Current Ulcerative Colitis News and Events

Current Ulcerative Colitis News and Events, Ulcerative Colitis News Articles.
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First multi-whole-genome study of IBD in African Americans
In African Americans, the genetic risk landscape for inflammatory bowel disease (IBD) is very different from that of people with European ancestry, according to results of the first whole-genome study of IBD in African Americans. The authors say that future clinical research on IBD needs to take ancestry into account. (2021-02-19)

New potential therapy for Crohn's disease in children
Scientists from the Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago demonstrated that a nanotherapy reduces intestinal inflammation and shrinks lesions in a rodent model of severe Crohn's disease. (2021-02-17)

Response to cancer immunotherapy may be affected by genes we carry from birth
For all their importance as a breakthrough treatment, the cancer immunotherapies known as checkpoint inhibitors still only benefit a small minority of patients, perhaps 15 percent across different types of cancer. Moreover, doctors cannot accurately predict which of their patients will respond. (2021-02-10)

Scientists switch on tissue repair in inflammatory bowel disease
Researchers have developed a method that instructs immune system cells to help repair damaged tissue in the intestine. The finding opens the way for more effective treatment of inflammatory bowel disease. (2021-02-08)

Probiotics or prebiotics? Exploring the complex world of 'gut' health
Elena Goun at the University of Missouri and an international team of scientists have developed a noninvasive diagnostic imaging tool to measure the levels of a naturally occurring enzyme -- bile salt hydrolase -- inside the body's entire gastrointestinal tract. This research could lead to better precision medicine treatments by providing a way for scientists to better understand how a person's individual gut health is connected to various human pathologies, or the origin and nature of human diseases. (2021-02-04)

Surgery to heal inflamed gut may create new target for disease
A surgical procedure meant to counter ulcerative colitis, an immune disease affecting the colon, may trigger a second immune system attack, a new study shows. (2021-02-02)

Our gut-brain connection
MIT researchers developed an 'organs-on-a-chip' system that replicates interactions between the brain, liver, and colon. They modeled the influence microbes living in the gut have on both healthy brain tissue and tissue samples derived from patients with Parkinson's disease. (2021-01-29)

Scientists find key function of molecule in cells crucial for regulating immunity
UNC School of Medicine scientists led by Jenny Ting, PhD, the William Kenan Distinguished Professor of Genetics, and Yisong Wan, PhD, professor of microbiology and immunology, discovered that AIM2 is important for the proper function of regulatory T cells, or Treg cells, and plays a key role in mitigating autoimmune disease. Treg cells are a seminal population of adaptive immune cells that prevents an overzealous immune response, such as those that occurs in autoimmune diseases. (2021-01-28)

Gut microbiota reveals whether drug therapies work in inflammatory bowel diseases
A study recently completed at the University of Helsinki indicates that the gut microbiota of patients suffering from inflammatory gastrointestinal disorders can be used to predict whether they will benefit from expensive therapies. The study also confirms the key role of therapies that have a beneficial effect on the gut microbiota in inflammatory bowel diseases. (2021-01-26)

Uncovering basic mechanisms of intestinal stem cell self-renewal and differentiation
The gut plays a central role in the regulation of the body's metabolism and its dysfunction is associated with a variety of diseases, such as obesity, diabetes, colitis and colorectal cancer that affect millions of people worldwide. Targeting endocrine dysfunction by stimulating the formation of specific enteroendocrine cells from intestinal stem cells could be a promising regenerative approach for diabetes therapy. For this, a detailed understanding of the intestinal stem cell lineage and the signals regulating the recruitment of intestinal cell types is critical. (2021-01-11)

Researchers engineer novel disease model to identify potential targets for ulcerative colitis drugs
As reported in Nature Communications, researchers from Cleveland Clinic's Lerner Research Institute have developed a novel, patient-derived model of ulcerative colitis, which will help advance studies into new treatments for the chronic inflammatory bowel disease. The team used the model to identify a promising target that could be inhibited to slow disease progression. (2021-01-11)

Multi-population risk scores could improve risk prediction for inflammatory bowel diseases, study finds
New study illustrates how studying diverse populations can help predict patient outcomes and reduce health disparities (2020-12-24)

Potential preventative treatment demonstrated for Crohn's disease
A potential preventive treatment for Crohn's disease, a form of inflammatory bowel disease, has been demonstrated in a mouse model and using immune-reactive T cells from patients with Crohn's disease. (2020-12-21)

UBCO researchers suggest stool transplants can battle serious infections
Could number two be number one when it comes to combating recurrent Clostridium difficile (CDI) infections? Using genetic material analysis and machine learning, UBC researchers have pinpointed several key factors to ensure successful fecal microbiota transplants (FMT), which have proven successful in treating bacterial infections in the gut including illnesses like C. difficile, Crohn's Disease, Colitis and even obesity, explains lead author Negin Kazemian. (2020-12-09)

Research reveals how a fungal infection activates inflammation
Scientists at St. Jude Children's Research Hospital have shed light on the mechanisms that underlie how Aspergillus fumigatus activates the inflammasome, with implications for therapeutic development. (2020-12-02)

Vitamin D regulates calcium in intestine differently than previously thought
A Rutgers study has discovered that vitamin D regulates calcium in a section of the intestine that previously was thought not to have played a key role. The findings have important implications on how bowel disease, including ulcerative colitis and Crohn's disease, may disrupt calcium regulation. (2020-12-01)

Genetic risk for fatal blood clots identified in IBD patients
In a retrospective study recently published in the journal Gastroenterology, Cedars-Sinai investigators found that a combination of rare and common genetic variants in some IBD patients significantly increased their risk of developing clot-causing thromboembolic diseases. (2020-11-11)

Therapeutic drug monitoring does not improve remission for patients starting infliximab
New research presented at ACR Convergence, the American College Rheumatology's annual meeting, showed that patients with rheumatic diseases whose infliximab treatment was individually assessed and adjusted with a new strategy called therapeutic drug monitoring did not achieve remission at higher rates compared to those who received standard care. (2020-11-06)

COVID-19: Enzyme targeted by virus also influences gut inflammation
An enzyme that helps COVID-19 (coronavirus) infect the body also plays a role in inflammation and patient outcomes in inflammatory bowel disease (IBD), according to a new study led by Cedars-Sinai. The findings raise the possibility that anti-inflammatory drug therapies for IBD may aid recovery from coronavirus. (2020-11-05)

CHOP genomic study reveals role for hypothalamus in inflammatory bowel disease
Using sophisticated 3D genomic mapping and integrating with public data resulting from genome-wide association studies (GWAS), researchers at Children's Hospital of Philadelphia (CHOP) have found significant genetic correlations between inflammatory bowel disease (IBD) and stress and depression. (2020-10-29)

High-sugar diet can damage the gut, intensifying risk for colitis
DALLAS - Oct. 28, 2020 - Mice fed diets high in sugar developed worse colitis, a type of inflammatory bowel disease (IBD), and researchers examining their large intestines found more of the bacteria that can damage the gut's protective mucus layer. (2020-10-28)

Severe form of Inflammatory Bowel Disease linked to a strain of mouth bacteria
Bacteria from the mouth could hold clues to understanding - and potentially treating - severe ulcerative colitis, a painful bowel disease. (2020-10-28)

Discoveries reshape understanding of gut microbiome
The findings redefine how the so-called gut microbiome operates and how our bodies coexist with some of the 100 trillion bacteria that make it up. The discoveries could lead to new therapies for inflammatory bowel disease and people who've had portions of their bowels removed due to conditions like colon cancer and ulcerative colitis. They also help explain why the use of antibiotics can create a multitude of problems in the digestive system. (2020-10-22)

Multi-mucus barrier segregates colon microbiota from host tissue
Whole-colon imaging in mice has revealed a continuous colonic mucus system, which forms a protective barrier between potentially harmful gut microbiota and host tissue by encapsulating fecal pellets as they form and as they are eliminated from the colon. (2020-10-22)

More turkey dinners for people with celiac disease?
An international team of researchers led by McMaster University has found that tryptophan, an amino acid present in high amounts in turkey, along with some probiotics, may help them heal and respond better to a gluten-free diet (2020-10-21)

Treatment for inflammatory bowel disease doesn't always work; new study uncovers why
In preclinical study, researchers at Children's Hospital Los Angeles uncover role for TNF, the most common target in Inflammatory Bowel Disease. Results pave way for better understanding of how TNF functions in normal intestinal development and provide foundation for future new therapies. (2020-10-20)

Protein that keeps immune system from freaking out could form basis for new therapeutics
Treatment with a peptide that mimics the naturally occurring protein GIV prevents immune overreaction and supports a mechanism critical for survival in mouse models of sepsis and colitis, according to a UC San Diego study. (2020-10-14)

Medical mystery: 'Creeping fat' in Crohn's patients linked to bacteria
Cedars-Sinai researchers might have solved a mystery surrounding Crohn's disease: Why does fat appear to migrate into patients' small intestines? (2020-09-30)

Drug found to correct gene defect that causes immune-driven gut leakiness
A team of researchers led by biomedical scientist Declan McCole at the University of California, Riverside, has found that the drug tofacitinib, also called Xeljanz and approved by the FDA to treat rheumatoid arthritis and ulcerative colitis, can repair permeability defects in the intestine. ''Our work could help improve identification of patients who will be better responders to this drug,'' says McCole, a professor of biomedical sciences in the School of Medicine. (2020-09-29)

Cell therapy designed to treat inflammatory bowel disease
The UPV/EHU's NanoBioCel research group has for many years been developing systems enabling cells to be used as drugs. Cell therapy raises hopes for treating those diseases for which there are as yet no effective pharmacological solutions. Biomaterials, a leading journal in the field of materials sciences and medicine, has just published the paper 'Multifunctional biomimetic hydrogel systems to boost the immunomodulatory potential of mesenchymal stromal cells'. (2020-09-28)

Team develops wearable sensor to help people with inflammatory bowel disease
University of Texas at Dallas researchers have designed a wearable device that monitors sweat for biomarkers that could signal flare-ups of inflammatory bowel disease (IBD). A team of bioengineers demonstrated the wristwatch-like device in a proof-of-concept study funded by the Crohn's & Colitis Foundation and published online July 28 and in the October print edition of the foundation's journal, Inflammatory Bowel Diseases. (2020-09-28)

University of South Carolina study reveals how cannabinoids may be useful to prevent colon cancer
Inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis are caused by inflammation of the gastrointestinal tract. Patients with IBD are at a higher risk of developing colorectal cancer. A UofSC study shows that THC suppressed inflammation in the colon, preventing the onset of cancers caused by a carcinogen. (2020-09-15)

High-risk patients for colorectal cancer lack knowledge about colonoscopy
Many clinicians rely on self-reports from their high-risk patients about their need and proper interval for repeat surveillance colonoscopy. Researchers analyzed data on high-risk patients and found that 28 percent were unaware of either the need for a repeat colonoscopy or the proper surveillance interval. Of these, 16.6 percent were unaware of the proper three-year interval to obtain a follow-up surveillance colonoscopy. Also, 12 percent did not know that they required a follow-up surveillance colonoscopy. (2020-09-14)

Rare immune cells drive gut repair
Scientists from King's College London have discovered an unexpected tissue reparative role for a rare immune cell type in the gut that could tip toward fibrosis or cancer if dysregulated. The breakthrough will have important implications for treating patients who suffer from inflammatory bowel diseases (IBD) such as Crohn's disease and ulcerative colitis. (2020-09-07)

Inflammatory bowel disease linked to an immune cell run amok
Researchers at UC San Diego School of Medicine report that the lasting nature of inflammatory bowel disease may be due to a type of long-lived immune cell that can provoke persistent, damaging inflammation in the intestinal tract. (2020-08-24)

Researchers identify enzyme linked to colitis
An enzyme that usually stops bacterial growth in the large intestine stimulates inflammation in some people, resulting in ulcerative colitis - a chronic digestive disease. The gut enzyme lysozyme which normally functions to restrain bacterial growth, instead stimulates inflammation and results in the formation of ulcers and sores. (2020-08-18)

Antibiotics associated with increased risk of inflammatory bowel disease
Antibiotics use, particularly antibiotics with greater spectrum of microbial coverage, may be associated with an increased risk of new-onset inflammatory bowel disease (IBD) and its subtypes ulcerative colitis and Crohn's disease. That is according to a study by researchers at Karolinska Institutet in Sweden and Harvard Medical School in the United States, published in The Lancet Gastroenterology & Hepatology. The association between antimicrobial treatment and IBD remained when patients were compared with their siblings. (2020-08-17)

Enzyme discovered in the gut could lead to new disease biomarker
Enzymes used by bacteria to break down mucus in the gut could provide a useful biomarker for intestinal diseases, according to new research published in Nature Communications. (2020-08-11)

Tool could improve success in translating drugs from animal studies to humans
A new computational tool developed by researchers from Purdue University and MIT could help better determine which drugs should move from animal testing to humans. It could also sooner detect a reason why a drug might fail, guiding how a clinical trial should be set up. (2020-08-04)

Antibiotics use early in life increases risk of inflammatory bowel disease later in life
Even short, single antibiotic courses given to young animals can predispose them to inflammatory bowel disease (IBD) when they are older, according to Rutgers researchers. The study, published in Genome Medicine, provides further evidence supporting the idea that the use of antibiotics in children under 1 year old disrupts the intestinal microbiota - the trillions of beneficial microorganisms that live in and on our bodies - that play a crucial role in the healthy maturation of the immune system and the prevention of diseases. (2020-07-28)

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