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Current Clinical trials News and Events

Current Clinical trials News and Events, Clinical trials News Articles.
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Nephrology and Public Policy Committee (NPPC) aims to intensify research activity
Epidemiological and clinical research and public policy in Europe are generally considered to be comprehensive and successful - and the European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) is playing a key role in the field of nephrology research. (2019-06-14)
PCSK9 inhibitors: Specific studies are mandatory to prove efficacy and safety in CKD
High cardiovascular morbidity and mortality remains a persisting problem in patients with CKDPCSK9 inhibition represents a novel and successful treatment approach to reduce LDL-C in patients with normal to moderately impaired kidney function. (2019-06-13)
Clinical trials and research priorities in dialysis patients: Time for a new approach?
Historically, the number of ESRD RCTs has been very low compared to other subspecialties. (2019-06-13)
Common conditions keep many patients out of knee cartilage research studies
Issues like age or existing arthritis may preclude patients from participating in clinical studies for new therapies that could benefit them (2019-06-13)
Carboplatin & paclitaxel chemotherapy alone should remain standard treatment for endometrial cancer
The New England Journal of Medicine recently published the primary endpoint of the NRG Oncology clinical trial NRG-GOG 0258, which showed that carboplatin and paclitaxel chemotherapy preceded by radiotherapy with concurrent cisplatin, or combined modality therapy, did not significantly increase recurrence-free survival for women with stage 3-4A endometrial cancer when compared to chemotherapy with carboplatin and paclitaxel alone. (2019-06-13)
Brighter possibilities for treating blindness
Advances in preclinical research are now being translated into innovative clinical solutions for blindness, a review published in the 10th anniversary series of science Translational Medicine depicts. (2019-06-05)
Lymphoma trial finds combination targeted therapy effective prior to chemotherapy
Results of a Phase II clinical trial conducted at The University of Texas MD Anderson Cancer Center revealed that combination targeted therapy, consisting of rituximab, lenalidomide and ibrutinib (RLI), had an 84.6 percent overall response rate (ORR) and 38.5% complete response rate (CRR) when given prior to any chemotherapy for newly diagnosed patients with a specific type of diffuse large b-cell lymphoma (DLBCL). (2019-06-04)
Patients who received PBI without chemotherapy experienced less fatigue, slightly poorer cosmesis
Patient-reported outcome (PRO) data indicates that partial breast irradiation (PBI) is more convenient than whole breast irradiation (WBI) for women with breast cancer who do not receive adjuvant chemotherapy. (2019-06-03)
NRG Oncology trial sets new standard regimen for women with uterine carcinosarcomas
Results from the phase III NRG Oncology clinical trial GOG 0261 comparing paclitaxel plus carboplatin (PC) to paclitaxel plus ifosfamide (PI) in women with stage I-IV, recurrent carcinosarcoma of the uterus or ovary, indicate that the PC combination treatment should be considered a standard of care for this patient population. (2019-06-03)
Immunotherapy drug found safe in treating cancer patients with HIV
The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA. (2019-06-03)
ASCO: Finally, a tool to predict response to chemotherapy before bladder cancer surgery
'The idea is that for any individual tumor, its gene expression could tell us whether the cancer will respond to a certain kind of chemotherapy,' says Thomas Flaig, MD. (2019-05-31)
Patient groups untested in cancer immunotherapy trials found to also benefit
Cancer patients previously excluded and underrepresented in immunotherapy clinical trials, such as African Americans and patients with HIV or viral hepatitis, actually benefit at the same rate as patients tested in the clinical trials, according to a Georgetown-led study to be presented at the 2019 ASCO Annual Meeting in Chicago. (2019-05-30)
ASCO: Entrectinib gets edge over crizotinib against ROS1+ lung cancer
Median time to treatment discontinuation (TTD) on crizotinib was 8.8 months; TTD of patients using entrectinib was 14.6 months. (2019-05-30)
ASCO 2019: 40-50 percent response rate for brigatinib after other next-gen ALK inhibitors
University of Colorado Cancer Center study presented at ASCO 2019 shows that brigatinib remains effective even after treatment with another next-generation ALK inhibitor (2019-05-30)
Researchers standardise test for predicting transplant rejection
Researchers from The Westmead Institute for Medical Research have developed a standardised method of measuring the immune response in islet transplant recipients, helping predict patient outcomes. (2019-05-29)
'Ecstasy' shows promise for post-traumatic stress treatment
An international study involving researchers from UBC Okanagan has shown that MDMA, also known as ecstasy, may be a valuable tool for treating post-traumatic stress disorder (PTSD). (2019-05-29)
Female patients more likely to survive but experience worse side effects from cancer treatment
An analysis of over 3,000 patients with cancer of the esophagus and stomach suggests female patients are more likely to survive longer than male patients, but experience more nausea, vomiting and diarrhea during therapy. (2019-05-28)
Gene therapy towards a clinical trial for gamma-sarcoglycanopathy, limb-girdle muscular dystrophy
Isabelle Richard's team, a CNRS researcher in an Inserm unit at Genethon, the AFM-Telethon laboratory, has demonstrated the efficacy of gene therapy and determined the effective dose for treating a rare muscle disease, gamma-sarcoglycanopathy, in mouse models of the disease. (2019-05-24)
Virtual reality can spot navigation problems in early Alzheimer's disease
Virtual reality (VR) can identify early Alzheimer's disease more accurately than 'gold standard' cognitive tests currently in use, suggests new research from the University of Cambridge. (2019-05-23)
Black men less likely than nonblack men to adopt active surveillance
At a time when a growing number of men with prostate cancer considered 'low risk' are opting for active surveillance or watchful waiting rather than immediate treatment with surgery or radiation, a new study reveals that black men are less likely than white men to adopt an active surveillance strategy for their disease. (2019-05-22)
Translational research led by Singapore scientists uncovers new treatment for fatty liver disease
A new treatment approach that involves blocking a protein has, for the first time, shown promising results in the treatment of fatty liver disease, in a landmark translational research collaboration between Duke-NUS Medical School, National Heart Centre Singapore and biotech company Enleofen Bio. (2019-05-22)
Global agreement reached on standards for clinical trials in children with MS
The International Pediatric MS Study Group -- a group of care providers and researchers looking to optimize worldwide care, education and research in pediatric multiple sclerosis -- was convened with sponsorship by the National MS Society and the MS Society of Canada. (2019-05-21)
Children with cancer wait an average of 6.5 years longer than adults to access new drugs
An analysis of 117 cancer drugs approved by the US FDA over a 20-year period finds the drugs took a median of 6.5 years to go from the first clinical trial in adults to the first trial in children. (2019-05-21)
Long-term use of benralizumab appears safe, effective for severe asthma
Patients with severe eosinophilic asthma, who participated in three different Phase 3 trials of benralizumab (brand name Fasenra) and then enrolled in a long-term trial of the drug's efficacy and safety, continued to experience fewer exacerbations and improved pulmonary function and quality of life. (2019-05-20)
Baylor Scott & White gastroenterology researchers share key takeaways from DDW 2019
Dr. Stuart J. Spechler among researchers from Baylor Scott & White Research Institute available to provide key takeaways from Digestive Disease Week 2019. (2019-05-20)
Study paves way for better treatment of lingering concussion symptoms
The results of the study, released in Neuroscience journal, show that significant levels of fatigue and poorer brain function can persist for months, or even years, following concussion. (2019-05-15)
Complete removal of tumor reduces risk of recurrence of cancer in dogs
The relative risk of a recurrence of cancer is reduced by 60% in dogs whose tumors are completely removed, a new analysis by Oregon State University researchers has found. (2019-05-14)
Glucosamine supplements may be linked to lower risk of cardiovascular disease
Regular use of glucosamine supplements may be related to a lower risk of cardiovascular disease (CVD) events, suggests an analysis of data from the UK Biobank study, published in The BMJ today. (2019-05-14)
BU finds rare gene mutations may prevent heart disease
A kind of rare gene mutation may prevent heart disease, according to a new study co-led by a Boston University School of Public Health (BUSPH) researcher. (2019-05-13)
How genomics profiling can help identify the best treatment for bladder cancer
A new computational tool -- a single-patient classifier -- effectively enables physicians to assign a bladder cancer subtype to an individual patient's cancer using that patient's genomic data. (2019-05-09)
Study shows MD Anderson-developed drug effective in overcoming ibrutinib resistance in mantle cell lymphona
A study at The University of Texas MD Anderson Cancer Center demonstrated how a small molecule drug discovered at the institution may help overcome resistance to treatment with ibrutinib in patients with mantle cell lymphoma. (2019-05-08)
Soy protein lowers cholesterol, study suggests
With the US Food and Drug Administration (FDA) planning to remove soy from its list of heart healthy foods, researchers at St. (2019-05-06)
DNA test is an effective cervical cancer screening tool for women in low-income countries
Dartmouth researchers have introduced an inexpensive DNA-based test for human papillomavirus (HPV), the cause of cervical cancer, in Honduras. (2019-05-03)
Stephenson Cancer Center physician is senior author on major study
A gynecologic oncologist at the Stephenson Cancer Center at OU Medicine was a national leader of a newly published research study that reveals good news for women with ovarian cancer -- longer survival times plus a treatment option that causes fewer difficult side effects. (2019-05-03)
ASTRO and AUA update joint clinical guidance for radiation therapy after prostatectomy
The American Society for Radiation Oncology (ASTRO) and the American Urological Association (AUA) today announced updates to their joint clinical guideline on adjuvant and salvage radiotherapy after prostatectomy in patients with and without evidence of prostate cancer recurrence to include new published research related to adjuvant radiotherapy. (2019-05-01)
Modulating a hormonal pathway improves social function in 2 clinical trials of adults and children with autism spectrum disorder
Results from two clinical trials reveal that modulating the hormone vasopressin's biological pathway safely enhanced social functioning in 223 adult men and 30 children with autism spectrum disorder (ASD). (2019-05-01)
When is Alzheimer's not Alzheimer's? Researchers characterize a different form of dementia
Alzheimer's is dementia, but not all dementias are Alzheimer's (which may explain why so many Alzheimer's drugs have failed in clinical trials). (2019-04-30)
Simple clinical features can help personalize type 2 diabetes treatment
A new study from the University of Exeter Medical School has shown that a person's characteristics such as weight and age at diabetes diagnosis provide a simple way to select the diabetes drug that is likely to be best for them. (2019-04-29)
When designing clinical trials for huntington's disease, first ask the experts
Progress in understanding the genetic mutation responsible for Huntington's disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments. (2019-04-23)
A deep-learning model may help predict lung cancer survival and outcomes
A deep-learning model developed using serial image scans of tumors from patients with non-small cell lung cancer (NSCLC) predicted treatment response and survival outcomes better than standard clinical parameters. (2019-04-22)
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