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Current Urine News and Events, Urine News Articles.
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The dioxin poisoning of Victor Yushchenko -- methods needed for routine analysis of metabolites of the poison TCDD
An article published online first tracks the science behind the poisoning of Ukrainian President Victor Yushchenko in 2004, and concludes that routine analytical techniques are needed to test for metabolites of TCDD so that appropriate treatment can be given. The article is written by Professor Jean Saurat, Swiss Center for Human Applied Toxicology, and University Hospital, Geneva, Switzerland, and colleagues. (2009-08-04)

IgM in urine acts as prognostic indicator in diabetes
A marker of the likely course of diabetic nephropathy has been found. An 18-year study, published in the open access journal BMC Medicine, has shown that Immunoglobulin M is a reliable predictor of cardiovascular complications in DN patients. (2009-08-03)

Induction of labor after 37 weeks recommended for women with gestational hypertension/mild pre-eclampsia (Hypitat study)
Pregnant women with mild hypertensive disorders such as high blood pressure/mild pre-eclampsia should have their labor induced once they complete 37 weeks of their pregnancy. This is the conclusion of the Hypitat study, published in an article online first and in an upcoming edition of the Lancet, written by Dr. Corine M. Koopmans, Department of Obstetrics and Gynaecology, University Medical Centre Groningen, Netherlands, and colleagues. (2009-08-03)

Common household pesticides linked to childhood cancer cases in Washington area
A study by Georgetown's Lombardi Comprehensive Cancer Center researchers finds a higher level of common household pesticides in the urine of children with acute lymphoblastic leukemia (ALL), a cancer that develops most commonly between 3 and 7 years of age. The findings, published in the August issue of the journal Therapeutic Drug Monitoring, should not be seen as cause-and-effect, but suggests an association between pesticide exposure and development of childhood ALL. (2009-07-28)

New chlamydia test offers rapid, pain-free test for men
A new urine test developed with funding from the Wellcome Trust will allow doctors to diagnose chlamydia infection in men within the hour, improving the ability to successfully treat the infection on the spot and prevent re-transmission. (2009-07-28)

Protein excreted in urine may be help in diagnosing kidney disease caused by HIV
New data collected at Columbia University Medical Center and by the Mount Sinai School of Medicine are helping researchers understand the extent to which a certain protein -- NGAL -- can play a significant role in marking chronic kidney disease resulting from HIV while at the same time distinguishing nephropathy from more common causes such as diabetes and hypertension. (2009-07-23)

New lab test helps predict kidney damage
Acute kidney injury (AKI) is a frequent complication in patients in intensive care. A new laboratory test called urine neutrophil gelatinase associated lipocalin (NGAL) helps predict if patients will develop acute kidney injury, reports an upcoming study in the Journal of the American Society of Nephrology. (2009-07-23)

An inner 'fingerprint' for personalizing medical care
Fingerprints, move over. Scientists are reporting evidence that people have another defining trait that may distinguish each of the 6.7 billion humans on Earth from one another almost as surely as the arches, loops, and whorls on their fingertips. In a study scheduled for the Aug. 7 issue of ACS' monthly publication the Journal of Proteome Research, they report evidence from studies in humans for the existence of unique patterns in metabolism. (2009-07-22)

Daily potassium citrate wards off kidney stones in seizure patients on high-fat diet
Children on the high-fat ketogenic diet to control epileptic seizures can prevent the excruciatingly painful kidney stones that the diet can sometimes cause if they take a daily supplement of potassium citrate the day they start the diet, according to research from Johns Hopkins Children's Center. (2009-07-21)

UT Southwestern researchers investigate high-risk populations for bladder-cancer screenings
A new study by UT Southwestern Medical Center researchers sheds light on the challenges involved in identifying which high-risk population would benefit most from bladder-cancer screening. (2009-07-16)

Less trouble at mill, thanks to earthworms
Waste from the textiles industry could with the assistance of earthworms and some animal manure become a rich compost for agriculture, according to a report in the International Journal of Environment and Pollution. (2009-07-16)

Chemicals in common consumer products may play a role in pre-term births
A new study of expectant mothers suggests that a group of common environmental contaminants called phthalates, which are present in many industrial and consumer products including everyday personal care items, may contribute to the country's alarming rise in premature births. (2009-07-06)

Clocking salt levels in the blood: A link between the circadian rhythm and salt balance
New research, to be published in the Journal of Clinical Investigation, suggests a link between the circadian rhythm and control of sodium (salt) levels in the blood of mice. Specifically, the circadian clock protein Period 1 was found to function downstream of the hormone aldosterone (a known controller of blood sodium levels and thereby blood pressure) to regulate levels of the alpha-subunit of the epithelial sodium channel in the mouse kidney. (2009-07-01)

New discovery to aid in diagnosis and treatment of kidney disease
Researchers from Boston University School of Medicine in collaboration with scientists at the University of Louisville and the University of Nice Sophia Antipolis in France, have identified the target antigen PLA2R in patients with idiopathic membranous nephropathy (kidney disease), which has implications for the diagnosis and treatment of this disease. These findings appear in the July 2 issue of the New England Journal of Medicine. (2009-07-01)

Microproteinuria: Indicator to monitor CNI-related nephrotoxicity in liver transplant recipients?
Calcineurin inhibitor-related renal dysfunction has been widely reported in liver transplant recipients. The monitoring of transplant patients, however, is still dependent on somewhat old indicators: serum creatinine, BUN, total urine output. Microproteinuria is a hallmark of early changes in the glomeruli and proximal tubular function. A research group in China demonstrated that microproteinuria could be used as an early and sensitive indicator to monitor CNI-related nephrotoxicity in liver transplant recipients. (2009-06-27)

Proteins in gel
Biochips carrying thousands of DNA fragments are widely used for examining genetic material. Experts would also like to have biochips on which proteins are anchored. This requires a gel layer which can now be produced industrially. (2009-06-24)

A urine test for appendicitis?
Appendicitis is the most common childhood surgical emergency, but can be hard to diagnose, often leading to either unnecessary surgery or serious complications when the condition is missed. Now, emergency physicians and proteomics researchers at Children's Hospital Boston have identified a urine protein that might serve as a (2009-06-23)

Cellular telephones to expand knowledge of health behaviors and microorganisms in adolescent males
A $4.15 million, four-year NIH grant will enable researchers at the Indiana University School of Medicine to conduct the first health study of teenage boys using cellular telephones. The objective of the study is to identify and characterize changes in the microorganisms in the urethra of the adolescent male. (2009-06-17)

News briefs from the June issue of Chest
News briefs from the June issue of Chest highlight pulmonary hypertension, managing pain in the critically ill patient and sleep disorders in children. (2009-06-04)

Knock-out drugs: Narrow window for detection
Drug-facilitated sexual crimes are increasing. The Bonn Institute for Forensic Medicine has recorded that the number of examinations on the use of intoxicants in sexual offenses within their catchment area increased tenfold between 1997 and 2006. In the current edition of Deutsches Arzteblatt International, Burkhard Madea and Frank Musshoff present the modes of action and the detection windows for the most frequent substances. (2009-05-29)

BPA, chemical used to make plastics, found to leach from polycarbonate drinking bottles into humans
A new study from Harvard School of Public Health researchers found that participants who drank for a week from polycarbonate bottles, the popular, hard-plastic drinking bottles and baby bottles, showed a two-thirds increase in their urine of the chemical bisphenol A. (2009-05-21)

Study finds novel genetic risk factors for kidney disease
An international team of researchers has identified three genes containing common mutations that are associated with altered kidney disease risk. One of the discovered genes, the UMOD gene, produces Tamm-Horsfall protein, the most common protein in the urine of healthy individuals. Although the Tamm-Horsfall protein has been known for almost 60 years, its functions are not well understood and its relationship to chronic kidney disease risk was not known previously. (2009-05-10)

System that regulates blood pressure is amiss in some healthy, young blacks
When stress increases blood pressure, a natural mechanism designed to bring it down by excreting more salt in the urine doesn't work well in about one-third of healthy, black adolescents, researchers report. (2009-05-08)

Elevated level of certain protein in urine linked to increased risk for blood clots
Preliminary research suggests that higher than normal levels of the protein albumin in urine is associated with an increased risk for blood clots in the deep veins of the legs or lungs (venous thromboembolism; VTE), according to a study in the May 6 issue of JAMA. (2009-05-05)

Urine screening test may one day predict coronary artery disease
Seventeen specific protein fragments seem to distinguish people who have coronary artery disease from those who don't. A small study indicates that a newly created urine analysis may identify patients with these proteins and accurately diagnose atherosclerosis in 84 percent of the cases. These data encourage further development of a urine-based screening method for noninvasive diagnosis of atherosclerosis and coronary artery disease. (2009-04-29)

Long-term complications of melamine consumption in children
Children with a history of consuming melamine-contaminated milk powder are at an increased risk of developing kidney stones and other urological complications. Researchers presenting two studies at the 104th Annual Scientific Meeting of the American Urological Association found that melamine calculus occurred mostly in infants at six months to 18 months after consuming melamine-contaminated milk powder after birth but that the stones could be effectively managed with noninvasive treatment. (2009-04-26)

Rice students win NASA national design award
Five senior bioengineering students have designed a device to help astronauts keep their skeletons strong and healthy by measuring bone mineral density loss, literally on the fly. Their design of a bone-remodeling monitor for use in microgravity shared the top prize in NASA's third annual Systems Engineering Competition. (2009-04-23)

Urine test may determine if a smoker is at risk for lung cancer
Researchers may have uncovered why lung cancer afflicts some smokers and not others, according to data presented at the American Association for Cancer Research 100th Annual Meeting 2009. (2009-04-19)

Newly discovered epidermal growth factor receptor active in human pancreatic cancers
Finally some promising news about pancreatic cancer, one of the most fatal cancers, due to the difficulties of early detection and the lack of effective therapies: Johns Hopkins University pathologist Akhilesh Pandey has identified an epidermal growth factor receptor aberrantly active in approximately a third of the 250 human pancreatic cancers studied. (2009-04-18)

Gene fusion discovery may lead to improved prostate cancer test
A newly discovered gene fusion is highly expressed in a subset of prostate cancers, according to a new study. The findings may lead to more accurate tests for prostate cancer. The gene fusion biomarker may also represent an entirely new mechanism that cancer cells use to outgrow their healthy neighbors. (2009-04-09)

Test predicts who will develop end-stage renal disease
Measuring kidney function by assessing two different factors -- glomerular filtration rate and urinary albumin levels -- helps determine which patients with chronic kidney disease will develop end-stage renal disease, according to a study appearing in the May 2009 issue of the Journal of the American Society Nephrology. This combination test could help physicians identify patients at high risk of serious kidney trouble and allow them to intervene at an early stage. (2009-04-08)

The UK Biobank: Transforming an unpleasant afternoon
The methods of the UK Biobank project are criticized in an editorial in this week's edition of the Lancet. The UK Biobank is a research project aiming to enlist 500,000 people aged between 40 years, and costing about £62 million ($89.2 million) so far, and uses questions, medical tests and histories. (2009-04-02)

A new approach to prostate cancer detection
US researcher Dr. Chris Beecher from the University of Michigan gave a well attended lecture about sarcosine at the 24th Annual EAU Congress in Stockholm, Sweden. Dr Beecher is a colleague of lead author Dr. Arun Sreekumar. The research looked at more than 1,000 small molecules in tissues associated with prostate cancer. These findings suggest that not only is sarcosine a marker of cancer aggressiveness, it also has a role in endowing a cancer with malignant properties. (2009-03-25)

Proteins from garden pea may help fight high blood pressure, kidney disease
Researchers in Canada are reporting that proteins found in a common garden pea show promise as a natural food additive or new dietary supplement for fighting high blood pressure and chronic kidney disease. Those potentially life-threatening conditions affect millions of people worldwide. Their study is scheduled for presentation in March at the 237th National Meeting of the American Chemical Society. (2009-03-22)

Is it really only our kidneys that control blood pressure?
The latest issue of Experimental Physiology includes the first-ever published dialogue between experts debating whether the kidney or the brain is to blame for high blood pressure -- a common cause of premature death through heart attacks, strokes and kidney disease. Their frank exchange of views provides an interesting and informative summary of the latest research into how blood pressure is controlled. (2009-03-13)

Steroid doping tests ignore vital ethnic differences in hormone activity
Current steroid (testosterone) doping tests should be scrapped for international sport, because they ignore vital ethnic differences in hormone activity, suggests research published ahead of print in the British Journal of Sports Medicine. (2009-03-11)

Breath or urine analysis may detect cancer, diabetes
A University of Missouri researcher is developing a device that will analyze breath or urine samples for volatile markers inside the body that indicate disease. These volatile markers, such as alkanes, acetones or nitric oxide, give doctors clues about what is happening inside the body and can be used as a diagnostic tool. (2009-03-10)

Metastasis-promoting protein identified; could provide a prognostic test or target for breast cancer
A small protein detectable in urine can predict a breast cancer's aggressiveness, and possibly provide a new avenue for treating the disease. When its production is shut down, cell migration -- a key step in progression and metastasis -- is inhibited. The protein, which has been licensed for clinical development, also plays a key biological role in advancing cancer, triggering the epithelial-to-mesenchymal transition and reducing cells' response to the hormone estrogen. (2009-02-23)

Bacteria in urinary tract infections caught making burglar's tools
Bacteria that cause urinary tract infections make more tools for stealing from their host than friendly versions of the same bacteria found in the gut, researchers at Washington University School of Medicine in St. Louis and the University of Washington have found. The tools help the bad bacteria to survive and reproduce. But they also provide a potential way to target them without adversely affecting the good strains. (2009-02-19)

Healthy people with high urinary protein levels have elevated kidney disease risk
Measuring the amount of protein lost in the urine can identify individuals at risk of developing kidney disease, according to a study appearing in the April 2009 issue of the Journal of the American Society Nephrology. The results suggest that a simple and low-cost urine screen is a promising way to address the epidemic of chronic kidney disease. (2009-02-11)

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