Current Transplant News and Events

Current Transplant News and Events, Transplant News Articles.
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Lab-grown 'mini-bile ducts' used to repair human livers in regenerative medicine first
Scientists at the University of Cambridge have used a technique to grow bile duct organoids - often referred to as 'mini-organs' - in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. (2021-02-18)

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors. (2021-02-11)

STING activation reduces graft-versus-host disease in a mouse model
MUSC Hollings Cancer Center researcher Yongxia Wu, Ph.D., identified a new target molecule in the fight against graft-versus-host disease. (2021-02-11)

Fecal microbiota transplants help patients with advanced melanoma respond to immunotherapy
For patients with cancers that do not respond to immunotherapy drugs, adjusting the composition of microorganisms in the intestines--known as the gut microbiome--through the use of stool, or fecal, transplants may help some of these individuals respond to the immunotherapy drugs, a new study suggests. Researchers at the NCI, part of the National Institutes of Health, conducted the study in collaboration with investigators from UPMC Hillman Cancer Center at the University of Pittsburgh. (2021-02-04)

Racial disparities: Young, Black adults had significantly worse heart transplant outcomes
Young, Black adults (ages 18-30) are more than twice as likely to die in the first year after a heart transplant compared to non-Black transplant recipients who are the same age. By age 61 and older, there was no significant racial disparity in the health outcomes among heart transplantation recipients. (2021-02-02)

Hematopoietic stem cell transplants may provide long-term benefit for people with MS
A new study shows that intense immunosuppression followed by a hematopoietic stem cell transplant may prevent disability associated with multiple sclerosis (MS) from getting worse in 71% of people with relapsing-remitting MS for up to 10 years after the treatment. The research is published in the January 20, 2021, online issue of Neurology®, the medical journal of the American Academy of Neurology. The study also found that in some people their disability improved over 10 years after treatment. (2021-01-20)

Armouring anti-cancer T cells against immunosuppressants
New 'armoured' T cells attack cancer without being suppressed by drugs given to transplant patients to avoid organ rejection. (2021-01-18)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

Hope for children with rare heart condition: novel stem cell therapy to save the day
In a new study, scientists at Okayama University isolated cardiac stem cells and assessed their potential use as regenerative therapy in young patients with cardiac defects. They confirmed the safety and effectiveness of their proposed treatment in early-phase trials and even identified the mechanism through which the stem cells improved cardiac function. Based on these preliminary findings, they hope to proceed to larger clinical trials and move towards pharmaceutical approval in the future. (2021-01-12)

Non-Hispanic Black patients are disproportionately left off liver transplant waitlists
A new study of liver transplant centers confirms that non-Hispanic white patients get placed on liver transplant waitlists at disproportionately higher rates than non-Hispanic Black patients. (2021-01-11)

IU research findings could reduce treatment-related complication for blood cancer patients
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia. (2021-01-07)

COVID-19 outcomes for patients on immunosuppressive drugs on par with non- immunosuppressed patients
People taking immunosuppressive drugs to prevent organ transplant rejection or to treat inflammatory or autoimmune diseases do not fare worse than others on average when they are hospitalized with COVID-19. (2021-01-07)

New clues on why pregnancy may increase risk of organ transplant rejection
A research study at the University of Chicago has found that in pregnancy, while the T cell response to a fetus becomes tolerant to allow for successful pregnancy, the part of the immune system that produces antibodies (known as the humoral response) becomes sensitized, creating memory B cells that can later contribute to the rejection of a transplanted organ. (2021-01-04)

Frailty is a factor in higher mortality for women awaiting liver transplants
Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (2020-12-30)

Liquid bandage detects tissue oxygenation without the drawbacks of wired oximeters
A paint-on, transparent bandage containing phosphorescent materials reads the amount of oxygen reaching transplanted tissue -- a critical component of a transplant's success. Existing oximeter technology is complicated to use, restricts patients' movements, and is subject to false alarms. The first human trial of the liquid bandage in women undergoing breast reconstruction after cancer found that it performed as well as a wired oximeter device, the current clinical standard. (2020-12-22)

Virtual kidney transplant evaluation allows patients to be evaluated from home
A virtual telehealth platform is allowing the surgery program at the Medical University of South Carolina to evaluate and wait-list patients for kidney transplantation despite reductions in direct, in-person health care visits brought about by the COVID-19 pandemic. (2020-12-21)

Finding a personalized approach to treating chronic rejection after lung transplantation
By studying the roles of an inflammatory protein and antibodies in chronic rejection after lung transplantation, researchers discover possibilities for new treatments. (2020-12-17)

UMD paves the way for growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new paper, University of Maryland researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs. (2020-12-17)

Too many donor kidneys are discarded in U.S. before transplantation
a large portion of the discarded kidneys would function acceptably if transplanted, according to a new study from a team led by researchers in the Perelman School of Medicine at the University of Pennsylvania and the Paris Translational Research Center for Organ Transplantation. (2020-12-15)

One-year kidney allograft outcomes do not differ by hepatitis C status of donor
Study published in AJKD shows that kidney allograft outcomes one year post-transplantation in hepatitis C virus (HCV)-negative recipients do not differ by the HCV status of the donor. (2020-12-14)

Phase 1 trial assesses whether fecal microbiota transplant impacts cancer patients resistant to immu
In one of the first in-human studies to investigate whether modifying the gut microbiome by a fecal microbiota transplant could make cancer immunotherapy more effective, researchers analyzing this in ten cancer patients with refractory melanoma suggest the treatment can improve patient outcomes. (2020-12-10)

UBCO researchers suggest stool transplants can battle serious infections
Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian. (2020-12-09)

Circulating tumor DNA indicates risk of relapse after transplant in DLBCL patients
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse. (2020-12-07)

Study reveals surprising benefit of clonal hematopoiesis in allogeneic transplants
Clonal hematopoiesis (CH) is a recently identified condition in which mutations associated with blood cancers are detected in the blood of some healthy, usually older, individuals who don't have cancer. People with CH, while asymptomatic, have an elevated risk of developing blood cancers and other negative health outcomes, including heart attacks and strokes. (2020-12-05)

Venetoclax added to standard treatments shows promise in high-risk myeloid blood cancers
The novel oral drug venetoclax can be safely added to standard therapies for some high-risk myeloid blood cancers and in early studies the combination shows promise of improved outcomes, say scientists from Dana-Farber Cancer Institute. (2020-12-05)

Donor stem cell transplant shown to improve survival in older patients with MDS
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. (2020-12-04)

Why long-suffering hosts grow a thick skin
Researchers from the University of Tsukuba have shown that the skin fibrosis seen in chronic graft-versus-host disease is mediated by transforming growth factor-β1 expressed by epidermal cells undergoing programmed death when they are stimulated by interferon-γ. Further investigations elucidate the sclerodermatous changes characteristic of autoimmune and inflammatory conditions such as systemic sclerosis, discoid lupus erythematosus and toxic epidermal necrolysis, thus opening up research avenues in pharmacotherapeutics based on targeting apoptosis and interferon-γ. (2020-12-01)

Afro-Caribbean patients with severe kidney disease at greater risk of hospitalisation from COVID-19
Afro-Caribbean people with end stage kidney disease (ESKD) are more likely to be hospitalised with COVID-19 than other ethnicities, a study has found. (2020-11-19)

Stem cell transplantation: undesirable rejection mechanism identified
In the treatment of leukaemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers in Vienna has now identified an immune mechanism that is partially responsible for this. (2020-11-19)

American Heart Association Scientific Sessions to feature Brigham breakthroughs
Leading cardiologists worldwide will convene virtually from November 13-17 at the American Heart Association's 2020 Scientific Sessions, sharing the latest advancements in cardiovascular science and clinical care. The three studies highlighted below represent only a sample of the cutting-edge research Brigham experts in the field will present at the conference. (2020-11-13)

Simultaneous kidney transplant plus weight loss surgery safe for obese patients
A new study shows that robotic-assisted kidney transplant and weight loss surgery can be performed safely. (2020-11-10)

The natural artistry of disease: a wintry landscape in the eye
Researchers from Tokyo Medical and Dental University (TMDU) report a case of frosted branch angiitis in a woman presenting years after being treated for leukemia-lymphoma with allogeneic human stem cell transplant. The relevance of this ocular finding is discussed and its value as an early warning sign of immune activation following therapeutic immunological interventions is highlighted. (2020-11-09)

Baking soda treatment may help prevent leukemia relapse after stem cell transplants
Scientists have discovered that sodium bicarbonate - also known as baking soda or bicarbonate of soda - can reprogram T cells in leukemia patients to resist the immune-suppressing effects of cancer cells, which can drive leukemia relapse after stem cell transplants. (2020-10-28)

Poverty linked to higher risk of death in children with cancer undergoing transplant
Despite the increasing use and promise of hematopoietic cell transplantation (HCT) as curative therapy for children with cancer and other life-threatening diseases, new research suggests that children transplanted for cancer are more likely to die from treatment-related complications if they live in poorer neighborhoods. The study, published today in the journal Blood, also found that having Medicaid versus private insurance, another marker of poverty, was associated with a higher chance of dying. (2020-10-26)

Cell-Free DNA provides a dynamic window into health
A new study presented at the ASHG 2020 Virtual Meeting shows how cfDNA testing can be used to provide insight into a patient's health. (2020-10-26)

Study reveals details behind transplant disparities experienced by black patients
In an analysis of information on patients with kidney failure, Black patients are less likely than white patients to be placed on transplant waiting lists. For patients on such lists, Blacks are less likely to receive transplants than whites. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-25)

The effects of social determinants of health on kidney transplant candidates
Social determinants of health are associated with patient-reported outcomes in adults who are eligible to undergo kidney transplantation evaluations. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-25)

Type 1 diabetes: Tannic acid encapsulation protects transplanted islets from rejection
One therapy for Type 1 diabetes is promising -- transplanting pancreatic islets from cadavers -- but a need for immunosuppression and a reactivated autoimmunity lead to low graft viability and function after five years. Now researchers show that a protective coating of alternating layers of two biopolymers delays allograft and autoimmune-mediated rejection in mouse models of T1D. (2020-10-22)

Does the new heart transplant allocation policy encourage gaming by providers?
A new national policy was created to make determining who receives a heart transplant more fair. But new data shows it changed some practice patterns, too. (2020-10-20)

UT Southwestern leads national efforts around childhood blood disorders
When a child has a rare blood disorder, clinicians can struggle to find the best diagnostic and treatment methods. New research led by UT Southwestern shows the effectiveness of a treatment for aplastic anemia and reveals the range of diagnosis and treatment options used by hospitals around the country for a related disease - myelodysplastic syndrome (MDS). (2020-10-15)

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