Current Antiretroviral therapy News and Events

Current Antiretroviral therapy News and Events, Antiretroviral therapy News Articles.
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In-stent thrombosis after antiplatelet therapy conversion while awaiting coronary bypass
In a new publication from Cardiovascular Innovations and Applications; DOI https://doi.org/10.15212/CVIA.2019.0589, Nathan Burke, Tawanna Charlton, Hussam Hawamdeh, and Ki Park from the University of Florida College of Medicine, Gainesville, Florida, USA consider a case study of in-stent thrombosis after antiplatelet therapy conversion while awaiting coronary bypass. (2020-11-19)

NIH gene therapy startup to increase AAV gene therapy efficiency
Maximizing the efficiency of the adeno-associated virus (AAV) platform for gene therapy is the aim of a new pilot project of the National Institutes of Health (NIH). (2020-11-17)

Discovery of protein's 'Achilles heel' paves way for novel class of anti-HIV drugs
it is increasingly clear how Nef manages to subvert human cells' defense mechanisms, enabling HIV to replicate and bringing the symptoms of AIDS closer. (2020-11-16)

Risk of AAV mobilization in gene therapy
New data highlight safety concerns for the replication of recombinant adeno-associated viral (rAAV) vectors commonly used in gene therapy. These findings, which emphasize the need for mobilization resistant AAV vectors (2020-11-13)

Is proton therapy the silver bullet for children with brain cancer?
How safe is proton therapy for children with brain cancer compared to the conventional x-ray radiation delivered post-surgery? (2020-11-11)

3D printed stents that treat inflammation
POSTECH Professor Dong-Woo Cho's research team develops bioink-loaded esophageal stents for treating radiation esophagitis. (2020-11-10)

Induced liver regeneration enhances CRISPR/Cas9-mediated gene repair
Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver. (2020-11-10)

New cause of inflammation in people with HIV identified
A new study led by researchers at Boston Medical Center examined what factors could be contributing to this inflammation, and they identified the inability to control HIV RNA production from existing HIV DNA as a potential key driver of inflammation. (2020-10-30)

ASTRO: Proton therapy for lung cancer may help reduce risk of heart diseases
Treating lung cancer patients with proton therapy may help reduce the risk of radiation-induced heart diseases. (2020-10-23)

Antiretroviral therapy can't completely stop accelerated cell aging seen in HIV
Untreated HIV infection is linked with epigenetic changes that suggest rapid aging. A new study by UCLA researchers shows that antiretroviral therapy given over two years was unable to completely restore age-appropriate epigenetic patterns, leaving patients more susceptible to aging-related illnesses. (2020-10-22)

Serum creatinine-to- cystatin C ratio predicts mortality
In patients initiating continuous renal replacement therapy for acute kidney injury, higher serum creatinine-to-cystatin C ratios were associated with lower mortality. (2020-10-21)

New research comparing HIV medications set to change international recommendations
A new study by UBC researchers is set to change international treatment recommendations for people who are newly diagnosed with HIV--an update that could affect nearly two million people per year worldwide. (2020-10-16)

Therapy plus medication better than medication alone in bipolar disorder
A review of 39 randomized clinical trials by scientists from UCLA and their colleagues from other institutions has found that combining the use medication with psychoeducational therapy is more effective at preventing a recurrence of illness in people with bipolar disorder than medication alone. (2020-10-14)

HSE University researcher develops global HIV prevention index for drug users
St. Petersburg, together with colleagues from Georgia State University (USA) and Tarbiat Modares University (Tehran), have developed the HIV-PWID Policy Index (HPPI)--an international policy index for HIV prevention among people who inject drugs. This is the first major tool for assessing and comparing the extent to which HIV/AIDS prevention policies among PWID have been developed in 105 countries. (2020-10-09)

Treating cystic fibrosis with mRNA therapy or CRISPR
The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation. CF clinical trials showing that a genotype-agnostic gene therapy for CF is possible (2020-10-08)

Fostamatinib in chronic immune thrombocytopenia: No comparison -- added benefit not proven
Fostamatinib in chronic immune thrombocytopenia: no comparison -- added benefit not proven The manufacturer conducted no direct or indirect comparison of its drug with an appropriate comparator therapy (eltrombopag or romiplostim). (2020-10-06)

Ezintsha study provides new data on current ART regimens with concerns about weight gain
The South African study ADVANCE by Ezintsha, a research group at the University of the Witwatersrand, which focuses on investigating better options for first-line antiretroviral treatment for people with HIV, today published its 96-week outcomes, providing new safety data, especially on weight gain. (2020-10-01)

Scientists propose immune cocktail therapy to boost cancer-immunity cycle in multiple aspects
A research team led by Prof. TIAN Huayu from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences proposed an innovative immune cocktail therapy that combined ICT along with other therapeutic approaches. The cocktail therapy achieved multiple boosting of the cancer-immunity cycle by utilizing a nano-delivery system. (2020-09-30)

Novel dual CAR T cell immunotherapy holds promise for targeting the HIV reservoir
A recent study published in the journal Nature Medicine, led by researchers James Riley, PhD, a professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania, and Todd Allen, PhD, a professor of Medicine at Harvard Medical School and Group Leader at the Ragon Institute of MGH, MIT and Harvard, describes a new Dual CAR T cell immunotherapy that can help fight HIV infection. (2020-09-23)

The pharmacist's role in HIV care in France
In France, antiretroviral treatment (ARV) can be dispensed by hospitals and/or community pharmacies. A recent study published in Pharmacology Research & Perspectives examined the pharmacist's role in HIV care in this country. (2020-09-10)

Quality over quantity in recovering language after stroke
New Edith Cowan University (ECU) research has found that intensive therapy is not necessarily best when it comes to treating the loss of language and communication in early recovery after a stroke. (2020-09-06)

Antiretroviral therapy fails to treat one-third of HIV patients in Malawi hospital
Antiretroviral therapy (ART) failure and drug resistance are extremely common in patients living with HIV who are admitted to hospital in Malawi, according to new research published in Lancet HIV. (2020-09-02)

Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function
Skin exposure to ultraviolet B (UVB) induces expansion of regulatory T (Treg) cells with immunosuppressive activity. Here researchers found that UVB-expanded skin Treg (UVB-skin Treg) cells had a tissue repair function. UVB-skin Treg cells expressed proenkephalin (PENK) and amphiregulin (AREG), which promoted keratinocyte outgrowth and skin wound healing. Their results provide a new implication in developing a therapy using UVB-skin Treg cells. (2020-09-01)

Hope for 500 000 insomniacs in Norway
Digital sleep therapy could offer help to people with sleep problems and enable many of them to reduce their sleep medication after treatment. (2020-09-01)

Nanomaterials based strategies for treatment of hypoxic tumor
Hypoxic tumor microenvironment restricts efficiency of tumor therapies and leads to serious results of tumor recurrence and high mortality. Different strategies to treat hypoxic tumors based on nanomaterials have been utilized to eliminate the side effects of hypoxia on tumor therapies. The strategies could be summarized into two classes, i) elevating oxygen level in tumor by nanomaterials and ii) diminishing oxygen dependence of nanomaterials for hypoxic tumor therapy. (2020-08-31)

Black children with cancer three times less likely to receive proton radiotherapy than White children
A retrospective analysis led by investigators from Brigham and Women's Hospital has found racial disparities in the use of the therapy for patients enrolled in trials. (2020-08-27)

The patients left behind by HIV research
People from BAME communities, women and heterosexual men are being left behind by HIV research. Medication to manage HIV is effective at keeping people well. But over half of people with HIV do not take their medication correctly. New research shows that the problem could be in the way studies are designed - with BAME communities, women and straight men under-represented. The researchers say this imbalance must be fixed, to keep a diverse population of HIV patients living longer, healthier lives. (2020-08-26)

Long-acting, injectable drug could strengthen efforts to prevent, treat HIV
Scientists have developed an injectable drug that blocks HIV from entering cells. They say the new drug potentially offers long-lasting protection from the infection with fewer side effects. The drug, which was tested in non-human primates, could eventually replace or supplement components of combination drug ''cocktail'' therapies currently used to prevent or treat the virus. (2020-08-21)

Study explores the association of malaria, HIV with anemia during pregnancy
Pregnant women from sub-Saharan Africa with malaria and human immunodeficiency virus (HIV) have a higher prevalence of anemia than pregnant women without infections, according to Penn State College of Medicine researchers. The findings may have implications for reducing the risk of death in pregnant women and preventing low birth weights and neurocognitive impairment in their children as a result of anemia. (2020-08-14)

Delaying prostate cancer radiation therapy offers room for flexibility in pandemic peak
A new study by investigators from Brigham and Women's Hospital found that for men with unfavorable intermediate-risk or high-risk localized prostate cancer, who are receiving radiation and hormone therapy, delaying radiation while remaining on hormone therapy is unlikely to impact survival. (2020-08-13)

Multiple sclerosis drug blocks HIV infection and transmission in human immune cells
An immunomodulatory drug called fingolimod, which is approved for the treatment of multiple sclerosis, blocks human immunodeficiency virus (HIV) infection and transmission in human immune cells, according to a study published August 13 in the open-access journal PLOS Pathogens by Postdoctoral Fellow Rachel Resop and Assistant Professor Alberto Bosque of The George Washington University, and colleagues. These preliminary findings suggest that this compound may be a promising novel therapy for HIV treatment and prevention. (2020-08-13)

MS drug may be used to inhibit hiv infection and reduce latent reservoir
A multiple sclerosis drug may be used to block HIV infection and reduce the latent reservoir, according to research published in PLOS Pathogens by a team at the RGeorge Washington University. (2020-08-13)

Engineered capsids for efficient gene delivery to the eye
A rational design approach created novel variants of adeno-associated viral (AAV) capsids. These have improved transduction properties in the mouse retina and cornea. (2020-08-13)

Gene therapy targets inner retina to combat blindness
Batten disease is a group of fatal, inherited lysosomal storage disorders that predominantly affect children. The most prevalent form is CLN3 disease, for which there is no cure. Retinal degeneration and resulting vision loss is one of the symptoms. (2020-08-10)

Sugar-based signature identifies T cells where HIV hides despite antiretroviral therapy
Wistar scientists may have discovered a new way of identifying and targeting hidden HIV viral reservoirs during treatment with antiretroviral therapy (ART). These findings were published in Cell Reports and may have translational implications for improving the long-term care of HIV positive people. (2020-08-07)

Research suggests greater access to specific HIV and tuberculosis medications is needed
A specific combination of HIV and TB treatments, difficult to obtain in certain parts of the world, decreased mortality risk for patients with HIV and multidrug-resistant TB. (2020-08-07)

COVID-19 may cause deadly blood clots
COVID-19 may increase the risk of blot cots in women who are pregnant or taking estrogen with birth control or hormone replacement therapy, according to a new manuscript published in the Endocrine Society's journal, Endocrinology. (2020-07-29)

Fracture risk associated with bisphosphonate drug holidays
Bisphosphonates have been shown to reduce the risk of osteoporotic fractures. To avoid possible side effects of long-term therapy, many patients take a drug holiday after several years of bisphosphonate therapy. Researchers have examined the implications of such drug holidays on fracture risk. They found that in patients who had previously suffered a vertebral fracture, a longer bisphosphonate drug holiday was associated with an increase in the risk of so-called major osteoporotic fractures. (2020-07-29)

Traditional PTSD therapy doesn't trigger drug relapse
Johns Hopkins researchers have now demonstrated that behavior therapy that exposes people to memories of their trauma doesn't cause relapses of opioid or other drug use, and that PTSD severity and emotional problems have decreased after the first therapy session. (2020-07-20)

Study highlights multiple health risks among a people living longer with HIV
A suite of articles in The Journal of Infectious Diseases contains the first swath of important data from the world's largest study of cardiovascular disease (CVD) prevention in people with HIV. (2020-07-10)

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