Current Transplantation News and Events

Current Transplantation News and Events, Transplantation News Articles.
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Lab-grown 'mini-bile ducts' used to repair human livers in regenerative medicine first
Scientists at the University of Cambridge have used a technique to grow bile duct organoids - often referred to as 'mini-organs' - in the lab and shown that these can be used to repair damaged human livers. This is the first time that the technique has been used on human organs. (2021-02-18)

Organoids grown from bile duct cells repair human livers; may aid liver transplant processes
Organoids grown from bile duct epithelial cells can be used to repair damaged bile ducts in transplanted human livers, researchers report. (2021-02-18)

Researchers explore how to protect gut integrity to improve outcomes in blood cancers
MUSC Hollings Cancer Center researchers found that a single strain of bacteria may be able to reduce the severity of graft-versus-host disease. (2021-02-10)

"Genetic SD-card": Scientists obtained new methods to improve the genome editing system
Researchers take a step in the development of genome editing technology. Currently it is possible to deliver genetic material of different sizes and structures to organs and tissues. This is the key to eliminating DNA defects and treating more patients. (2021-02-02)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

IU research findings could reduce treatment-related complication for blood cancer patients
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center published promising findings today in the New England Journal of Medicine on preventing a common complication to lifesaving blood stem cell transplantation in leukemia. (2021-01-07)

Frailty is a factor in higher mortality for women awaiting liver transplants
Women awaiting liver transplants in the United States are known to be about one-third more likely than men to become too ill to undergo surgery or die before receiving a liver. Now a study headed by UC San Francisco and Columbia University highlights the role that frailty plays in this gender gap. (2020-12-30)

Heart transplantations: prospects of success increase with larger case volumes
Heart transplantations: prospects of success increase with larger case volumes The survival probabilities for patients undergoing surgery are higher in hospitals where heart transplants are performed more frequently. (2020-12-28)

Virtual kidney transplant evaluation allows patients to be evaluated from home
A virtual telehealth platform is allowing the surgery program at the Medical University of South Carolina to evaluate and wait-list patients for kidney transplantation despite reductions in direct, in-person health care visits brought about by the COVID-19 pandemic. (2020-12-21)

New study: available drugs can prevent rejection and tissue injury after transplantation
Controlling inflammation after transplantation of organs, cells, or tissues is critical for graft survival; however, it can be difficult. Continuing injuries due to chronic rejection can be particularly problematic. Now, a team of researchers from Albert Einstein College of Medicine report that neutralizing the cell signaling molecule, tumor necrosis factor (TNF), can prevent cascades of injurious molecules and signals after cell transplantation in The American Journal of Pathology, published by Elsevier. (2020-12-21)

Stem cell treatment for vascular diseases can be predicted through real-time observation
The Korea Institute of Science and Technology(KIST) recently announced that the collaborative research team led by Dr. Kwangmeyung Kim from Center for Theragnosis and Sung-Hwan Moon from Stem Cell Research Institute, T&R Biofab Co. Ltd developed a method that can predict the therapeutic efficacy based on the distribution of the initial transplantation of hEPCs by tracking the initial distribution and migration of the transplanted cells using fluorescence romographic images. (2020-12-18)

Finding a personalized approach to treating chronic rejection after lung transplantation
By studying the roles of an inflammatory protein and antibodies in chronic rejection after lung transplantation, researchers discover possibilities for new treatments. (2020-12-17)

UMD paves the way for growing human organs for transplantation with new proof-of-concept
With the number of people who suffer from organ failures and the growing need for available organs for transplant, finding a new way to provide organs and therapeutic options to transplant patients is a critical need. In a new paper, University of Maryland researchers show for the first time that newly established stem cells from pigs could provide a solution, laying the groundwork for growing transplantable human organs. (2020-12-17)

Too many donor kidneys are discarded in U.S. before transplantation
a large portion of the discarded kidneys would function acceptably if transplanted, according to a new study from a team led by researchers in the Perelman School of Medicine at the University of Pennsylvania and the Paris Translational Research Center for Organ Transplantation. (2020-12-15)

One-year kidney allograft outcomes do not differ by hepatitis C status of donor
Study published in AJKD shows that kidney allograft outcomes one year post-transplantation in hepatitis C virus (HCV)-negative recipients do not differ by the HCV status of the donor. (2020-12-14)

Findings about cilia on cells of the vessel wall may be relevant for diabetes treatment
A new study from Karolinska Institutet and the Helmholtz Diabetes Research Center shows that primary cilia, hair-like protrusions on endothelial cells inside vessels, play an important role in the blood supply and delivery of glucose to the insulin-producing beta cells in the pancreatic islets. The findings are published in eLife and may be relevant for transplantation therapies in diabetes, as formation of functional blood vessels is important for the treatment to be successful. (2020-12-04)

Donor stem cell transplant shown to improve survival in older patients with MDS
A new clinical trial offers the most compelling evidence to date that a donor stem cell transplant can improve survival rates for older patients with higher-risk myelodysplastic syndrome (MDS), Dana-Farber Cancer Institute investigators report at the virtual 62nd American Society of Hematology (ASH) Annual Meeting. (2020-12-04)

To increase organs available for transplant, reassess organ procurement organizations' metrics
A new paper analyzes the metrics used to evaluate organ procurement organizations and proposes three complimentary metrics to reflect more accurate and equitable performance rankings. (2020-12-02)

Stem cell transplantation: undesirable rejection mechanism identified
In the treatment of leukaemia, stem cell transplantation subsequent to chemotherapy and radiation can often engender severe adverse inflammatory reactions - especially in the skin or in the gut, since these so-called barrier organs are more frequently affected. Up until now, the reason for this was unclear. A team of researchers in Vienna has now identified an immune mechanism that is partially responsible for this. (2020-11-19)

New European consensus on management of osteoporosis in advanced chronic kidney disease
This Consensus is authored by the European Renal Osteodystrophy Working Group, with expertise from the European Renal Association-European Dialysis and Transplant Association and the International Osteoporosis Foundation. It provides a succinct review of current clinical practice, and outlines practical recommendations for diagnosis, assessment of fracture risk, intervention thresholds, non-pharmacological and pharmacological intervention strategies, monitoring, and secondary fracture prevention. (2020-11-11)

Simultaneous kidney transplant plus weight loss surgery safe for obese patients
A new study shows that robotic-assisted kidney transplant and weight loss surgery can be performed safely. (2020-11-10)

Baking soda treatment may help prevent leukemia relapse after stem cell transplants
Scientists have discovered that sodium bicarbonate - also known as baking soda or bicarbonate of soda - can reprogram T cells in leukemia patients to resist the immune-suppressing effects of cancer cells, which can drive leukemia relapse after stem cell transplants. (2020-10-28)

Poverty linked to higher risk of death in children with cancer undergoing transplant
Despite the increasing use and promise of hematopoietic cell transplantation (HCT) as curative therapy for children with cancer and other life-threatening diseases, new research suggests that children transplanted for cancer are more likely to die from treatment-related complications if they live in poorer neighborhoods. The study, published today in the journal Blood, also found that having Medicaid versus private insurance, another marker of poverty, was associated with a higher chance of dying. (2020-10-26)

Study reveals details behind transplant disparities experienced by black patients
In an analysis of information on patients with kidney failure, Black patients are less likely than white patients to be placed on transplant waiting lists. For patients on such lists, Blacks are less likely to receive transplants than whites. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-25)

Gut bacteria linked to weight gain following chemotherapy treatment for breast cancer
A new study suggests that gut bacteria are partially responsible for metabolic changes that lead to weight gain following chemotherapy treatment. If the composition of intestinal bacteria may predict which women will gain weight as a result of chemotherapy, researchers say they eventually hope to identify women at risk of gaining weight and offer methods to prevent it. (2020-10-21)

Octopus-inspired sucker transfers thin, delicate tissue grafts and biosensors
Thin tissue grafts and flexible electronics have a host of applications for wound healing, regenerative medicine and biosensing. A new device inspired by an octopus's sucker rapidly transfers delicate tissue or electronic sheets to the patient, overcoming a key barrier to clinical application, according to researchers at the University of Illinois at Urbana-Champaign and collaborators. (2020-10-16)

Hearts harvested from pigs may soon help solve chronic shortages of these donor organs
An analysis discusses scientific breakthroughs that have overcome obstacles to cardiac xenotransplantation. (2020-10-07)

Effects of acute and chronic graft-versus-myelodysplastic syndrome on long-term outcomes following a
A research group led by Assistant Professor Takaaki Konuma in the Department of Hematology/Oncology, the Hospital of the Institute of Medical Science, the University of Tokyo (IMSUT Hospital) has demonstrated a graft-versus-tumor (GVT) effect of a previously unknown/novel allogeneic hematopoietic cell transplantation in MDS patients. In addition, they succeeded in identifying a category of patients for whom the GVT effect was identified. (2020-10-06)

A small switch with a big impact
Minor changes in immune cells can significantly affect the immune response, scientists of the University of W├╝rzburg have now discovered. Their findings could be relevant for stem cell therapy. (2020-10-05)

Could a poo transplant one day be the secret of eternal youth?
Poo transplants could one day be used to restore cognitive decline among the elderly - according to new research. A new study published today shows how faecal transplants from older to younger mice altered their gut microbiome, which in turn impacted their spatial learning and memory. The research team hope the reverse could also be true, and one day used as a therapy to restore cognitive function in older people. (2020-10-02)

AGA releases largest report on safety and effectiveness of fecal microbiota transplantation
Today, the American Gastroenterological Association (AGA) released the first results from the NIH-funded AGA Fecal Microbiota Transplantation (FMT) National Registry, the largest real-world study on the safety and effectiveness of FMT. Published in Gastroenterology, the registry reported that FMT led to a cure of Clostridioides difficile (C. difficile) infection in 90% of patients across 20 North American FMT practice sites. Few serious side effects were reported. (2020-10-01)

Super-potent blood stem cells discovered in human embryos
In research recently published in Stem Cell Reports, Andrejs Ivanovs, Alexander Medvinsky (a.medvinsky@ed.ac.uk) and colleagues from the University of Edinburgh discovered that HSCs from early human embryos, when HSCs are just starting to form, are more robust at expanding than those from the cord blood. (2020-09-17)

EBMT trial shows improvements in treatment of Severe Aplastic Anaemia
The European Society for Blood and Marrow Transplantation (EBMT), Europe's collaborative peer network of professionals working in the field of stem cell transplantation and cellular therapy, announced today the results of the phase III RACE trial during EBMTs virtual 46th Annual Meeting. Preliminary data show that adding Eltrombopag to standard immunosuppressive treatment is safe and increases response rates in patients with Severe Aplastic Anaemia (SAA). (2020-08-31)

A soft-hearted approach to healing
Researchers at the University of Tsukuba and Keio University have clarified the roles of matrix stiffness and mechanotransduction as well as the signaling pathways in the transformation of cardiac fibroblasts into contractile cardiomyocytes and show that soft substrates comparable to native myocardium improve the efficiency of this cardiac reprogramming. This has potential for research into biomaterials and may lead to clinical advances in regenerative treatment for heart failure. (2020-08-30)

Rejuvenating old organs could increase donor pool
Investigators from Brigham and Women's Hospital are leading efforts to breathe new life into older organs by leveraging a new class of drugs known as senolytics, which target and eliminate old cells. (2020-08-27)

Ratio of two proteins may add kidneys to the transplant donor pool
An investigation by researchers at Johns Hopkins Medicine, in collaboration with researchers at 13 other medical institutions in the United States, has shown that two proteins found in deceased donor urine can be measured to define which donor organs -- including those with AKI -- are the best candidates for saving the lives of patients with kidney failure. (2020-08-18)

Immune response to Sars-Cov-2 following organ transplantation
Even patients with suppressed immune systems can achieve a strong immune response to Sars-Cov-2. A test helps to adapt therapy following an infection. (2020-08-17)

Heart regeneration using stem cells: Why irregular heartbeats occur after transplantation
Increased predominance of the matured ventricular subtype in embryonic stem cell-derived cardiomyocytes in vivo elucidated why arrhythmia occurs post-transplant of hESC-CMs. (2020-08-05)

Move over Akita: Introducing 'Kuma mutant' mice for islet transplantation research
Scientists at the Tokyo Institute of Technology (Tokyo Tech) have used a gene editing technique to establish a novel mouse model of permanent neonatal diabetes--the immune-deficient Kuma mutant mice with a specific deletion in the Insulin2 (Ins2) gene. This model is expected to be useful for studying the mechanisms governing insulin-producing cell dysfunctions in the pancreas as well as for evaluating human stem-cell derived or interspecies-derived insulin-producing cell transplantation. (2020-08-05)

Insights on the gut microbiome could shape more powerful, precise treatment
In a recently published study, investigators from Brigham and Women's Hospital explore how the dynamics of bacterial species may influence the success of fecal microbiota transplantation in treating recurrent C. difficile infection. In Nature Communications, the team presents an algorithm to design personalized probiotic cocktails for patients with unhealthy gut microbiomes due to rCDI. (2020-07-31)

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