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Current Transplantation News and Events, Transplantation News Articles.
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Lungs clothed in fresh cells offer new hope for transplant patients
Now Daniel Weiss at the Vermont Lung Center in collaboration with Cheryl Nickerson and her colleagues at the Biodesign Institute at Arizona State University are exploring a radically new approach for developing viable lung tissue suitable for transplantation. (2012-02-01)

Cardiopulmonary exercise testing may predict post-liver transplantation survival
Researchers from the UK determined that preoperative cardiopulmonary exercise testing is a specific predictor of 90-day survival following liver transplantation. Study results available in the February issue of Liver Transplantation, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, shows that the CPET measurement -- the anaerobic threshold or fitness level -- significantly predicts mortality in patients post-transplantation. (2012-01-31)

New agent improves kidney transplant survival in mice, likely to speed replacement of other organs
New research published online in the FASEB Journal details a new antibody, called (2012-01-31)

Lung transplant system often skips over those most in need
The system for allocating donated lungs based on proximity and not on need appears to decrease the potential benefits of lung transplantation and increase the number of patients who die waiting. In 2009, lungs were routinely allocated to less urgent, local candidates even when there were patients within the region but outside the local donor service who were in much greater need. (2012-01-31)

Extracorporeal membrane oxygenation as a bridge to lung transplantation
Extracorporeal membrane oxygenation support in awake, non-intubated patients may be an effective strategy for bridging patients to lung transplantation, according to a new study from Germany. (2012-01-20)

U-M News: Kidney failure risk higher for liver transplant patients following policy change
Research from the University of Michigan Health System shows the risk for kidney failure among liver transplant recipients is higher following the implementation of Model of End Stage Liver Disease (MELD), a policy change in 2002 that altered how liver transplant allocation is decided. (2012-01-17)

Thousands of seniors lack access to lifesaving organs, despite survival benefit
Thousands more American senior citizens with kidney disease are good candidates for transplants and could get them if physicians would get past outdated medical biases and put them on transplant waiting lists, according to a new study by Johns Hopkins researchers. (2012-01-12)

Maternal liver grafts more tolerable for children with rare disease
Children with a rare, life-threatening disease that is the most common cause of neonatal liver failure -- biliary atresia -- better tolerate liver transplants from their mothers than from their fathers, according to a UCSF-led study. (2012-01-03)

An inside look at face transplantation
Researchers describe details of patient preparation, novel design and execution of the operation as well as unique immunosuppression protocol allowing for lowest long-term maintenance drug regimen. (2011-12-28)

Grafting of human spinal stem cells into ALS rats best with immunosuppressant combination
Researchers grafting human spinal stem cells into rats modeled with amyotrophic lateral sclerosis (ALS) tested four immunosuppressive protocols to determine which regimen improved long-term therapeutic effects. Combined, systematically delivered immunosuppression regimens of tacrolimus (FK506) and mycophenolate significantly improved the survival of transplanted human spinal stem cells. While the two in combination were most effective and led to a robust graft survival three weeks after grafting, a longer half-life for mycophenolate may have been responsible. (2011-12-19)

Bone marrow-derived cells differentiate in the brain through mechanisms of plasticity
When bone marrow-derived stem cells (BMDCs) were grafted into mutant mice suffering from degeneration of specific neuronal populations at different ages, more bone marrow-derived microglial cells were observed in olfactory bulbs of the test animals where degeneration of mitral cells was still in progress, rather than in the cerebellum where cell degeneration had been completed, showing that BMDCs contribute to the central nervous system variably in the same animal depending on region and cell-specific factors. (2011-12-19)

Obesity and diabetes epidemics spur increase in nonalcoholic steatohepatitis
Nonalcoholic steatohepatitis (NASH) is rapidly increasing in the US mainly related to the epidemics of obesity and diabetes. As a result, the proportion of liver transplantations performed for NASH cirrhosis rose dramatically from roughly 1 percent in 1997-2003 to more than 7 percent in 2010. However, according to new research published in Liver Transplantation, a peer-reviewed journal of the American Association for the Study of Liver Diseases, post-transplantation survival for NASH patients is excellent, with one-year survival rates near 88 percent. (2011-12-14)

NewYork-Presbyterian/Columbia surgeons perform first 'ex vivo' lung transplants in New York
A 59-year-old woman from upstate New York and a 60-year-old woman from the New York metro area were the first patients in New York state and among the first in the United States to receive transplanted lungs that were assessed and reconditioned in the operating room -- a technique that has the potential to dramatically increase the availability of lungs for transplant. The experimental procedure was performed by Dr. Frank D'Ovidio at NewYork-Presbyterian Hospital/Columbia University Medical Center. (2011-12-12)

Moffitt researchers will be strong participants in American Society of Hematology meeting
When the American Society of Hematology convenes its 53rd Annual Meeting and Exposition on Dec. 10-13 in San Diego, Calif., researchers from Moffitt Cancer Center will break a new record for Moffitt participants with one plenary presentation, 16 oral presentations and more than 50 poster presentations on new research results in a variety of meeting programs that focus on blood cancer basic science and clinical applications, including bone marrow transplantation and clinical trials results. (2011-12-05)

Green tea flavonoid may prevent reinfection with hepatitis C virus following liver transplantation
German researchers have determined that epigallocatechin-3-gallate (EGCG) -- a flavonoid found in green tea -- inhibits the hepatitis C virus from entering liver cells. Study findings available in the December issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases, suggest that EGCG may offer an antiviral strategy to prevent HCV reinfection following liver transplantation. (2011-12-01)

Transplant candidates seek 'best quality' livers despite having to remain on waiting list
New research reveals that liver transplantation candidates want to be involved in decisions regarding quality of the donor organ, and many are reluctant to accept organs with a higher risk of failure. In fact, more than 42 percent of patients would choose to remain on the waiting list rather than accept a (2011-12-01)

Transplant candidates seek best quality livers, even if it means waiting longer
U-M researcher finds patients would rather be on waiting list than accept an organ with higher risk of failure. (2011-12-01)

Integrated 3-D imaging facilitates human face transplantation
By combining conventional medical imaging with some of the same 3-D modeling techniques used in Hollywood blockbusters, researchers are offering new hope to victims of serious facial injuries who may be candidates for human facial transplants. (2011-11-28)

New hope for young leukemia patients?
The development of simple tests to predict a leukemic relapse in young patients is a step closer thanks to researchers from the Sainte-Justine University Hospital Research Center and the University of Montreal. (2011-11-17)

Should doctors encourage people to donate a kidney to a stranger?
With three people on the kidney transplant list dying in the UK every day, should doctors encourage their patients to put themselves at risk for the benefit of others? Two experts debate the issue on today. (2011-11-15)

Racial inequalities exist for kids with kidney disease
Pediatric racial minorities are much less likely than whites to get kidney transplants before they need dialysis, regardless of their families' income. Among children with kidney failure waiting for a transplant, blacks with no health insurance are more likely to die than whites, while Hispanics are less likely to die than other racial groups regardless of insurance status. (2011-11-10)

Adult living donor liver transplants safe, study finds
Desperately needed adult living donor liver transplantation is a safe surgery for the donor, according to researchers at Henry Ford Hospital. The study looked at donor safety from a single center over a period of 10 years and found there were no patient deaths and no life-threatening complications requiring ICU care. (2011-11-08)

Experimental drug suppresses rebound of hepatitis C virus in liver transplant patients
A human monoclonal antibody developed by MassBiologics of the University of Massachusetts Medical School (UMMS) given to patients with chronic hepatitis C virus (HCV) infection undergoing liver transplantation significantly suppressed the virus for at least a week after transplant and delayed the time to viral rebound. (2011-11-07)

Reprogramming stem cells to a more basic form results in more effective transplant, study shows
Chinese stem cell scientists have published new research that improves the survival and effectiveness of transplanted stem cells. The research led by Dr. Hsiao Chang Chan, from the Chinese University of Hong Kong, is published in Stem Cells. (2011-11-03)

Age no longer a barrier to stem cell transplantation for older patients
Age alone no longer should be considered a defining factor when determining whether an older patient with blood cancer is a candidate for stem cell transplantation. (2011-11-01)

Recipients of organ transplants at increased risk for broad range of cancers
Patients who have received a solid organ transplant, such as kidney, liver, heart or lung, have an overall cancer risk that is double that of the general population, with an increased risk for many different types of malignancies, according to a study in the Nov. 2 issue of JAMA. (2011-11-01)

UK HealthCare surgeons are first to perform novel procedures prior to transplant
Surgeons at UK HealthCare recently became the first ever to perform two specific procedures together as a bridge to lung transplantation. (2011-10-31)

Heart transplant surgery safe and effective: A Canadian retrospective spanning 3 decades
Researchers at the University of Ottawa Heart Institute heart transplant program revealed results from 25 years of follow-up on a total of 461 transplant patients. Mean age at transplant was 49 ±13 years. Patients were followed and managed according to guidelines in effect at the time. They found that survival rates have improved by more than 20 percent over the years since modern heart transplantation became available in 1980. (2011-10-24)

Joint preservation in osteoarthritis
Reconstructive surgical approaches can help delay endoprosthetic joint replacement in patients with osteoarthritis. Henning Madry and coauthors introduce such procedures in the current issue of Deutsches Aerzteblatt International. (2011-10-21)

Successful pregnancy possible after kidney transplant
A new study recently published in the American Journal of Transplantation reveals that the ability to successfully carry a pregnancy after kidney transplantation is very high, with 73.5 percent live birth rates. (2011-10-20)

Genetically engineered pigs have brought us to the cusp of xenotransplantation
Xenotransplantation (the use of animal organs, tissues or cells in humans) has made great strides in the past decade. Previous difficulties in helping a human host accept such transplants have been overcome thanks to the increasing availability of genetically modified pigs equipped with genes to protect them from the human immune response. (2011-10-20)

Altering present criteria for matching donors and recipients could improve transplant survival
Selecting better matched recipients and donors than is currently required for umbilical-cord blood transplantation could substantially reduce transplant-related deaths. The findings, published Online First in The Lancet Oncology should change standard practice for cord-blood donor selection. (2011-10-06)

Researchers devise index for predicting long-term survival after liver re-transplantation
UCLA researchers have identified eight risk factors for potential re-transplantation failure and, using mathematical modeling, developed a risk scoring system ranging from 0 to 12 to gauge the risk of re-transplantation failure. (2011-09-28)

High-risk donor livers used with greater frequency in transplantations
The shortage of available organs for transplantation has driven up use of high-risk donor livers. New research published in the October issue of Liver Transplantation, a journal of the American Association for the Study of Liver Diseases, reported that high volume transplant centers more frequently utilized livers with a high donor risk index, but achieved better risk-adjusted graft and recipient survival rates compared with lower volume centers. (2011-09-28)

Living donor liver transplantation improves survival over deceased donor transplants
New research shows liver transplantation candidates without hepatocellular carcinoma (HCC) derive a greater survival benefit from a living donor liver transplant (LDLT) than waiting for a deceased donor liver transplant (DDLT). The study is now available in the October issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases. (2011-09-27)

Cell Transplantation study shows bone growth from implanted tooth and dental pulp stem cells
Dental pulp stem cells and stem cells from deciduous teeth can be easily extracted from deciduous teeth, which are routinely lost in childhood and discarded. Here, stem cells derived from deciduous canine teeth and dental pulp from puppies were grafted to their parents, resulting in well-formed mature bone and neovascularization with increased immunosuppressive activity, demonstrating potential clinical applications in allogenic, in vivo stem cell transplantation calcified tissue reconstruction. (2011-09-26)

FDA grants cardiotrophin-1 Orphan Drug status for acute liver failure treatment to Digna Biotech
Biotechnological company Digna Biotech announced that the Food and Drug Administration granted cardiotrophin-1 Orphan Drug status for use in the treatment of acute liver failure. (2011-09-22)

Time to stop giving toxic drugs to kidney transplant patients?
A new analysis has found that transplant patients can safely minimize or avoid using calcineurin inhibitors. The study, conducted by Richard Borrows, MD and his colleagues at the Renal Institute of Birmingham, in England, appears in an upcoming issue of the Journal of the American Society Nephrology (JASN), a publication of the American Society of Nephrology. (2011-09-22)

Anti-reflux surgery helps airway function both before and after lung transplant
Surgery to correct gastroesophageal reflux disease, or GERD, can preserve lung function in patients with end-stage pulmonary disease both before and after transplantation, according to a new study from the University of Pittsburgh School of Medicine. The findings, published in the Archives of Surgery, suggest that esophageal testing should be performed more frequently among these patients to determine if anti-reflux surgery is needed. (2011-09-19)

Substitution of brand name with generic drug proves safe for transplant recipients
A new study published in the American Journal of Transplantation reveals that substitution of a brand name immunosuppressive drug with a generic (manufactured by Sandoz) for preventing rejection of transplanted organs appears to be safe for transplant recipients. (2011-09-13)

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