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Current Clinical trials News and Events

Current Clinical trials News and Events, Clinical trials News Articles.
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Breakthrough with cancer vaccine
Scientists have developed a new cancer vaccine with the potential to activate the body's immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers. (2020-07-09)
A new nanoconjugate blocks acute myeloid leukemia tumor cells without harming healthy ones
The nanoparticle targets only leukemic cells and therefore would reduce the severe adverse effects of current treatments. (2020-07-09)
New Human Gene Therapy editorial: Concern following gene therapy adverse events
Response to the recent report of the deaths of two children receiving high doses of a gene therapy vector (AAV8) in a Phase I trial for X-linked myotubular myopathy (MTM). (2020-07-02)
Routine revascularization vs. medical therapy: Meta-analysis and review
Revascularization is often performed in patients with stable ischemic heart disease (SIHD). (2020-06-25)
Two-year outcomes after revascularisation deferral based on FFR or iFR measurements
Revascularisation deferral (i.e. decision to treat medically) is a key aspect of physiology-based coronary revascularisation. (2020-06-25)
Blocking a 'jamming signal' can unleash immune system to fight tumors
Yale researchers have discovered a ''jamming signal'' that blocks a powerful immune system stimulant called interleukin-18 (IL-18) from reaching tumors, including in cancers that are resistant to conventional immunotherapy treatments, they report June 24 in the journal Nature. (2020-06-24)
New research highlights potential cardiovascular risk of novel anti-osteoporotic drug
Research presents new evidence which strengthens the plausibility that treatment with the novel anti-osteoporotic medicine, romosozumab, may lead to excess cardiovascular complications. (2020-06-24)
Study shows better option for treatment of inoperable anal cancer
People with inoperable anal cancer treated with carboplatin-paclitaxel had fewer complications and lived longer than those who received another chemotherapy that has been more often administered. (2020-06-24)
Drug used to slow kidney disease found to be ineffective
In a major clinical trial, clinicians have found the drug allopurinol does not prevent worsening of kidney disease, despite up to 20 per cent of kidney disease patients being prescribed the medication. (2020-06-24)
Black cancer patients better represented in publicly-funded clinical trials
Black patients are better represented in taxpayer-funded clinical trials testing new cancer treatments compared to trials run by pharmaceutical companies - although black patients are not fully represented in cancer clinical trials, regardless of sponsor. (2020-06-22)
New class of precision medicine strips cancer of its DNA defenses
A new precision medicine targeting cancer's ability to repair its DNA has shown promising results in the first clinical trial of the drug class. (2020-06-22)
Anal cancer's first randomized trial for inoperable disease sets the treatment standard
Results from first randomized trial for inoperable anal cancer suggest that carboplatin-paclitaxel become the standard treatment for these patients. (2020-06-18)
Combination biomarker predicts response to immune checkpoint therapy in patients with advanced bladder cancer
A combination of two biomarkers was predictive of improved clinical responses and prolonged survival following treatment with immune checkpoint inhibitors in patients with advanced bladder cancers. (2020-06-17)
Combination of healthy lifestyle traits may substantially reduce Alzheimer's disease risk
Data from two NIH studies shows that combining four or five healthy lifestyle behaviors -- physical activity, not smoking, light-to-moderate alcohol consumption, a high-quality diet, and cognitive activities -- may lower risk of Alzheimer's disease by 60%. (2020-06-17)
Fred Hutch and University of Washington experts: Treat COVID-19 earlier to save lives
Infectious disease experts from Fred Hutchinson Cancer Research Center and UW Medicine are advocating for earlier actions to reduce hospitalizations and deaths from COVID-19. (2020-06-16)
Experts clarify subtypes of multiple sclerosis to improve care and clinical trials
An international committee has clarified previously published descriptors of courses of MS and disease activity. (2020-06-11)
Warburg effect: Sugar-tagging helps drug compounds to target human prostate cancer cells
Scientists of Far Eastern Federal University (FEFU), together with German and Russian colleagues, have developed a lead compound to fight chemotherapy-resistant prostate cancer. (2020-06-11)
Chronic exposure to interferons being tested for COVID-19 therapy may increase the risk of bacterial
Two separate studies in mice suggest that a class of interferons being evaluated in clinical trials as a therapy for COVID-19 may increase susceptibility to bacterial infections, depending on how long patients are exposed to it, and when they receive it. (2020-06-11)
New in Ethics and Human Research
Covid-19: Why Challenge Trials of Vaccines Could be Ethical, Despite Severe Risks, Equitably Sharing the Benefits and Burdens of Research. (2020-06-10)
Pre-term deliveries due to COVID-19 could be avoided by studying EHRs
Using electronic health record (EHR) data to simulate drug trials for pregnant patients could one day offer a solution to the current practice of delivering babies pre-term if an expectant mother contracts COVID-19, according to a position paper published in Nature Medicine. (2020-06-10)
Majority of first-wave COVID-19 clinical trials have significant design shortcomings, study finds
Most of the registered clinical trials of potential treatments for COVID-19 underway as of late March were designed in ways that will greatly limit their value in understanding potential treatments, according to a study from researchers at Johns Hopkins Bloomberg School of Public Health. (2020-06-09)
Study shows cannabis temporarily relieves PTSD symptoms
People suffering from post-traumatic distress disorder report that cannabis reduces the severity of their symptoms by more than half, at least in the short term, according to a recent study led by WSU psychology professor Carrie Cutler. (2020-06-09)
Photodynamic therapy used to treat ovarian cancer
Photodynamic therapy (PDT) is one of the most promising methods of treating localized tumors. (2020-06-08)
More evidence of no survival benefit in COVID-19 patients receiving hydroxychloroquine
A study of electronic medical records from US Veterans Health Administration medical centers has found that hydroxychloroquine -- with or without azithromycin -- did not reduce the risk of ventilation or death and was associated with longer length of hospital stay. (2020-06-05)
Why we should trust registered clinical trials
In a time when we have to rely on clinical trials for COVID-19 drugs and vaccines, a new study brings good news about the credibility of registered clinical trials. (2020-06-04)
Growth factors and Parkinson's disease -- Where next?
Growth factors such as glial cell line-derived neurotrophic factor (GDNF) were initially thought to be exciting new treatments for Parkinson's disease (PD), but trials have been disappointing. (2020-06-04)
Largest ever study of radiosurgery for brain metastases from small cell lung cancer
The international First-line Radiosurgery for Small-Cell Lung Cancer (FIRE-SCLC) analysis led by University of Colorado Cancer Center researchers and published today in JAMA Oncology shows no overall survival benefit with whole-brain radiation therapy compared with radiosurgery in patients with small cell lung cancer. (2020-06-04)
What are the risks and benefits of low-dose aspirin?
Low-dose aspirin significantly lowers cardiovascular disease risk but increases the risk of bleeding, according to a review published in the British Journal of Clinical Pharmacology. (2020-06-03)
Cognitive behavior therapy tops other psychotherapies in reducing inflammation
A review of 56 randomized clinical trials finds that psychological and behavioral therapies may be effective non-drug treatments for reducing disease-causing inflammation in the body. (2020-06-03)
Clinical trials in the era of digital engagement: A SWOG call to action
Social media is an integral part of medicine, and an increasingly important conduit for sharing information about clinical trials. (2020-06-03)
Tulane scientists find a switch to flip and turn off breast cancer growth and metastasis
Researchers at Tulane University School of Medicine identified a gene that causes an aggressive form of breast cancer to rapidly grow. (2020-06-02)
Trastuzumab combined with trimodality treatment does not improve outcomes for patients
Results of the NRG Oncology clinical trial RTOG 1010 indicated that the addition of the monoclonal antibody trastuzumab to neoadjuvant trimodality treatment did not improve disease-free survival (DFS) outcomes for patient with HER2 overexpressing local and locally advanced esophageal adenocarcinoma. (2020-05-29)
Carfilzomib does not improve outcomes in newly diagnosed myeloma compared to bortezomib
The combination of carfilzomib, lenalidomide, and dexamethasone (KRd) did not improve progression-free survival in patients with newly diagnosed myeloma absent a high-risk disease prognosis, compared with the standard of care -- bortezomib, lenalidomide, and dexamethasone (VRd). (2020-05-28)
Target trials support drug safety in pregnant patients
Out of concern for fetal safety, pregnant people have typically been excluded from drug trials. (2020-05-27)
Women and minorities lacking in research and clinical trials for new cardiometabolic medications
Women and minorities have low participation rates in pivotal trials for new medications. (2020-05-27)
Still not enough women and older adults in cholesterol drug trials, study finds
Although heart disease is the leading cause of death in women, and older adults are more likely to have heart and vascular disease than young people, randomized clinical trials testing medications to lower cholesterol have historically underenrolled both groups. (2020-05-22)
No improvement in death rate for COVID-19 patients who received hydroxychloroquine
A research team led by investigators from Brigham and Women's Hospital has evaluated real-world evidence related to outcomes for COVID-19 patients who were treated with hydroxychloroquine or chloroquine analogues (with or without a macrolide). (2020-05-22)
When developing vaccines against COVID-19, 'fast is slow, and slow is fast'
Bypassing clinical trials for a potential SARS-CoV-2 vaccine would be ''catastrophic,'' says Science Advances deputy editor Douglas Green in this Editorial. (2020-05-22)
NUI Galway research show blood pressure lowering reduces risk of developing dementia
Research completed in NUI Galway has shown that lowering blood pressure by taking blood pressure medications reduces the risk of developing dementia and cognitive impairment by 7%. (2020-05-21)
Some patients with bladder cancer 'can't wait' for treatment during the COVID-19 pandemic
Bladder cancer is associated with significant illness and mortality, particularly if treatment is delayed. (2020-05-21)
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