Current Tumor Growth News and Events | Page 25

Current Tumor Growth News and Events, Tumor Growth News Articles.
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Circulating tumor DNA gives treatment options for the most common ovarian cancer type
According to a new research, circulating tumor DNA can be used detect treatment options for ovarian cancer patients who don't benefit from chemotherapy. (2019-05-04)

Study reveals amyloid clumps of a truncated p53 structure related to endometrial cancer
Brazilian scientists have discovered that a truncated variant of the tumor suppressor protein p53 is present as amyloid aggregates in endometrial cancer cells. Published in the Journal of Biological Chemistry, the study points to new perspectives for treating tumors in which p53 variants are important components of these clusters, given that alterations in the p53 protein are associated with more aggressive versions of these tumors, with a high mortality rate. (2019-05-03)

Cancer cells have a problem with junk RNA that makes them vulnerable
The important role of the ADAR enzyme and junk RNA in cancer cells opens an entirely new playbook for the treatment of tumors, one that is focused on RNA rather than DNA. (2019-05-03)

Why can't we all get along (like Namibia's pastoralists and wildlife?)
Scientists interviewed pastoralists in Namibia's Namib Desert to see how they felt about conflicts with wildlife, which can include lions and cheetahs preying on livestock and elephants and zebras eating crops. (2019-05-02)

Biomarker may predict if immunotherapy is right choice for colorectal cancer patients
Foundational research could help metastatic colorectal cancer patients decide whether to choose immunotherapy or chemotherapy as a first treatment option. 'Immunotherapy is the hot thing, but sometimes traditional chemotherapy can be better. Our study suggests tumor genomics could help doctors decide what kind of treatment will benefit each patient most. Taking this kind of personalized medicine approach, we will be able to provide patients with options that yield better outcomes and are more cost-effective.' (2019-05-02)

Researchers putting the brakes on lethal childhood cancer
Reporting this week in the journal Nature Communications, the researchers conclude that blocking MYC could be 'unexpectedly effective' in treating MRT as well as other cancers driven by inactivation of SNF5. (2019-05-02)

Hearing loss weakens skills that young cancer survivors need to master reading
Researchers have identified factors that explain why severe hearing loss sets up pediatric brain tumor survivors for reading difficulties with far-reaching consequences. The findings lay the foundation for developing interventions to help survivors become better readers. The findings suggest that interventions should focus on improving neurocognitive and language-based skills like processing speed and phonemics before tackling more complex tasks like reading comprehension. (2019-05-02)

Here's how cancer hijacks wound healing to create its own blood supply
Researchers at the University of Virginia School of Medicine have shed light on how cancers hijack the body's natural wound-healing response to grow and spread. (2019-05-01)

Mouse studies show minimally invasive route can accurately administer drugs to brain
In experiments in mice, Johns Hopkins researchers say they have developed a technique that facilitates the precise placement of cancer drugs at their intended targets in the brain. (2019-05-01)

Changes in the metabolism of normal cells promotes the metastasis of ovarian cancer cells
A systematic examination of the tumor and the tissue surrounding it -- particularly normal cells in that tissue, called fibroblasts -- has revealed a new treatment target that could potentially prevent the rapid dissemination and poor prognosis associated with high-grade serous carcinoma (HGSC), a tumor type that primarily originates in the fallopian tubes or ovaries and spreads throughout the abdominal cavity. (2019-05-01)

Researchers find new target to improve response to cancer immunotherapy
Researchers at the University of Michigan Rogel Cancer Center looked at a little-understood type of cell death called ferroptosis. They found ferroptosis occurs in tumor cells and plays a role in cancer immunity, suggesting the potential of targeting this pathway to improve immunotherapy treatments. (2019-05-01)

Circadian rhythm disruption tips the cell-cycle balance toward tumor growth
Disrupting normal circadian rhythms promotes tumor growth and suppresses the effects of a tumor-fighting drug, according to a new study publishing April 30, 2019 in the open-access journal PLOS Biology by Yool Lee, Amita Sehgal, and colleagues at the University of Pennsylvania. (2019-04-30)

Chronic disruptions to circadian rhythms promote tumor growth, reduce efficacy of therapy
In a study published today in the journal PLOS Biology, researchers at Penn Medicine show circadian disruptions trigger an increase in cell proliferation that, ultimately, shifts the cell-cycle balance and stimulates the growth of tumors in mice. The findings also suggest that 'chronotherapy' -- the delivery of treatment timed to the host's circadian rhythm -- can improve disease outcomes of drugs that inhibit tumor growth in mice. (2019-04-30)

Diving into the details: A lipid-binding pocket is a target for new cancer therapies
Cell growth is tightly controlled; however, cancer cells overcome the normal growth controls and proliferate uncontrollably. Researchers at the Medical University of South Carolina examined the molecular details underlying the interaction of ceramide, a lipid that plays a critical role in several signaling pathways, with a protein complex involved in modulating cell growth. They showed that ceramide and a similar compound, fingolimod, disrupt the interaction of SET with PP2A to repress cell growth. (2019-04-29)

NeurExo Sciences and Henry Ford present preclinical data on exposomes at ISEV2019
NeurExo Sciences, LLC and Henry Ford Health System today announced the presentation of new data on exosomes at the International Society for Extracellular Vesicles (ISEV) 2019 Annual Meeting being held April 24-28, 2019 in Kyoto, Japan. Among their key findings, Henry Ford researchers demonstrated the ability of exosomes to suppress chemotherapy-induced peripheral neuropathy and enhance the anti-tumor effects of platinum drugs, which are commonly used to treat cancers. (2019-04-26)

Novel vaccine for colorectal cancer shows positive phase I results
The vaccine proves safe in a small sample of human subjects, opening the way for the next phase of testing. (2019-04-25)

Analyzing colon cancer proteins and genes uncovers new potential treatments
Analyzing both the entire set of genes and all the proteins produced by colon cancer tissues from patient samples has revealed a more comprehensive view of the tumor that points at novel cancer biological mechanisms and possible new therapeutic strategies. (2019-04-25)

Fishing for cures: New zebrafish model identifies drugs that kill pediatric cancer cells
A new immunodeficient zebrafish model developed by Massachusetts General Hospital investigators promises to be less expensive, easier to use and to improve personalized therapies for cancers and potentially other diseases. The ability of the model to visualize drug responses at single-cell resolution in live animals allowed the team to identify a promising new treatment for rhabdomyosarcoma. (2019-04-25)

Study in mice uncovers an unknown pathway for breast cancer tumors to recur
Experimenting in mice, the researchers tracked a series of events that enable a small reservoir of treatment-resistant cancer cells to awake from dormancy, grow and spread. (2019-04-25)

Hopkins researchers ID neurotransmitter that helps cancers progress
Using human cancer cells, tumor and blood samples from cancer patients, researchers at Johns Hopkins Medicine have uncovered the role of a neurotransmitter in the spread of aggressive cancers. Neurotransmitters are chemical ''messengers'' that transmit impulses from neurons to other target cells. (2019-04-24)

Moffitt Researchers find BRAF protein modification could slow tumor growth
Researchers in Moffitt Cancer Center's Donald A. Adam Melanoma and Skin Cancer Center of Excellence have discovered a signaling pathway between cytokines and BRAF that promotes tumor growth. The finding could provide a potential therapeutic target. (2019-04-24)

Chemotherapy or not?
Case Western Reserve University researchers and partners, including a collaborator at Cleveland Clinic, are pushing the boundaries of how 'smart' diagnostic-imaging machines identify cancers -- and uncovering clues outside the tumor to tell whether a patient will respond well to chemotherapy. (2019-04-24)

Biologists design new molecules to help stall lung cancer
University of Texas at Dallas scientists have demonstrated that the growth rate of the majority of lung cancer cells relates directly to the availability of a crucial oxygen-metabolizing molecule called heme. In a preclinical study recently published in Cancer Research, they showed that the expansion of lung tumors in mice slowed when access to heme was restricted. They also engineered new molecules aimed at starving the cancer cells of heme. (2019-04-23)

Study: Drugs reprogram genes in breast tumors to prevent endocrine resistance
Treating breast tumors with two cancer drugs simultaneously may prevent endocrine resistance by attacking the disease along two separate gene pathways, scientists at the University of Illinois found in a new study. The two drugs used in the study, selinexor and 4-OHT, caused the cancer cells to die and tumors to regress for prolonged periods. (2019-04-23)

Shining light on rare nerve tumors illuminates a fresh path for fighting cancer
A discovery about the rare nerve disease NF2 suggests that targeting mechanical signaling between cells could become another weapon against many forms of cancer. Findings published online in Science Signaling were led by experts at Cincinnati Children's. (2019-04-23)

A deep-learning model may help predict lung cancer survival and outcomes
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. (2019-04-22)

Hole-forming protein may suppress tumor growth
A gene called gasdermin E, which is downregulated in many cancers, aids cells in dying in an unexpected way, and may also suppress tumor growth. (2019-04-22)

FEFU scientists are developing brand-new method to heal brain cancer
Scientists from Far Eastern Federal University (FEFU) in cooperation with colleagues from Blokhin Russian Cancer Research Center (Moscow), Switzerland, and Sweden for the first time studied proteins, which constitute WNT signaling pathway of the cancer stem cells of glioblastoma multiforme (GBM CD133+ CSCs), one of the most aggressive brain tumors. Researchers revealed a number of proteins, which are potential targets to attack during complex antitumor therapy. A related article was published in Oncology Reports. (2019-04-22)

Molecular target UNC45A is essential for cancer but not normal cell proliferation
Identifying a protein that plays a key role in cancer cell growth is a first step toward the development of a targeted cancer therapy. It is especially promising when this protein is dispensable for the growth of normal cells. Their discovery that UNC45A fits these criteria has researchers, led by Dr. Ahmed Chadli, of the Georgia Cancer Center at Augusta University, excited about potential new cancer therapeutic strategies involving the inhibition of UNC45A. (2019-04-19)

IDIBELL -- ICO researchers set new bases to develop therapies against colorectal cancer
IDIBELL -- ICO researchers in Barcelona have found that inactivation of two proteins make tumoral cells more sensitive to chemotherapy. This sets new bases to develop therapies against colorectal cancer. (2019-04-17)

New study targets Achilles' heel of pancreatic cancer, with promising results
Advanced pancreatic cancer is often symptomless, leading to late diagnosis only after metastases have spread throughout the body. Now, Salk Institute researchers, along with an international team of collaborators, have uncovered the role of a signaling protein, called LIF, that may be the Achilles' heel of pancreatic cancer. The findings show that pancreatic stellate cells -- resident cells typically dormant in normal tissue -- secrete LIF to convey stimulatory signals to tumor cells to drive pancreatic cancer development and progression. (2019-04-17)

Triple negative breast cancers can adopt reversible state that is resistant to chemotherapy
Researchers at The University of Texas MD Anderson Cancer Center have discovered that triple negative breast cancer (TNBC) cells can develop resistance to frontline, or neoadjuvant, chemotherapy not by acquiring permanent adaptations, but rather transiently turning on molecular pathways that protect the cells. (2019-04-17)

New study explains how inflammation causes gastric cancer
Researchers from Kanazawa University and the Japan Agency for Medical Research and Development have solved the decades-old mystery of how stomach bacterium Helicobacter pylori causes gastric cancer. Using mouse models and human cancer cell lines, they showed that inflammation resulting from bacterial infection leads to the proliferation of gastric epithelial cells, which ultimately form gastric tumors. By blocking the protein pathway responsible for this proliferation, they prevented gastric tumor formation. (2019-04-16)

New role for innate immune sensor: Suppressing liver cancer
UT Southwestern researchers have found that a protein in the body's innate immune system that responds to gut microbes can suppress the most common type of liver cancer. (2019-04-16)

The fluid that feeds tumor cells
MIT biologists have found that the nutrient composition of the interstitial fluid that normally surrounds pancreatic tumors is different from that of the culture medium normally used to grow cancer cells. (2019-04-16)

Three studies show how tumors hijack the immune system to resist radiation therapy
Treg cells turn off the immune system. Three recent studies show that targeting tregs may increase the effectiveness of anti-cancer immunotherapies. (2019-04-16)

Princeton scientists discover an interaction that helps cancers spread to bone
A Princeton-led team of researchers have discovered a factor that promotes the spread of cancers to bone, opening the way toward treatments that could mitigate cancer's ability to colonize bone. The study by Mark Esposito, Yibin Kang and colleagues appears in the April 15 issue of Nature Cell Biology. (2019-04-15)

Precise decoding of breast cancer cells creates new option for treatment
Researchers at the University of Zurich and from IBM Research have investigated the vary-ing composition of cancer and immune cells in over one hundred breast tumors. They've found that aggressive tumors are often dominated by a single type of tumor cell. If certain immune cells are present as well, an immune therapy could be successful for a specific group of breast cancer patients. (2019-04-15)

Bright spot analysis for photodynamic diagnosis of brain tumors using confocal microscopy
A Japan-based research team led by Kanazawa University have found that bright spot areas have generally lower fluorescence in brain tumors than in normal tissues in images captured by irradiation with a 405 nm wavelength laser and 544.5-619.5 nm band-pass filter. This may facilitate discrimination of glioblastoma with or without 5-aminolevulinic acid fluorescence and could be applicable to other tumors. (2019-04-11)

Shutting down deadly pediatric brain cancer at its earliest moments
Cell-by-cell genetic analyses of developing brain tissues in neonatal mice and laboratory models of brain cancer allowed scientists to discover a molecular driver of the highly aggressive, deadly, and treatment-resistant brain cancer, glioblastoma. Published in Cell Stem Cell, the findings present an opportunity to find out if new therapeutic approaches can stop glioblastoma at its earliest stages of initial formation or recurrence. (2019-04-11)

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