genes can jump into DNA breaks
When Dna2 is absent, small DNA fragments jump from all over the genome into chromosome breaks. This novel mechanism may explain similar events commonly seen in cancer or during antibody diversification. (2018-12-05)

Dana-Farber to present new research on stem cell transplantation for myeloid cancers
Improving outcomes for patients with myeloid cancers who undergo stem cell transplantation is a focus of several studies to be presented by Dana-Farber Cancer Institute scientists at the ASH Annual Meeting. (2018-12-03)

Endurance but not resistance training has anti-aging effects
Researchers have discovered evidence that endurance exercise, such as running, swimming, cross-country skiing and cycling, will help you age better than resistance exercise, which involves strength training with weights. Endurance exercise but not resistance exercise can prevent telomeres shortening, or can even lengthen them, according to the first prospective randomized controlled study of the effect of different forms of exercise on this indicator of healthy aging published in the European Heart Journal. (2018-11-27)

Stanford researchers modify CRISPR to reorganize genome
Researchers at Stanford University have reworked CRISPR-Cas9 gene-editing technology to manipulate the genome in three-dimensional space, allowing them to ferry genetic snippets to different locations in a cell's nucleus. (2018-10-11)

Understanding why women may age slower than men
Why do women typically live longer than men? The Keynote Address at The North American Menopause Society (NAMS) Annual Meeting in San Diego, Oct. 3-6, reviews some old and provides some new answers, highlighting the latest studies on the protective effects of sex hormones and estrogen, as well as other tips for slowing the aging process by improving telomere health. (2018-10-03)

Exercise reduces stress, improves cellular health in family caregivers
Exercising at least three times a week for six months reduced stress in a group of family caregivers and even appeared to lengthen a small section of their chromosomes that is believed to slow cellular aging, new UBC research has found (2018-10-03)

Study finds that enzymes 'partner up' to accelerate cancer, aging diseases
Indiana University researchers have identified cellular processes that appear to supercharge both the growth and shrinkage of the chemical 'caps' on chromosomes associated with aging, called telomeres. (2018-09-25)

RUDN biochemists described a new mechanism for autoimmunity suppression
RUDN biochemists suggested a new mechanism following which a human body prevents the development of autoimmune diseases (i.e. conditions caused by the damaging influence of the immune system on a body's own organs and tissues), allergies, and implant rejection. It turned out that regulatory T-cells are able to suppress the reproduction of autoimmune cells. The work was published in the Molecular Immunology journal. (2018-09-07)

Short chromosome tips linked to lower physical function in the elderly
Elderly people with short telomeres -- the 'caps' at the ends of each chromosome -- are more likely to have difficulty performing daily activities such as carrying groceries, climbing stairs and walking. The study of more than 1,200 people from five European countries suggests that short telomeres are an independent risk factor for age-related functional decline, and opens the possibility that slowing telomere shortening may have a positive effect on physical ability in old age. (2018-09-06)

Breeder meerkats age faster, but their subordinates still die younger
Despite rapidly aging, dominant animals live longer because their underlings are driven out of the group -- becoming easy targets for predators. The secret of a long meerkat life is to be 'ruler of your community ... cracking down on would-be rivals,' say scientists. (2018-08-30)

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