Current Aortic aneurysm News and Events

Current Aortic aneurysm News and Events, Aortic aneurysm News Articles.
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Scoring system improves screening for "dual" heart disease
Aortic stenosis is one of the most common heart valve defects. As well as conventional valve replacement involving open-heart surgery, a less invasive procedure has now been available for some time in the form of transcatheter aortic valve replacement (TAVR). (2020-11-24)

TAVR is dominant form of aortic valve replacement, outcomes steadily improving in the US
Since the approval of the first TAVR device in 2011, more than 276,000 patients have undergone a TAVR procedure in the U.S. According to an STS/ACC TVT Registry report, volumes have increased every year and in 2019 TAVR exceeded all forms of SAVR. While 30-day mortality and stroke rates have decreased, pacemaker need remains largely unchanged. The report was published in the Journal of the American College of Cardiology and The Annals of Thoracic Surgery. (2020-11-16)

Rivaroxaban may be as effective as warfarin for bioprosthetic mitral valves, AF
The RIVER trial is the largest study assessing the efficacy and safety of the anticoagulant rivaroxaban in patients with an artificial mitral valve to correct an irregular heart rhythm. Researchers concluded that rivaroxaban worked as well as the standard anticoagulant medication warfarin. (2020-11-14)

New bioprosthetic valve for TAVR fails to demonstrate non-inferiority
In a randomized clinical trial, SCOPE II, a new self-expanding bioprosthetic valve used in transcatheter aortic valve replacement (TAVR) failed to demonstrate non-inferiority compared to an existing self-expanding valve. (2020-10-15)

Results from the REFLECT II Trial reported at TCT Connect
The REFLECT II randomized clinical trial evaluating the safety and efficacy of a device designed to reduce cerebral embolization and ischemic stroke, complications of transcatheter aortic valve replacement (TAVR), found that the device met the primary safety endpoint compared to historical controls but did not demonstrate superiority of the device for the primary hierarchical efficacy endpoint. (2020-10-15)

Tied to undiagnosed disease, aortic dissection in pregnancy proves difficult to predict
The 100th report out of the International Registry of Acute Aortic Dissection details the experiences of 29 women who faced this rare life-threatening complication while pregnant. (2020-10-14)

Scientists developed key principles for creating an artificial vessel
Researchers from St. Petersburg provided a unique experiment. They implanted a polymer scaffold as a vascular prosthesis into the rat abdominal aorta and monitored the process of its bioresobtion for 16 months. An artificial vessel was formed where the scaffold was located. It posess similar characteristics as a natural vessel. (2020-10-08)

Aortic valve replacement during COVID-19 pandemic
The outcomes associated with deferred compared with expedited aortic valve replacement in patients with severe aortic stenosis during the COVID-19 pandemic are evaluated in this observational study. (2020-09-30)

Patients deferred for transcatheter aortic valve replacement because of COVID-19
This single-center study of 77 patients describes the outcomes of patients with symptomatic severe aortic stenosis during the COVID-19 pandemic. (2020-09-30)

Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mixture of heart muscle cells, endothelial cells and smooth muscle cells -- which were all derived from human induced pluripotent stem cells -- yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells. (2020-09-29)

New abdominal aortic aneurysm genes identified, could help pinpoint those at risk
A study of US veterans identified 14 genes that may predict the risk of abdominal aortic aneurysm. The related-risk score identifies those at risk regardless of known factors such as smoking or family history. Diastolic blood pressure, the bottom number in a blood pressure reading, may be a better indicator of developing abdominal aortic aneurysm. (2020-09-28)

Post-COVID syndrome severely damages children's hearts
Multisystem inflammatory syndrome in children (MIS-C) appears even after asymptomatic cases of COVID-19, a case review confirms, and in some children damages the heart to the extent that the children will need long-term monitoring and interventions. (2020-09-04)

Study reveals best anti-clotting strategy after heart valve intervention
The POPular TAVI trial has challenged current guideline recommendations on antiplatelet treatment after transcatheter aortic valve implantation (TAVI) in patients not taking oral anticoagulation. The findings are presented in a Hot Line session today at ESC Congress 2020. (2020-08-31)

Research brief: Researchers 3D print lifelike heart valve models
Researchers from the University of Minnesota, with support from Medtronic, have developed a groundbreaking process for multi-material 3D printing of lifelike models of the heart's aortic valve and the surrounding structures that mimic the exact look and feel of a real patient. (2020-08-28)

Computational modeling enables heart valve visualizations
Computational modeling has provided new insights into the heart's vascular system, a complex and mechanically demanding system that remains poorly understood. (2020-08-05)

New research: Treatment advancements help reduce mortality from unruptured brain aneurysms
Mortality rates after treatment of unruptured intracranial aneurysms have substantially decreased in the past decade, according to new findings presented today at the Society of NeuroInterventional Surgery's (SNIS) 17th Annual Meeting. The study, Trends in Mortality and Morbidity after Treatment of Unruptured Intracranial Aneurysm in the United States, 2006-2016, analyzed data from 21,609 patients in the Nationwide Inpatient Sample (NIS) database across a 10-year period. The research compares two treatments for unruptured intracranial aneurysms: microsurgical clipping and endovascular embolization. (2020-08-04)

Engineers find thinner tissues in replacement heart valves create problematic flutter
Iowa State and University of Texas engineers have developed high-fidelity computational models of replacement heart valves to examine the performance of biological tissues built into the valves. They found that thinner tissues can flap and flutter, which can damage the valves and even the blood that flows by. (2020-07-29)

Diagnosing acute aortic syndrome: New guideline for hard-to-diagnose condition
A new guideline aimed at helping clinicians identify the difficult-to-diagnose acute aortic syndrome is published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.200021. (2020-07-20)

Hyperactive immune cells accelerate heart valve disease: Study
Aortic valve stenosis is the most common type of heart valve disease in the elderly and affects more than one in eight people aged over 75. Researchers used organ-on-a-chip technology to discover the disease is made worse by the damaging hyperactivity of immune cells, which are activated by the constant stress of squeezing through the narrow aortic valve. (2020-07-08)

External ultrasound therapy of calcific aortic stenosis -- First-in-man
Cardiawave (France) has developed a Non-Invasive Ultrasound Therapy (NIUT) for the treatment of cardio-valvular diseases such as aortic stenosis. This is the primary valve disease in adults and one of the leading causes of cardiovascular death worldwide which affects 10 million people in Europe and the USA. (2020-06-25)

Long-term outcomes after TAVI in failed bioprosthetic valves in the VIVID Registry
Due to bioprosthetic valve degeneration, aortic valve-in-valve (ViV) procedures are increasingly performed. There is no data on long-term outcomes after aortic ViV. Our aim was to perform a large-scale assessment of long-term survival and reintervention after aortic ViV. (2020-06-25)

Molecular landscape of the hematopoietic stem cell cradle
Researchers from the group of Catherine Robin at the Hubrecht Institute characterized the molecular landscape of the aorta where all hematopoietic stem cells are initially formed in zebrafish, chicken, mouse and human embryos. Understanding the regulatory function of the local HSC microenvironment will pave the way for improved HSC production in vitro and clinical cell therapy for blood related diseases. (2020-06-04)

Researchers identify secretion mechanisms for a protein necessary for maintaining healthy connective
Researchers have discovered that a defective form of the protein aortic carboxypeptidase-like protein (ACLP) from patients with Ehlers-Danlos syndrome (EDS) is retained in cells and induces cellular stress. This finding may provide targets for pharmacologic and therapeutic interventions in treating individuals with EDS as well as wound healing disorders and fibrosis. (2020-06-03)

Temple researchers track new path to therapeutic prevention of abdominal aortic aneurysm
New research by scientists at the Lewis Katz School of Medicine at Temple University suggests that abdominal aortic aneurysm (AAA) can be prevented therapeutically. In work published online May 28 in the journal Cardiovascular Research, they show for the first time in animals that blocking a molecule known as dynamin-related protein 1 (Drp1) can stop AAA from developing. (2020-05-28)

Doxycycline ineffective at shrinking aortic aneurysms in two-year study
Patients with a vascular condition called abdominal aortic aneurysm did not benefit from taking the common antibiotic doxycycline for two years to shrink the aneurysm when compared to those who took a placebo, according to a Vanderbilt University Medical Center (VUMC) study published in the Journal of the American Medical Association (JAMA). (2020-05-27)

Study finds TAVR is safe treatment for patients with bicuspid valve disease
For many patients with a bicuspid aortic valve that needs replacing, transcatheter aortic valve replacement (TAVR) appears to be a safe treatment option with low complication rates, according to a study published in JACC: Cardiovascular Interventions. The study found patients with bicuspid valves who were at increased risk for surgery had a 30-day and one-year mortality rate and stroke rate that was similar to patients with the more common tricuspid valves. (2020-05-27)

Researchers find no benefit for treatment used to avoid surgery for abdominal aortic aneurysm
A new landmark study by researchers at the University of Maryland School of Medicine (UMSOM) found that patients with a vascular condition, called abdominal aortic aneurysm, received no benefits from taking a common antibiotic drug to reduce inflammation. (2020-05-26)

One in ten patients with major vascular event, infection, or cancer will be misdiagnosed
According to a new study published in De Gruyter's open access journal Diagnosis, approximately one in 10 people (9.6%) in the United States with symptoms caused by major vascular events, infections, or cancers will be misdiagnosed. (2020-05-15)

Study finds association between atherosclerosis and changes in the structure, heart function
Even among individuals free of heart failure and myocardial infarction, there appears to be evidence of an association between calcium buildup in the coronary arteries (atherosclerosis) and changes in the structure and function of the heart. (2020-05-15)

Genetic study ties higher alcohol consumption to increased stroke and PAD risk
Using genetic analysis, researchers found higher alcohol consumption increased risks for stroke and peripheral artery disease (PAD). Studies using genetic analysis don't rely on observational data, which often use self-reported data and could be subject to unreported risk factors. (2020-05-05)

Genetic scoring can identify more men at risk for aortic aneurysm
A genetic risk score from a blood test identified more men age 50 and older who are at higher risk of an aortic aneurysm and could benefit from ultrasound screening. Weakness and bulging in the wall of the aorta, the major blood vessel that sends blood to the abdomen and lower body, can result in life-threatening rupture. Ultrasound screening is currently recommended to detect an aneurysm prior to rupture in men ages 65-75 who have any history of smoking. (2020-05-05)

Arteries respond in opposite ways for males and females
A protein known to expand blood vessels -- key to controlling conditions like high blood pressure -- actually has different functions in males and females, new UC Davis Health research shows. Conducted using arterial cells from mice, the study is the first to identify sex-based distinctions in how the protein -- Kv2.1 -- works. (2020-04-29)

Feeling the pressure: How blood vessels sense their environment
Researchers from the University of Tsukuba discovered that Thbs1 is a key extracellular mediator of mechanotransduction upon mechanical stress. Using a mice model of pressure overload, they showed that mice lacking Thbs1 are less likely to withstand high mechanical stress. These findings help understand the biomechanical impact of cardiovascular diseases. (2020-04-24)

With a heavy heart: How men and women develop heart disease differently
A new study by researchers from McGill University has uncovered that minerals causing aortic heart valve blockage in men and women are different, a discovery that could change how heart disease is diagnosed and treated. (2020-04-24)

Medicare changes may increase access to TAVR
The number of hospitals providing TAVR could double with changes to Medicare requirements. Researchers see reason for both excitement and concern. (2020-04-06)

Study finds that Pilates significantly improves blood pressure in young, obese women
A new paper in the American Journal of Hypertension, published by Oxford University Press, finds that mat Pilates may be an effective strategy to improve cardiovascular health for young obese women, a population that is at risk for hypertension and early vascular complications. (2020-04-01)

TAVR found non-inferior to surgery in broad patient population
Patients who underwent transcatheter aortic valve replacement (TAVR) did not have a higher rate of death at one year compared with those who had their heart valve replaced via open-heart surgery, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)

Antiplatelet drugs increase risk for TAVR patients with atrial fibrillation
Patients with atrial fibrillation who took oral anticoagulants alone after undergoing transcatheter aortic valve replacement (TAVR) had a lower rate of bleeding complications without an increased risk of clotting-related complications compared to patients who took antiplatelet medication in addition to oral anticoagulants, in a trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)

TAVR equivalent to surgery at 2 years among low-risk patients
Patients undergoing transcatheter aortic valve replacement (TAVR) fared equally well compared with those undergoing open heart valve replacement surgery in terms of the combined risk of death, stroke or rehospitalization at two years, the primary endpoint of the PARTNER 3 trial being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)

New findings boost understanding of arterial aneurysm
Abdominal arterial (or aortic) aneurysm in older men is associated with levels of certain subtypes of white blood cells, a study from the University of Gothenburg, Sweden, shows. The study results belong to an expanding research field that is expected improve both knowledge of the disease and treatment options. (2020-03-16)

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