Current Advanced cancer News and Events

Current Advanced cancer News and Events, Advanced cancer News Articles.
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Study shows minimal impact of APPs on ED productivity, flow, safety, patient experience
Advanced practice providers (APPs) have lower productivity compared with emergency department physicians, seeing fewer and less complex patients and generating less relative value units per hour, and having no apparent impact on patient satisfaction and safety metrics. (2020-11-25)

RASi associated with reduced risk of KRT compared with CCB in CKD patients
In a population-based Swedish database, researchers studied the clinical outcomes of starting renin-angiotensin system inhibitor (RASi) or calcium channel blockers (CCB) in 2,458 patients with CKD G4-5. Compared with CCB, RASi initiation was associated with a lower risk of KRT, but similar risks of mortality and major adverse cardiovascular events. These findings suggest that RASi initiation might slow the progression of kidney disease compared with CCB in patients with advanced CKD, and offer similar cardiovascular protection. (2020-11-24)

Prostate cancer: CRYM protein inhibits tumour growth
Prostate cancer is caused by elevated hormone levels, and tumours are generally treated using hormone therapy. A research team headed by Lukas Kenner of MedUni Vienna in collaboration with David Heery from the University of Nottingham/UK and Sarka Pospisilova and Suzanne Turner of the University of Brno/Czech Republic have shown that the protein μ-crystallin (CRYM) plays a significant part in tumour growth. The higher the levels of this protein that are present, the better the prognosis. (2020-11-18)

Vitamin D supplements may reduce risk of developing advanced cancer
In a secondary analysis of VITAL, a team led by investigators at Brigham and Women's Hospital has narrowed in on the connection between taking vitamin D supplements and risk of metastatic or fatal cancer. In a paper published in JAMA Network Open, the team reports that vitamin D was associated with an overall 17 percent risk reduction for advanced cancer. (2020-11-18)

Existing antidepressant helps to inhibit growth of cancer cells in lab animals
New research has shown that the antidepressant sertraline helps to inhibit the growth of cancer cells. The substance acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and lab animals by researchers at KU Leuven. (2020-11-17)

A new diagnostic method predicts which cancer patients will respond to immunothe
An international group led by Dr Banafshe Larijani, an Ikerbasque researcher seconded to the Biofisika Institute (UPV/EHU-University of the Basque Country, CSIC), has developed a new diagnostic method making it possible to accurately predict which cancer patients will respond positively to immunotherapy. This method will allow oncologists to tailor treatment to each patient and avoid therapies that are not going to be successful. (2020-11-16)

Shining a light on the role of the genome's 'dark matter' in cancer development
Innovative research by scientists at Duke-NUS Medical School has shed light on the mysterious role of long non-coding RNAs in the development of pancreatic cancer and suggests potential new targets for precision cancer therapies. (2020-11-13)

State-level lung cancer screening rates not aligned with lung cancer burden in the US
A new study reports that state-level lung cancer screening rates were not aligned with lung cancer burden. (2020-11-12)

The lung microbiome may affect lung cancer pathogenesis and prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association for Cancer Research. (2020-11-11)

MD Anderson researchers present immunotherapy advances at Society for Immunotherapy of Cancer Annual Meeting
Promising clinical results with combination treatments for patients with melanoma and lung cancer highlight immunotherapy advances being presented by researchers from The University of Texas MD Anderson Cancer Center at The Society for Immunotherapy of Cancer (SITC) 35th Anniversary Annual Meeting & Pre-Conference Programs (SITC 2020) . (2020-11-11)

Gene signature predicts whether localized prostate cancer is likely to spread
Columbia researchers have identified a gene signature in localized prostate cancer that predicts the cancer's odds of spreading and its response to a common treatment for advanced disease. (2020-11-10)

New analysis finds lung cancer screening reduces rates of lung cancer-specific death
Low-dose CT screening methods may prevent one death per 250 at-risk adults screened, according to a meta-analysis of eight randomized controlled clinical trials of lung cancer screening. Researchers at the University of Georgia analyzed the health outcomes of 90,275 patients, comparing those who were screened versus those who received usual medical care or chest x-rays. (2020-11-10)

Blood cell mutations confound prostate cancer liquid biopsy results
Unrelated mutations, when present in the blood, can give false positive results in men with advanced prostate cancer undergoing liquid biopsies. Such tests, which look for variants in cell-free DNA that tumors shed into the blood plasma, help determine suitable treatment options. Incorrect test results might mean the patient gets therapies unsuited for his cancer. A simple solution overcomes this problem. (2020-11-05)

Precision chemo-immunotherapy for pancreatic cancer?
Pancreatic cancer is highly lethal: according to the National Cancer Institute, only about 10 percent of patients remain alive five years after diagnosis. Now, a preclinical study from the lab of Marsha Moses, PhD at Boston Children's Hospital, reports marked and lasting tumor regression in a mouse model, using a highly selective, potent, engineered antibody-drug combination. (2020-11-05)

Immunotherapy may work better in stomach cancer when combined with chemo, given earlier
Immunotherapy, often ineffective against stomach cancer, was more effective when combined with chemotherapy and given earlier, finds a new study in mice. (2020-11-05)

Skilled surgeons boost colon cancer survival by 70%
Patients of more technically skilled surgeons, as assessed by review of operative video, have better long-term survival after surgery for the treatment of colon cancer, reports a new study. Patients whose surgery was performed by a highly skilled surgeon had a 70 percent lower risk of dying over five years compared to patients with a lower skilled surgeon. (2020-10-30)

Giving the immune system a double boost against cancer
Cancer immunotherapies are very effective for some patients, but many cancers do not respond to the currently available treatments. Researchers are developing a new approach that expands the number of treatable tumor types. (2020-10-30)

Researchers find source of breast tumor heterogeneity and pathway that limits emergence
A team of researchers led by Dartmouth's and Dartmouth-Hitchcock's Norris Cotton Cancer Center has identified mammary basal cells as a contributing source to the development of heterogeneous tumor cell subpopulations and found that activation of the PKA signaling pathway can curtail their emergence, providing opportunities for new therapeutic approaches to breast cancer. (2020-10-28)

Scientists discover second key pathway in colon cancer stem cell growth
Scientists have discovered a link between two key signaling pathways crucial to the development and growth of colon cancer. The scientists identified the link between the retinoic acid or RA signaling pathway and another pathway critical to tumor development, called the Wingless-related integration site or WNT pathway. WNT signaling gone wrong is associated with numerous cancers, likely contributing to drug resistance and tumor recurrence. (2020-10-28)

What do breast cancer cells feel inside the tumour?
Using a new technique, a team of McGill University researchers has found tiny and previously undetectable 'hot spots' of extremely high stiffness inside aggressive and invasive breast cancer tumours. Their findings suggest, for the first time, that only very tiny regions of a tumor need to stiffen for metastasis to take place. Though still in its infancy, the researchers believe that their technique may prove useful in detecting and mapping the progression of aggressive cancers. (2020-10-27)

Liver cancer diagnoses and deaths impacted by geography and household income
An analysis of information from a large U.S. cancer database indicates that patients with liver cancer from rural regions and lower income households often have more advanced cancer at the time of diagnosis and face a higher risk of death compared with other patients. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS). (2020-10-26)

Adding advanced PET scans to radiation plans for prostate cancer increases FFS rates
Adding the advanced PET radiotracer fluciclovine to conventional imaging to help guide radiation treatments for recurrent prostate cancer can improve disease-free survival rates, a new study finds. Findings from the randomized phase II/III EMPIRE-1 trial (NCT01666808) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting. (2020-10-26)

Indian and Pakistani women diagnosed with more aggressive breast cancer at younger age
Indian and Pakistani women are diagnosed with breast cancer, including more aggressive forms of the disease, at a younger age, according to Rutgers researchers. (2020-10-25)

Targeted inhibitor of mutated KRAS gene shows promise in lung, bowel, & other solid tumors
A novel agent that targets a mutated form of the KRAS gene - the most commonly altered oncogene in human cancers and one long considered ''undruggable'' - shrank tumors in most patients in a clinical trial with manageable side effects, researchers reported today at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Therapeutic, which is taking place online. (2020-10-25)

Next generation BRAF inhibitor cancer drug shows promise in early patient trial
A new drug designed to work on cancers with an altered BRAF gene has shown promise in an early patient trial presented at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (2020-10-25)

ASTRO highlights Winship study showing increased failure-free survival in prostate cancer
The EMPIRE-1 trial is the first randomized trial of men with prostate cancer with recurring cancer to show that treatment based on advanced molecular imaging can improve disease-free survival rates. (2020-10-23)

Achieving high concentrations of sunitinib in tumors is linked to improved survival
A strategy for giving intermittent, high doses of the anti-cancer drug sunitinib is well-tolerated by patients with advanced cancer and increases concentrations of the drug in tumors, which is associated with improved survival, according to research to be presented at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, which is taking place online. (2020-10-23)

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications. (2020-10-22)

Cholesterol medications linked to lower cancer-related deaths in women
Among women with breast cancer, colorectal cancer, or melanoma, those who were taking cholesterol-lowering medications, were less likely to die from cancer, according to an analysis published in the British Journal of Clinical Pharmacology. (2020-10-21)

ASTRO issues clinical guideline on radiation therapy for rectal cancer
A new clinical guideline from the American Society for Radiation Oncology (ASTRO) provides guidance for physicians who use radiation therapy to treat patients with locally advanced rectal cancer. Recommendations outline indications and best practices for pelvic radiation treatments, as well as the integration of radiation with chemotherapy and surgery for stage II-III disease. The guideline, which replaces ASTRO's 2016 guidance for rectal cancer, is published in Practical Radiation Oncology. (2020-10-21)

Oncotarget: quantitative ultrasound radiomics in prediction of treatment response for breast cancer
The cover for Issue 42 of Oncotarget features Figure 4, ''Generation of parametric and texture maps from radiofrequency data,'' recently published in ''Quantitative ultrasound radiomics using texture derivatives in prediction of treatment response to neo-adjuvant chemotherapy for locally advanced breast cancer'' by Dasgupta, et al. which reported that to investigate quantitative ultrasound based higher-order texture derivatives in predicting the response to neoadjuvant chemotherapy in patients with locally advanced breast cancer. (2020-10-21)

UC studies tobacco use, cancer connection
Researchers at the University of Cincinnati have identified new clues into ways tobacco use impacts patients with kidney cancer. (2020-10-20)

Nature Communications publishes Bluestar Genomics' technology for cancer detection study
Bluestar Genomics, an innovative company leading the development of next-generation epigenomic approaches to early cancer detection, announced today the publication of study results in the peer-reviewed journal Nature Communications. The study demonstrates the power of the company's platform to detect pancreatic cancer in its early stages, addressing the unmet need of more than 60,000 patients diagnosed with the disease each year in the United States alone. (2020-10-20)

One way to prevent cancer: map the fundamentals of how cells go awry
Wilmot Cancer Institute scientists focused on proteins involved in breast and brain cancer and melanoma, and made a new discovery. (2020-10-20)

Rutgers finds new way to personalize treatments for prostate cancer
Rutgers researchers have discovered human gene markers that work together to cause metastatic prostate cancer - cancer that spreads beyond the prostate. (2020-10-19)

Novel mechanical mechanism of metastatic cancer cells in substrates of different stiffness revealed
Metastasis, the spread of cancer cells to a different body part from where it started, is considered as the most dangerous phase of cancer development. When cancer cells break away from the main tumor and enter the bloodstream or lymphatic system, they can travel to anywhere of the body, proliferate and creating a secondary tumor in a new location. It is often said that metastasis is responsible for around 90% of cancer deaths. (2020-10-16)

Even mild fatty liver disease is linked to increased mortality
Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the journal Gut. (2020-10-12)

Advanced prostate cancer has an unexpected weakness that can be targeted by drugs
Kanazawa University researchers reported that the SUCLA2 gene is frequently involved in the deletion of the tumor suppressor gene RB1 in advanced prostate cancer. RB1 deletion makes cells resistant to hormone therapy but SUCLA2 deletion induces a metabolic weakness. The study showed that thymoquinone selectively killed SUCLA2-deficient prostate cancer cells in vitro and in vivo. The findings highlight a vulnerability of advanced prostate cancer cells that can be targeted by drugs. (2020-10-07)

Colorectal cancer treatment: the winning combinations
Chemotherapy has distressing side effects for patients and increases the risk of developing resistance to the treatment. In an attempt to solve these problems, scientists from the University of Geneva have developed a technique for quickly identifying from a large number of existing drugs the optimal synergistic combination and dose of products that can kill the tumour cells without affecting healthy cells. This study further paves the way for personalised, effective and safe cancer treatment. (2020-10-06)

Liquid biopsies timely and effective testing method for NSCLC patients in Canada
Next-generation sequencing (NGS) of cell-free DNA (cfDNA) obtained from blood samples may improve diagnostic testing in patients with advanced NSCLC, and may also be faster and less expensive compared to standard tissue profiling, according to research presented today at the IASLC 2020 Lung Cancer Hot Topic: Liquid Biopsy Virtual Conference. (2020-10-02)

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