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Current Transplantation News and Events

Current Transplantation News and Events, Transplantation News Articles.
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Poverty linked to higher risk of death in children with cancer undergoing transplant
Despite the increasing use and promise of hematopoietic cell transplantation (HCT) as curative therapy for children with cancer and other life-threatening diseases, new research suggests that children transplanted for cancer are more likely to die from treatment-related complications if they live in poorer neighborhoods. (2020-10-26)
Study reveals details behind transplant disparities experienced by black patients
In an analysis of information on patients with kidney failure, Black patients are less likely than white patients to be placed on transplant waiting lists. (2020-10-25)
Gut bacteria linked to weight gain following chemotherapy treatment for breast cancer
A new study suggests that gut bacteria are partially responsible for metabolic changes that lead to weight gain following chemotherapy treatment. (2020-10-21)
Octopus-inspired sucker transfers thin, delicate tissue grafts and biosensors
Thin tissue grafts and flexible electronics have a host of applications for wound healing, regenerative medicine and biosensing. (2020-10-16)
Hearts harvested from pigs may soon help solve chronic shortages of these donor organs
An analysis discusses scientific breakthroughs that have overcome obstacles to cardiac xenotransplantation. (2020-10-07)
Effects of acute and chronic graft-versus-myelodysplastic syndrome on long-term outcomes following a
A research group led by Assistant Professor Takaaki Konuma in the Department of Hematology/Oncology, the Hospital of the Institute of Medical Science, the University of Tokyo (IMSUT Hospital) has demonstrated a graft-versus-tumor (GVT) effect of a previously unknown/novel allogeneic hematopoietic cell transplantation in MDS patients. (2020-10-06)
A small switch with a big impact
Minor changes in immune cells can significantly affect the immune response, scientists of the University of Würzburg have now discovered. (2020-10-05)
Could a poo transplant one day be the secret of eternal youth?
Poo transplants could one day be used to restore cognitive decline among the elderly - according to new research. (2020-10-02)
AGA releases largest report on safety and effectiveness of fecal microbiota transplantation
Today, the American Gastroenterological Association (AGA) released the first results from the NIH-funded AGA Fecal Microbiota Transplantation (FMT) National Registry, the largest real-world study on the safety and effectiveness of FMT. (2020-10-01)
Super-potent blood stem cells discovered in human embryos
In research recently published in Stem Cell Reports, Andrejs Ivanovs, Alexander Medvinsky (a.medvinsky@ed.ac.uk) and colleagues from the University of Edinburgh discovered that HSCs from early human embryos, when HSCs are just starting to form, are more robust at expanding than those from the cord blood. (2020-09-17)
EBMT trial shows improvements in treatment of Severe Aplastic Anaemia
The European Society for Blood and Marrow Transplantation (EBMT), Europe's collaborative peer network of professionals working in the field of stem cell transplantation and cellular therapy, announced today the results of the phase III RACE trial during EBMTs virtual 46th Annual Meeting. (2020-08-31)
A soft-hearted approach to healing
Researchers at the University of Tsukuba and Keio University have clarified the roles of matrix stiffness and mechanotransduction as well as the signaling pathways in the transformation of cardiac fibroblasts into contractile cardiomyocytes and show that soft substrates comparable to native myocardium improve the efficiency of this cardiac reprogramming. (2020-08-30)
Rejuvenating old organs could increase donor pool
Investigators from Brigham and Women's Hospital are leading efforts to breathe new life into older organs by leveraging a new class of drugs known as senolytics, which target and eliminate old cells. (2020-08-27)
Ratio of two proteins may add kidneys to the transplant donor pool
An investigation by researchers at Johns Hopkins Medicine, in collaboration with researchers at 13 other medical institutions in the United States, has shown that two proteins found in deceased donor urine can be measured to define which donor organs -- including those with AKI -- are the best candidates for saving the lives of patients with kidney failure. (2020-08-18)
Immune response to Sars-Cov-2 following organ transplantation
Even patients with suppressed immune systems can achieve a strong immune response to Sars-Cov-2. (2020-08-17)
Heart regeneration using stem cells: Why irregular heartbeats occur after transplantation
Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo elucidated why arrhythmia occurs post-transplant of hESC-CMs. (2020-08-05)
Move over Akita: Introducing 'Kuma mutant' mice for islet transplantation research
Scientists at the Tokyo Institute of Technology (Tokyo Tech) have used a gene editing technique to establish a novel mouse model of permanent neonatal diabetes--the immune-deficient Kuma mutant mice with a specific deletion in the Insulin2 (Ins2) gene. (2020-08-05)
Insights on the gut microbiome could shape more powerful, precise treatment
In a recently published study, investigators from Brigham and Women's Hospital explore how the dynamics of bacterial species may influence the success of fecal microbiota transplantation in treating recurrent C. difficile infection. (2020-07-31)
Kidney transplantation between people with HIV is safe, NIH study finds
Kidney transplantation from deceased donors with HIV to people living with both HIV and end-stage kidney disease is feasible and safe, investigators supported by the National Institutes of Health have found. (2020-07-23)
Healthy offspring from testicular tissue plantation in mice: Retinoic acid key
Germ cell depletion in recipient testis has adverse effects on spermatogenesis in orthotopically transplanted testis pieces via retinoic acid insufficiency. (2020-07-16)
New hope for kidney revival for transplant
Cell therapy delivered directly to the kidney can revive a 'marginal' organ, improving function and could offer new hope for providing more kidneys for transplant. (2020-07-14)
Human lungs rejected for transplant recovered using novel technique
A multidisciplinary team from Vanderbilt University Medical Center (VUMC) and Columbia University has demonstrated that injured human donor lungs declined for transplant can be recovered by cross-circulation between the human lung and a xenogeneic host. (2020-07-13)
A bioartificial system acts as 'dialysis' for failing livers in pigs
A bioartificial system that incorporates enhanced liver cells can act as an analogous form of dialysis for the liver in pigs, effectively carrying out the organ's detoxifying roles and preventing further liver damage in animals with acute liver failure. (2020-07-08)
Loss of intestinal goblet cells causes fatal disease after stem cell transplantation
Allogeneic stem cell transplantation can cause a loss of protective goblet cells from the colon's inner lining, which can be fatal. (2020-07-01)
A revolutionary new treatment alternative to corneal transplantation
A new approach in ophthalmology that offers a revolutionary alternative to corneal transplantation has just been developed by researchers and clinicians in North America, Europe, and Oceania. (2020-06-30)
Researchers have found a promising therapy for cardiac regeneration
New research gives information in order to understand safety, efficacy and mechanisms of action of a new cardiac therapy. (2020-06-30)
Study finds HCV-positive livers safe for transplantation; Patients cured afterward
UC researchers find similar results for positive outcomes when comparing patients receiving livers infected with hepatitis C to patients who receive livers without infection. (2020-06-22)
A novel radioisotope therapy for children with neuroblastoma
Researchers from Kanazawa University retrospectively analyzed children with refractory or relapsed high-risk neuroblastoma who were treated with high-dose 131I-metaiodobenzylguanidine at Kanazawa University Hospital. (2020-06-19)
Liver perfusion could save 7 in 10 rejected donor livers
A major study investigating the effectiveness of liver perfusion as a technique to improve the function of donor livers that would have otherwise been rejected has shown that up to 7 in every 10 could be used after just 4-6 hours of the assessment. (2020-06-17)
For babies born with a rare immune deficiency, a unique new test to better target care
A new test developed at CHU Sainte-Justine in Montreal will enable better management of patients with severe combined immunodeficiency (SCID). (2020-06-17)
Fred Hutch and University of Washington experts: Treat COVID-19 earlier to save lives
Infectious disease experts from Fred Hutchinson Cancer Research Center and UW Medicine are advocating for earlier actions to reduce hospitalizations and deaths from COVID-19. (2020-06-16)
Women are not more likely to die of cirrhosis than men, despite fewer liver transplants
Prior studies suggested women might have higher mortality of cirrhosis of the liver than men. (2020-06-04)
Kidney transplantations: Better results with larger case volumes
Kidney transplantations: better results with larger case volumes. Survival probabilities increase in hospitals where kidneys are transplanted more frequently. (2020-05-25)
Kidney transplants: Better results can be inferred from a larger number of cases
Kidney transplants: Better results can be derived with larger numbers of cases. (2020-05-22)
Critical window for re-infection with HIV after stem cell transplantation
So far, allogeneic stem cell transplantation for the treatment of severe blood cancers has been the only medical intervention to have cured at least three people infected with the HI virus. (2020-05-14)
Immune system discovery paves way to lengthen organ transplant survival
A new discovery in mice shows the innate immune system has 'memory,' previously thought to be a unique feature of the adaptive immune system. (2020-05-08)
Researchers have found accumulation of gene mutations in chronic Graft-versus-host disease
Mutations in white blood cells can contribute to abnormal immune profile after hematopoietic stem cell transplantation. (2020-05-07)
UB investigators uncover cellular mechanism involved in Krabbe disease
Researchers determined which cells are involved in Krabbe disease and by which mechanism. (2020-05-05)
Research suggests new therapeutic target for kidney diseases
Researchers have published a new study that suggests a signaling pathway called ROBO2 is a therapeutic target for kidney diseases, specifically kidney podocyte injury and glomerular diseases. (2020-05-04)
Landmark 30-year study on Crigler-Najjar syndrome underscores the need for new therapies
A new study summarizes more than 30 years of clinical experience and describes the clinical course of 28 individuals homozygous for damaging mutations in the UGT1A1 gene who were born between 1984 and 2015 with Crigler-Najjar syndrome. (2020-04-16)
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