Current Tumor Growth News and Events

Current Tumor Growth News and Events, Tumor Growth News Articles.
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Study shows new treatment pathway to prevent and treat endometrial cancer recurrence
In a new study led by Yale Cancer Center, researchers demonstrate sex hormones and insulin growth factors are associated with recurrence risk of endometrial cancer. (2021-02-23)

Cancer cell vulnerability points to potential treatment path for aggressive disease
A new study in Nature Communications describes the discovery of a unique dependence of cancer cells on a particular protein, which could lead to desperately needed treatment for hard-to-treat cancers. (2021-02-22)

Scientists model a peculiar type of breast cancer
Scientists led by EPFL have developed a breakthrough in vivo model for invasive lobular carcinoma, a serious yet understudied type of breast cancer. The work will open up previously inaccessible study of the tumor's biology and help discover new therapies. (2021-02-22)

Cancer control: Non-DNA changes induce metabolism variations in hepatocellular carcinomas
Mechanisms underlying metabolic variations in hepatocellular carcinoma (HCC), a fast growing and invasive cancer, remain unclear. Now, researchers from Fudan University, China identified signatures of ''m6A,'' the most abundant ''post-transcriptional RNA modification,'' that segregate HCC into sub-types with distinct metabolic characteristics. They have also developed a novel m6A score that can quantify such modifications and aid risk assessment, prediction of prognosis, and response to treatment in patients with HCC. (2021-02-22)

NYUAD researchers develop high throughput paper-based arrays of 3D tumor models
By engineering common filter papers, similar to coffee filters, a team of NYU Abu Dhabi researchers have created high throughput arrays of miniaturized 3D tumor models to replicate key aspects of tumor physiology, which are absent in traditional drug testing platforms. With the new paper-based technology, the formed tumor models can be safely cryopreserved and stored for prolonged periods for on-demand drug testing use. (2021-02-22)

Improving immunotherapies for blood cancers: real-time exploration in the tumor
Monoclonal antibodies are part of the therapeutic arsenal for eliminating cancer cells. Some make use of the immune system to act and belong to a class of treatment called ''immunotherapies.'' But how do these antibodies function within the tumor? And how can we hope to improve their efficacy? Using innovative in vivo imaging approaches, scientists from the Institut Pasteur and Inserm visualized in real time how anti-CD20 antibodies, used to treat B-cell lymphoma, guide the immune system to attack tumor cells. (2021-02-21)

Good cop, bad cop
Serendipitous observation leads to novel insight into how cancer-immune crosstalk can either promote or suppress tumour growth. Ultimately, this study's results may help develop novel cancer therapies as well as an assay to select patients for immunotherapy treatment. (2021-02-19)

3D biopsies to better understand brain tumors
Researchers at the Institut de Neurociències of the Universitat Autònoma de Barcelona (INc-UAB) obtained a highly accurate recreation of human glioblastoma's features using a novel 3D microscopy analysis. The study, published in the journal Acta Neuropathologica Communications, provides new information to help with the diagnose, by finding therapeutical targets and designing immunotherapeutical strategies. (2021-02-19)

UCLA study finds combination therapy suppresses pancreatic tumor growth in mice
UCLA Jonsson Comprehensive Cancer Center researchers have uncovered a potential new way to target pancreatic tumors that express high intratumoral interferon signaling (IFN). (2021-02-18)

Chatter between cell populations drives progression of gastrointestinal tumors
Researchers at University of California San Diego School of Medicine identified new therapeutic targets for gastrointestinal stromal tumors (GISTs) that could lead to new treatment options for patients. (2021-02-18)

Handcuffing the culprit cancer: Immunotherapy for cold tumors with trispecific antibody
The recent discovery of ''bispecific antibodies'' has led to the development of effective immunotherapies against various cancers. Researchers have constructed a protein made up of anti-CD16, -IL-15, and -CD19 motifs, specifically designed to capture CD19-positive cancer cells and redirect them to natural killer (NK) cells. This protein also enhances the proliferation, homeostasis, activation, and survival of NK cells. This concoction has shown to induce killing of cancer cells in both cell cultures and in mouse models. (2021-02-18)

Antibiotic could be repurposed and added to tuberculosis treatment arsenal
Research has found fidaxomicin, an antibiotic usually used to treat bowel infections, prevents growth of resistant strains of Mycobacterium tuberculosis (MTb) in the lab. (2021-02-17)

Cosmetic laser may boost effectiveness of certain anti-cancer therapies
In mice treated with cancer immunotherapy, shining a cosmetic laser on a tumor boosted the therapy's effectiveness. The strategy stimulated the immune system to attack nonmutated proteins on the tumor. The findings may help investigators make cancer immunotherapy effective against currently incurable cancers. (2021-02-17)

Dr. Frederick Boop presents at the ISPN 2020 Virtual Meeting
Understanding the molecular biology of brain tumors is key to prognosis and treatment said Le Bonheur Neuroscience Institute Co-Director Frederick Boop, MD, in his presentation ''How Molecular Biology Impacts Clinical Practice'' at the International Society for Pediatric Neurosurgery (ISPN) 2020 Virtual Meeting. (2021-02-17)

Photosynthetic bacteria-based cancer optotheranostics
Natural purple photosynthetic bacteria (PPSB) can play a key role as a highly active cancer immunotheranostics agent that uses the bio-optical-window I and II near-infrared (NIR) light. PPSB have high tumor specificity and non-pathogenicity. Active anticancer efficacy and powerful multi-functions such as NIR-I-to-NIR-II fluorescence, photothermal conversion, reactive oxygen species generation, and contrasty photoacoustic effect, can be expressed using NIR light exposure to PPSB. (2021-02-16)

Combination treatment for common glioma type shows promise in mice
Gliomas are common brain tumors that comprise about one third of all cancers of the nervous system. In a study funded by the National Institutes of Health (NIH), researchers tested a novel combination treatment approach on mice with tumors with characteristics similar to human astrocytomas and found tumor regression in 60 percent of the mice treated. These encouraging results could be the first step toward developing a treatment for this type of brain cancer. (2021-02-16)

Suppressive immune cells' metabolic vulnerability may be targeted for cancer immunotherapy
A Ludwig Cancer Research study has identified a novel mechanism by which a type of cancer immunotherapy known as CTLA-4 blockade can disable suppressive immune cells to aid the destruction of certain tumors. (2021-02-16)

New immunotherapy target discovered for malignant brain tumors
Scientists say they have discovered a potential new target for immunotherapy of malignant brain tumors, which so far have resisted the ground-breaking cancer treatment based on harnessing the body's immune system. The discovery, reported in the journal CELL, emerged from laboratory experiments and has no immediate implications for treating patients. (2021-02-15)

Insight about tumor microenvironment could boost cancer immunotherapy
A paper published today in Nature shows how chemicals in the areas surrounding tumors - known as the tumor microenvironment - subvert the immune system and enable cancer to evade attack. These findings suggest that an existing drug could boost cancer immunotherapy. (2021-02-15)

Moffitt uses mathematical modeling to identify factors that determine adaptive therapy success
In a new article featured on this month's cover of Cancer Research, Moffitt Cancer Center researchers, in collaboration with Oxford University, report results from their study using mathematical modeling to show that cell turnover impacts drug resistance and is an important factor that governs the success of adaptive therapy. (2021-02-15)

Oncotarget: Targeting engineered cytokine with interleukin to the neovasculature of tumors
''The results suggest that this product, or similar fusion proteins featuring an N-terminal fusion in the diabody format, may deserve to be investigated in clinical trials'' (2021-02-15)

Oncotarget: Cancer stem cells and macrophages against cancer
The aim of this Oncotarget review is to define the complex crosstalk between these two cell types and to highlight potential future anti-cancer strategies (2021-02-15)

Oncotarget: Hemoglobin increases the effectiveness of chemotherapy in lung cancer
Additional animal studies revealed that co-administration of PolyHb with cisplatin attenuated tumor growth without alleviating hypoxia (2021-02-15)

To improve immunotherapy, researchers look to shift immune cells' access to sugar
New research from Memorial Sloan Kettering scientists suggests that a way to improve immunotherapy is by altering immune cells' access to sugar. (2021-02-15)

Antitumoral effects of LXR activation
Tumor cells are able to avoid the attack of the immune system through several mechanisms. For instance, these can secrete factors that turn macrophages -cells in the immune system- into dual action agents that contribute to the tumor progress and will protect it from immune body defences: these become, thus, the tumor-associated macrophages (TAMs). (2021-02-12)

Medication-based starvation of cancer cells
Immunomodulatory drugs, including the Contergan derivatives lenalidomide and pomalidomide have significantly improved the therapy of hematologic malignancies such as multiple myeloma. Researchers at the Technical University of Munich (TUM) have now further decoded the mode of action in this class of medications. At the same time, they identified new innovative targeted cancer therapies. (2021-02-12)

Bacterial degradation of the MYC oncogene -- a new cancer treatment strategy?
Scientists at Lund University have discovered how E. coli bacteria target and degrade the well-known oncogene MYC, which is involved in many forms of cancer. The study is now published in Nature Biotechnology. (2021-02-12)

Liquid biopsy for colorectal cancer could guide therapy for tumors
A new study from Washington University School of Medicine in St. Louis demonstrates that a liquid biopsy examining blood or urine can help gauge the effectiveness of therapy for colorectal cancer that has just begun to spread beyond the original tumor. Such a biopsy can detect lingering disease and could serve as a guide for deciding whether a patient should undergo further treatments due to some tumor cells evading an initial attempt to eradicate the cancer. (2021-02-12)

Get a load of ZIF! Better delivery of cancer immunotherapy
An antibody loaded onto a porous metal organic framework is released by the acidic environment that surrounds tumors, avoiding the adverse effects of administering the antibody alone. (2021-02-11)

Ionic liquid uniformly delivers chemotherapy to tumors while destroying cancerous tissue
A Mayo Clinic team, led by Rahmi Oklu, M.D., Ph.D., a vascular and interventional radiologist at Mayo Clinic, in collaboration with Samir Mitragotri, Ph.D., of Harvard University, report the development of a new ionic liquid formulation that killed cancer cells and allowed uniform distribution of a chemotherapy drug into liver tumors and other solid tumors in the lab. This discovery could solve a problem that has long plagued drug delivery to tumors. (2021-02-11)

Aggressive brain tumor mapped in genetic, molecular detail
A new study led by Washington University School of Medicine in St. Louis has revealed a detailed map of the genes, proteins, infiltrating cells and signaling pathways that play key roles in driving glioblastoma. The study, of 99 tumors from patients, is the largest and most detailed schematic of this deadly brain tumor. (2021-02-11)

SRC-3 is a novel regulator of human immune T regulatory cells
SRC-3, a prognostic marker for aggressive human breast and other cancers, also regulates human immune T regulatory cells (Tregs), which are involved in fighting cancer. (2021-02-11)

Researchers find parallels in spread of brain cancer in mammals, zebrafish
Virginia Tech scientists have identified a new zebrafish model that could help advance glioblastoma multiforme research. Glioblastoma is an aggressive form of primary brain tumor - fewer than one in 20 patients survive five years after diagnosis. (2021-02-11)

Why Black men's prostate cancer may be more responsive to immunotherapy
Black men die more often of prostate cancer yet have greater survival benefits from immunotherapy treatment. A new study discovered the reason appears to be an increase of a surprising type of immune cell in the tumor. The findings could lead to immune-based precision medicine treatment for men of all races with localized aggressive and advanced prostate cancer. (2021-02-10)

Brain tumor study reveals surprising gene deletion and method to overcome drug resistance
Experts at Cincinnati Children's report success at averting drug resistance in a subtype of brain tumors called glioblastomas. Importantly, the research indicates that the approach may also work in other cancers, such as melanoma, that exhibit a similar pathway of drug resistance. (2021-02-10)

Evidence for routine brain tumor imaging is murky, but research can shed light
After treatment, medical staff use routine brain scans to monitor progress in brain tumor patients. However, how often such scans should occur is unclear. A Position Statement from a large group of UK experts highlights that the evidence behind current scanning routines is weak. The article highlights numerous ways that researchers can gather evidence to improve scanning routines so that they are most effective and do not interfere with patient quality of life. (2021-02-09)

New factor in the carbon cycle of the Southern Ocean identified
The Southern Ocean is one of the key regions for understanding the climate system. The photosynthesis-performing plankton there contribute significantly to controlling the CO2 concentration in the atmosphere. But which factors favor or limit plankton growth? Researchers have now published a study showing for the first time that, in addition to the micronutrient iron, manganese can play an important role. Among other things, the results have implications for understanding ice ages in the past. (2021-02-09)

Drug is promising against pancreatic and breast cancers
The drug is effective at treating pancreatic cancer and prolonging survival in mice, according to a study published in the journal Cellular and Molecular Gastroenterology and Hepatology. A second study, published in the Journal of Experimental Medicine, shows the drug is also effective against triple-negative breast cancer, a fast-growing and hard-to-treat type of breast cancer that carries a poor prognosis. Clinical trials are set to begin in 2021. (2021-02-09)

STINGing tumors with nanoparticles
DALLAS - Feb. 8, 2021 - A new nanoparticle-based drug can boost the body's innate immune system and make it more effective at fighting off tumors, researchers at UT Southwestern have shown. Their study, published in Nature Biomedical Engineering, is the first to successfully target the immune molecule STING with nanoparticles about one millionth the size of a soccer ball that can switch on/off immune activity in response to their physiological environment. (2021-02-08)

Technion researchers discover new pathway for attacking cancer cells
The folate cycle is a process essential to DNA and RNA production. As a result, it is highly important to both cancer cells and healthy cells. Because DNA production is a critical stage in cell division, and thus in tumor growth, the folate cycle is a common target for chemotherapy. However, for the very same reason, there are significant side effects to attacking it. (2021-02-05)

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