Current Clostridium difficile News and Events

Current Clostridium difficile News and Events, Clostridium difficile News Articles.
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Cellular powerplant recycles waste gases
Carbon monoxide is a very poisonous gas. Humans die within minutes when they inhale it. However, some microorganisms tolerate carbon monoxide. Knowledge about how these bacteria survive opens a window into the primeval times of the earth and the origin of life. At the same time, they might be useful for the future as they can be used to clean waste gases and produce biofuels. Scientists from the Max Planck Institute for Marine Microbiology in Bremen have now made a surprising discovery. (2020-11-16)

In your gut: How bacteria survive low oxygen environments
Researchers from ITQB NOVA, in collaboration with the Institut Pasteur in Paris, have shed light on the mechanisms that allow Clostridioides difficile, a pathogen that can only grow in oxygen-free environments, to survive low oxygen levels. C. difficile is a major cause of intestinal problems associated with the use of antibiotics, causing an estimated number of 124k cases per year in the EU, costing on average 5k€ per patient, as a direct consequence of healthcare-associated contagion. (2020-11-02)

Microbial strains show individualized patterns of stability in the developing infant gut
Microbial strain stability studies of human infants and children, ages shortly after birth (about 6 months) to 6 years, show individualized patterns of microbial strain specificity as the infant gut microbiomes developed. (2020-10-28)

Discovery of pH-dependent 'switch' in interaction between pair of protein molecules
All biological processes are in some way pH-dependent. Our human bodies, and those of other organisms, need to maintain specific- and constant- pH regulation in order to function. Changes in pH can have serious biological consequences or, as researchers at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS) found, serious benefits. (2020-10-23)

Caesarean birth, prolonged labour influence infant gut bacteria, risk of childhood obesity
Events at birth may affect the microbes living in a baby's gut during the first few months of life, leading to a higher risk of childhood obesity and allergies, according to a new study published in the journal Gastroenterology. (2020-10-02)

AGA releases largest report on safety and effectiveness of fecal microbiota transplantation
Today, the American Gastroenterological Association (AGA) released the first results from the NIH-funded AGA Fecal Microbiota Transplantation (FMT) National Registry, the largest real-world study on the safety and effectiveness of FMT. Published in Gastroenterology, the registry reported that FMT led to a cure of Clostridioides difficile (C. difficile) infection in 90% of patients across 20 North American FMT practice sites. Few serious side effects were reported. (2020-10-01)

Fecal transplantation can restore the gut microbiota of C-section babies
Birth by Cesarean section is detrimental to normal gut microbiota development. Researchers demonstrated that the intestinal microbiota development can be restored by postnatal, orally-delivered transplantation of maternal fecal microbiota. (2020-10-01)

New drug could stop deadly superbug, save tens of thousands of lives
A pair of Purdue University researchers from the College of Pharmacy and the College of Veterinary Medicine developed small molecules to combat deadly, drug-resistant enterococcus. (2020-09-10)

Too many COVID-19 patients get unneeded 'just in case' antibiotics
More than half of patients hospitalized with suspected COVID-19 in Michigan during the state's peak months received antibiotics soon after they arrive, just in case they had a bacterial infection in addition to the virus, a new study shows. But testing soon showed that 96.5% of them only had the coronavirus, which antibiotics don't affect. (2020-08-26)

Influence of vitamin D supplementation on a baby's gut microbiome
New research from the CHILD Cohort Study has shed light on the influence of vitamin D supplementation on a baby's developing gut microbiome. The study, published in the journal Gut Microbes, found that vitamin D supplementation is associated with compositional changes in a baby's microbiome -- notably a lower abundance of the bacteria Megamonas -- at three months of age. (2020-08-18)

Insights on the gut microbiome could shape more powerful, precise treatment
In a recently published study, investigators from Brigham and Women's Hospital explore how the dynamics of bacterial species may influence the success of fecal microbiota transplantation in treating recurrent C. difficile infection. In Nature Communications, the team presents an algorithm to design personalized probiotic cocktails for patients with unhealthy gut microbiomes due to rCDI. (2020-07-31)

Rapid genome sequencing and screening help hospital manage COVID-19 outbreaks
Cambridge researchers have shown how rapid genome sequencing of virus samples and enhanced testing of hospital staff can help to identify clusters of healthcare-associated COVID-19 infections. (2020-07-14)

Viral dark matter exposed: Metagenome database detects phage-derived antibacterial enzyme
In a pioneer study published in Cell Host & Microbe - Researchers at Osaka City University and The Institute for Medical Science, The University of Tokyo, reported intestinal bacterial and viral metagenome information from the fecal samples of 101 healthy Japanese individuals. This analysis, leveraging host bacteria-phage associations, detected phage-derived antibacterial enzymes that control pathobionts. As proof-of-concept, phage-derived endolysins are shown to regulate C. difficile infection in mice. (2020-07-10)

Researchers develop software to find drug-resistant bacteria
The program could make it easier to identify the deadly antimicrobial resistant bacteria that exist in the environment. Such superbugs annually cause more than 2.8 million difficult-to-treat pneumonia or bloodstream infections and 35,000 deaths in the US. (2020-07-06)

Faecal microbial transplantation more effective and less costly than antibiotics
An innovative treatment for patients with Clostridium difficile infection (CDI) which uses transplanted gut bacteria to treat the infection, is a more effective and more cost-efficient treatment than using antibiotics, a new UK study has found. (2020-06-29)

Superbug impact on the gut
Monash University researchers have discovered that the devastating bacterial superbug Clostridioides difficile hijacks the human wound healing system in order to cause serious and persistent disease, opening up the development of new therapies to treat the disease. (2020-06-25)

Why bacterial toxins are 'fascinating machines of death'
Bacterial toxins causing different illnesses share similar molecular mechanisms in a finding that could help treatment development as well as explain the emergence of new diseases. (2020-06-25)

Accelerating biological systems design for sustainable biomanufacturing
A new cell-free platform developed by Professor Michael Jewett rapidly identifies optimal enzyme combinations for sustainable fuels and materials. (2020-06-15)

AGA does not recommend the use of probiotics for most digestive conditions
After a detailed review of available literature, the American Gastroenterological Association (AGA) has released new clinical guidelines finding that for most digestive conditions there is not enough evidence to support the use of probiotics. This is the first clinical guideline to focus on probiotics across multiple GI diseases while also considering the effect of each single-strain or multi-strain formulation of probiotics independently instead of grouping them all under the single umbrella of 'probiotics.' These guidelines are published in Gastroenterology, AGA's official journal. (2020-06-09)

Deadly bacterial infection in pigs deciphered
New-born piglets often die painfully from infection with an intestinal bacterium. A team of researchers from 3 faculties at the University of Bern has now discovered how the bacterium causes fatal intestinal bleeding. They have thus made a breakthrough in veterinary research. Promising prospects for vaccinations and medications for use in humans too have now opened up. (2020-06-04)

New review helps translate probiotic science into practical primary care recommendations
Probiotic supplements are widely available and are promoted as a general way to support the gut microbiome and promote health. A new publication in the Journal of Family Practice summarizes the latest evidence on using probiotics for a variety of specific health conditions, providing practical recommendations to assist primary care physicians in advising their patients. The article, authored by current International Scientific Association for Probiotics and Prebiotics board members. (2020-06-01)

Gut ecology
For something that has evolved with us over millions of years, and remains part of our physiology over our entire lives, our gut microbiome, oddly, remains somewhat of a mystery. Comprised of trillions of microbes of at least a thousand different species, this community of bacteria, viruses, protozoa and fungi in our gastrointestinal tracts is unique to each individual and has been found to be intimately connected to various fundamental aspects of our fitness, from our immunity to our metabolism and mental health. (2020-05-13)

Individualized mosaics of microbial strains transfer from the maternal to the infant gut
Researchers have used a microbiome 'fingerprint' method to report that an individualized mosaic of microbial strains is transmitted to the infant gut microbiome from a mother giving birth through vaginal delivery. They detailed this transmission by analyzing existing metagenomic databases of fecal samples from mother-infant pairs, as well as analyzing mouse dam and pup transmission in a germ-free, or gnotobiotic, mouse model, where the dams were inoculated with human fecal microbes. (2020-05-08)

Large population study links blood infection with certain bacteria to increased risk of colorectal cancer
New research due to be presented at this year's European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) shows a link between blood infections with certain anaerobic bacteria and the risk of developing colorectal cancer. The study is by Dr. Ulrik Stenz Justesen, Odense University Hospital, Denmark, and colleagues. (2020-04-20)

Drug used for liver disease also affects C. diff life cycle, reduces inflammation in mice
Researchers have found that a commonly used drug made from secondary bile acids can affect the life cycle of Clostridioides difficile (C. diff) in vitro and reduce the inflammatory response to C. diff in mice. (2020-03-30)

Bacterial enzyme could become a new target for antibiotics
Scientists discover the structure of an enzyme, found in the human gut, that breaks down a component of collagen. (2020-03-17)

Solving the riddle of superbug toxin damage to gut
A powerful Monash Biomedicine Discovery Institute (BDI) collaboration has revealed that a bacterial superbug can prevent stem cells in the gut from carrying out their vital role of regenerating the inner lining of the intestine. (2020-03-16)

Fecal microbiota transplants successfully treat patients with C. diff
A new study from the University of Birmingham has shown that fecal microbiota rransplants (FMT) are highly successful in treating patients with Clostridioides difficile (C. diff) infection. (2020-03-15)

Study shows CRISPR effectiveness against colitis pathogen
Research at North Carolina State University shows that the CRISPR-Cas system can be used to effectively target and eliminate specific gut bacteria, in this case Clostridioides difficile, the pathogen that causes colitis -- a chronic, degenerative disease of the colon. In a proof-of-concept study published in the journal mBio, researchers were able to show pathogen reductions in experiments conducted both on the lab bench and in mice. (2020-03-10)

Bacteria killed by new light-activated coating
A new coating that activates in low intensity light to kill bacteria such as Staphylococcus aureus and Escherichia coli has been developed by a UCL-led team of researchers. (2020-03-05)

Outsmarting pathogens
A new influenza strain appears each flu season, rendering past vaccines ineffective. Antibiotic resistant 'superbugs' quickly develop genetic resistance to existing drugs. Rapidly changing viruses and bacteria complicate vaccine and drug research. Scientists at the 2020 American Physical Society March Meeting in Denver will share their work on the emergence and evolution of modern pathogens. (2020-02-27)

Artificial intelligence yields new antibiotic
Using a machine-learning algorithm, MIT researchers have identified a powerful new antibiotic compound. In laboratory tests, the drug killed many of the world's most problematic disease-causing bacteria, including some strains that are resistant to all known antibiotics. It also cleared infections in two different mouse models. (2020-02-20)

Study: Diet makes a difference in fight against hospital-acquired infection
Popular diets low in carbs and high in fat and protein might be good for the waistline, but a new UNLV study shows that just the opposite may help to alleviate the hospital-acquired infection Clostridioides difficile. (2020-02-12)

Clostridioides difficile infection flourishes with a high-protein, high-fat diet
Mice fed a high-fat, high-protein diet were more likely to develop and die from antibiotic-driven Clostridioides difficile infections than mice fed a standard diet. In the same study, published in the journal mSystems, a high-carbohydrate diet was protective against severe C. difficile infection--but the researchers suspect that such a diet could produce healthy, asymptomatic carriers that can spread the pathogen. (2020-02-11)

Fly model offers new approach to unraveling 'difficult' pathogen
Clostridium difficile, a bacterium known to cause symptoms from diarrhea to life-threatening colon damage, is part of a growing epidemic for the elderly and hospitalized patients. Biologists have now developed models of the common fruit fly to help develop novel therapies to fight the pathogen. (2020-02-07)

Feeding bluebirds helps fend off parasites
If you feed the birds in your backyard, you may be doing more than just making sure they have a source of food: you may be helping baby birds give parasites the boot. (2020-02-04)

Clostridium perfringens enterotoxin induces claudin-4 to activate YAP in oral squamous cell
Oncotarget Volume 11, Issue 4: Treatment of human oral squamous cell carcinoma cell lines HSC3 and HSC4 with Clostridium perfringens enterotoxin, induced CLDN4 nuclear translocation to enhance epithelial-mesenchymal transition, stemness, cell proliferation, and invasive ability. (2020-02-04)

Sticky antibiotic provides glue for successful treatment
Researchers have found how an antibiotic used to treat a debilitating gut infection stays put inside the body giving it time to effectively treat the problem, a discovery that will pave the way for the development of more effective antibiotic treatments to fight superbugs. (2020-01-22)

Persistence of gut microbial strains in twins, living apart after cohabitating for decades
Using a genomics strain-tracking bioinformatics tool, researchers investigated whether shared bacterial strains remain stable and resilient to changes in diet or environment after adult twins -- who had lived together for decades -- began to live apart. The study analyzed two metagenomic sequencing databases from pairs of twins -- one for children who were still living together and the other from adult twins, ages 36 to 80, who then lived apart for periods from one to 59 years. (2020-01-08)

Researchers identify starting point for designing drugs that cure clostridium difficile
A newly published paper in PNAS details a research breakthrough that provides a promising starting point for scientists to create drugs that can cure C. diff -- a virulent health care-associated infection that causes severe diarrhea, nausea, internal bleeding, and potentially death. (2020-01-02)

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