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Current Cystic fibrosis News and Events

Current Cystic fibrosis News and Events, Cystic fibrosis News Articles.
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Researchers use gene editing with CRISPR to treat lethal lung diseases before birth
Using CRISPR gene editing, a team has thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth. (2019-04-17)
Bacteria-infecting viruses exacerbate chronic infections in cystic fibrosis
A study of samples from 92 patients with cystic fibrosis (CF) has revealed that certain bacteriophages -- viruses that infect bacteria -- worsen the severity of bacterial infections associated with the disorder. (2019-04-17)
Some viruses help protect harmful bacteria in CF patients, Stanford-led study finds
Chronic bacterial infections in the lungs of cystic fibrosis patients are worsened by a previously unappreciated biological agent: a group of viruses that infect the bacteria. (2019-04-17)
Novel biomarkers for noninvasive diagnosis of NAFLD-related fibrosis
With an estimated 25% of people worldwide affected by nonalcoholic fatty liver disease (NAFLD), there is a large unmet need for accurate, noninvasive measures to enhance early diagnosis and screening of hepatic fibrosis. (2019-04-16)
Scientists report new approach to reduce or prevent renal fibrosis
Renal fibrosis, the abnormal accumulation of fibrotic material within the kidney, hinders kidney function and may lead to eventual renal failure. (2019-04-16)
Three studies show how tumors hijack the immune system to resist radiation therapy
Treg cells turn off the immune system. Three recent studies show that targeting tregs may increase the effectiveness of anti-cancer immunotherapies. (2019-04-16)
Aldo-keto reductase family 1 member B10 predicts advanced nonalcoholic steatohepatitis
AKR1B10 is a useful serum biomarker for advanced liver fibrosis in Nonalcoholic steatohepatitis and, combined with serum WFA(+)-M2BP, it can predict hepatocellular carcinoma development, gastroesophageal varix formation, and poor prognosis. (2019-04-11)
Study suggests the majority of tourniquets used in medical procedures are contaminated
New research presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Netherlands (April 13-16) shows that a majority of tourniquets inspected contained microbes which could put patient safety and care quality at risk. (2019-04-11)
Obeticholic acid improves liver fibrosis and other histological features of NASH
A prespecified interim analysis of the ongoing Phase 3 REGENERATE study has confirmed that obeticholic acid (OCA) is effective in the treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. (2019-04-10)
Common virus linked to faster disease progression in cystic fibrosis
A new study has found that cystic fibrosis patients who have a common virus may experience faster disease progression than patients who do not have the virus. (2019-04-07)
Researchers' breakthrough in tackling challenge of antifungal resistance
Ground-breaking work by university experts in Tennessee, Texas and Swansea is helping develop a better understanding of the growing threat posed by antifungal drug resistance. (2019-04-03)
Discovery shows how mucus build-up, not infections, triggers cystic fibrosis lung damage
The build-up of abnormally thick mucus and the associated inflammation appear to be the initiating cause of damage to the lungs of children with cystic fibrosis (CF), rather than bacterial infections, according to a UNC School of Medicine study published in Science Translational Medicine. (2019-04-03)
New study identifies genetic variant that could help reduce need for liver transplants
A new study from the Westmead Institute for Medical Research has identified a genetic variant associated with liver fibrosis (scarring) in chronic hepatitis C patients. (2019-04-02)
WHO guidelines fail to detect half of chronic hepatitis B patients in Ethiopia needing treatment
Current World Health Organization (WHO) guidelines for chronic hepatitis B (CHB) fail to detect half of the patients in need of treatment in Ethiopia, report scientists in the Journal of Hepatology, published by Elsevier. (2019-03-28)
Stabilizing ends of chromosomes could treat age-related disease
A study has uncovered a new strategy that can potentially treat age-related disease and decline. (2019-03-28)
Bacteria partners with virus to cause chronic wounds, Stanford study finds
A common bacterial pathogen called Pseudomonas aeruginosa produces a virus that substantially increases the pathogen's ability to infect us, according to a study by investigators at the Stanford University School of Medicine. (2019-03-28)
Study: Protein linked to cancer growth drives deadly lung disease
A protein associated with cancer growth appears to drive the deadly lung disease known as idiopathic pulmonary fibrosis, according to new research from Cedars-Sinai. (2019-03-20)
Neutrons paint atomic portrait of prototypical cell signaling enzyme
Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme -- protein kinase A or PKA -- will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis. (2019-03-20)
Oral bacteria in pancreas linked to more aggressive tumours
The presence of oral bacteria in so-called cystic pancreatic tumours is associated with the severity of the tumour, a study by researchers at Karolinska Institutet in Sweden published in the journal Gut reports. (2019-03-14)
Determining what binds to mucus
The human body is full of mucus. This viscous goo isn't just a nuisance that gets coughed up or sneezed out -- it can bind to drugs, toxins or microbes, potentially impacting human health. (2019-03-13)
Potential cystic fibrosis treatment uses 'molecular prosthetic' for missing lung protein
An approved drug normally used to treat fungal infections could also do the job of a protein channel that is missing or dysfunctional in the lungs of people with cystic fibrosis, operating as a prosthesis on the molecular scale, says new research from the University of Illinois and the University of Iowa. (2019-03-13)
Scientists find new approach that shows promise for treating cystic fibrosis
Researchers say a widely-used antifungal drug may hold promise for treating people with cystic fibrosis, a life-threatening genetic disorder that causes serious damage to the lungs. (2019-03-13)
Two papers describe how a membrane protein can move both lipids and ions
The TMEM16 family of membrane proteins was hailed as representing the elusive calcium-activated chloride channels. (2019-03-12)
Diabetes' sworn enemy could ultimately be a valuable ally
Montreal research team unravels an adaptive mechanism involved in controlling insulin action, showing that glucagon plays a crucial part in it and can thus be a protective asset. (2019-03-06)
Growing evidence: water as a potential treatment for inherited cause of kidney failure
People with polycystic kidney disease (PKD) could benefit from a moderate increase in water intake, according to new research. (2019-03-06)
Researchers find window of opportunity for treatment of early cystic fibrosis lung infections
New research from DTU Biosustain and Rigshospitalet suggests that disease-causing microbes in young cystic fibrosis (CF) patients change rapidly within two to three years after first infection. (2019-03-04)
Researchers discover sustainable and natural alternative to man-made chemical pesticides
Repurposing a strain of beneficial bacteria could offer a safe, sustainable and natural alternative to man-made chemical pesticides, according to research from Cardiff University. (2019-03-04)
Inhibiting cancer-causing protein could prevent scleroderma fibrosis
Examining the autoimmune disease at the molecular level led researchers to a specific molecule that could be contributing to the disease progression in patients. (2019-02-26)
Bacteria walk (a bit) like we do
EPFL biophysicists have been able to directly study the way bacteria move on surfaces, revealing a molecular machinery reminiscent of motor reflexes. (2019-02-25)
How genetic background shapes individual differences within a species
Study reveals how genetic background influences trait inheritance laying the grounds for predicting personal risk of disease. (2019-02-25)
Correct antibiotic dosing could preserve lung microbial diversity in cystic fibrosis
Children and young adults with cystic fibrosis whose lung infections were treated with suboptimal doses of antibiotics had fewer changes in lung microbial diversity during the IV treatment, and their microbial diversity levels were higher 30 days later, a multi-institutional study that includes Children's researchers shows. (2019-02-22)
New blood test may map fetal genome for countless mutations
Tel Aviv University researchers have developed a new blood test for genetic disorders that may allow parents to learn about the health of their baby as early as 11 weeks into pregnancy. (2019-02-20)
Novel gene therapy approach creates new route to tackle rare, inherited diseases
A new study reveals a novel approach and robust technology platform for suppressing nonsense mutations using engineered transfer RNA (tRNA) molecules. (2019-02-19)
New method uses fluorescence to identify disease-causing forms of proteins
A new method uses fluorescence to detect potentially disease-causing forms of proteins as they unravel due to stress or mutations. (2019-02-13)
UCI biomedical engineers develop wearable respiration monitor with children's toy
Using Shrinky Dinks, a popular children's toy, engineers at the University of California, Irvine have created wearable, disposable respiration sensors that track the rate and volume of a wearer's breath. (2019-02-13)
Vitamin D and immune cells stimulate bone marrow disease
The bone marrow disease myelofibrosis is stimulated by excessive signaling from vitamin D and immune cells known as macrophages, reveals a Japanese research team. (2019-02-08)
How fibrosis develops in butterfly syndrome patients
Researchers have pinpointed how fibrosis develops in butterfly syndrome patients. (2019-02-06)
Connective tissue on the wrong road -- when organs start to scar
The increased deposition of connective tissue is a problem in chronic diseases of many organs. (2019-02-05)
New clues discovered to lung transplant rejection
Researchers at Washington University School of Medicine in St. Louis have discovered clues to a particularly deadly form of rejection that can follow lung transplantation. (2019-02-04)
It's all in the code: protein production efficiency can be predicted by gene sequence
Scientists from the Federal University of Rio de Janeiro explored mRNA and protein public databases to unravel hidden meanings of the genetic code. (2019-02-04)
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