Current Tumor News and Events | Page 25

Current Tumor News and Events, Tumor News Articles.
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Study suggests way to attack deadly, untreatable nerve tumors
Genomic profiling of mostly untreatable and deadly nerve sheath tumors led scientists to test a possible therapeutic strategy that inhibited tumor growth in lab tests on human tumor cells and mouse models, according to research in the journal Cancer Cell. When the international team of researchers analyzed complete screens of genes and genetic material in malignant peripheral nerve sheath tumors (MPNSTs), it revealed previously unknown genetic information about the disease. (2018-02-12)

Novel classification can lead to new ways to diagnose and treat cancer
A novel approach to studying cancer has enabled researchers to group about 10,000 human cancers of 32 different types into 10 classes based on the molecular pathways that drive tumor growth. A better understanding of these pathways can potentially lead to novel ways to diagnose and treat cancer. (2018-02-12)

TSRI scientists take big step toward stopping cancer metastasis
TSRI scientists identify molecule that fuels cancer metastasis. (2018-02-08)

Versatile sensor against tumor initiating cells
The IBS researchers developed the first fluorescent sensor to visualize TICs. Functional in lung, central nervous system, melanoma, breast, renal, ovarian, colon, and prostate cancer cell cultures, this could become a useful tool for biopsy-free post-treatment assessment and anti-TIC drug development. (2018-02-07)

Recreating liver tumors as organoids for faster, more accurate drug screening
A major challenge in developing liver cancer drugs is that preclinical testing occurs in tumor models that do not accurately reflect human tumor features, causing drug candidates to later fail in clinical testing. Now, Singaporean researchers have grown organoids from liver tumors on specially engineered 3-D scaffolds. These organoids replicate important features of the original tumor, including genetic changes and intra-tumor heterogeneity, and could serve as tumor avatars for high-throughput drug screening. (2018-02-07)

Scientists target glioma cancer stem cells, which could improve patient survival
Brain tumors are responsible for 25 percent of cancer-related deaths in children and young adults. Despite initial response to treatment, most aggressive brain tumors eventually recur and are ultimately incurable. Multiple studies suggest that cancer stem cells within these tumors resist therapy and are responsible for tumor recurrences. Researchers at Dartmouth's Norris Cotton Cancer Center have devised a strategy to treat these tumors by identifying a secretion-mediated pathway that's essential for maintaining glioma cancer stem cells. (2018-02-05)

UA Cancer Center team targets tumor suppressor to treat 'triple-negative' breast cancer
A team led by UA Cancer Center researchers Agnieszka Witkiewicz, MD, and Erik Knudsen, PhD, screened for drugs that could target triple-negative breast cancer tumors, producing several new therapeutic candidates for this difficult-to-treat cancer. (2018-02-05)

Lobachevsky University scientists synthesize a new compound with anti-tumor properties
A research team of the UNN Faculty of Chemistry led by Professor Alexei Fedorov has developed and synthesized a new multifunctional compound that possesses anti-tumor properties that are due to several independent effects. The active compound is a conjugate of a photoactive organic dye (photosensitizer), a derivative responsible for selective delivery of the medicine to tumor tissues and targeted therapy (biological vector), a linker, and special groups that increase the water solubility of the entire compound. (2018-02-02)

Why basal cell tumors return when drug treatment stops
A new study pinpoints a mechanism that controls how basal cell cancers respond to treatment and offers new ideas for controlling this disease when it gets tricky. (2018-02-01)

Stealth virus for cancer therapy
Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (2018-01-31)

Cancer 'vaccine' eliminates tumors in mice, Stanford researchers find
Injecting minute amounts of two immune-stimulating agents directly into solid tumors in mice can eliminate all traces of cancer in the animals, including distant, untreated metastases, according to a study by researchers at the Stanford University School of Medicine. (2018-01-31)

Moffitt researchers discover new approach to stimulate an immune response against tumor cells
A team of Moffitt Cancer Center researchers is trying to find new ways to further enhance the activity of the immune system against cancer. In an article published in the January issue of Cancer Cell, the researchers describe how a new type of immunotherapy drug targeting the protein TIM-3 works to stimulate the immune system. (2018-01-30)

Expert panel issues new guidelines for lung cancer molecular testing
Guidelines add ROS1 to list of tests matching lung cancer with targeted treatments, among other updated recommendations. (2018-01-30)

Microbubbles make breast cancer more susceptible to radiation therapy
Bursting oxygen-filled microbubbles in breast cancer makes tumors three times more sensitive to radiation therapy in preliminary tests with animal models of the disease (2018-01-29)

Making milestones against non-small cell lung cancer
Progress concerning Lung cancer has been enormous in the past 20 years, according to a new review from researchers at Yale Cancer Center. (2018-01-24)

Study provides first systematic survey of metabolites across tumor types
In an advance reminiscent of the earliest maps of genomic mutations in cancer, investigators at Dana-Farber Cancer Institute and Memorial Sloan Kettering Cancer Center have completed the first systematic survey of the products of biochemical reactions within cancer and their relation to the progress of the disease. The products, known as metabolites, arise from the myriad chemical reactions that keep cells alive and functioning. (2018-01-24)

Scientists block the siren call of two aggressive cancers
Aggressive cancers like glioblastoma and metastatic breast cancer have in common a siren call that beckons the bone marrow to send along whatever the tumors need to survive and thrive. (2018-01-23)

Starving tumors: New target discovered
Actively growing tumors have a high demand for oxygen and nutrients. Therefore, they stimulate the growth of blood vessels. This process is called angiogenesis. If tumor-associated angiogenesis is suppressed, this may limit tumor growth. Scientists from the German Cancer Research Center and the European Center for Angioscience at Heidelberg University have now discovered a new target for anti-angiogenic tumor therapy (2018-01-23)

Developing the VTX-1 liquid biopsy system: Fast and label-free enrichment of circulating tumor cells
A new article in the February 2018 issue of SLAS Technology describes a new platform that could change the way cancer is diagnosed and treated by automating the isolation of circulating tumor cells (CTCs) directly from cancer patient blood. This article provides unique insight into the development of a commercial system that has the potential to change the standard of care in cancer diagnosis and treatment. (2018-01-22)

Boosting cancer therapy with cross-dressed immune cells
Researchers at EPFL have created artificial molecules that can help the immune system to recognize and attack cancer tumors. The study is published in Nature Methods. (2018-01-22)

Multifunctional platform for the delivery of gene therapeutics
Gene editing is one of the hottest topics in cancer research. A Chinese research team has now developed a gold-nanoparticle-based multifunctional vehicle to transport the 'gene scissors' to the tumor cell genome. As the authors report in the journal Angewandte Chemie, their nonviral transport and release platform of gene-editing systems has the additional advantage of combining hyperthermal cancer therapy with genetic modification. (2018-01-22)

Enzyme inhibitor combined with chemotherapy delays glioblastoma growth
In animal experiments, a human-derived glioblastoma significantly regressed when treated with the combination of an experimental enzyme inhibitor and the standard glioblastoma chemotherapy drug, temozolomide. (2018-01-22)

How cancer metastasis happens: Researchers reveal a key mechanism
Cancer metastasis, the migration of cells from a primary tumor to form distant tumors in the body, can be triggered by a chronic leakage of DNA within tumor cells, according to a team led by Weill Cornell Medicine and Memorial Sloan Kettering Cancer Center researchers. (2018-01-18)

DIPG tumor patterns offer new insight on survival
A small subset of patients with tumors that bear mutations in a gene in the basic packaging of DNA (known as histone mutations) may have better outcomes than others, suggests new research from Michigan Medicine's Pediatric Brain Tumor Research Initiative. (2018-01-17)

Dulling cancer therapy's double-edged sword
Researchers have discovered a very promising new pathway to preventing tumor recurrence -- 'resolvins' could be used in complement with chemotherapy, radiation and targeted therapies to stave off the tumor-promoting effects of dead cancer cell debris. (2018-01-17)

T-cells engineered to outsmart tumors induce clinical responses in relapsed Hodgkin lymphoma
A research team that includes Children's National Health System clinician-researchers has validated a way to outfox tumors. They engineered T-cells, essential players in the body's own immune system, to strip tumors of their self-preservation skill and were able to hold Hodgkin lymphoma at bay in patients with relapsed disease for more than four years. (2018-01-16)

Who might benefit from immunotherapy? New study suggests possible marker
New research finds that PDL-1 expressed in antigen presenting cells -- macrophages and dendritic cells found in the tumor microenvironment and in the nearby lymph nodes -- is a better indicator than PDL-1 in the tumor of who will respond to immunotherapy drugs. (2018-01-16)

Cancer's gene-determined 'immune landscape' dictates progression of prostate tumors
The field of immunotherapy -- the harnessing of patients' own immune systems to fend off cancer -- is revolutionizing cancer treatment today. However, clinical trials often show marked improvements in only small subsets of patients, suggesting that as-yet unidentified variations among tumors result in distinct paths of disease progression and response to therapy. (2018-01-12)

Bridging tumor moats with potent drug delivery particles
Despite herculean efforts, cancer remains a formidable disease, with each malignant subtype responding differently to therapeutics. One hurdle specific to treating solid tumors is a protective layer called an extracellular matrix that can prevent chemotherapeutic agents from penetrating the tumor's core. Scientists now report results in ACS' Chemistry of Materials showing that, by cloaking anti-cancer drugs in a specially designed particle, they could target and destroy tumor cells deep inside a malignant mass in vitro. (2018-01-10)

Researchers discover that a 'muscle' cancer is not really a muscle cancer
St. Jude Children's Research Hospital oncologists have discovered the cell type that gives rise to rhabdomyosarcoma, the most prevalent soft tissue cancer in children. Previously, scientists thought the cancer arose from immature muscle cells, because the tumor resembled muscle under the microscope. However, the St. Jude researchers discovered the cancer arises from immature progenitors that would normally develop into cells lining blood vessels. (2018-01-08)

World first multimodal biomicroscopic system enhances the accuracy of cancer treatment
A research team from Korea has developed the world's first multimodal biomicroscopic system based on high-frequency ultrasound and optical spectroscopy. It is expected to be used for the analysis of the quantitative characteristics of the tumor removed during surgery and for the accurate cancer resection technique researches. (2018-01-07)

Researchers create novel compound targeting melanoma cells
An international team of researchers has developed a novel compound that successfully inhibits growth of melanoma cells by targeting specific epigenetic modifying proteins in these cells. (2018-01-04)

A new therapeutic target to fight metastasis in ovarian cancer
Researchers of IDIBELL - ICO have described a key cellular receptor in the processes of metastasis in ovarian cancer. The finding might lead to the use of inhibitors of this receptor as a therapeutic target in the most aggressive variants of the disease. (2018-01-04)

New cancer model shows genomic link between early-stage and invasive breast cancer types
A new genetic-based model may explain how a common form of early-stage breast cancer known as ductal carcinoma in situ (DCIS) progresses to a more invasive form of cancer say researchers at The University of Texas MD Anderson Cancer Center. (2018-01-04)

Specific microbes in digestive tract can boost success for cancer immunotherapy
Specific strains of intestinal bacteria can improve the response rate to immunotherapy for patients being treated for advanced melanoma. Patients with a higher ratio of 'beneficial' bacteria to 'non-beneficial' bacteria all showed a clinical response: a reduction in tumor size. (2018-01-04)

Tumor suppressor gene variants identified as cancer 'double whammy' for leukemia patients
A study led by St. Jude Children's Research Hospital found germline variations in a key tumor suppressor gene that may prompt changes in treatment and follow-up care for certain high-risk leukemia patients (2018-01-04)

Novel nanomedicine inhibits progression of pancreatic cancer in mice
A new Tel Aviv University study pinpoints the inverse correlation between a known oncogene -- a gene that promotes the development of cancer -- and the expression of an oncosuppressor microRNA as the reason for extended pancreatic cancer survival. The study may serve as a basis for the development of an effective cocktail of drugs for this deadly disease and other cancers. (2018-01-02)

Uncovering molecular targets for childhood cancer therapeutics
Neuroblastoma (NB) is the most common solid tumor found in children and is associated with poor prognosis; however, little is known regarding the molecular targets located in the long arm of chromosome 11 (11q). Tokyo Medical and Dental University (TMDU)-centered researchers revealed the loss or imbalance of genes ATM, MRE11A, H2AFX, and/or CHEK1 in 11q in 20.7% of NBs. Furthermore, they found 83.3% NB-derived cell lines exhibited sensitivity to PARP inhibitors. (2017-12-28)

Cancer overrides the circadian clock to survive
Tumor cells use the unfolded protein response to alter circadian rhythm, which contributes to more tumor growth, researchers at the Medical University of South Carolina (MUSC) find. A key part of the the circadian clock opposes this process, according to a report published online on December 11 in Nature Cell Biology. (2017-12-28)

LSUHealthNo contributes to 1s- of-its-kind study of upper aerodigestive cancers
Using data interpreted by LSU Health New Orleans' Louisiana Tumor Registry, a case-control study found for the first time that older people who have gastroesophageal reflux disease (GERD) are at higher risk for cancers of the upper respiratory and digestive tract. (2017-12-21)

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