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Current Cystic fibrosis News and Events

Current Cystic fibrosis News and Events, Cystic fibrosis News Articles.
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Stem cells from placental amniotic membrane slow lung scarring in pulmonary fibrosis
In a study released today in STEM CELLS Translational Medicine (SCTM), researchers show for the first time how stem cells collected from human amniotic membrane can slow the progression of scarring in pulmonary fibrosis. (2020-05-26)
ACMG updates seminal laboratory standard on CFTR variant testing
This technical standard includes revised information about CF and the CFTR gene, new testing considerations and methodologies, and updated recommendations for the interpretation and reporting of test results. (2020-05-14)
Global spread of the multi-resistant pathogen Stenotrophomonas maltophilia
An international consortium found a remarkable global spread of strains of a multi-resistant bacterium that can cause severe infections - Stenotrophomonas maltophilia. (2020-05-14)
Compact electronic nose to identify human lung diseases
Researchers from Russia and Italy have proposed a compact sensor system that can implement the functionality of the electronic nose and developed a reproducible technology for its manufacture. (2020-05-14)
Long-lasting, low toxicity antimicrobial peptide fights 'superbug' lung infections
Through serendipity, researchers considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections. (2020-05-01)
Can vaping scar your lungs? New insights and a possible remedy
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body's tissue repair process to go haywire and lead to scarring inside the lungs. (2020-04-27)
Researchers identify key mechanisms involved in pulmonary fibrosis development
Working alongside research groups from Heidelberg, researchers from Charité - Universitätsmedizin Berlin have elucidated the novel disease processes involved in the development of pulmonary fibrosis. (2020-04-27)
TGF-β-driven reduction of CYGB is associated with oxidative DNA damage of HSCs in NASH
This study shows that the molecular regulatory mechanism of TGF-β-induced downregulation of CYGB expression in human HSCs, leading to the loss of cellular tolerance to exogenous oxidative stress and oxidative DNA damage in activated HSCs in human NASH with advanced fibrosis. (2020-04-21)
Keep children from hospital during crisis
With stressed hospital services, and concerns about the spread of COVID-19, experts are reminding carers of children and young people of the importance of safely adhering to their supported chronic condition self-management plans from the safety of their home. (2020-04-21)
Simulations show how to make gene therapy more effective
Diseases with a genetic cause could be treated by supplying a correct version of the faulty gene. (2020-04-17)
International consortium investigates overactive immune cells as cause of COVID-19 deaths
In the urgent battle to treat COVID-19 patients, a group of eleven international medical research organizations is investigating whether overactive immune cells that produce neutrophil extracellular traps (NETs) cause the most severe cases. (2020-04-16)
COPD as a lung stem cell disease
Two internationally renowned stem cell researchers at the University of Houston have found an abundance of abnormal stem cells in the lungs of patients who suffer from Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death worldwide. (2020-04-15)
Successful MERS vaccine in mice may hold promise for COVID-19 vaccine
In a new study, published April 7 in mBio, researchers from the University of Iowa and the University of Georgia demonstrate that a new vaccine fully protects mice against a lethal dose of MERS, a close cousin of COVID-19. (2020-04-07)
Engineered virus might be able to block coronavirus infections, mouse study shows
No vaccines exist that protect people against infections by coronaviruses, including SARS-CoV-2, which causes COVID-19, or the ones that cause SARS and MERS. (2020-04-07)
New 3D cultured cells mimic the progress of NASH
A research team led by scientists from Tokyo University of Agriculture and Technology (TUAT), Japan, has successfully established 3D cultured tissue that mimics liver fibrosis, a key characteristic of non-alcoholic steatohepatitis (NASH). (2020-04-01)
Researchers reverse muscle fibrosis from overuse injury in animals, hope for human trials
High-force, high-repetition movements create microinjuries in muscle fibers. Muscle tissue responds by making repairs. (2020-03-30)
Cells must age for muscles to regenerate in muscle-degenerating diseases
Exercise can only improve strength in muscle-degenerating diseases when a specific type of muscle cell ages, report a Hokkaido University researcher and colleagues with Sapporo Medical University in Japan. (2020-03-30)
Study compares funding, research productivity for 2 diseases
This study compared federal and foundation research funding for sickle cell disease and cystic fibrosis and investigated whether funding was associated with differences in drug development and research productivity. (2020-03-27)
How tissues harm themselves during wound healing
Researchers from Osaka University discovered that increased expression of Rbm7 in apoptotic tissue cells results in the recruitment of segregated-nucleus-containing atypical monocytes, leading to tissue fibrosis. (2020-03-25)
Bacterial protein fragment kills lung cells in pulmonary fibrosis, study finds
A bacterial protein fragment instigates lung tissue death in pulmonary fibrosis, a mysterious disease affecting millions of people worldwide, according to a new study from researchers at the University of Illinois at Urbana-Champaign and Mie University in Japan. (2020-03-24)
Closing in on liver fibrosis: Detailing the fibrosis process at unprecedented resolution
Today, there is no effective way to treat liver fibrosis. (2020-03-09)
Liver fibrosis tied to specific heart failure, regardless of HIV or hepatitis C status
While there is an association between liver fibrosis and heart failure, the mechanisms for this association are currently unclear but may be of particular importance for people living with human immunodeficiency virus (HIV) and/or hepatitis C, both of which are chronic infections that affect the liver and heart. (2020-03-06)
Study: Tuberculosis bacteria trigger cough, facilitating spread
The bacteria that cause the deadly lung disease tuberculosis appear to facilitate their own spread by producing a molecule that triggers cough. (2020-03-05)
SFU team helps discover potential superbug-killing compound
Researchers in Simon Fraser University's Brinkman Laboratory are collaborating with US researchers to test a new drug that can kill a wide range of superbugs -- including some bacteria now resistant to all common antibiotics. (2020-03-03)
Drug development for rare diseases affecting children is increasing
The number of treatments for rare diseases affecting children has increased, a new study suggests. (2020-03-03)
Study finds 'silent' genetic variations can alter protein folding
New research from the University of Notre Dame shows these silent mutations are worth a closer look. (2020-03-02)
Repeat antibiotic prescribing linked to higher risk of hospital admissions
Epidemiologists at the University of Manchester have discovered an association between the number of prescriptions for antibiotics and a higher risk of hospital admissions. (2020-03-01)
Inhalation therapy shows promise against pulmonary fibrosis in mice, rats
A new study shows that lung stem cell secretions -- specifically exosomes and secretomes -- delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats. (2020-02-28)
Scientists discover three genes associated with fatal lung disease
Researchers at the Universities of Leicester and Nottingham have discovered parts of the DNA that put some people at higher risk of an incurable lung disease called idiopathic pulmonary fibrosis (IPF). (2020-02-28)
Roberts Individualized Medical Genetics Center outlines centralized genetic testing model
In a special report published today in the journal Pediatrics, Roberts Individualized Medical Genetics Center researchers, physicians, and genetic and financial counselors describe the success of the model, their plans to build on that success for the future, and the important lessons learned from their first four years in operation. (2020-02-26)
How resident microbes restructure body chemistry
A comparison of normal and germ-free mice revealed that as much as 70% of a mouse's gut chemistry is determined by its gut microbiome. (2020-02-26)
New bile discovery will rewrite textbooks
Forget what you know about bile because that's about to change, thanks to a new discovery made by Michigan State University and published in the current issue of Nature. (2020-02-26)
Plant-based relatives of cholesterol could give boost to gene therapy
Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells. (2020-02-20)
Research team tackles superbug infections with novel therapy
Superbug infections kill 35,000 people in the US annually. A team of researchers has found that a treatment known as AB569 kills pseudomonas aeruginosa in humanized cells in mouse models. (2020-02-20)
Curing genetic disease in human cells
Scientists from the groups of Hans Clevers (Hubrecht Institute) and Jeffrey Beekman (UMC Utrecht) show for the first time that a newer type of CRISPR, called base-editing, can safely cure cystic fibrosis in stem cells derived from patients. (2020-02-20)
Survey finds Americans strongly support organ and tissue donation for research
A strong majority of Americans agree that organ and tissue donation for research contributes to health and medical breakthroughs and acknowledge significant shortfalls for donation. (2020-02-18)
Second wind: New technology to help diagnose and manage respiratory diseases
Researchers at Australia's Monash University have developed radical non-invasive technology that can be used to diagnose respiratory lung diseases, such as cystic fibrosis and lung cancer, and potentially fast-track treatments for patients. (2020-02-12)
Researchers find test to ID children at higher risk for cystic fibrosis liver disease
A major multi-center investigation of children with cystic fibrosis has identified a test that allows earlier identification of those at risk for cystic fibrosis liver disease. (2020-02-12)
Eternygen presents data demonstrating INDY inhibition as novel therapeutic option in NASH
Study to be presented at 3rd Global NASH Congress in London, U.K., February 10, 11. (2020-02-10)
Yale studies suggest new path for reversing type-2 diabetes and liver fibrosis
In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice, and has shown that the underlying processes are conserved in humans. (2020-02-04)
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