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Current Cystic fibrosis News and Events

Current Cystic fibrosis News and Events, Cystic fibrosis News Articles.
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Scientists develop promising drug for treating ovarian, pancreatic cancers
Cancer scientists at Houston Methodist have been looking for more effective late-stage treatments for ovarian and pancreatic cancers and may have found one. (2019-07-22)
Ivacaftor may reduce common infections in patients with CF
Patients with cystic fibrosis who take ivacaftor appear to have fewer respiratory infections over time than those not taking the drug, according to new research published online in the Annals of the American Thoracic Society. (2019-07-19)
Waking up sleeping bacteria to fight infections
Researchers in the group of Jan Michiels (VIB-KU Leuven Center for Microbiology) identified a mechanism of how sleepy bacteria wake up. (2019-07-18)
TGen-led study finds link between gene and severe liver damage
Researchers have found that a gene known as AEBP1 may play a central role in the development, severity and potential treatment of liver disease, according to a study by Temple University, the Geisinger Obesity Institute and the Translational Genomics Research Institute (TGen), an affiliate of City of Hope. (2019-07-18)
Rare inherited enzyme disorder yields insight into fibrosis
St. Jude investigators have discovered an association between a deficiency in the enzyme neuraminidase 1 and the build-up of connective tissue in organs, suck as the muscle, kidney, liver, heart and lungs. (2019-07-17)
Shaky scaffold changes lung infrastructure
Researchers identify changes in enzymes that may contribute to lung damage in rare genetic disorder. (2019-07-17)
Human pancreas on a chip opens new possibilities for studying disease
Scientists created human pancreas on a chip that allowed them to identify the possible cause of a frequent and deadly complication of cystic fibrosis (CF) called CF-Related Diabetes, or CFRD. (2019-07-16)
Hinge-like protein may open new doors in cystic fibrosis treatment
Drugs known as potentiators alleviate some symptoms of cystic fibrosis. (2019-07-09)
UBC scientists capture images of gene-editing enzymes in action
For the first time, scientists have captured high-resolution, three-dimensional images of an enzyme in the process of precisely cutting DNA strands. (2019-07-08)
Combining antibiotics, researchers deliver one-two punch against ubiquitous bacterium
By combining two well-established antibiotics for the first time, a scientific team led by Case Western Reserve University School of Medicine and Louis Stokes Cleveland VA Medical Center has delivered a 'double whammy' against the pervasive Pseudomonas aeruginosa, a potentially deadly form of bacteria that is a major source of hospital-based infections. (2019-07-08)
CFTR inhibition: The key to treating bile acid diarrhea?
Estimates are that roughly 1% of people in Western countries may have bile acid diarrhea, including patients with Crohn's disease, ileal resection, diarrhea-predominant irritable bowel syndrome (IBS-D), and chronic functional diarrhea. (2019-07-03)
A better way to encapsulate islet cells for diabetes treatment
MIT researchers have come up with a novel way to prevent fibrosis, which can lead to rejection of implantable medical devices, by incorporating a crystallized immunosuppressant drug into the devices. (2019-06-26)
Adding clinical variables improves accuracy of lung allocation score
Implemented in 2005, the lung allocation score is used to prioritize patients awaiting lung transplants in the US. (2019-06-25)
Scientists identify genes associated with biliary atresia survival
Scientists at Cincinnati Children's Hospital Medical Center have identified an expression pattern of 14 genes at the time of diagnosis that predicts two year, transplant-free survival in children with biliary atresia -- the most common diagnosis leading to liver transplants in children. (2019-06-19)
How certain antibiotic combinations could defeat 'superbugs'
In hospitalized patients with bacterial infections, heteroresistance is more widespread than previously appreciated. (2019-06-17)
Dickkopf-related protein 3 (DKK3) predicts AKI
Acute kidney injury (AKI) is a common complication after cardiac surgery. (2019-06-14)
Still an unmet need: New therapeutic targets in Alport syndrome
Alport syndrome (AS) is a hereditary disease that leads to progressive proteinuria, renal fibrosis, and kidney failure. (2019-06-13)
The nicotine in e-cigarettes appears to impair mucus clearance
E-cigarette vaping with nicotine appears to hamper mucus clearance from the airways, according to new research published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (2019-06-07)
'Organs in a dish' pave the way for personalized medicine in gut and liver disease
One of the most exciting advancements in stem cell research has been the development of organoid systems, which are organ-like three-dimensional structures that mimic their corresponding organ in vivo. (2019-06-03)
Occupational hazards account for more than one in ten people with range of lung diseases
More than 1 in 10 people with a range of non-cancerous lung diseases may be sick as a result of inhaling vapors, gas, dust or fumes at work, according to a joint American Thoracic Society and the European Respiratory Society statement published in the ATS's American Journal of Respiratory and Critical Care Medicine. (2019-05-31)
Scientists bioengineer human liver disease in the lab to find new treatments
Scientists successfully bioengineered human liver organoids that faithfully mimic key features of fatal liver disease in the laboratory. (2019-05-30)
Manuka honey to kill drug-resistant bacteria found in cystic fibrosis infections
Manuka honey could provide the key to a breakthrough treatment for cystic fibrosis patients following preliminary work by experts at Swansea University. (2019-05-29)
Holidays disrupt drug routines of children with diabetes
Children with type 1 diabetes find it difficult to adhere to their drug routines during school holidays and weekends. (2019-05-23)
Worst form of black lung disease is on the rise but the cause remains unknown
Progressive massive fibrosis (PMF), the worst form of black lung disease, is rising among coal miners, but the reasons for this trend remain unclear, according to research presented at ATS 2019. (2019-05-20)
Button batteries can rapidly damage stomach lining before symptoms appear
Damage to the lining of the stomach can occur quickly when children swallow button batteries; therefore, clinicians should consider prompt endoscopic removal, even when the child is symptom free and the battery has passed safely through the narrow esophagus, according to research presented at Digestive Disease Week® (DDW) 2019. (2019-05-18)
Phage therapy treats patient with drug-resistant bacterial infection
Scientists have used an experimental therapy that relies on bacteria-infecting viruses collected, in part, through HHMI's SEA-PHAGES program to fight a Mycobacterium infection in a 15-year-old girl. (2019-05-08)
Genome editing helps decipher a congenital liver disease
Congenital hepatic fibrosis (CHF) is a rare genetic disease that can lead to severe liver impairment. (2019-05-07)
New treatment for severe dry eye disease promising in early clinical trials
Participants in a phase I/II clinical trial of a new enzyme-based treatment for severe dry eye disease experienced reduced signs of disease and discomfort, according to a paper in Translational Vision Science and Technology. (2019-05-07)
Darwin can help your doctor
Taking an evolutionary view can inspire new ideas in clinical microbiology. (2019-04-29)
The cellular source of fat tissue formation
Researchers working in mice and human tissue have identified several classes of adipocyte progenitor cells, which give rise to fat tissue, some of which reside in a recently discovered anatomical niche. (2019-04-25)
Photoacoustic endoscopy could improve Crohn's disease treatment
A newly developed endoscope could give doctors a better view of intestinal changes caused by Crohn's disease. (2019-04-24)
Researchers use gene editing with CRISPR to treat lethal lung diseases before birth
Using CRISPR gene editing, a team has thwarted a lethal lung disease, in an animal model, in which a harmful mutation causes death within hours after birth. (2019-04-17)
Bacteria-infecting viruses exacerbate chronic infections in cystic fibrosis
A study of samples from 92 patients with cystic fibrosis (CF) has revealed that certain bacteriophages -- viruses that infect bacteria -- worsen the severity of bacterial infections associated with the disorder. (2019-04-17)
Some viruses help protect harmful bacteria in CF patients, Stanford-led study finds
Chronic bacterial infections in the lungs of cystic fibrosis patients are worsened by a previously unappreciated biological agent: a group of viruses that infect the bacteria. (2019-04-17)
Novel biomarkers for noninvasive diagnosis of NAFLD-related fibrosis
With an estimated 25% of people worldwide affected by nonalcoholic fatty liver disease (NAFLD), there is a large unmet need for accurate, noninvasive measures to enhance early diagnosis and screening of hepatic fibrosis. (2019-04-16)
Scientists report new approach to reduce or prevent renal fibrosis
Renal fibrosis, the abnormal accumulation of fibrotic material within the kidney, hinders kidney function and may lead to eventual renal failure. (2019-04-16)
Three studies show how tumors hijack the immune system to resist radiation therapy
Treg cells turn off the immune system. Three recent studies show that targeting tregs may increase the effectiveness of anti-cancer immunotherapies. (2019-04-16)
Aldo-keto reductase family 1 member B10 predicts advanced nonalcoholic steatohepatitis
AKR1B10 is a useful serum biomarker for advanced liver fibrosis in Nonalcoholic steatohepatitis and, combined with serum WFA(+)-M2BP, it can predict hepatocellular carcinoma development, gastroesophageal varix formation, and poor prognosis. (2019-04-11)
Study suggests the majority of tourniquets used in medical procedures are contaminated
New research presented at this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Netherlands (April 13-16) shows that a majority of tourniquets inspected contained microbes which could put patient safety and care quality at risk. (2019-04-11)
Obeticholic acid improves liver fibrosis and other histological features of NASH
A prespecified interim analysis of the ongoing Phase 3 REGENERATE study has confirmed that obeticholic acid (OCA) is effective in the treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. (2019-04-10)
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