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Current Drug development News and Events

Current Drug development News and Events, Drug development News Articles.
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Competitive people are more prone to drug consumption
A Psychology research team at the University of Cordoba (Spain) studied how personality influences substance abuse among young people. (2019-10-16)
AI could offer warnings about serious side effects of drug-drug interactions
Researchers at Penn State have developed a machine learning system that may be able to warn doctors and patients about possible negative side effects that might occur when drugs are mixed. (2019-10-15)
Crohn's disease study identifies genetic variant with potential to personalize treatment
A genetic variant carried by 40% of the population explains why some patients develop antibodies against the anti-TNF drugs, infliximab and adalimumab and lose response. (2019-10-07)
Just add water: U-M chemists suggest a fix for insoluble drugs
Stable metal organic frameworks are prized for their ability to capture carbon dioxide or harvest atmospheric water, but U-M researchers have developed a use for unstable metal organic frameworks: as a system for drug delivery. (2019-10-03)
Researchers apply fat cells to deliver drug to suppress tumor growth
UCLA researchers have identified a new drug delivery pathway that may help stop tumor growth and keep cancer from coming back in mice. (2019-09-25)
Scientists tackle potential drug resistance by using new single-cell genetic method
Using a new technique that can identify genetic profiles of individual cells, Notre Dame researchers modeled a breast cancer tumor's potential resistance to a drug, and then identified a drug combination that reversed that resistance. (2019-09-25)
More efficient drug delivery within the brain by utilizing LAT1
According to a new study carried out at the University of Eastern Finland, the distribution of drug molecules within the brain can be improved by utilizing LAT1, which is expressed highly in the brain. (2019-09-24)
Novel anti-cancer nanomedicine for efficient chemotherapy
Researchers have developed a new anti-cancer nanomedicine for targeted cancer chemotherapy. (2019-09-17)
Why transporters really matter for cell factories
Scientists discover the secret behind some protein transporters' superiority. One transporter, MAE1, can export organic acids out of yeast spending close-to-zero energy. (2019-09-04)
Chronic cocaine use modifies gene expression
Chronic cocaine use changes gene expression in the hippocampus, according to research in mice recently published in JNeurosci. (2019-09-02)
One-third of pre-approved prescription drugs have not completed the FDA approval process
The Food and Drug Administration's (FDA) Accelerated Approval Program was created in 1992 to significantly accelerate the ability to bring certain new drugs to market. (2019-08-26)
Nearly 1 in 2 swingers uses recreational drugs to intensify sex, survey suggests
Nearly one in two swingers uses recreational drugs to intensify the experience, with women more likely to do so than either straight or bisexual men, suggest the results of a Dutch survey, published online in the journal Sexually Transmitted Infections. (2019-08-12)
Bringing cancer medication safely to its destination
Treating cancer more selectively and more effectively -- this could be achieved with an innovative technology developed by teams of researchers at the Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP) and the Ludwig-Maximilians-Universität München (LMU). (2019-08-08)
Medication in the environment affects feeding behavior of fish
Scientists are increasingly warning that prescription drugs can affect wildlife and ecosystems when they find their way into the environment. (2019-08-07)
Heart-on-a-chip mimics drug response seen in humans
Researchers show that TARA's heart-on-a-chip system replicates drug responses found in adult humans, validating it as an accurate model for cardiac safety during drug development. (2019-08-06)
Closing the door: breaking new ground related to a potential anticancer drug target
In order to sustain fast growth, cancer cells need to take up nutrients at a faster rate than healthy cells. (2019-07-31)
Blocking dopamine weakens effects of cocaine
Blocking dopamine receptors in different regions of the amygdala reduces drug seeking and taking behavior with varying longevity, according to research in rats published in eNeuro. (2019-07-29)
New drug providing hope for babies with aggressive Acute Lymphoblastic Leukaemia
A breakthrough new drug is providing hope to tiny babies at risk of dying from an aggressive form of Acute Lymphoblastic Leukaemia and could help all cancer patients. (2019-07-27)
Clinical trial identifies new breast cancer drug as a potential therapy for glioblastoma
Ivy Brain Tumor Center at the Barrow Neurological Institute, has released the results of its recent Phase 0 clinical trial of the breast cancer drug ribociclib (Kisqali®) for the treatment of recurrent glioblastoma. (2019-07-25)
Critical heart drug too pricey for some Medicare patients
An effective drug to treat chronic heart failure may cost too much for senior citizens with a standard Medicare Part D drug plan, said a study co-authored by a John A. (2019-07-22)
Understanding the mode of action of the primaquine: New insights into a 70 year old puzzle
Researchers at LSTM have taken significant steps in understanding the way that the anti-malarial drug primaquine (PQ) works, which they hope will lead to the development of new, safer and more effective treatments for malaria. (2019-07-19)
'Trojan horse' anticancer drug disguises itself as fat
A stealthy new drug-delivery system disguises chemotherapeutics as fat in order to outsmart, penetrate and destroy tumors. (2019-07-18)
Heart drug could increase survival rates for children with aggressive form of brain tumor
Researchers at the University of Nottingham have discovered that repurposing a heart drug could significantly increase the survival rate for children with ependymoma - a type of brain tumour. (2019-07-16)
An entry to optically active oxazolidinones: The use of neutral phosphonium salt catalysts
Oxazolidinones are coveted in the field of pharmacology for their bioactive properties. (2019-07-12)
Early benefit assessment reveals weaknesses in the development of new drugs
In the British Medical Journal, IQWiG researchers analyse the first 216 AMNOG assessments of new drugs and derive proposals for more targeted drug development. (2019-07-11)
Scientists opening the door to a new era of medicinal chemistry
A new molecular descriptor estimates molecular complexity and defines the evolution of small molecules in medicinal chemistry. (2019-07-11)
Larger drug trials that intervene earlier needed for Alzheimer's disease
There are currently no drugs that stop or inhibit Alzheimer's disease. (2019-07-10)
No evidence of added benefit for most new drugs, say researchers
More than half of new drugs entering the German healthcare system have not been shown to add benefit, argue researchers in The BMJ today. (2019-07-10)
Metabolic reprogramming of branched-chain amino acid facilitates drug resistance in lung cancer
Research teams led by Dr. Ji Hongbin at the Institute of Biochemistry and Cell Biology of the Chinese Academy of Sciences, Dr. (2019-07-09)
New method reveals how well TB antibiotics reach their targets
Scientists have developed a new technique that enables them to visualise how well antibiotics against tuberculosis (TB) reach their pathogenic targets inside human hosts. (2019-06-27)
SLAS Discovery announces its July feature article, '3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis'
In July's SLAS Discovery feature article, '3D Cell-Based Assays for Drug Screens: Challenges in Imaging, Image Analysis, and High-Content Analysis,' Tijmen H. (2019-06-24)
Reconfigurable multi-organ-on-a-chip system reliably evaluates chemotherapy toxicity
Christopher McAleer and colleagues have created a new multiorgan-on-a-chip system that can accurately capture the toxic effects of chemotherapies that have been metabolized by the liver -- effects usually not seen in standard cell culture preclinical drug development. (2019-06-19)
New methods from material sciences in physics find their way into cancer research
A new study on the behavior of water in cancer cells shows how methods usually limited to physics can be of great use in cancer research. (2019-06-18)
Stem cells reprogrammed into neurons could reveal drugs harmful to pregnancy
Soham Chanda, an assistant professor in the Department of Biochemistry and Molecular Biology, has designed a new experimental system that can rapidly assess the pathogenic effects of a drug on a baby's developing brain. (2019-06-17)
Researchers develop drug-targeting molecules to improve cancer treatment
A compound was developed from a new material, described as an easily injected hydrogel, which acts as a 'homing' cue to attract drug molecules to sites bearing a tumor. (2019-06-12)
Proof of sandwiched graphene-membrane superstructure opens up a membrane-specific drug delivery mode
Researchers from the Institute of Process Engineering (IPE) of the Chinese Academy of Sciences and Tsinghua University (THU) proved a sandwiched superstructure for graphene oxide (GO) that transport inside cell membranes for the first time. (2019-06-07)
Stellenbosch University researchers study resistance to 'protect' anti-TB drug
Scientists from Stellenbosch University are trying to conserve the life-saving treatment bedaquiline, by studying how the bacterium that causes TB can develop resistance to this drug. (2019-05-30)
How bacteria acquire antibiotic resistance in the presence of antibiotics
A new study's disconcerting findings reveal how antibiotic resistance is able to spread between bacteria cells despite the presence of antibiotics that should prevent them from growing. (2019-05-23)
New method simplifies the search for protein receptor complexes, speeding drug development
A a new method of assessing the actions of medicines by matching them to their unique protein receptors has the potential to greatly accelerate drug development and diminish the number of drug trials that fail during clinical trials. (2019-05-20)
Early in vitro testing for adverse effects on embryos
ETH researchers have combined embryonic cells and liver cells in a new cell culture test. (2019-05-14)
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