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Current Chronic myeloid leukemia News and Events

Current Chronic myeloid leukemia News and Events, Chronic myeloid leukemia News Articles.
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Identified the genetic landscape of myelodysplastic/myeloproliferative neoplasms
Researchers from the MDS Group of the Josep Carreras Leukaemia Research Institute and the Munich Leukemia Laboratory map the mutations that can ease and accelerate the diagnosis of Myelodysplastic/Myeloproliferative Neoplasms rare malignancies. (2020-07-01)
Meeting recommended weekly physical activity levels linked to lower risk of death
Adults who meet recommended weekly physical activity levels have a lower risk of death, finds a US study published by The BMJ today. (2020-07-01)
The burden of non-COVID patients: Caring for the left-behind
Coronavirus disease 2019 (COVID-19) has exposed gaps in health care systems. (2020-06-25)
Merits of revascularisation and medical treatment for chronic coronary syndromes
There are two treatment goals for patients with chronic coronary syndromes: reducing the risk of hard outcomes (i.e., death, myocardial infarction) and improving health outcomes (i.e. angina symptoms, quality of life). (2020-06-25)
Blood cell mutations linked to leukemias are inevitable as we age
A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. (2020-06-24)
Starved cancer cells became more sensitive to chemotherapy
By preventing sugar uptake, researchers succeeded in increasing the cancer cells' sensitivity to chemotherapeutic treatment. (2020-06-23)
Prenatal stress associated with infant gut microbes
Mother's chronic prenatal psychological distress and elevated hair cortisol concentrations are associated with gut microbiota composition of the infant, according to a new publication from the FinnBrain research project of the University of Turku, Finland. (2020-06-23)
CAR T cell therapy: potential for considerable savings
Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer. (2020-06-23)
Existing drugs may limit damage caused by HIV
Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. (2020-06-23)
Oncotarget: RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation
The cover for issue 25 of Oncotarget features Figure 8, 'BI-D1870 in combination with vincristine increase metaphase arrest and apoptosis synergistically,' by Chae, et al. (2020-06-23)
MMR vaccine could protect against the worst symptoms of COVID-19
Administering the MMR (measles, mumps, rubella) vaccine could serve as a preventive measure to dampen septic inflammation associated with COVID-19 infection, say a team of experts in this week's mBio, a journal of the American Society for Microbiology. (2020-06-19)
New therapy reduces chronic low back pain in large international study
A new study has found that tanezumab, a monoclonal antibody that inhibits nerve activity, provides relief in patients with chronic low back pain, one of the leading reasons why people seek medical care and the number one cause of disability worldwide. (2020-06-19)
Researchers attempt new treatment approach for blood cancer
In an effort to improve the survival of patients with myeloproliferative neoplasms, a type of leukemia, researchers inhibited a specific protein (alpha5beta1 integrin) to decrease the number of large bone marrow cells (megakaryocytes) in an experimental model. (2020-06-19)
Nanoparticle for overcoming leukemia treatment resistance
One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. (2020-06-18)
Call for caution for using a CAR-T immunotherapy against acute myeloid leukemia
Researchers from the Josep Carreras Leukaemia Research Institute prove that the preclinical implementation of Acute Myeloid Leukaemia immunotherapy, based on CD123-redirected CAR T-cells, affects hematopoiesis, blood cells production, and reconstitution. (2020-06-17)
Team led by Children's Hospital LA researcher generates developmental map of human T-cells
Chintan Parekh, MD, of the The Saban Research Institute of Children's Hospital Los Angeles, has led a team of investigators that generated a comprehensive roadmap for how T-cells develop in the human thymus. (2020-06-16)
The novel mechanisms for inflammation and cancer induced by HTLV-1
A Japanese research group has clarified the mechanism by which human T-cell leukemia virus type 1 (HTLV-1) causes inflammation and oncogenesis. (2020-06-16)
Muscles support a strong immune system
In the fight against cancer or chronic infections, the immune system must be active over long periods of time. (2020-06-15)
Two new, powerful small molecules may be able to kill cancers that other therapies can't
Scientists have identified and developed two potent small molecules that appear to suppress tumor growth in multiple cancers even when other treatments cease to work, possibly due to the development of drug resistance. (2020-06-15)
Cytokine implicated in HLH treatment resistance
Research sheds light on cytokine storm syndromes and how ruxolitinib may benefit patients with hemophagocytic lymphohistiocytosis. (2020-06-12)
Shift to online consultations helps patients with chronic pain receive support in lockdown
Academics and practitioners from the Centre for Pain Research at the University of Bath (UK) have been active in ensuring those with debilitating chronic pain conditions continue to receive support throughout lockdown, including by championing virtual consultations. (2020-06-11)
Putting 'super' in natural killer cells
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells -- a type of immune cell -- with measurably stronger activity against a form of leukemia, both in vivo and in vitro. (2020-06-11)
Immune cell discovery could improve the fight against hepatitis B
For the first time, researchers at The Westmead Institute for Medical Research (WIMR) have identified and described a new and unique subset of human cells that are involved in the immune response against hepatitis B (HBV) infection. (2020-06-09)
For acute myeloid leukemia, genetic testing is often worth the wait
New tailored therapies offer exciting prospects for treating acute myeloid leukemia (AML), but taking advantage of them may require waiting a week or more for genetic testing before starting treatment, posing a dilemma for doctors and patients facing this deadly and often fast-moving disease. (2020-06-04)
Leukemia immune profiles predict drug resistance and benefits of immunotherapy
By analyzing 442 samples from three groups of children and adults with acute myeloid leukemia (AML), researchers have identified new immune classes of the disease that predict the likelihood of drug resistance and positive responses to immunotherapy. (2020-06-04)
Cognitive behavior therapy tops other psychotherapies in reducing inflammation
A review of 56 randomized clinical trials finds that psychological and behavioral therapies may be effective non-drug treatments for reducing disease-causing inflammation in the body. (2020-06-03)
Key gene in leukemia discovered
Acute myeloid leukemia (AML) is one of the most common forms of blood cancer among adults and is associated with a low survival rate, and leads to the inhibition of normal blood formation. (2020-06-03)
Discovery in human acute myeloid leukemia could provide novel pathway to new treatments
Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited. (2020-06-02)
Human lifelong immunity depends on APRIL
Researchers from Tokyo Medical and Dental University (TMDU) identified the protein APRIL as a key regulator of plasmacyte maintenance and immunoglobulin production in humans. (2020-06-01)
Nilotinib appears safe and affects biomarkers in Alzheimer's disease clinical trial
A Georgetown University Medical Center clinical trial investigating the cancer drug nilotinib in people with Alzheimer's disease finds that it is safe and well-tolerated, and researchers say the drug should be tested in a larger study to further determine its safety and efficacy as a potential disease-modifying strategy. (2020-05-29)
UTEP study examines COVID-19 stress, coping strategies, and well-being
Emre Umucu, Ph.D., assistant professor of rehabilitation counseling, and Beatrice Lee, an incoming rehabilitation counseling faculty member, examined the perceived stress levels and coping mechanisms related to COVID-19, and how coping affects well-being in people with self-reported chronic conditions and disabilities. (2020-05-29)
Combination therapy well-tolerated and highly effective for patients with IDH1-mutated AML
A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center. (2020-05-28)
New cancer immunotherapy targeting myeloid cells slows tumor growth
Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. (2020-05-27)
Scientists find a new way to reverse symptoms of Fragile X
MIT scientists have identified a potential new strategy for treating Fragile X syndrome, a disorder that is the leading heritable cause of intellectual disability and autism. (2020-05-20)
At the crossroads
In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (2020-05-20)
Mucus breakthrough could help patients breathe easy
New insights into the molecular mechanisms driving mucus viscosity were discovered by a Melbourne research team led by Associate Professor Ethan Goddard-Borger from the Walter and Eliza Hall Institute. (2020-05-13)
Assassin cells armed with anticancer drugs kill cancer masses
POSTECH Professor Won Jong Kim's team uses immunological synapse formation of natural killer cells to treat cancer. (2020-05-13)
A disease trigger for pancreatitis has been identified
One factor contributing to the development of pancreatitis lies in mutations within a cell membrane ion channel that is characterized by its specific permeability for calcium ions. (2020-05-13)
Coffee linked to lower body fat in women
Women who drink two or three cups of coffee a day have been found to have lower total body and abdominal fat than those who drink less, according to a new study published in The Journal of Nutrition. (2020-05-13)
Total synthesis of cotylenin A for a new anticancer drug without side effects
Waseda University scientists succeeded in developing the world's first method for a total synthesis of cotylenin A, a plant growth regulator which has attracted considerable attention from the scientific community due to its promising bioactivity as an anti-cancer agent. (2020-05-12)
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