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Current Clinical trials News and Events

Current Clinical trials News and Events, Clinical trials News Articles.
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Clinical research improves health of UK economy and NHS
The value of clinical research to the NHS, the UK economy and jobs market has been evaluated in a new report, which provides an assessment of the economic impact of the National Institute for Health Research Clinical Research Network's (NIHR CRN) activities to support clinical research in England. (2019-10-15)
CF patients experience improved lung health with lumacaftor-ivacaftor but with caveats
In adolescent and adult patients with cystic fibrosis taking lumacaftor-ivacaftor (ORKAMBI®), the combination drug appears to improve lung function and body weight and reduce the need for intravenous antibiotic treatment, according to a French study published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (2019-10-11)
Taking RTKI drugs during radiotherapy may not aid survival, worsens side effects
Taking certain cancer-fighting drugs while undergoing radiation therapy may not increase survival for patients, but may, instead, increase side effects, according to a team of researchers. (2019-10-10)
Long-term dupilumab benefits adolescents with eczema
Results from a phase IIa open-label trial and a subsequent phase III open-label extension trial reinforce findings from an earlier short-term trial that adolescents with moderate-to-severe atopic dermatitis, or eczema, can experience significant improvements with dupilumab. (2019-10-09)
Study demonstrates antibody responses within 6 weeks of initial vaccination
Early phase clinical trial demonstrates that DNA (DNA-HIV-PT123) and protein (AIDSVAX® B/E) combination vaccine regimens induced high magnitude and long-lasting binding antibody responses and that more rapid potentially protective immune responses were observed when the vaccine regimens were co-administered. (2019-10-01)
New in Ethics & Human Research, September-October 2019
Ethical questions about efforts to 'do research differently' in response to past injustices, and more in the September - October issue. (2019-10-01)
In major meta-analysis, omega-3 fish oil supplements linked with lower cardiovasc
People who received omega-3 fish oil supplements in randomized clinical trials had lower risks of heart attack and other cardiovascular disease (CVD) events compared with those who were given placebo (2019-09-30)
Poorly reported placebos could lead to mistaken estimates of benefits and harms
Researchers at the University of Oxford have found that placebo controls are almost never described according to standard reporting guidelines. (2019-09-29)
Tasmanian devil research could help tackle immunotherapy resistance
A cluster of interacting proteins that are active in both human cancers and Tasmanian devil facial tumours, may give clues to how cancers evade the immune system, according to a study part-funded by Cancer Research UK and published in Cancer Cell today (Thursday). (2019-09-26)
Task force provides insights and direction on cell-based therapies
A new report published in the Journal of Bone and Mineral Research and concurrently in the Journal of Orthopaedic Research highlights the latest advances in cell-based therapies for the treatment of disorders of the musculoskeletal system, such as arthritis and osteoporosis, and it identifies key unanswered questions that should be addressed through ongoing research. (2019-09-23)
New UW study questions value of fluoride varnish
A new study by 2 University of Washington researchers and their colleagues questions the cost-effectiveness of fluoride varnish for preschoolers and calls its anti-cavity effects 'modest and uncertain' in this age group. (2019-09-19)
Study quantifies impact of NCI-sponsored trials on clinical cancer care
A new study shows that nearly half of phase 3 cancer clinical trials carried out by the National Cancer Institute-sponsored SWOG Cancer Research Network, one of five groups in NCI's National Clinical Trials Network, were associated with clinical care guidelines or new drug approvals. (2019-09-18)
Combination therapies could help treat fatal lung cancers
Combining a new class of drug with two other compounds can significantly shrink lung tumours in mice and human cancer cells, new research shows. (2019-09-18)
A promising HIV vaccine shows signs of cross-protective benefits
One of the most successful candidate HIV vaccines to date -- initially tested in Thailand, where it had modest effects -- showed surprisingly strong efficacy when evaluated in a South African cohort, where a different strain of HIV is known to circulate. (2019-09-18)
Speeding up the drug discovery process to help patients
An international research team is perfecting a method to predict the potential clinical implications of new drugs before clinical trials even start. (2019-09-13)
A promising treatment for an incurable, deadly kidney disease
A potential treatment for polycystic kidney disease -- a genetic disorder that causes the kidneys to swell with multiple cysts and can eventually lead to organ failure -- has shown promising results in animal testing. (2019-09-12)
Deworming programmes for soil-transmitted helminths -- a Cochrane review update
Should global government and philanthropic aid be invested in large public health deworming programmes in low- and middle-income countries? (2019-09-11)
Some cancer drugs in clinical trials don't work by hitting their targets
Multiple cancer drug candidates in clinical trials kill tumor cells through off-target effects instead of by interacting with their intended molecular targets, according to a new study. (2019-09-11)
Europeans face significant challenges to participate in lung cancer clinical trials
A survey of patients with lung cancer in several European countries revealed that half did not know what a cancer clinical trial is, and 22% had never heard of a cancer clinical trial. (2019-09-10)
Patients taking nivolumab experience five-fold increase in overall survival compared to chemotherapy
Pooled data on two clinical trials demonstrate patients taking nivolumab realized a greater than five-fold increase in five-year overall survival rate compared with the chemotherapy docetaxel. (2019-09-10)
Medicinal products receiving expedited approval in Europe may not provide intended clinical benefit
The majority of marketing authorizations granted through two expedited assessment pathways in Europe are based on non-validated surrogate endpoints rather than clinical outcomes, according to a study published September 10 in the open-access journal PLOS Medicine by Patricia McGettigan of Queen Mary University of London, and colleagues. (2019-09-10)
Major gaps exist in patient understanding of genomic test results, Lung-MAP study shows
A majority of cancer patients don't understand key aspects of the genomic test results they receive as participants in biomarker-driven clinical trials, according to a first-of-its-kind pilot study conducted under the Lung Cancer Master Protocol (Lung-MAP). (2019-09-09)
Overcoming resistance in pancreatic cancer
In pancreatic cancer cells' struggle to survive, the cells choose alternative routes when their main pathways are blocked by drugs. (2019-09-09)
Study supports germline testing for all metastatic breast cancer patients
Genetic testing for all metastatic breast cancer patients may be an optimal strategy for identifying additional patients with increased risk as well as response to targeted therapies, according to research published in JAMA Oncology. (2019-09-09)
Dietary supplement may help with schizophrenia
A dietary supplement, sarcosine, may help with schizophrenia as part of a holistic approach complementing antipsychotic medication, according to a UCL researcher. (2019-09-09)
Tobacco cessation after cancer diagnosis: Declaration from the IASLC
The International Association for the Study of Lung Cancer today used the platform of its largest international meeting to call attention to the importance of tobacco cessation after cancer diagnosis, and urged all physicians to screen cancer patients for tobacco use and recommend tobacco cessation. (2019-09-07)
Preclinical study reveals the impact of age on immunotherapy treatment for breast cancer
In order to understand the influence of aging on the effectiveness of immune checkpoint blockade therapy, researchers from Brigham and Women's Hospital, the Dana Farber Cancer Institute, and Harvard Medical School conducted preclinical studies using younger and older mice with triple negative breast cancer, finding that age affects the efficacy of ICB therapy. (2019-09-06)
Low income cancer patients and those without insurance see fewer trial benefits
When it comes to benefiting from experimental treatments offered in cancer clinical trials, your health insurance status and where you live matters, according to results of two new research studies to be presented at the 2019 ASCO Quality Care Symposium, held September 6 and 7, 2019 in San Diego. (2019-09-04)
New sequencing study provides insight into HIV vaccine protection
Scientists led by the US Military HIV Research Program (MHRP) identified a transcriptional signature in B cells associated with protection from SIV or HIV infection in five independent trials of HIV-1 vaccine candidates. (2019-08-28)
Omega-3 fats have little or no effect on type 2 diabetes
Increasing omega-3 fats in the diet has little or no effect on risk of type 2 diabetes, finds an evidence review published by The BMJ today. (2019-08-21)
Promising gene replacement therapy moves forward at Ohio State
Research led by Dr. Krystof Bankiewicz, who recently joined The Ohio State University College of Medicine, shows that gene replacement therapy for Niemann-Pick type A disease is safe for use in nonhuman primates and has therapeutic effects in mice. (2019-08-21)
Study finds lack of racial diversity in cancer drug clinical trials
New research published this week in JAMA Oncology has found a lack of racial and ethnic diversity in clinical trials for cancer drugs. (2019-08-15)
Ultrasound: The potential power for cardiovascular disease therapy
In the current issue of Cardiovascular Innovations and Applications volume 4, issue 2, pp. (2019-08-15)
First clinical trial of drug-inducible gene therapy yields encouraging preliminary results
A new clinical trial by investigators from Brigham and Women's Hospital and Dana-Farber Cancer Institute set out to test the safety and effectiveness of controlling a powerful immunotherapy, known as human interleukin-12 (hIL-12), by using an oral activator -- a drug that can give finer control over when a gene gets turned on -- in patients with recurrent glioblastoma. (2019-08-14)
Exercise associated with benefit to patients with advanced colorectal cancer
Patients with metastatic colorectal cancer who engaged in moderate exercise while undergoing chemotherapy tended to have delayed progression of their disease and fewer severe side effects from treatment, according to the results of a new study. (2019-08-14)
Kids might be naturally immunized after C. difficile colonization in infancy
Exposure to C. difficile in infancy produces an immune response that might protect against this gastrointestinal infection later in childhood, according to a study published in Clinical Infectious Diseases journal. (2019-08-06)
'Spin' found in over half of clinical trial abstracts published in top psychiatry journals
'Spin' -- exaggerating the clinical significance of a particular treatment without the statistics to back it up -- is apparent in more than half of clinical trial abstracts published in top psychology and psychiatry journals, finds a review of relevant research in BMJ Evidence Based Medicine. (2019-08-05)
Model predicts cognitive decline due to Alzheimer's, up to two years out
An artificial intelligence model developed at MIT predicts cognitive decline of patients at risk for Alzheimer's disease by predicting their cognition test scores up to 2 years in the future. (2019-08-02)
Blood test is highly accurate at identifying Alzheimer's before symptoms arise
A blood test to detect the brain changes of early Alzheimer's disease has moved one step closer to reality. (2019-08-01)
Microbiome diversity builds a better mouse model
The path to building a better mouse model starts with the microorganisms that colonize it. (2019-08-01)
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