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Current Viral Load News and Events, Viral Load News Articles.
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Combatting viruses: Code breakers turn code writers
Researchers who successfully cracked a code that governs infections by a major group of viruses have gone a step further, creating their own artificial code. (2017-10-30)

Zika virus infects developing brain by first infecting cells meant to defend against it
Researchers at the University of California San Diego School of Medicine, with colleagues in Brazil, report that the Zika virus is transmitted from mother to fetus by infected cells that, ironically, will later develop into the brain's first and primary form of defense against invasive pathogens. (2017-10-27)

Hush little virus, don't say a word: How Princeton scientists investigate sleeping viruses
Four in five adults are infected with herpes simplex virus, say researchers, but most don't show symptoms like cold sores because the virus infection is 'latent' -- sleeping -- within the nervous system. While many virus researchers are interested in understanding what causes these sleeping viruses to wake up, or reactivate, Princeton scientists are trying to understand what prevents the infection from going to sleep in the first place. (2017-10-26)

Taking a tip from mussels to make materials both strong and flexible
A network of loosely-linked polymers mimicking a mussel's adhesive qualities offers a way to make materials that are both strong and flexible, elements that have been widely sought but hard to produce. (2017-10-26)

A new player helping viruses hijack their hosts
A particular long noncoding RNA gives viruses a replication boost as they infect their hosts, helping them alter their host cell's metabolism to their advantage, scientists report. (2017-10-26)

Is Alzheimer's disease a disorder of energy metabolism?
McLean Hospital researchers found a connection between disrupted energy production and the development of late-onset Alzheimer's disease. (2017-10-26)

Mathematically modeling HIV drug pharmacodynamics
Complete elimination of Human Immunodeficiency Virus (HIV) presents a challenge due to latent viral reservoirs within the body that can help re-establish infection. In a paper publishing this week in the SIAM Journal on Applied Mathematics, researchers propose a mathematical model that investigates the effects of drug parameters and dosing schedules on HIV latent reservoirs and viral load dynamics. (2017-10-19)

Gene editing in the brain gets a major upgrade
Genome editing technologies have revolutionized biomedical science, providing an easy way to modify genes. However, the technique allowing scientists to carryout the most precise edits, doesn't work in cells that are no longer dividing - which includes most neurons in the brain. Researchers at Max Planck Florida Institute for Neuroscience have developed a new tool called vSLENDR that, for the first time, allows precise genome editing in mature neurons, opening up new possibilities in neuroscience research. (2017-10-19)

Last unknown structure of HIV-1 solved, another step in efforts to disarm the AIDS virus
UAB researchers have solved the last unknown protein structure of HIV-1, the retrovirus that can cause AIDS. Knowledge of this structure, called the cytoplasmic tail of gp41 protein, will further explain how the virus infects human cells and how progeny viruses are assembled and released from infected cells. The cytoplasmic tail appears to play a key role in virus assembly to help incorporate the envelope spike structures into the surface of viral particles. (2017-10-19)

Newly discovered viral marker could help predict flu severity in infected patients
Flu viruses contain defective genetic material that may activate the immune system in infected patients, and new research published in PLOS Pathogens suggests that lower levels of these molecules could increase flu severity. (2017-10-19)

Study: New simple method determines rate at which we burn calories walking up, down, flat
A new way to predict the energy a person expends walking will help predict and monitor the physiological status of walkers, including foot soldiers. Researchers at Southern Methodist University, Dallas, developed the Army-funded method, which significantly improves on two existing standards, and relies on three readily available variables. Accurate prediction is important because the rate at which people burn calories walking can vary tenfold depending on speed, carried load and whether uphill, at-grade or downhill. (2017-10-18)

New research opens the door to 'functional cure' for HIV
Scientists have for the first time shown that a novel compound effectively suppresses production of the virus in chronically infected cells. (2017-10-17)

Nidoviruses redundantly express genes and encode more proteins than previously believed, study finds
Arteriviruses, a family of single-stranded RNA viruses that belongs to the order Nidovirales, produce more proteins and messenger RNAs than previously reported, a finding that provides important insights about a virus that could potentially evolve to infect humans in the future, according to a new research study. (2017-10-16)

Novel reagent detects memory immune response in vaccinated animals
Researchers have developed a novel reagent capable of detecting rare, antigen-specific B cells that indicate successful vaccination in veterinary animals. (2017-10-16)

Penn team shows how seemingly acute viral infections can persist
Led by Carolina López of the University of Pennsylvania, a multi-disciplinary research team has resolved a paradox of viral infection. They've identified how a viral product can both trigger an immune response aimed at eliminating the virus or, conversely, allow the virus to survive and persist. (2017-10-06)

Tiny protein offers major insight into foot-and-mouth virus
Scientists have identified that a tiny protein, which plays a major role in the replication of foot-and-mouth disease virus, demonstrates a greater level of genetic economy than previously reported. (2017-10-03)

Scientists bring new insights into the heritability of HIV infection severity
Using a population of HIV-1 infected individuals (the 2014 Swiss HIV Cohort Study data), an international research team of 17 institutions, led by ETH Zurich's Roland Regoes of the Institute of Integrative Biology, has now examined all aspects of HIV virulence, with a particular focus on how it ravages the human immune system. (2017-10-03)

A new method for removing cells infected with the AIDS virus
With the successful suppression of the AIDS virus (HIV) through medication, the focus turns toward its eradication. Japanese researchers have developed a new compound that is key to the destruction of HIV. When the compound is introduced into infected cells, viral budding is suppressed thereby confining it within the host cells. The cell then dies naturally through apoptosis. This treatment is believed to lead to the complete recovery from AIDS in the near future. (2017-10-02)

Earth's tectonic plates are weaker than once thought
Research by University of Pennsylvania geophysicists and colleagues has resolved a long-standing question regarding the strength of olivine, the primary component of Earth's mantle. The results have implications for how tectonic plates form and move. (2017-10-02)

Study finds driving speed affected when a driver's mind 'wanders'
Research finds that driving speed fluctuates more when a driver's mind wanders from focusing on the act of driving - and that the outside environment influences how often a driver's mind wanders. (2017-09-28)

Arrowhead data reveal important considerations for future hepatitis B treatment
Arrowhead Pharmaceuticals Inc. today announced results from studies of ARC-520, a prior-generation RNAi therapeutic candidate against chronic hepatitis B virus (HBV) infection, in a Phase 2 clinical study in HBV patients and a complementary study in chimpanzees chronically infected with HBV. These studies demonstrated that HBV DNA integrated into the host genome is an under-appreciated source of HBV surface antigen, a key protein implicated in maintaining chronic HBV infection. (2017-09-27)

Fast and accurate 'dipstick' test for diagnosing Zika
A newly developed, fast, and cost-effective dipstick test sensitively and specifically identified Zika virus and all four dengue virus subtypes without any detectable cross-reactivity. (2017-09-27)

Researchers identify novel way to target Ebola
Researchers have identified a potential new way to attack Ebola. Scientists have discovered that a protein called Tim-1 (T-cell immunoglobulin and mucin domain-containing protein 1) plays a key role in the development of the cytokine storm seen in the last stages of Ebola infection. The research was published this week in mBio, an open-access journal of the American Society for Microbiology. (2017-09-26)

Biochemists discover mechanism that helps flu viruses evolve
A new study from MIT reveals that flu viruses' rapid evolution relies in part on hijacking some of the cellular machinery of the infected host cell -- a group of proteins called chaperones, which help other proteins fold into the correct shape. When viruses are unable to get help from these proteins, they do not evolve as rapidly. (2017-09-26)

Discovering what makes organelles connect could help understand neurodegenerative diseases
Organelles must exchange signals and materials to make the cell operate correctly. New technologies are allowing researchers to see and understand the networks that connect these organelles, allowing them to build maps of the trade routes that exist within a cell. (2017-09-25)

Study finds being in a good mood for your flu jab boosts its effectiveness
New research by a team of health experts at the University of Nottingham has found evidence that being in a positive mood on the day of your flu jab can increase its protective effect. (2017-09-25)

Study finds no-tillage not sufficient alone to prevent water pollution from nitrate
A new IUPUI study funded by the US Department of Agriculture answers a long-debated agricultural question: whether no-tillage alone is sufficient to prevent water pollution from nitrate. The answer is no. (2017-09-22)

A rapid alternative to standard safety tests for lentiviral vectors
A new, publicly available test to assess the safety of cell therapy products altered by lentivirus generates results within a few hours, potentially hastening the pace at which viral immunotherapies move into clinical trial. Current assays required by the US Food and Drug Administration take about six weeks to complete. The rapid test, which does not have a significant risk of false positives, is also a fraction of the cost of the standard approach. (2017-09-21)

Fish may use different behaviors to protect against parasites
New research indicates that fish may adapt their behavior to defend against parasite infection. The findings are published in the Journal of Zoology. (2017-09-20)

Weighing nonsurgical treatment options for knee osteoarthritis pain
Osteoarthritis of the knee may not be totally preventable but according to Elizabeth Matzkin, MD, an orthopaedic surgeon specializing in sports medicine with Brigham and Women's Hospital, there are some key factors that we can control to minimize the chances of developing bone and joint pain. What's the best treatment option for those who already have knee OA? Dr. Matzkin explains her study's findings published in the Journal of the American Academy of Orthopaedic Surgeons. (2017-09-19)

HIV-AIDS: Following your gut
Researchers find a way to reduce replication of the AIDS virus in the gastrointestinal tract. (2017-09-18)

Study: Girl soccer players who give up other sports may feel more stressed, less rested
An abstract of new research being presented at the American Academy of Pediatrics 2017 National Conference & Exhibition found sport specialization was associated with significantly worse mood, stress, fatigue, soreness, and sleep quality among female youth soccer players, even after controlling for factors such as age and hours spent training. (2017-09-15)

Viral hepatitis kills more people than HIV, malaria or tuberculosis
The study illustrates that in 2016, the total deaths caused by viral hepatitis, including liver cancer, acute cases, cirrhosis, hepatitis A, E, B, C and D account for 1.34 million deaths globally, exceeding tuberculosis (1.2 million), HIV/AIDS (1 million) and malaria (719,000). (2017-09-14)

'Missing link' explains how viruses trigger immunity
A discovery by Melbourne researchers has solved a longstanding mystery of how viruses trigger protective immunity within our body. The research team demonstrated a protein called SIDT2 was crucial for cells to detect viral components in their environment, and initiate an immune response to reduce the virus' spread. (2017-09-12)

TSRI study reveals new clues to how a successful HIV vaccine could work
Scientists at the Scripps Research Institute have made a discovery that could speed efforts to develop a successful HIV vaccine. (2017-09-12)

Certara paper shows viral kinetic modeling grows flu knowledge, advances drug development
As the number of drug-resistant influenza strains grows, and the challenge to identify the best strains to include in the next year's vaccine continues, researchers are searching for better ways to develop safer, more effective anti-viral drugs. Viral kinetic modeling, combined with pharmacokinetic/pharmacodynamic modeling, is proving a fruitful resource. Certara's review paper in Current Pharmacology Reports highlights the benefits of combining mathematical modeling types to maximize the use of all pre-clinical, clinical and epidemiological data. (2017-09-06)

Racial and ethnic differences seen in antibiotics prescribed for viral illnesses in pediatric EDs
Non-Latino white children seeking treatment for viral infections in the Emergency Department are about twice as likely to receive an antibiotic unnecessarily compared with non-Latino black children or Latino children, a multi-center study indicates. (2017-09-05)

Virus hijacks cell's transportation system
A deadly tick-borne virus uses the host neuron's transportation system to move their RNA, resulting in the local reproduction of the virus and severe neurological symptoms. (2017-09-01)

Inherited herpesvirus study finds links to ancient humans
Research into inherited human herpesvirus 6 identifies origins in a small number of people thousands of years ago and highlights the potential to 'reactivate.' (2017-08-30)

T cell responses may help dodge dengue virus symptoms during infection
Scientists now have new insight into the immune responses that prevent people infected with dengue virus from experiencing clinical symptoms, which could help optimize ongoing vaccine development efforts. (2017-08-30)

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