Current Antibiotic News and Events

Current Antibiotic News and Events, Antibiotic News Articles.
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Experimental evolution reveals how bacteria gain drug resistance
A research team at RIKEN in Japan has succeeded in experimentally evolving the common bacteria under pressure from a large number of individual antibiotics, and identified the mechanisms and constraints underlying evolved drug resistance. Their findings help develop drug-treatment strategies that minimize the chance that bacteria will develop resistance. (2020-11-24)

Potential treatment against antibiotic-resistant bacteria causing gonorrhea and meningitis
A team from the Institut national de la recherche scientifique (INRS) has demonstrated the effectiveness of an inexpensive molecule to fight antibiotic-resistant strains of the bacteria responsible for gonorrhea and meningococcal meningitis. These two infections affect millions of people worldwide. The results of this research, led by Professor Frédéric Veyrier and Professor Annie Castonguay, have just been published online in the Antimicrobial Agents and Chemotherapy journal. (2020-11-24)

Insights in the search for new antibiotics
A collaborative research team from the University of Oklahoma, the Memorial Sloan Kettering Cancer Center and Merck & Co. published an opinion article in the journal, Nature Chemical Biology, that addresses the gap in the discovery of new antibiotics. (2020-11-19)

Antibiotic resistance genes in three Puerto Rican watersheds after Hurricane Maria
In the aftermath of Hurricane Maria, a category 5 hurricane that made landfall in September 2017, flooding and power outages caused some wastewater treatment plants (WWTPs) to discharge raw sewage into waterways in Puerto Rico. Six months later, researchers monitored antibiotic resistance genes (ARGs) in three Puerto Rican watersheds, finding that the abundance and diversity of ARGs were highest downstream of WWTPs. They report their results in ACS' Environmental Science & Technology. (2020-11-18)

Antibiotic resistance surveillance tools in Puerto Rican watersheds after Hurricane Maria
Virginia Tech researchers and international collaborators have further developed an innovative antibiotic resistance surveillance approach by applying DNA sequencing techniques to detect the spread of disease in watersheds impacted by large-scale storms. (2020-11-18)

Compound for Alzheimer's combats bacterial resistance to last-resort antibiotics in mice
An experimental drug for neurodegenerative diseases can also reverse resistance to ''last-resort'' polymyxin antibiotics among bacteria that cause sepsis, a life-threatening complication from infections. (2020-11-18)

New research reveals Australia's multi-billion dollar superbug crisis
Analysis by national consortium, OUTBREAK, highlights how urinary tract infections (UTIs) are becoming more persistent and harder to treat, resulting in more people being admitted to hospital where they require longer stays and more costly medicines. (2020-11-17)

Environmental scientists' new ozonation method treats water from antibiotic residues
Clean drinking water is considered to be one of the earth's most precious and threatened resources. Recent studies show that increasing concentrations of pharmaceuticals can be found in surface waters, which can end up in drinking water. TalTech environmental scientists are looking for ways to treat drinking water from hazardous pharmaceutical residues. (2020-11-17)

Antibiotic exposure in children under age 2 associated with chronic conditions
Children under age 2 who take antibiotics are at greater risk for childhood-onset asthma, respiratory allergies, eczema, celiac disease, obesity and attention deficit hyperactivity disorder, according to a paper written jointly by Mayo Clinic and Rutgers researchers. While previous studies have looked at the association of antibiotics with single diseases, this is the first to look at the association across many diseases. (2020-11-16)

Rise in antibiotics prescribed to dental patients in England during COVID-19 lockdown
One of the unintended consequences of the COVID-19 lockdowns in England earlier this year has been a 25 per cent increase in the prescription of antibiotics by dentists, according to a new study published today in the British Dental Journal (BDJ). Prescription rates were the highest in London, with an increase of 60% for the same period and the lowest increases, less than 10%, were in the South-West of England. (2020-11-13)

Review of plants' role in antibacterial activity clears new paths for drug discovery
Chemical Reviews published the work by researchers at Emory University, which includes 459 plant natural products that met rigorous criteria for demonstrating antibacterial activity. The review is also deposited on the Shared Platform for Antibiotic Research and Knowledge (SPARK), sponsored by Pew Charitable Trusts. (2020-11-11)

Pediatric surgeon establishes first-ever guidelines for pediatric opioid prescribing
In addition to adults, opioid addiction and misuse affects the pediatric population. Pediatric surgeon forms group of health care providers and advocates to establish first ever pediatric opioid prescribing guidelines. (2020-11-11)

Researchers discover bacterial DNA's recipe for success
Biomedical engineers at Duke University have developed a way of modeling how potentially beneficial packages of DNA called plasmids circulate and accumulate through a complex environment that includes many bacterial species. The researchers hope that their new model will lay the groundwork for others to better model and predict how important traits such as antibiotic resistance in pathogens or metabolic abilities in bacteria bred to clean environmental pollution will spread and grow in a given environment. (2020-11-09)

Clinicians who prescribe unnecessary antibiotics fuel future antibiotic use
Receipt of antibiotics for acute respiratory infections makes it more likely that patients and their families will seek care and receive antibiotics for future respiratory viral infections. In the year after their visit, patients randomly assigned to clinicians who prescribed more antibiotics got 15 percent more antibiotics for viral respiratory infections compared with patients seen by clinicians who prescribed the fewest antibiotics. Antibiotics work against bacteria but not against viruses, and improper use can make bacteria resistant to these drugs. (2020-11-09)

Could SARS-CoV-2 evolve resistance to COVID-19 vaccines?
Similar to bacteria evolving resistance to antibiotics, viruses can evolve resistance to vaccines, and the evolution of SARS-CoV-2 could undermine the effectiveness of vaccines that are currently under development, according to a paper published November 9 in the open-access journal PLOS Biology by David Kennedy and Andrew Read from Pennsylvania State University, USA. The authors also offer recommendations to vaccine developers for minimizing the likelihood of this outcome. (2020-11-09)

Resensitizing 'last-resort' antibiotics for treatment of infections
A research team led by Professor Hongzhe SUN, Chair Professor from the Department of Chemistry, Faculty of Science, in collaboration with Dr Pak-Leung HO, Director of the HKU Carol Yu Centre for Infection from the Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong (HKU) discovers that by repurposing an antirheumatic gold drug, auranofin (AUR), 'last-resort' antibiotics can be resensitized for treatment of infections caused by multidrug-resistant superbugs including bloodstream infections, pneumonia and wound infections. (2020-11-05)

New decision support tool can provide personalized antibiotic treatment recommendations
A new study led by researchers at the Harvard Pilgrim Health Care Institute developed an algorithm that could greatly reduce use of broad-spectrum antibiotics in outpatient settings, a step toward reducing antibiotic resistance. The findings will be published online November 4, 2020 in Science Translational Medicine. (2020-11-04)

Harnessing the 'wisdom of crowds' can help combat antibiotic over prescription
A new study has demonstrated that using the 'wisdom of crowds' (also known as collective intelligence) of three or more medical prescribers, can improve decisions about antibiotic prescribing and help combat rising levels of antibiotic resistance. (2020-11-03)

Decennial 2020 research sets the agenda for advancing safe healthcare
More than 700 studies, including 250 international abstracts, highlighting worldwide progress in preventing and controlling healthcare-associated infections and addressing antibiotic resistance were published today as part of the proceedings from the Sixth Decennial International Conference on Healthcare-Associated Infections. The Sixth Decennial, a conference co-hosted by the Centers for Disease Control and Prevention and SHEA, was cancelled in March due to the COVID-19 pandemic. All abstracts accepted for the meeting appear in a supplement for the journal Infection Control & Hospital Epidemiology. (2020-11-02)

A new lead for disarming antibiotic-resistant bacteria
A virus can stop bacteria from sharing genes for antibiotic resistance among themselves, Texas A&M AgriLife researchers have discovered. The results hint at new ways to treat infections and describe a new feature of a highly diverse, largely unexplored part of the biosphere. (2020-11-02)

Hospital floors are hotspot for bacteria, creating route of transfer to patients
The floors of hospital rooms are frequently contaminated with antibiotic-resistant bacteria within hours of patient admission, creating a route of transfer of potentially dangerous organisms to patients, according to a study published today as part of the proceedings from Decennial 2020: The Sixth International Conference on Healthcare-Associated Infections. Decennial 2020, an initiative of the CDC and SHEA, was cancelled in March due to the pandemic. (2020-10-30)

Microbial strains show individualized patterns of stability in the developing infant gut
Microbial strain stability studies of human infants and children, ages shortly after birth (about 6 months) to 6 years, show individualized patterns of microbial strain specificity as the infant gut microbiomes developed. (2020-10-28)

Drug resistance linked to antibiotic use and patient transfers in hospitals
Understanding the role of antibiotic use patterns and patient transfers in the emergence of drug-resistant microbes is essential to crafting effective prevention strategies, suggests a study published today in eLife. (2020-10-27)

New tricks for old antibiotics
The study published in the journal Immunity reveals that tetracyclines (broad spectre antibiotics), by partially inhibiting cell mitochondria activity, induce a compensatory response on the organism that decreases tissue damage caused during infection. This finding opens new doors in the field of disease tolerance and positions this group of antibiotics as potential adjuvant treatment for sepsis, due to their effects that go beyond the control of bacterial burden. (2020-10-22)

Boron nitride nanofilms for protection from bacterial and fungal infections
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical negative side effects. The results of the work are published in the international scientific journal ACS Applied Materials & Interfaces. (2020-10-20)

Scientists discover a new mechanism for cellular defense against viral and bacterial infections
Researchers of IDIBAPS, the University of Barcelona and CNIC have coordinated a study, published in Science, which describes a new mechanism of innate immunity by which cells fight viruses and bacteria. (2020-10-15)

World first study shows that some microorganisms can bend the rules of evolution
The dominant thinking in evolution focuses on inheritance between parent and offspring - or 'vertical gene transfer (VGT)'. But now scientists are paying more attention to 'horizontal gene transfer (HGT)': the transmission of DNA other than from parent to offspring, as this transfer can tell us about the evolution of a number of other organisms such as bacteria. It can also help us to better understand antibiotic resistance. (2020-10-13)

Benefits, risks seen with antibiotics-first for appendicitis
Antibiotics are a good choice for some patients with appendicitis but not all, according to study results published today in the New England Journal of Medicine. Although surgery has been the standard treatment for 120 years, CODA, the largest trial of appendicitis treatment, found that study participants assigned to antibiotics reported a quality of life no worse than that of those assigned to surgery, and seven out of 10 safely avoided surgery by 90 days. (2020-10-05)

Research shows benefits/risks of treating appendicitis with antibiotics instead of surgery
NEJM: Results of a first-of-its-kind clinical trial shed light on when antibiotics instead of surgery might be the better choice for treating appendicitis in some patients, according to researchers with UTHealth, who led the Houston trial sites. (2020-10-05)

Coupling antibiotics with stem cells to fight off bone infections
Researchers from Kanazawa University investigated the effects of adipose-derived stem cells (ADSCs) loaded with the antibiotic ciprofloxacin on osteomyelitis caused by implants. By administering ADSC-loaded ciprofloxacin to the site of bone infection in rats, the researchers found a significant improvement of the infection, as shown by reduced soft tissue swelling, abscess formation, and bone degradation. These findings suggest a potential new therapy for implant-related bone infections that have traditionally been difficult to treat with antibiotics. (2020-10-01)

A single-application treatment for ear infections that doesn't need refrigeration
Outer ear infections, which affect millions of people each year, are typically caused by the bacteria Pseudomonas aeruginosa or Staphylococcus aureus. Repeatedly administering antibiotic drops, the standard treatment, can be a problem for some people, and the only single-use suspension currently available needs to be kept and handled cold. Now, researchers reporting in ACS Biomaterials Science & Engineering have developed a single-use treatment that doesn't require refrigeration. (2020-09-30)

Study could be first step in providing personalized care to patients with ureteral stents
Published today in Cell Reports Medicine, researchers at Lawson Health Research Institute and Western University conducted a novel microbiome study to examine bacteria associated with ureteral stents. They found that nearly all the stents, whether visibly coated or not, had unique bacterial profiles that were most associated with a patient's medical condition rather than antibiotic use. For patients with ureteral stents, they may benefit from a personalized approach to care and antibiotic treatment. (2020-09-25)

Genome of Alexander Fleming's original penicillin-producing mould sequenced
Researchers have sequenced the genome of Alexander Fleming's penicillin mould for the first time and compared it to later versions. (2020-09-24)

Key genetic clue missing in fight against superbugs
For the first time, researchers have discovered how antibiotic resistance genes are spreading, at a continental scale, via bacterial plasmids in the hospital superbug, Klebsiella pneumoniae. The researchers say it is critical that plasmids are included when tracking antibiotic resistance in order to have the best chance of stopping superbugs. (2020-09-24)

Customizable synthetic antibiotic outmaneuvers resistant bacteria
Antibiotic resistance is one of the world's most urgent public health threats. In the United States alone, tens of thousands of deaths result each year from drug-resistant strains of common bacteria such as Staphylococcus aureus and Enterococcus faecium, which can cause virtually untreatable hospital-acquired infections. Perilously few new classes of antibiotics are being developed to fight infections that have become resistant to traditional treatments, and bringing any new drugs to market could take decades. (2020-09-23)

Magnetic 'T-Budbots' made from tea plants kill and clean biofilms (video)
Biofilms -- microbial communities that form slimy layers on surfaces -- are difficult to treat and remove, often because the microbes release molecules that block the entry of antibiotics and other therapies. Now, researchers reporting in ACS Applied Materials & Interfaces have made magnetically propelled microbots derived from tea buds, which they call ''T-Budbots,'' that can dislodge biofilms, release an antibiotic to kill bacteria, and clean away the debris. (2020-09-23)

Study on the effect of rosemary and ginger essential oils against Klebsiella pneumoniae
This study aims at investigating the antimicrobial and antibiofilm effect of rosemary and ginger essential oil-based nano-sized formulations on colistin resistant K. pneumonia clinical isolates. (2020-09-21)

New high-speed test shows how antibiotics combine to kill bacteria
Researchers at Uppsala University have developed a new method to determine - rapidly, easily and cheaply - how effective two antibiotics combined can be in stopping bacterial growth. The new method is simple for laboratories to use and can provide greater scope for customising treatment of bacterial infections. The study is published in PLOS Biology. (2020-09-17)

Potential COVID-19 drug azithromycin may increase risk for cardiac events
Azithromycin -- a commonly-prescribed antibiotic -- also is being investigated as a potential treatment for COVID-19. Researchers have found that azithromycin by itself is not associated with an increase in cardiac events; however, if the drug is taken with certain other drugs that affect the electrical functioning of the heart, then cardiac events increased. (2020-09-16)

Social distancing and microbial health
Social distancing is a key component of the expert-recommended strategy to reduce the spread of COVID-19. Avoiding contact with others, however, may have repercussions in a person's gut microbiome. In a perspective published this week in mSphere, an open-access journal of the American Society for Microbiology, a group of microbiologists in Portugal call for scientists to more closely examine the ways in which COVID-19 -- and our response to it--interact with microbial health. (2020-09-16)

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