Current Cell types News and Events

Current Cell types News and Events, Cell types News Articles.
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Mapping out the mystery of blood stem cells
Princess Margaret scientists have revealed how stem cells are able to generate new blood cells throughout our life by looking at vast, uncharted regions of our genetic material that hold important clues to subtle biological changes in these cells. (2020-11-25)

New type of immunotherapy may pave the way for better cancer treatments
Immunotherapy for cancer has made great advances and many patients can now receive effective treatments that were not available ten years ago. However, there are certain types of cancer that do not respond to existing immunotherapy. A study from Karolinska Institutet in Sweden published in Proceedings of the National Academy of Sciences (PNAS) reports on a new kind of immunotherapy that gives hope of more treatment options for cancer in the future. (2020-11-23)

Many unresolved questions remain regarding T cell immunity to SARS-CoV-2
T cell responses are critical for providing early control and clearance of many viral infections, but there remain many unknowns concerning T cell immunity in COVID-19. Some T cell responses may even have a detrimental impact on the clinical outcome and contribute to long COVID, a phenomenon that affects roughly 10% of COVID-19 patients, causing them to experience an array of symptoms for a month or longer. (2020-11-18)

Existing antidepressant helps to inhibit growth of cancer cells in lab animals
New research has shown that the antidepressant sertraline helps to inhibit the growth of cancer cells. The substance acts on a metabolic addiction that allows different types of cancer to grow. This is shown by a study on cell cultures and lab animals by researchers at KU Leuven. (2020-11-17)

Certain CBD oils no better than pure CBD at inhibiting certain cancer cell lines
Cannabidiol (CBD) oils are equally or less effective at inhibiting the growth of certain cancer cells compared to pure CBD, according to Penn State College of Medicine researchers. The results of their recent study indicate that future research into the clinical applications of cannabinoids should include an analysis of whether the pure cannabinoid compound or intact plant material is more effective at achieving the therapeutic effect. (2020-11-17)

Study identifies patients with lung cancer most likely to respond to immunotherapy
In a new study, researchers at UCLA found patients with a particular type of HLA, a protein scaffold involved in presenting pieces of proteins described as peptides to the immune system, were particularly likely to benefit from immunotherapy. (2020-11-16)

A new diagnostic method predicts which cancer patients will respond to immunothe
An international group led by Dr Banafshe Larijani, an Ikerbasque researcher seconded to the Biofisika Institute (UPV/EHU-University of the Basque Country, CSIC), has developed a new diagnostic method making it possible to accurately predict which cancer patients will respond positively to immunotherapy. This method will allow oncologists to tailor treatment to each patient and avoid therapies that are not going to be successful. (2020-11-16)

New technique isolates brain cells associated with Parkinson's disease
Carnegie Mellon University researchers have developed a new technique for isolating a type of brain cell associated with Parkinson's disease symptoms, enabling them to study that cell type in detail. (2020-11-16)

Pharmacology - An unconventional ion channel
Scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have identified the first mechanosensitive ion channel to be found in an intracellular vesicle system. It responds to concentration changes within the vesicle, and probably controls the initiation of immune reactions. (2020-11-13)

New study reveals a holistic way to look at neurons in the brain
A new lens on visual neurons is laying the groundwork for a more complete ''family tree'' of the mammalian brain. A team of researchers from the Allen Institute for Brain Science, a division of the Allen Institute, published a study -- the largest of its kind to date -- in the journal Cell today revealing a new categorization of mouse neurons that relies on multiple types of data drawn from each individual cell. (2020-11-12)

New molecular atlases reveal how human cells grow and develop
Two cell atlases have been created that track gene expression and chromatin accessibility during the development of human cell types and tissues. The atlases provide a fundamental resource for understanding gene expression and chromatin accessibility in human development that is unprecedented in scale. One maps gene expression within individual cells across 15 fetal tissues. The other maps chromatin accessibility of individual genes within cells. (2020-11-12)

Scientists can now scoop contents of individual cells from their local environment
The new tool combines cell microscopy with the single-cell DNA and protein sequencing technology to enable connecting important information about the cell's physical features and its local environment to its molecular makeup. (2020-11-11)

New prognostic markers for colon cancer identified
The study recently published by MedUni Vienna and collaborative partners nominates ILSs as novel prognostic players orchestrating the pathobiology of metastatic colorectal cancer. (2020-11-11)

Researchers discover enzyme suppressing immune response to viral infections
Viruses such as HIV, hepatitis B and hepatitis C evade or disrupt the immune system to create persistent infections. These viruses remain a serious health threat, but researchers from the University of Missouri School of Medicine have discovered how an enzyme that regulates several cellular processes might be a key target to preventing viruses from disarming the human immune response. (2020-11-10)

HKUST scientists make breakthrough discovery of new therapeutic targets for Alzheimer's
An HKUST team have identified several new potential molecular targets in endothelial cells and microglia for AD drug development. (2020-11-05)

Large-scale cancer proteomics study profiles protein changes in response to drug treatments
Through large-scale profiling of protein changes in response to drug treatments in cancer cell lines, researchers at The University of Texas MD Anderson Cancer Center have generated a valuable resource to aid in predicting drug sensitivity, to understand therapeutic resistance mechanisms and to identify optimal combination treatment strategies. (2020-11-05)

Biologists create "atlas" of gene expression in neurons, documenting diversity of brain cells
New York University researchers have created a ''developmental atlas'' of gene expression in neurons, using gene sequencing and machine learning to categorize more than 250,000 neurons in the brains of fruit flies. Their study, published in Nature, finds that neurons exhibit the most molecular diversity during development and reveals a previously unknown type of neurons only present before flies hatch. (2020-11-04)

'Monster tumors' could offer new glimpse at human development
Finding just the right model to study human development--from the early embryonic stage onward--has been a challenge for scientists over the last decade. Now, bioengineers at the University of California San Diego have homed in on an unusual candidate: teratomas. (2020-11-04)

Langerhans cells are up to the job, they just need a chance
Researchers from the University of Tsukuba found that Langerhans cells (LCs) play a crucial role in mucocutaneous acute guest-versus-host disease (aGVHD). Their experiments in mice showed that when the LCs of a recipient were depleted, the formation of mucocutaneous lesions was enhanced because the infiltration of CD8+ T cells was inhibited. Their findings have significant implications for improving blood stem cell transplantation treatments and clinical outcomes for patients. (2020-10-27)

A question of affinity
A collaboration of scientists from the Max Planck Institute for Polymer Research (MPI-P) in Germany and the King Abdullah University of Science and Technology (KAUST) in Saudi Arabia have recently scrutinized organic solar cells and derived design rules for light-absorbing dyes that can help to make these cells more efficient, while tailoring the absorption spectrum of the cells to the needs of the chosen application. (2020-10-27)

New therapeutic approach against leukemia
Using an RNA molecule complex, researchers can prevent retention of cancer stem cell in their tumor supporting niche (2020-10-23)

Acute kidney injury among African Americans with sickle cell trait and disease
New research examines the risk of acute kidney injury in people with sickle cell trait or disease, as well as the effect of acute kidney injury on kidney function decline in these individuals. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-23)

New blood cancer treatment works by selectively interfering with cancer cell signalling
University of Alberta scientists have identified the mechanism of action behind a new type of precision cancer drug for blood cancers that is set for human trials, according to research published in Nature Communications. (2020-10-22)

The consequences of mating at the molecular level
Researchers from the University of Tsukuba identified a novel mechanism by which mating affects the behavior of germline stem cells (GSCs). By studying Drosophila melanogaster, the researchers showed that the neurons that are activated during mating result in increased intracellular calcium signaling in cells adjacent to GSCs, which in turn resulted in the activation of the protein matrix metalloproteinase to increase GSCs. This study describes how stem cell behavior is regulated by environmental cues. (2020-10-20)

AI methods of analyzing social networks find new cell types in tissue
In situ sequencing enables gene activity inside body tissues to be depicted in microscope images. To facilitate interpretation of the vast quantities of information generated, Uppsala University researchers have now developed an entirely new method of image analysis. Based on algorithms used in artificial intelligence, the method was originally devised to enhance understanding of social networks. The researchers' study is published in The FEBS Journal. (2020-10-19)

'Multi-omics' adds new cell to immune family tree
Australian researchers have used powerful 'single cell multi-omics' technologies to discover a previously unknown ancestor of T and B lymphocytes, which are critical components of our immune system. (2020-10-19)

Gel instrumental in 3D bioprinting biological tissues
The eventual creation of replacement biological parts requires fully three-dimensional capabilities that two-dimensional and three-dimensional thin-film bioprinting cannot supply. Now, using a yield stress gel, Penn State engineers can place tiny aggregates of cells exactly where they want to build the complex shapes that will be necessary to replace bone, cartilage and other tissues. (2020-10-16)

Study shows main cell type in the liver has key role in defending against some viruses
Scientists at Scripps Research have uncovered an important disease-fighting role for cells called hepatocytes, which constitute most of the liver. The discovery could potentially be harnessed to develop new medicines for viral illnesses. (2020-10-16)

Mammalian lipid droplets organize and support innate host immunity
Mammalian lipid droplets -- tiny lipid-filled pockets floating amidst a cell's cytoplasm -- represent an intracellular first line of defense against microbial pathogens, researchers report. (2020-10-15)

Researchers identify the mechanism behind bone marrow failure in Fanconi anaemia
Researchers at the University of Helsinki and the Dana-Farber Cancer Institute have identified the mechanism behind bone marrow failure developing in children that suffer from Fanconi anaemia. (2020-10-14)

Technique to recover lost single-cell RNA-sequencing information
MIT and Ragon Institute researchers have greatly boosted the amount of information that can be obtained using Seq-Well, a technique for rapidly sequencing RNA from single cells. This advance should enable scientists to learn more about the critical genes expressed in each cell, and to discover subtle differences between healthy and diseased cells for designing new preventions and cures. (2020-10-13)

Computational approach to optimise culture conditions required for cell therapy
Collaboration by researchers in Singapore and Australia lead to first-of-its-kind computational biology algorithm that could enable more effective cellular therapies against major diseases. (2020-10-12)

Stem cell sheets harvested in just two days
POSTECH and Pohang Semyung Christianity Hospital joint research team develops a thermoresponsive nanotopography cell culture platform. (2020-10-08)

New perspectives to treat neuropschychiatric diseases
Researchers studied the major types of neurons of the prefrontal cortex of the brain in an international collaboration. The research team has identified molecular differences in neurons that may support drug development for the treatment of psychiatric disorders such as schizophrenia or depression. (2020-10-08)

The world's first successful identification and characterization of in vivo senescent cells
A research team led by Professor Makoto Nakanishi of the Institute of Medical Science, the University of Tokyo, generated a p16-Cre ERT2 -tdTomato mouse model to characterize in vivo p16 high cells at the single-cell level. They found tdTomato-positive p16 high cells detectable in all organs, which were enriched with age. They also found that these cells failed to proliferate and had half-lives ranging from 2.6 to 4.2 months, depending on the tissue examined. (2020-10-07)

Research shows cell perturbation system could have medical applications
Research by a team from Northwestern Engineering shows that the Nanofountain Probe Electroporation system may lead to quicker and more customized medical treatment plans. (2020-10-02)

How cells build organisms
Researchers at Harvard Medical School have discovered a key control mechanism that cells use to self-organize in early embryonic development. The findings, published in Science, shed light on a process fundamental to multicellular life and open new avenues for improved tissue and organ engineering strategies. (2020-10-01)

Sticking together
In unraveling how a single cell develops into a complex organism, one vexing question has remained for developmental biology: How do robust patterns form in the body? An answer has now been found for the zebrafish neural tube. In this paradigm of patterned tissues, the varying stickiness of cells combined with gradients of signaling molecules is responsible for generating a robust pattern. This is the result of a study published in Science. (2020-10-01)

Innate lymphoid cells regenerate within lung
Max Planck researcher Dominic Grün teamed up with colleagues from Würzburg headed by Georg Gasteiger and generated a comprehensive atlas of Innate lymphoid cells (ILCs) of the lung. Thus, they identified progenitor ILCs, comprising circulating and lung-resident progenitors, which differentiate and mature within the lung. They demonstrate that during parasitic worm infections these cells adopt the identity of mature lung ILCs, independent of their origin, and thus help to maintain the population of lung-resident ILCs. (2020-09-30)

Scientists propose immune cocktail therapy to boost cancer-immunity cycle in multiple aspects
A research team led by Prof. TIAN Huayu from the Changchun Institute of Applied Chemistry (CIAC) of the Chinese Academy of Sciences proposed an innovative immune cocktail therapy that combined ICT along with other therapeutic approaches. The cocktail therapy achieved multiple boosting of the cancer-immunity cycle by utilizing a nano-delivery system. (2020-09-30)

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