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Current Apoptosis News and Events

Current Apoptosis News and Events, Apoptosis News Articles.
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Genetic cause of congenital malformation discovered
Spontaneous mutations of a single gene are likely to cause serious developmental disorders of the excretory organs and genitalia. (2020-08-07)
Neurons are genetically programmed to have long lives
Most neurons are created during embryonic development and have no ''backup'' after birth. (2020-07-24)
Oncotarget: RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation
The cover for issue 25 of Oncotarget features Figure 8, 'BI-D1870 in combination with vincristine increase metaphase arrest and apoptosis synergistically,' by Chae, et al. (2020-06-23)
Slow release of two chemicals protects the heart after experimental heart attacks
A novel treatment reduces heart damage after serious heart attacks in two animal models. (2020-06-22)
New technique may quickly and accurately predict effective therapies in solid tumors
A new method of screening thousands of drugs in freshly collected human tumor cells can help identify which of the drugs are most likely to be effective against those cancers. (2020-06-16)
Silicones may lead to cell death
Silicone molecules from breast implants can initiate processes in human cells that lead to cell death. (2020-06-12)
Newly synthesized fungal compound can switch on a self-destruct button for cancer
Cancers cells use a special technique to propagate; they delete their 'programmed death' gene through mutation, 'forget' to die when their lifetime is over, and continue to grow instead. (2020-06-10)
Physical activity in all of its forms may help maintain muscle mass in midlife
Loss of estrogen has an effect on muscles and leads to a decline in muscle mass. (2020-06-08)
Atherosclerosis -- How a microRNA protects vascular integrity
Ludwig-Maximilian-Universitaet (LMU) in Munich researchers have discovered a hitherto unknown molecular function of a specific microRNA that preserves integrity of the endothelium and reduces the risk of atherosclerosis. (2020-06-04)
Near-atomic 'blueprint' reveals inner workings of drug target for cancer, other diseases
Van Andel Institute scientists have for the first time described the near-atomic level structure of a molecular pathway that plays critical roles in human development, blood pressure regulation, inflammation and cell death. (2020-06-03)
Study resolves controversy surrounding tumor suppressor gene's role in pluripotent ESCs
A new study released in STEM CELLS sorts through the maze of contradictions to finally determine that the multiple roles of p53 in cell cycle regulation and apoptosis are acquired during pluripotent stem cell differentiation. (2020-06-01)
New LAT1 inhibitor can boost cancer treatment
Researchers at the University of Eastern Finland have developed a new and promising drug compound for the treatment of cancer that inhibits natural amino acids from entering cancer cells. (2020-05-18)
New players in the programmed cell death mechanism
Skoltech researchers have identified a set of proteins that are important in the process of apoptosis, or programmed cell death. (2020-04-30)
A cellular mechanism protecting against cancer
Susanne Hellmuth and Olaf Stemmann from the University of Bayreuth have discovered a natural protective mechanism that leads to the programmed death of potentially diseased cells. (2020-04-23)
Discovering the secrets of the enigmatic caspase-6
Researchers identified the mechanisms underlying the innate immune function of the enzyme caspase-6, offering ways to combat viral infection, inflammatory diseases and cancer. (2020-04-15)
Keratin scaffolds could advance regenerative medicine and tissue engineering for humans
Researchers at Mossakowski Medical Research Center of the Polish Academy of Science have developed a simple method for preparing 3D keratin scaffold models which can be used to study the regeneration of tissue. (2020-04-14)
A direct protein-to-protein binding couples cell survival to cell proliferation
The regulators of apoptosis watch over cell replication and the decision to enter the cell cycle. (2020-04-03)
Physical activity contributes to positive mental well-being in menopausal women
Late menopausal status is associated with an elevated level of depressive symptoms that indicate the negative dimension of mental well-being. (2020-04-01)
Destroying DNA to save the genome -- study offers new insights into sepsis and its treatment
Sepsis is a life-threatening condition that kills millions annually; it is poorly understood and has no specific treatment. (2020-03-26)
How trans fats assist cell death
Tohoku University researchers in Japan have uncovered a molecular link between some trans fats and a variety of disorders, including cardiovascular and neurodegenerative diseases. (2020-03-25)
Antioxidant treatment in acute ischemic stroke may delay the onset of Alzheimer's dementia
There is a considerable overlap between vascular risk factors and risk factors of Alzheimer's disease (AD). (2020-03-17)
'Zombie' brain cells develop into working neurons
Preventing the death of neurons during brain growth means these 'zombie' cells can develop into functioning neurons, according to research in fruit flies from the Crick, the University of Lausanne (UNIL) and the Max Planck Institute for Chemical Ecology. (2020-03-11)
Oncotarget: Both BRCA1-wild type and -mutant triple-negative breast cancers show
Oncotarget Volume 11 Issue 8 features Figure 8, 'MLN4924 treatment induces DNA damage by stabilizing CDT1 and accumulates the cells in S phase which are enhanced by MLN4924/cisplatin co-treatment,' by Misra, et al. (2020-02-26)
New study shows the effects of obesity mirror those of aging
In their paper published in the journal Obesity Reviews, researchers argue that obesity should be considered premature aging. (2020-02-25)
Key modifier identified in large genetic deletion related to neurodevelopmental disorders
Neurodevelopmental disorders, including schizophrenia and autism, likely result from complex interactions that modify the effects of individual genes, according to new research. (2020-02-14)
Cell 'hands' to unlock doors in health research, drug design, and bioengineering
A previously overlooked cell membrane protein could help to further cancer research, drug design, and bioengineering, according to new research. (2020-01-06)
Bacteria can 'outsmart' programmed cell death
To be able to multiply, bacteria that cause diarrhoea block mediators of programmed cell death, a new study in 'Nature Microbiology' shows. (2019-12-24)
Breaking the dogma: Key cell death regulator has more than one way to get the job done
Immunologists from St. Jude Children's Research Hospital have revealed two independent mechanisms driving self-defense molecules to trigger cell death. (2019-12-23)
Metabolic adaptation ensures survival of colon cancer cells
Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. (2019-12-12)
Recruitment of miR-8080 by luteolin inhibits AR-V7 in castration-resistant prostate cancer
Patients with castration-resistant prostate cancer (CRPC) have a poor clinical response to drugs for CRPC, including enzalutamide. (2019-12-05)
NOTCH1 signaling in oral squamous cell carcinoma via a TEL2/SERPINE1 axis
In this study, the research team investigated NOTCH1 mutations in keratinocyte lines derived from OSCC biopsies that had been subjected to whole exome sequencing. (2019-12-04)
Insights into a versatile molecular death switch
The enzyme caspase-8 regulates different modes of cell death, a publication by Hamid Kashkar in 'Nature' shows. (2019-11-26)
High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers: an innovative target
78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment. (2019-11-25)
Cell death or cancer growth: A question of cohesion
Activation of CD95, a receptor found on all cancer cells, triggers programmed cell death -- or does the opposite, namely stimulates cancer cell growth. (2019-11-19)
Avoidance of apoptotic death via a hyperploid salvage survival pathway after platinum treatment in high grade serous carcinoma cell line models
The cover for issue 62 of Oncotarget features Figure 7, 'Proposed model of the hyperploid pathway as a salvage survival strategy regulated by the G2-M checkpoint,' by Yeung, et al. (2019-11-19)
High expression of apoptosis protein (Api-5) in chemoresistant triple-negative breast cancers
78 TNBC biopsies from patients with different responses to chemotherapy were analysed for API-5 expression before any treatment. (2019-11-13)
Forget the Chardonay, pass me the grape stems! Anti-tumor activity in prostate cancer cells
Grape stems are discarded en masse during the production of wine. (2019-11-12)
Discovered a new process of antitumor response of NK cells in myeloma
The stem cell transplant and cell immunotherapy group of the Josep Carreras Leukemia Research Institute reveals how NK cells activate a set of actions that promote their antitumor capacity in the presence of myeloma cells. (2019-11-05)
A kinase identified as possible target to treat heart failure
An unexplored kinase in heart muscle cells may be a good target to treat heart failure, a disease that is only incrementally delayed by existing therapies. (2019-10-31)
Fullerene compounds will help in the fight against lung cancer
The team of scientists from Skoltech Center for Energy Science and Technology, the Institute for Problems of Chemical Physics of Russian Academy of Sciences and National Taiwan University have discovered that fullerene compounds can effectively kill non-small-cell lung carcinoma cells and found out the mechanisms behind their anti-tumor activity. (2019-10-22)
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