Current Tumors News and Events

Current Tumors News and Events, Tumors News Articles.
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CHOP researchers Find NTRK fusions more common than expected in pediatric tumors
Researchers from Children's Hospital of Philadelphia (CHOP) have found that NTRK fusions are more common in pediatric tumors and also involve a wider range of tumors than adult cancers, information that could help prioritize screening for NTRK fusions in pediatric cancer patients who might benefit from treatment with TRK inhibitors. (2021-01-15)

Study demonstrates efficacy of new treatment for neurofibromatosis type 1-related tumors
Based on preclinical studies of an investigational drug to treat peripheral nerve tumors, researchers at Children's Hospital of Philadelphia (CHOP) as part of the Neurofibromatosis Clinical Trials Consortium have shown that the drug, cabozantinib, reduces tumor volume and pain in patients with the genetic disorder neurofibromatosis type 1 (NF1). The results of the Phase 2 clinical trial, co-chaired by Michael J. Fisher, MD at CHOP, were published recently in Nature Medicine. (2021-01-14)

The role of T cells in fighting cancer
Why do some hosts' immune systems reject tumors easily, while others have a harder time doing so? It depends on the types of the immune cells known as CD8 T cells and how a host's specific T cells match up with the neoantigens present in the tumor. (2021-01-14)

Recurrent GBM brain tumors with few mutations respond best to immunotherapy
New insights from a team led by Duke's Preston Robert Tisch Brain Tumor Center provide potential answers about why immunotherapies have limited success against brain tumors. The team found that recurring glioblastoma tumors with very few mutations are far more vulnerable to immunotherapies than similar tumors with an abundance of mutations. (2021-01-13)

Texas A&M research explores how melanoma grows and spreads
The first step in treating cancer is understanding how it starts, grows and spreads throughout the body. A relatively new cancer research approach is the study of metabolites, the products of different steps in cancer cell metabolism, and how those substances interact. (2021-01-12)

Study identifies exposure to common food-borne pathogen linked to rare brain cancer
A new study suggests a link between toxoplasma gondii (T. gondii) infection and the risk of glioma, a type of brain cancer, in adults. (2021-01-11)

MRI frequently underestimates tumor size in prostate cancer
Improving imaging processes will lead to more successful treatments and help reduce morbidity in men with the disease. (2021-01-07)

Researchers uncover a potential treatment for an aggressive form of lung cancer
DALLAS - Jan. 5, 2021 - Researchers at the Children's Medical Center Research Institute at UT Southwestern (CRI) have discovered a new metabolic vulnerability in a highly aggressive form of non-small cell lung cancer (NSCLC). These findings could pave the way for new treatments for patients with mutations in two key genes - KRAS and LKB1. Patients whose tumors contain both of these mutations, known as KL tumors, have poor outcomes and usually do not respond to immunotherapy. (2021-01-05)

Study explains why patients with cancer spread to the liver have worse outcomes
A new study finds that tumors in the liver siphon off critical immune cells, rendering immunotherapy ineffective. But coupling immunotherapy with radiotherapy to the liver in mice restored the immune cell function and led to better outcomes. (2021-01-04)

Combined approach could boost breast cancer immunotherapy, study suggests
Activating an immune signaling pathway best known for fighting viral and bacterial infections can boost the ability of genetically engineered T cells to eradicate breast cancer in mice, according to a new study by researchers at the University of North Carolina. The study, to be published December 31 in the Journal of Experimental Medicine (JEM), suggests that CAR T cells, which are already used to treat certain blood cancers in humans, may also be successful against solid tumors if combined with other immunotherapeutic approaches. (2020-12-31)

Study points the way to boost immunotherapy against breast cancer, other solid tumors
UNC Lineberger Comprehensive Cancer Center researchers report that adding a small molecule to a chimeric antigen receptor-T (CAR-T) cell therapy can help immune system T cells to effectively attack solid tumors, such as breast cancers. The boost helps recruit more immune cells into battle at the tumor site, according to the study published in the Journal of Experimental Medicine. (2020-12-31)

Understanding nanoparticle entry mechanism into tumors
Announcing a new publication for BIO Integration journal. In this commentary the authors Phei Er Saw and Sangyong Jon from Sun Yat-Sen University, Guangzhou, China and the Korea Advanced Institute of Science and Technology, Daejeon, Korea, consider how the entry mechanism of nanoparticles into tumors determines the future direction of nanomedicine development. (2020-12-23)

Regulatory RNAs promote breast cancer metastasis
A gene-regulating snippet of RNA may contribute to the spread of many breast cancers. A molecule designed to destroy that RNA prevented metastases in animal models. The same strategy could be used to develop a new breast cancer drug. (2020-12-22)

Enzyme discovery can help rein in blood vessels that fuel cancer
Most living things need oxygen to grow and thrive. Even cancerous tumors. That's why tumors will readily sprout new blood vessels if their oxygen is starved, creating new lifelines for survival. A study published today from Scripps Research pinpoints the precise molecular machinery that makes this happen, providing scientific insights that can potentially be translated into medicines that help kill tumors and stop cancer from spreading in the body. (2020-12-22)

The Achilles' heel of cancer stem cells
Colon cancer stem cells have one weak spot: the enzyme Mll1. An MDC team led by Walter Birchmeier has now shown in Nature Communications that blocking this protein prevents the development of new tumors in the body. (2020-12-21)

Nanotechnology -- nanoparticles as weapons against cancer
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have developed a novel type of nanoparticle that efficiently and selectively kills cancer cells, thus opening up new therapeutic options for the treatment of tumors. (2020-12-18)

Scientists unlock promising key to preventing cancer relapse after immunotherapy
The researchers discovered that cancer immunotherapies that make use of immune system cells such as T cells and CAR-T cells kill not only tumor cells that express the drugs' target, but also adjacent tumor cells that lack the targets, because of the presence of fas. This process, known as bystander killing, can be made more effective by adding therapeutics that turn off the regulation of fas proteins, the researchers said. (2020-12-17)

Clemson researcher identifies gene teams working in subregions of brain
You must first understand how something works normally before you can figure out why it's broken. Clemson University researcher Yuqing ''Iris'' Hang has identified six mini gene co-expression networks for a normally functioning brain. That will allow researchers to test each of the gene teams to see if gene pairs are changing in brain tumors or people with intellectual disabilities. (2020-12-16)

Do tumors stiff-arm the immune system?
Cancer cells use an ancient mechanism of self-nonself discrimination to remain hidden from the immune system. A nanoscale molecular machine, akin to an arm that flexes and extends, allows cancer cell to fend off immune. defenders. The stiff-arm is delivered by components of the complement system. It prevents the initiation of immune responses, without which the current generations of immunotherapeutics, like checkpoint inhibitors, are not effective. The hypotheses presented in the paper are pre-clinical. (2020-12-15)

A first-in-human clinical trial shows microbubbles augments radiation in liver cancer patients
Bursting gas-filled microbubbles using ultrasound waves sensitizes tumors to targeted radiation, reducing tumor growth and improving overall survival after treatment. (2020-12-15)

Disrupting the cellular process that promotes pancreatic cancer's deadly growth
Researchers say they've identified a way to disrupt a process that promotes the growth of pancreatic cancers -- one of the most difficult and deadly cancers to treat. (2020-12-08)

β-AR agonist therapy puts the brakes on oral cancer progression
Oral cancer has a high mortality rate that is mainly attributed to metastasis. Researchers from Tokyo Medical and Dental University (TMDU) screened a panel of small chemical compounds for their ability to inhibit metastasis in oral cancer, identifying β2?AR-agonist isoxsuprine as a potential candidate. Treatment of various oral cancer cells with isoxsuprine suppressed their motility, while tumor size was significantly decreased in isoxsuprine-treated mice, suggesting that β-AR-agonist therapy could be an effective new treatment for oral cancer. (2020-12-03)

Stress hormones can reawaken sleeping tumor cells, raising risk of cancer recurrence
Stress hormones and immune cells called neutrophils may contribute to the recurrence of tumors years after treatment by awakening dormant cancer cells, suggests a study of mice and data from 80 patients with lung cancer. (2020-12-02)

IU researchers publish first article dedicated to Hoosier youth's donated tumor
Researchers at Indiana University School of Medicine have published their work about a specific type of childhood cancer in the peer-reviewed, international oncology journal, Cancers. This research involves a combination therapy that significantly slows tumor growth in models, which includes a model established from cells taken from tumors donated by Tyler Trent. (2020-12-01)

New immunotherapeutic approach takes aim at cancer's enzyme shield
A Brigham team observed that in a range of mouse models, inhibiting the protein SerpinB9 with a small molecule reduced tumor growth both by weakening the tumor's defense mechanisms and by triggering cell death in the tumors themselves. (2020-12-01)

Penn researchers unlock the door to tumor microenvironment for CAR T cells
Combining chimeric antigen receptor (CAR) T cell therapy with a PAK4 inhibitor drug allowed the engineered cells to punch their way through and attack solid tumors, leading to significantly enhanced survival in mice. (2020-11-30)

First large-scale proteogenomic analysis offers insights into pediatric brain tumors
A comprehensive ''proteogenomic'' analysis of the proteins, genes, and RNA transcription involved in pediatric brain tumors has yielded a more complete understanding of these tumors, which are the leading cause of cancer-related deaths in children. The results could help physicians more accurately identify different types of tumors and methods for treating them. (2020-11-25)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

Mediastinal tuberculoma mimicking malignant cardiac tumor
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0587, Yiqian Ding, Wei Li, Yanqiu Liu, Min Ye, Liangping Cheng, Donghong Liu, Hong Lin and Fengjuan Yao from The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China consider mediastinal tuberculoma mimicking malignant cardiac tumors. (2020-11-19)

Ovarian cancer cells cooperate to metastasize
In a study on human ovarian cancer cells in mice, Harvard Medical School researchers discovered a transient, cooperative interaction between cell subpopulations that allows otherwise nonmetastatic tumor cells to become aggressive and spread. (2020-11-18)

Study identifies patients with lung cancer most likely to respond to immunotherapy
In a new study, researchers at UCLA found patients with a particular type of HLA, a protein scaffold involved in presenting pieces of proteins described as peptides to the immune system, were particularly likely to benefit from immunotherapy. (2020-11-16)

A better test for the tumor-targeting of CAR-T therapies
Ludwig Cancer Research scientists have developed a method to significantly improve the preclinical evaluation of chimeric antigen-receptor (CAR) T cell therapies, in which the immune system's T cells are extracted from a patient, engineered to target a specific tumor-associated molecule and then grown and reinfused for cancer treatment. (2020-11-06)

Antiangiogenic therapy can cause malignancy in kidney cancers
In some cases, this type of therapy increases the invasiveness and metastasis of kidney tumors. The study led by IDIBELL and the ICO identifies a biomarker that could predict the malignant response of patients to therapy. (2020-11-05)

Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis. Now, a preclinical study from the lab of Marsha Moses, PhD at Boston Children's Hospital, reports marked and lasting tumor regression in a mouse model, using a highly selective, potent, engineered antibody-drug combination. (2020-11-05)

Immunotherapy may work better in stomach cancer when combined with chemo, given earlier
Immunotherapy, often ineffective against stomach cancer, was more effective when combined with chemotherapy and given earlier, finds a new study in mice. (2020-11-05)

Oncotarget: Predictive biomarkers in Trop-2-expressing triple-negative breast cancer
SG could provide better clinical benefit than irinotecan in patients with HRR-proficient tumors expressing high levels of Trop-2, as well as to patients with HRR-deficient tumors expressing low/moderate levels of Trop-2. (2020-11-03)

Melding biology and physical sciences yields deeper understanding of cancer
An evolving understanding of cancer that incorporates the physical properties of tumors and their surrounding tissues into existing biologic and genetic models can direct cancer researchers down previously uncharted avenues, potentially leading to new drugs and new treatment strategies, say investigators from Massachusetts General Hospital, Harvard Medical School (HMS) and the Ludwig Center at HMS. (2020-10-30)

Giving the immune system a double boost against cancer
Cancer immunotherapies are very effective for some patients, but many cancers do not respond to the currently available treatments. Researchers are developing a new approach that expands the number of treatable tumor types. (2020-10-30)

Eating less suppresses liver cancer due to fatty liver
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Fatty liver is often improved through eating less, getting more exercise, and reducing body weight. The research group posed the question, ''Can eating less also suppress liver cancer caused by fatty liver?'' (2020-10-29)

Greater prostate cancer incidence; mortality among Black men linked to genetic alterations
Prostate cancer tumors from African American men had higher frequencies of certain genetic alterations that may be associated with aggressive disease, compared with prostate cancer tumors from white men. (2020-10-28)

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