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Current Cystic fibrosis News and Events

Current Cystic fibrosis News and Events, Cystic fibrosis News Articles.
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Scientists discover curious clues in the war between cf bacteria
Several different kinds of bacteria can cause lung infections in people with cystic fibrosis. (2020-08-07)
Pulmonary fibrosis treatment shows proof of principle
A pre-clinical study led by scientists at Cincinnati Children's demonstrates that in mice the drug barasertib reverses the activation of fibroblasts that cause dangerous scar tissue to build up in the lungs of people with idiopathic pulmonary fibrosis (IPF). (2020-08-06)
Osteopontin, a protein not always as bad as it is made out to be
In an article published in the prestigious journal Aging Cell, the UPV/EHU's Lipids & Liver research group shows that contrary to expectations, physiological levels in the liver of osteopontin, a multifunctional protein linked to various serious diseases, need to be maintained during ageing to prevent the progression of ageing-related, non-alcoholic fatty liver disease. (2020-08-05)
New insights into wound healing
Research from a multidisciplinary team led by Washington University may provide new insights into wound healing, scarring and how cancer spreads (2020-07-29)
Sweat science: Engineers detect health markers in thread-based, wearable sweat sensors
Engineers at Tufts University have created a first-of-its-kind, flexible electronic sensing patch that can be sewn into clothing to analyze sweat for multiple markers. (2020-07-28)
Mix and match: New 3D cell culture model replicates fibrotic elements of pancreatic cancer
Pancreatic cancer is a deadly cancer characterized by prominent fibrosis, which plays a crucial role in disease progression and therapeutic resistance. (2020-07-22)
'Bystander' Cs meet their match in gene-editing technique
Biomolecular engineers at Rice University have developed new tools to increase the accuracy of CRISPR single-base editing to treat genetic diseases. (2020-07-15)
Cystic fibrosis: why so many respiratory complications?
Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders. (2020-07-13)
Yale, Baylor study reveals new cell types in lethal lung disease
A research team from Yale and Baylor College of Medicine has completed the largest single-cell analysis to date of lungs affected by Idiopathic Pulmonary Fibrosis (IPF), revealing how cells change in response to the disease and identifying previously unknown cell types. (2020-07-12)
World-first technology breathes new life into cystic fibrosis detection and treatment
World-first research, led by Monash University, has developed radical non-invasive X-ray technology aimed at helping diagnose, treat and manage people with cystic fibrosis. (2020-07-12)
Researchers find promising therapy to fight epidemic of liver disease
In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in preclinical mouse models, according to researchers at the University of Colorado Anschutz Medical Campus. (2020-07-08)
New clues to lung-scarring disease may aid treatment
Scientists at Vanderbilt University Medical Center (VUMC) and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF). (2020-07-08)
TGen-led study identifies unique cells that may drive lung fibrosis
This is one of the first comprehensive looks at lung cells using a technology called single-cell RNA sequencing. (2020-07-08)
Largest source of AATD stem cells collected
Researchers from the Center for Regenerative Medicine (CReM) at Boston University and Boston Medical Center (BMC) have assembled the largest repository of patient derived stem cells (iPSCs) from patients with alpha-1 antitrypsin deficiency (AATD). (2020-07-02)
Giant leap in diagnosing liver disease
A collaborative team of Salk Institute and UC San Diego scientists have created a novel microbiome-based diagnostic tool that, with the accuracy of the best physicians, quickly and inexpensively identifies liver fibrosis and cirrhosis over 90 percent of the time in human patients. (2020-07-01)
Chemist develops potential drug to treat type 2 diabetes without harsh side effects
Syracuse University chemistry professor Dr. Robert P. Doyle has developed a new drug lead to treat type 2 diabetes in millions of patients who are seeking to better control their blood sugar without the common side effects of nausea, vomiting, and in select cases, undesired weight loss. (2020-06-23)
Researchers identify novel genetic variants linked to type-2 diabetes
After examining the genes of more than 200,000 people all over the world who have type-2 diabetes, researchers from the Perelman School of Medicine at the University of Pennsylvania and the Veterans Health Administration's Corporal Michael J. (2020-06-23)
Silicosis: Ominous resurgence of an occupational lung condition reported
A new study appearing in the journal CHEST®, published by Elsevier, documents an increased incidence of silicosis, which progressed rapidly to massive pulmonary fibrosis in a significant proportion of patients who had previously worked artificial stone (AS), also called artificial quartz agglomerate or conglomerate, a popular new countertop material, despite cessation of exposure after diagnosis. (2020-06-18)
Researchers identify key steps in development of kidneys
The discovery of how certain key structures in the kidneys are formed could have important implications for treating renal fibrosis (or scarring), a feature of chronic kidney disease (CKD). (2020-06-18)
CAR T cells beyond cancer: Targeting senescence-related diseases
Scientists at Memorial Sloan Kettering have genetically engineered immune cells to find and kill cells that contribute to diseases caused by a tissue-damaging process called senescence. (2020-06-17)
Seeing corneal degeneration in a new light
The molecular changes that lead to Fuchs' endothelial corneal dystrophy (FECD) occur decades before the disease causes blurry vision and other noticeable symptoms in patients, new research by UT Southwestern scientists shows. (2020-06-17)
Off-the-shelf tool for making mouse models of COVID-19
Researchers at the University of Iowa and Medical University, Guangzhou, in China, have created a gene therapy vector that is essentially an off-the-shelf tool that allows labs to create their own COVID-19 mouse model within a matter of days. (2020-06-16)
A rare heart bone is discovered in chimpanzees
Experts from the University of Nottingham have discovered that some chimpanzees have a bone in their heart, which could be vital in managing their health and conservation. (2020-06-10)
A newly discovered disease may lead to better treatment of cystic fibrosis
Cystic fibrosis is the most frequent severe inherited disorder worldwide. (2020-06-05)
Uncuffing nitric oxide production: Beta-arrestin2 complexes regulate NO levels
In a new report, researchers at the Medical University of South Carolina have uncovered one of the mechanisms regulating the production of nitric oxide (NO) in liver endothelial cells. (2020-06-04)
Researchers identify secretion mechanisms for a protein necessary for maintaining healthy connective
Researchers have discovered that a defective form of the protein aortic carboxypeptidase-like protein (ACLP) from patients with Ehlers-Danlos syndrome (EDS) is retained in cells and induces cellular stress. (2020-06-03)
Atomic blueprint of 'molecular machine' reveals role in membrane protein installation
Van Andel Institute scientists have revealed the first known atomic structure of a 'molecular machine' responsible for installing critical signaling proteins into cellular membranes. (2020-06-03)
Long-term use of rituximab associated with lower rates of AAV relapse
An extra 18 months of rituximab infusions was associated with lower rates of relapse compared with standard maintenance therapy in patients with antineutrophil cytoplasmic antibody-associated vasculitis (AAV). (2020-06-01)
Stem cells from placental amniotic membrane slow lung scarring in pulmonary fibrosis
In a study released today in STEM CELLS Translational Medicine (SCTM), researchers show for the first time how stem cells collected from human amniotic membrane can slow the progression of scarring in pulmonary fibrosis. (2020-05-26)
ACMG updates seminal laboratory standard on CFTR variant testing
This technical standard includes revised information about CF and the CFTR gene, new testing considerations and methodologies, and updated recommendations for the interpretation and reporting of test results. (2020-05-14)
Global spread of the multi-resistant pathogen Stenotrophomonas maltophilia
An international consortium found a remarkable global spread of strains of a multi-resistant bacterium that can cause severe infections - Stenotrophomonas maltophilia. (2020-05-14)
Compact electronic nose to identify human lung diseases
Researchers from Russia and Italy have proposed a compact sensor system that can implement the functionality of the electronic nose and developed a reproducible technology for its manufacture. (2020-05-14)
Long-lasting, low toxicity antimicrobial peptide fights 'superbug' lung infections
Through serendipity, researchers considerably reduced the toxicity of a potential antibiotic against the most feared drug-resistant bacteria, while also improving its stability in fighting infections. (2020-05-01)
Can vaping scar your lungs? New insights and a possible remedy
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body's tissue repair process to go haywire and lead to scarring inside the lungs. (2020-04-27)
Researchers identify key mechanisms involved in pulmonary fibrosis development
Working alongside research groups from Heidelberg, researchers from Charité - Universitätsmedizin Berlin have elucidated the novel disease processes involved in the development of pulmonary fibrosis. (2020-04-27)
TGF-β-driven reduction of CYGB is associated with oxidative DNA damage of HSCs in NASH
This study shows that the molecular regulatory mechanism of TGF-β-induced downregulation of CYGB expression in human HSCs, leading to the loss of cellular tolerance to exogenous oxidative stress and oxidative DNA damage in activated HSCs in human NASH with advanced fibrosis. (2020-04-21)
Keep children from hospital during crisis
With stressed hospital services, and concerns about the spread of COVID-19, experts are reminding carers of children and young people of the importance of safely adhering to their supported chronic condition self-management plans from the safety of their home. (2020-04-21)
Simulations show how to make gene therapy more effective
Diseases with a genetic cause could be treated by supplying a correct version of the faulty gene. (2020-04-17)
International consortium investigates overactive immune cells as cause of COVID-19 deaths
In the urgent battle to treat COVID-19 patients, a group of eleven international medical research organizations is investigating whether overactive immune cells that produce neutrophil extracellular traps (NETs) cause the most severe cases. (2020-04-16)
COPD as a lung stem cell disease
Two internationally renowned stem cell researchers at the University of Houston have found an abundance of abnormal stem cells in the lungs of patients who suffer from Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death worldwide. (2020-04-15)
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