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Current Tumor News and Events, Tumor News Articles.
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New computational tool reliably differentiates between cancer and normal cells from single-cell RNA-sequencing data
MD Anderson researchers have developed a new computational tool to accurately differentiate between cancer cells and normal cells when analyzing large single-cell RNA-sequencing data. (2021-01-18)

A mathematical study describes how metastasis starts
A scientific study carried out by the Universidad Carlos III de Madrid (UC3M) and the Universidad Complutense de Madrid (UCM) has produced a mathematical description of the way in which a tumor invades the epithelial cells and automatically quantifies the progression of the tumor and the remaining cell islands after its progression. The model developed by these researchers could be used to better understand the biophysical characteristics of the cells involved when developing new treatments for wound healing, organ regeneration, or cancer progression. (2021-01-18)

Triggering tumor antiviral immune response in triple negative breast cancer
Researchers at Baylor College of Medicine have discovered how therapeutics targeting RNA splicing can activate antiviral immune pathways in triple negative breast cancers (TNBC) to trigger tumor cell death and signal the body's immune response. (2021-01-14)

Bladder cancer -- When to use chemotherapy
In patients with bladder cancer, chemotherapy effectiveness is partially determined by the body's immune system response to the malignancy. This is the conclusion of research conducted by a team of scientists from Charité -- Universitätsmedizin Berlin and the Berlin Institute of Health. The findings, which have been published in Science Translational Medicine*, can be used to predict treatment success and may increase survival in patients with bladder cancer. (2021-01-14)

Study demonstrates efficacy of new treatment for neurofibromatosis type 1-related tumors
Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1). The results of the Phase 2 clinical trial, co-chaired by Michael J. Fisher, MD at CHOP, were published recently in Nature Medicine. (2021-01-14)

Cancer models created by mechanical engineers offer new insight into tumor growth
In research published today in Integrative Biology, a team of engineers from Rensselaer developed an in vitro -- in the lab -- lymphatic vessel model to study the growth of tumor emboli, collections of tumor cells within vessels that are often associated with increased metastasis and tumor recurrence. (2021-01-14)

The role of T cells in fighting cancer
Why do some hosts' immune systems reject tumors easily, while others have a harder time doing so? It depends on the types of the immune cells known as CD8 T cells and how a host's specific T cells match up with the neoantigens present in the tumor. (2021-01-14)

Scoring system to redefine how U.S. patients prioritized for liver transplant
Researchers with Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine are collaborating with faculty at the University of Pennsylvania to develop a risk score that more comprehensively prioritizes liver cancer patients for transplantation. (2021-01-13)

Texas A&M research explores how melanoma grows and spreads
The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact. (2021-01-12)

Discovery of a new approach to inhibiting a highly treatment-refractory liver cancer
Blocking placental growth factor (PlGF), a member of the vascular endothelial growth factor family, inhibits the progression of intrahepatic cholangiocarcinoma (ICC) and enhances the efficacy of chemotherapy in mouse models. This novel approach to targeting the connective tissue microenvironment of ICC, a rare but notoriously treatment-resistant form of liver cancer, could pave the way for combination therapies, including chemotherapy and immune checkpoint blockade. (2021-01-12)

Oncotarget: Targeted lymphodepletion with a CD45-directed antibody radioconjugate
''Here the Oncotarget authors describe the results of preclinical studies with an anti-mouse CD45 antibody 30F11'' (2021-01-11)

Oncotarget: HIV +/- patients with lymphoma as a predictor of outcome & tumor proliferation
The Oncotarget author's hypothesis is that ADC values will inversely correlate with Ki-67 expression and that tumors with higher ADC values above the median will have improved OS and PFS (2021-01-11)

Novel RNA factors may help cancer cells thrive
Recent work by researchers at Brigham and Women's Hospital pinpoints critical changes in an enzyme known as DICER, which create a cascade of effects on this microRNAome. The team identified primary actors circ2082, a circular RNA, and RBM3, an RNA-binding protein, which form a complex with DICER to trap it in the nucleus of glioblastoma cells, therefore disrupting the cytoplasmic microRNAome. (2021-01-08)

Proteogenomics offers insight to treating head and neck squamous cell carcinoma
A new study identifies three molecular subtypes in head and neck squamous cell carcinoma (HNSCC) that could be used to better determine appropriate treatment. (2021-01-07)

Alternative cancer cell fuel source targeted as therapeutic approach for breast cancer
Wistar scientists characterized an inhibitor that targets acetate metabolism in cancer cells. This molecule caused tumor growth inhibition and regression in preclinical studies, demonstrating the promise of this approach as a novel therapeutic strategy for solid tumors. (2021-01-07)

MRI frequently underestimates tumor size in prostate cancer
Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease. (2021-01-07)

Liver cancer cells manipulate stromal cells involved in fibrosis to promote tumor growth
Researchers led by Osaka University have found that liver cancer cells induce autophagy in hepatic stellate cells, causing them to produce a growth factor called GDF15 that promotes tumor growth. GDF15 was more highly expressed in tumor tissue than normal liver tissue, and patients with higher levels of GDF15 had a poorer prognosis. New therapies targeting GDF15 may help prevent the development and proliferation of hepatocellular carcinoma. (2021-01-06)

Immunology study finds protein critical to T cell metabolism and anti-tumor immune response
Researchers at The University of Texas MD Anderson Cancer Center have discovered that a protein called NF-kappa B-inducing kinase (NIK) is essential for the shift in metabolic activity that occurs with T cell activation, making it a critical factor in regulating the anti-tumor immune response. (2021-01-04)

Study points the way to boost immunotherapy against breast cancer, other solid tumors
UNC Lineberger Comprehensive Cancer Center researchers report that adding a small molecule to a chimeric antigen receptor-T (CAR-T) cell therapy can help immune system T cells to effectively attack solid tumors, such as breast cancers. The boost helps recruit more immune cells into battle at the tumor site, according to the study published in the Journal of Experimental Medicine. (2020-12-31)

Molecular reporters expose the allies of the brain tumor
Until recently, it was unclear how and why cancer cells adapt to their environment. A team led by Gaetano Gargiulo at MDC has now developed a technology that can be used to observe the molecular processes in living cells. The researchers present their results in the journal Cancer Discovery. (2020-12-23)

Regulatory RNAs promote breast cancer metastasis
A gene-regulating snippet of RNA may contribute to the spread of many breast cancers. A molecule designed to destroy that RNA prevented metastases in animal models. The same strategy could be used to develop a new breast cancer drug. (2020-12-22)

Three-dimensionally reconstituted organoids that are just like human organs
POSTECH-Seoul National University Hospital research team publishes the new concept of assembloids in Nature. (2020-12-18)

Breast cancer study uncovers how macrophages may contribute to a therapeutic weak spot
Clinical trials have investigated pairing PARP inhibitor therapy with immunotherapy. Researchers are already looking ahead for ways to get even more benefit from PARP inhibitors plus checkpoint inhibitors in breast cancer patients. Investigators found macrophage-mediated immune suppression to be the weak spot of PARP inhibition treatment. Findings are published in Nature Cancer. (2020-12-18)

Nanotechnology -- nanoparticles as weapons against cancer
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors. (2020-12-18)

Scientists unlock promising key to preventing cancer relapse after immunotherapy
The researchers discovered that cancer immunotherapies that make use of immune system cells such as T cells and CAR-T cells kill not only tumor cells that express the drugs' target, but also adjacent tumor cells that lack the targets, because of the presence of fas. This process, known as bystander killing, can be made more effective by adding therapeutics that turn off the regulation of fas proteins, the researchers said. (2020-12-17)

Cancer: Tumor driver promoting EMT, metastasis and resistance to therapy
Publication in Nature: researchers at the Université libre de Bruxelles (ULB) identify, for the first time, the functions of FAT1, one of the most frequently mutated cancer gene drivers. They uncover that FAT1 mutations promotes invasive features, metastasis and resistance to commonly used anti-cancer drugs, and discover new therapy for FAT1 mutated cancers. (2020-12-16)

Drug for pulmonary hypertension may become an option against cancer
In experiments by Brazilian researchers with mice and tumor cell lines, the drug showed potential to combat metastasis. The scientists are planning to conduct clinical trials with patients who are on chemotherapy. (2020-12-15)

Immune cell that drives breast cancer could be effective target in novel immunotherapies
VCU Massey Cancer Center researcher Paula Bos, Ph.D., identified a type of immune cells that acts as a major driver of breast cancer growth by preventing the accumulation of a specific protein that induces anti-tumor responses. This new knowledge could be utilized for the development of novel immunotherapeutic approaches to treat the disease. (2020-12-15)

Hinder handing the message -- stopping tumors from creating new blood vessels
Researchers from Tokyo Medical and Dental University (TMDU) have found that vasohibin-1 (VASH1), a protein known to prevent the formation of new blood vessels, acts by changing the conditions of microtubules which bring blocking the certain signal from outside through encumbering transport of its message to the inner of cell. The unique function of this protein can inhibit tumor cells from spreading throughout the body, making it a notable finding for cancer therapeutic research. (2020-12-14)

Tasmanian devils may survive their own pandemic
Researchers have found strong evidence that a transmissible cancer that has decimated Tasmanian devil populations likely won't spell their doom. For the first time, a research team employed genomic tools of phylodynamics, typically used to track viruses, such as influenza and SARS-CoV-2 , to trace the Tasmanian devil facial tumor disease. The approach they pioneered has opened the door for application to other genetically complex pathogens. (2020-12-10)

Obesity impairs immune cell function, accelerates tumor growth
New study in mice finds that a high-fat diet allows cancer cells to outcompete immune cells for fuel, impairing immune function and accelerating tumor growth. Cancer cells do so by rewiring their metabolisms to increase fat consumption. Blocking this rewiring enhances anti-tumor immunity. Findings suggest new strategies to target cancer metabolism, improve immunotherapies. (2020-12-09)

PET/MRI, CT metrics assess pathologic response of pancreas cancer to neoadjuvant therapy
According to an open-access Editor's Choice article in ARRS' American Journal of Roentgenology (AJR), post-neoadjuvant therapy (NAT) changes in metabolic metrics from PET/MRI and morphologic metrics from CT were associated with pathologic response and overall survival in patients with pancreatic ductal adenocarcinoma (PDA). (2020-12-09)

Tiny nanospindles enhance use of ultrasound to fight cancer
Ultrasound can be used to treat cancer when used in combination with molecules that sensitize the system to sound waves. These sonosensitizers generate toxic reactive oxygen species that attack and kill tumor cells. In Applied Physics Review, scientists report a new type of sonosensitizer based on a vanadium-doped titanium dioxide that enhances the amount of damage ultrasound inflicts on tumors. Studies in mice showed tumor growth was markedly suppressed when compared to a control group. (2020-12-08)

Researchers discover treatment that suppresses liver cancer
Researchers from the University of Missouri School of Medicine have discovered a treatment combination that significantly reduces tumor growth and extends the life span of mice with liver cancer. This discovery provides a potentially new therapeutic approach to treating one of the leading causes of cancer-related death worldwide. (2020-12-08)

Circulating tumor DNA indicates risk of relapse after transplant in DLBCL patients
Many patients with diffuse large B-cell lymphoma (DLBCL) can be cured by a transplant using their own blood-forming stem cells, but as many as half eventually relapse. New research led by Dana-Farber Cancer Institute scientists suggests that patients whose blood or stem cell samples harbor tumor DNA are likely to relapse. (2020-12-07)

One for all
AI-based evaluation of medical imaging data usually requires a specially developed algorithm for each task. Scientists from the German Cancer Research Center (DKFZ) have now presented a new method for configuring self-learning algorithms for a large number of different imaging datasets - without the need for specialist knowledge or very significant computing power. (2020-12-07)

White blood cells may cause tumor cell death -- but that's not good news
White blood cells are part of many immune system responses in the human body. New research shows that a specific type of those cells may cause brain cancer tissues to die -- but that's not good news, according to researchers at Penn State College of Medicine. They said that higher amounts of this tissue death have been associated with poor survival in patients with aggressive glioblastomas, a deadly type of brain cancer that is common in adults. (2020-12-07)

β-AR agonist therapy puts the brakes on oral cancer progression
Oral cancer has a high mortality rate that is mainly attributed to metastasis. Researchers from Tokyo Medical and Dental University (TMDU) screened a panel of small chemical compounds for their ability to inhibit metastasis in oral cancer, identifying β2?AR-agonist isoxsuprine as a potential candidate. Treatment of various oral cancer cells with isoxsuprine suppressed their motility, while tumor size was significantly decreased in isoxsuprine-treated mice, suggesting that β-AR-agonist therapy could be an effective new treatment for oral cancer. (2020-12-03)

Stress hormones can reawaken sleeping tumor cells, raising risk of cancer recurrence
Stress hormones and immune cells called neutrophils may contribute to the recurrence of tumors years after treatment by awakening dormant cancer cells, suggests a study of mice and data from 80 patients with lung cancer. (2020-12-02)

IU researchers publish first article dedicated to Hoosier youth's donated tumor
Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent. (2020-12-01)

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