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Oral diabetes drug shows promise in preventing miscarriage in common infertility disorder
The anti-diabetes drug metformin appears to reduce the likelihood of early miscarriage in women with PCOS, a common form of female infertility, according to a study funded by the National Institute of Child Health and Human Development (NICHD). The study appears in the February issue of the Journal of Clinical Endocrinology and Metabolism. (2002-02-27)

Hormone therapy for prostate cancer causes weight gain and increased body fat
Prostate cancer patients often receive androgen-deprivation therapy to reduce their levels of the hormone testosterone, but the side effects have not been well studied. A Massachusetts General Hospital study published in the February issue of The Journal of Clinical Endocrinology and Metabolism reveals that unwanted weight gain, particularly increased fat body mass, is a common occurrence in these patients. (2002-02-22)

Cell interactions in spermatocyte apoptosis
Among their many unfortunate effects, heavy metals such as cadmium can impair male fertility. Whether oligospermia arises from environmental exposure to cadmium is unclear from epidemiological studies, but male rats treated with this metal reliably decrease their production of mature sperm. (2002-02-13)

Babies born with penis developmental disorder happier when raised male, say Johns Hopkins researchers
Genetically and physically, male babies born with a condition called (2002-01-23)

Testosterone dose-repsonse relationships in healthy young men
New study dispels belief that increasing the hormone level improves the sexual function. (2001-11-30)

New experimental drug shown to slow the growth of prostate cancer tumors in mice
A new experimental drug has been found to slow the growth of prostate cancer tumors in laboratory studies conducted at Cedars-Sinai Medical Center. The findings, presented at the AACR-NCI-EORTC International Conference in Miami Beach, Florida, may lead to a new way to treat prostate cancer, a disease that strikes about 198,000 men each year. (2001-11-01)

Hormonal changes during physiological development can alter immune response to viruses and infections
From the APS Conference (2001-10-18)

Medication prevents osteoporosis in men treated for prostate cancer
One of the fastest-growing osteoporosis risk groups consists of men with prostate cancer who receive androgen-deprivation therapy to lower testosterone levels. In the Sept. 27 issue of New England Journal of Medicine, researchers from the Massachusetts General Hospital describe how the drug pamidronate prevented bone loss in prostate cancer patients treated with what are called GnRH agonists. (2001-09-26)

Ending the cycle of premenstrual pain: Oral contraceptive found to relieve severe PMS and PMDD symptoms
Researchers report that a combination of components found in a unique oral contraceptive have been found to ease the symptoms of premenstrual syndrome (PMS) and premenstrual dysphoric disorder (PMDD). According to Ellen Freeman of the University of Pennsylvania School of Medicine and lead author of the study, the oral contraceptive may offset the major symptoms of premenstrual syndromes by suppressing ovulation, reducing water retention, and counteracting the effects of testosterone. (2001-08-22)

Left handers at twice the risk of inflammatory bowel disease
Left handers seem to be at twice the risk of developing inflammatory bowel disease, such as Crohn's disease and ulcerative colitis, suggests research in Gut. (2001-07-11)

New pilot study suggests flaxseed and low-fat diet can be protective against prostate cancer
low-fat diet supplemented with flaxseed may help reduce the risk of prostate cancer, researchers from Duke University Medical Center report in the July issue of Urology. (2001-07-10)

Testosterone therapy - spotlight on the older man at last
A spotlight is at last being turned on to the health needs of older men and there is going to be an upsurge of interest in combating the hormonal problems of male ageing, an international conference on reproductive medicine was told. (2001-07-03)

Study finds changes in hormone levels in men who become fathers
June 2001 The following stories detail news from Mayo Clinic. They are intended for use as individual stories or as part of a larger story on a particular medical topic. (2001-06-14)

Common prostate cancer treatment may cause severe bone loss, according to researchers at the University of Pittsburgh
Men may be losing bone at an alarming rate and increasing their risk of fracture as a result of a commonly used treatment for prostate cancer, according to researchers at the University of Pittsburgh Medical Center. The findings are published in the June issue of the Journal of Clinical Endocrinology and Metabolism. (2001-06-04)

Study looks at causes, consequences of sex differences
In their quest for improved health for both men and women, medical professionals and scientists must gain a better understanding of the basic biological differences between the sexes, says Dr. John Vandenbergh, professor of zoology at North Carolina State University. (2001-05-13)

More study recommended on long-term reproductive effects of traces of both natural and man-made hormone-like chemicals
There appear to be effects below the traditional 'no effect' level: A 36-member panel said the chemicals, called (2001-05-13)

Arsenic: A new type of endocrine disrupter?
Dartmouth Medical School investigators have uncovered the way chronic exposure to low levels of arsenic may increase the risk of certain diseases. Using cultured animal cells, the team found very low concentrations of arsenic disrupts the function of the glucocorticoid receptor, a steroid hormone receptor that regulates many biological processes. (2001-02-26)

Researchers seek women with premature ovarian failure for testosterone replacement study
Researchers at the National Institute of Child Health and Human Development are recruiting women who have premature ovarian failure--formerly known as premature menopause--to determine if providing them with testosterone will help prevent osteoporosis. (2001-02-15)

Testosterone in women?
Although testosterone is usually thought of as a male hormone, women also need it in small doses, according to the February issue of Mayo Clinic Women's HealthSource. (2001-01-30)

Annals of Internal Medicine, Tip Sheet, December 19, 2000
1). Hormone Replacement Protects Older Women From Heart Disease But May Increase Risk for Stroke; 2). Pap Tests for Older Women Indicated Only Every Two Years 3). Osteoporosis in Older Men May Be Related to Estrogen Levels 4). Club Drug Increases Heart Rate, Blood Pressure and Oxygen Consumption (2000-12-18)

Mayo Clinic study finds definitive evidence relating to the role of estrogen in elderly males
A Mayo Clinic study, published in the December edition of the Journal of Clinical Investigation, provides new evidence that estrogen is dominant in the regulation of bone resorption in elderly men. Based on the study conclusions, men also need to be concerned about the long-term effects of bone loss, or osteoporosis. (2000-12-12)

Immunotherapy slows disease progression and lowers PSA levels in some men with prostate cancer, UCSF study finds
A novel therapy that employs the immune system to attack and kill prostate cancer cells has been found to slow disease progression in some men and decrease levels of prostate specific antigen (PSA), a protein in the blood that often indicates prostate cancer, a UCSF study has found. (2000-11-30)

Commonly used herbal product lowers PSA level in men with advanced prostate cancer, UCSF study finds
A popular herbal supplement used by prostate cancer patients has been found to significantly reduce prostate specific antigen (PSA) levels--a protein in the blood that often indicates prostate cancer--in men with advanced disease, according to a University of California, San Francisco study. (2000-10-27)

High fat diet not associated with increased estrogen in postmenopausal women
Reversing a long held theory, a new, large Harvard Medical School study reports that a high fat diet does not predispose older women to breast cancer. (2000-10-26)

Researchers discover role of estrogen stimulator in making male hormone; finding may help explain infertility in some women and men
A hormone that stimulates the production of estrogen has a key role in making the testosterone women need as well, according to researchers at the Medical College of Georgia who say their finding may help explain previously unexplained infertility in women and men. (2000-10-18)

Estrogen therapy may help prevent memory decline in elderly women
Normal aging in women affects their capacity for learning - coding, consolidating, and retrieving new information. A McGill researcher has shown that hormone replacement therapy may help prevent some of the decline in explicit memory that occurs with normal aging (2000-10-10)

Decision to abolish gender testing at Sydney Olympics supported by Yale physician
The International Olympic Committee decided to abolish gender testing at the summer Olympics in Sydney, on a trial basis. A Yale physician writes in a commentary in The Journal of the American Medical Association that it's about time. Myron Genel, M.D., a pediatric endocrinologist at the Yale School of Medicine, says gender testing is difficult, expensive, potentially inaccurate and discriminatory against women with disorders of sexual development. (2000-09-28)

September tipsheet from Cedars-Sinai Medical Center
1) Researchers clone gene linked to Spinocerebellar Ataxia Type 10 and epilepsy; 2) Coronary calcium scan may help identify Type 1 diabetics at high risk for heart disease; 3) New pediatric neurosurgery program launched; 4) NEJM article reports that testosterone patch improves sexual function in surgically postmenopausal women; 5) Researchers shed new light on mechanisms causing neurodegeneration; 6) First lung- liver transplant in western U.S. (2000-09-27)

Moderate aggression may lead to stronger immune systems
Men who are moderately aggressive have stronger immune systems, according to new study by a team of researchers from Penn State and the University of Nebraska. (2000-09-07)

Study published in NEJM reports that testosterone patch improves sexual function and psychological well-being in surgically postmenopausal women
According to a study published in the Sept. 7 issue of the New England Journal of Medicine, an experimental testosterone patch improved the sexual function and psychological well- being of women who had undergone surgical menopause (removal of the ovaries and uterus). (2000-09-06)

Testosterone skin patch improves sexual functioning in surgically menopausal women
A multi-institutional research group has found that use of an experimental testosterone skin patch can relieve impaired sexual functioning in surgically menopausal women - that is, women who have had their ovaries removed before natural menopause. The report in the Sept. 7 New England Journal of Medicine comes from a team led by researchers from the Massachusetts General Hospital and Watson Laboratories, Inc.- Utah, the developers of the patch. (2000-09-06)

Moderate aggression may lead to stronger immune systems
Men who are moderately aggressive have stronger immune systems, according to new study by a team of researchers from Penn State and the University of Nebraska. (2000-08-27)

Researchers decipher fundamental signal for maleness
Researchers have deciphered the novel molecular structure of a protein that plays a critical role in determining male or female physical characteristics. Although the research was done in the fruit fly, researchers say the findings have implications in humans because similar genes were recently found in the human genome. (2000-07-26)

Is testosterone a cause of endometrial cancer?
The male hormone testosterone has been pinpointed by Dutch researchers as a surprising possible cause of endometrial cancer in postmenopausal women. (2000-06-27)

PRAECIS announces positive results for abarelix depot-M in two pivotal Phase III clinical trials
PRAECIS PHARMACEUTICALS announced results of two Phase III studies for abarelix depot-M for prostate cancer treatment. These studies, which included 520 prostate cancer patients, showed the intended benefits of abarelix depot-M when compared head to head with leuprolide acetate depot or leuprolide acetate depot and bicalutamide. (2000-05-22)

Is there such a thing as the male menopause?
The male menopause may not be the right term for it, but men do have a collection of symptoms in mid-life that equate to the female menopause, argue Gould and Petty of Goldcross Medical Services, London, in a debate in this week's BMJ. (2000-03-23)

Mysterious foot fractures may be sign of osteoporosis
A fractured foot bone could be a warning sign for osteoporosis. A study found that patients with fractured foot bones showed early signs of osteoporosis. The researchers considered these fractures (2000-03-20)

Common pesticide product reduces testosterone levels
The chemical HPTE, a metabolite of the common pesticide methoxychlor, reduces testosterone production and could be a contributory factor in male infertility, Population Council scientists report in the March 2000 issue of Biology of Reproduction. (2000-03-13)

American Urological Association supports Medicare Osteoporosis Supplement Act
Citing that increased access to bone density testing will save thousands of men with advanced prostate cancer from the permanent disability and debilitation of osteoporosis, the American Urological Association strongly gave its support to the Medicare Osteoporosis Management Act. (2000-03-09)

MGH research shows androstenedione can raise testosterone levels
A study led by researchers from the Massachusetts General Hospital (MGH) has found that 300 milligram (mg) doses of androstenedione -- a dietary supplement used by some athletes -- can raise blood testosterone levels in healthy young men. The report also showed an increase in estrogen levels with both 100 and 300 mg doses but did not examine whether taking androstenedione increases strength or muscle mass or leads to long-term side effects. (2000-02-08)

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