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Current Clinical trials News and Events

Current Clinical trials News and Events, Clinical trials News Articles.
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Clinical trial identifies new breast cancer drug as a potential therapy for glioblastoma
Ivy Brain Tumor Center at the Barrow Neurological Institute, has released the results of its recent Phase 0 clinical trial of the breast cancer drug ribociclib (Kisqali®) for the treatment of recurrent glioblastoma. (2019-07-25)
Artificial intelligence solution improves clinical trial recruitment
Clinical trials are a critical tool for getting new treatments to people who need them, but research shows that difficulty finding the right volunteer subjects can undermine the effectiveness of these studies. (2019-07-24)
Social isolation stresses rodents
The traditional method of housing mice and rats alone increases stress and worsens epilepsy, according to a new study published in eNeuro. (2019-07-22)
Review evaluates how AI could boost the success of clinical trials
In a review publishing July 17, 2019 in the journal Trends in Pharmacological Sciences, researchers examined how artificial intelligence (AI) could affect drug development in the coming decade. (2019-07-17)
Rewards incentivize people to stop smoking
Financial incentives work to help people stop smoking and remain smoke free -- according to research led by the University of East Anglia (UEA). (2019-07-16)
Persistent HIV DNA in spinal fluid may be associated with cognitive challenges
HIV DNA remained in the cerebrospinal fluid of half of participants with well-managed HIV (virologic suppression in the plasma), confirming that the central nervous system (CNS) is a major reservoir for latent HIV. (2019-07-15)
Larger drug trials that intervene earlier needed for Alzheimer's disease
There are currently no drugs that stop or inhibit Alzheimer's disease. (2019-07-10)
Yale-developed scorecard promotes better clinical trial data sharing
A tool developed by researchers at Yale, Stanford, and Bioethics International can promote greater sharing of clinical trial data by pharmaceutical companies. (2019-07-10)
Cleveland Clinic releases fourth installment of Alzheimer's Disease Drug Pipeline Report
Cleveland Clinic's fourth annual analysis of Alzheimer's disease drug development found that the pipeline has grown in the number and variety of agents being tested over the past year, while highlighting several advances in the field including new clinical trial designs, more detailed criteria for making a research diagnosis, and an increased use of biological tests reflecting of the disease. (2019-07-10)
Kidney patients are neglected in clinical trials
The exclusion of patients with kidney diseases from clinical trials remains an unsolved problem that hinders optimal care of these patients. (2019-07-09)
New analysis shows drug slows down respiratory decline
Duchenne muscular dystrophy occurs in boys and is characterized by progressive muscle degeneration and weakness leading to a decline in respiratory function. (2019-07-09)
Discovery of mechanism behind precision cancer drug opens door for more targeted treatment
New research that uncovers the mechanism behind the newest generation of cancer drugs is opening the door for better targeted therapy. (2019-07-04)
Blood pressure drug linked with increased risk of bowel condition
A type of blood pressure lowering medication, called a calcium-channel blocker, may be linked with an increased risk of a type of bowel condition called diverticulosis. (2019-07-03)
Are you sure it's burning mouth syndrome?
Not all burning mouths are the result of a medical condition known as 'burning mouth syndrome' (BMS) and physicians and researchers need better standards for an appropriate diagnosis, according to new research at the School of Dental Medicine at Case Western Reserve University. (2019-07-03)
Heart-healthy effects of soy consistent over time, University of Toronto meta-study finds
Researchers at the University of Toronto have found a consistent cholesterol-lowering effect for soy protein, with pooled data from dozens of clinical trials that span the last two decades. (2019-06-27)
UMN researcher studies hip fracture probability on women in late life
New University of Minnesota Medical School research evaluates the impact of multimorbidity on the probability of hip fractures. (2019-06-27)
New blood test for detecting Alzheimer's disease
Researchers from Lund University, together with the Roche pharmaceutical company, have used a method to develop a new blood marker capable of detecting whether or not a person has Alzheimer's disease. (2019-06-25)
Can deprescribing drugs linked to cognitive impairment actually reduce risk of dementia?
A JAMA Internal Medicine commentary by three Regenstrief Institute research scientists calls for randomized deprescribing trials to address anticholinergic drug use as a potentially modifiable and reversible risk factor for dementia, a growing public health issue. (2019-06-24)
Clinical trials beginning for possible preeclampsia treatment
For over 20 years, a team of researchers at Lund University has worked on developing a drug against preeclampsia -- a serious disorder which annually affects around 9 million pregnant women worldwide and is one of the main causes of death in both mothers and unborn babies. (2019-06-24)
High on iron? It stops anaemia but has a downside
A global study looking at the role that iron plays in 900 diseases has uncovered the impact of both low and high iron levels -- and the news is mixed. (2019-06-20)
Vitamin D supplementation not associated with reduced cardiovascular events
This study, called a meta-analysis, combined the results of 21 randomized clinical trials with about 83,000 patients to look at whether vitamin D supplementation was associated with reduced risk of cardiovascular disease events such as heart attack or stroke. (2019-06-19)
Synthetic joint lubricant holds promise for osteoarthritis
A new type of treatment for osteoarthritis, currently in canine clinical trials, shows promise for eventual use in humans. (2019-06-19)
Underenrollment in clinical trials: Patients not the problem
The authors of the study published this month in the Journal of Clinical Oncology investigated why many cancer clinical trials fail to enroll enough patients. (2019-06-17)
Nephrology and Public Policy Committee (NPPC) aims to intensify research activity
Epidemiological and clinical research and public policy in Europe are generally considered to be comprehensive and successful - and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) is playing a key role in the field of nephrology research. (2019-06-14)
PCSK9 inhibitors: Specific studies are mandatory to prove efficacy and safety in CKD
High cardiovascular morbidity and mortality remains a persisting problem in patients with CKDPCSK9 inhibition represents a novel and successful treatment approach to reduce LDL-C in patients with normal to moderately impaired kidney function. (2019-06-13)
Clinical trials and research priorities in dialysis patients: Time for a new approach?
Historically, the number of ESRD RCTs has been very low compared to other subspecialties. (2019-06-13)
Common conditions keep many patients out of knee cartilage research studies
Issues like age or existing arthritis may preclude patients from participating in clinical studies for new therapies that could benefit them (2019-06-13)
Carboplatin & paclitaxel chemotherapy alone should remain standard treatment for endometrial cancer
The New England Journal of Medicine recently published the primary endpoint of the NRG Oncology clinical trial NRG-GOG 0258, which showed that carboplatin and paclitaxel chemotherapy preceded by radiotherapy with concurrent cisplatin, or combined modality therapy, did not significantly increase recurrence-free survival for women with stage 3-4A endometrial cancer when compared to chemotherapy with carboplatin and paclitaxel alone. (2019-06-13)
Brighter possibilities for treating blindness
Advances in preclinical research are now being translated into innovative clinical solutions for blindness, a review published in the 10th anniversary series of science Translational Medicine depicts. (2019-06-05)
Lymphoma trial finds combination targeted therapy effective prior to chemotherapy
Results of a Phase II clinical trial conducted at The University of Texas MD Anderson Cancer Center revealed that combination targeted therapy, consisting of rituximab, lenalidomide and ibrutinib (RLI), had an 84.6 percent overall response rate (ORR) and 38.5% complete response rate (CRR) when given prior to any chemotherapy for newly diagnosed patients with a specific type of diffuse large b-cell lymphoma (DLBCL). (2019-06-04)
Patients who received PBI without chemotherapy experienced less fatigue, slightly poorer cosmesis
Patient-reported outcome (PRO) data indicates that partial breast irradiation (PBI) is more convenient than whole breast irradiation (WBI) for women with breast cancer who do not receive adjuvant chemotherapy. (2019-06-03)
NRG Oncology trial sets new standard regimen for women with uterine carcinosarcomas
Results from the phase III NRG Oncology clinical trial GOG 0261 comparing paclitaxel plus carboplatin (PC) to paclitaxel plus ifosfamide (PI) in women with stage I-IV, recurrent carcinosarcoma of the uterus or ovary, indicate that the PC combination treatment should be considered a standard of care for this patient population. (2019-06-03)
Immunotherapy drug found safe in treating cancer patients with HIV
The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA. (2019-06-03)
ASCO: Finally, a tool to predict response to chemotherapy before bladder cancer surgery
'The idea is that for any individual tumor, its gene expression could tell us whether the cancer will respond to a certain kind of chemotherapy,' says Thomas Flaig, MD. (2019-05-31)
Patient groups untested in cancer immunotherapy trials found to also benefit
Cancer patients previously excluded and underrepresented in immunotherapy clinical trials, such as African Americans and patients with HIV or viral hepatitis, actually benefit at the same rate as patients tested in the clinical trials, according to a Georgetown-led study to be presented at the 2019 ASCO Annual Meeting in Chicago. (2019-05-30)
ASCO: Entrectinib gets edge over crizotinib against ROS1+ lung cancer
Median time to treatment discontinuation (TTD) on crizotinib was 8.8 months; TTD of patients using entrectinib was 14.6 months. (2019-05-30)
ASCO 2019: 40-50 percent response rate for brigatinib after other next-gen ALK inhibitors
University of Colorado Cancer Center study presented at ASCO 2019 shows that brigatinib remains effective even after treatment with another next-generation ALK inhibitor (2019-05-30)
Researchers standardise test for predicting transplant rejection
Researchers from The Westmead Institute for Medical Research have developed a standardised method of measuring the immune response in islet transplant recipients, helping predict patient outcomes. (2019-05-29)
'Ecstasy' shows promise for post-traumatic stress treatment
An international study involving researchers from UBC Okanagan has shown that MDMA, also known as ecstasy, may be a valuable tool for treating post-traumatic stress disorder (PTSD). (2019-05-29)
Female patients more likely to survive but experience worse side effects from cancer treatment
An analysis of over 3,000 patients with cancer of the esophagus and stomach suggests female patients are more likely to survive longer than male patients, but experience more nausea, vomiting and diarrhea during therapy. (2019-05-28)
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