Current Drugs News and Events

Current Drugs News and Events, Drugs News Articles.
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The danger of Z-drugs for dementia patients
Strong sleeping pills known as 'Z-drugs' are linked with an increased risk of falls, fractures and stroke among people with dementia, according to new research. Sleep disturbance is common among people with dementia and the impact for patients and their families is significant. To date there are no proven effective treatments available, however people with dementia are often prescribed Z-drugs (zopiclone, zaleplon, and zolpidem). The new study reveals that stronger doses of these drugs are linked with an increased risk of adverse effects. (2020-11-23)

Paediatrics: Antiepileptic drug exposure in pregnancy and neurodevelopmental disorder risk
Children born to mothers who took the antiepileptic drug sodium valproate during pregnancy may have a four to five-fold increased risk of developing neurodevelopmental disorders in early childhood, according to a study in Scientific Reports. Fifty of the 991 French children (5%) who were exposed to sodium valproate were diagnosed with neurodevelopmental disorders in their first five years, compared to 15,270 of 1,710,441 children (0.89%) not exposed to any antiepileptic drugs. (2020-10-22)

Drug repurposing
University of New Mexico researchers identify three existing drugs with the potential to clear SARS-CoV-2 infections. (2020-10-16)

Mapping how three lethal coronaviruses engage their hosts reveals potential drug targets
Seeking to inform development of drugs effective against multiple pathogenic human coronaviruses, David E. Gordon and colleagues compared host interactions of MERS-CoV, SARS-CoV-1 and SARS-CoV-2, uncovering host pathways commonly hijacked by all three. (2020-10-15)

Study reveals most effective drugs for common type of neuropathic pain
More than 20 million people in the U.S. suffer neuropathic pain. At least 25% of those cases are classified as unexplained and considered cryptogenic sensory polyneuropathy (CSPN). There is no information to guide a physician's drug choices to treat CSPN, but a researcher from the University of Missouri School of Medicine and MU Health Care led a first-of-its-kind prospective comparative effectiveness study. (2020-10-15)

Big drug costs for small patients with rare diseases, study finds
Only about one in every 170 children take them. But ''orphan drugs'' accounted for 1 in every 15 private insurance dollars spent on children's health care in the United States in 2018, according to a new study. That's up 65% from just five years before. And even though insurance companies pay much of the cost of high-priced orphan drugs that treat rare childhood diseases, families' share of the cost has risen rapidly. (2020-10-06)

Cannabinoids associated with negative respiratory health effects in older adults with COPD
Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults with chronic obstructive pulmonary disease (COPD), according to the first published data on the impact of cannabinoids on the respiratory health of individuals with the lung disease. (2020-09-30)

Analysis reveals heart-related side effects of hydroxychloroquine and chloroquine
As the antimalarial drugs hydroxychloroquine and chloroquine have drawn attention as potential therapies for COVID-19 and are being widely used off-label, it's now more important than ever to have a thorough assessment of the safety of these medications. A recent analysis published in the British Journal of Clinical Pharmacology provides new insights. (2020-09-23)

Potential COVID-19 drug azithromycin may increase risk for cardiac events
Azithromycin -- a commonly-prescribed antibiotic -- also is being investigated as a potential treatment for COVID-19. Researchers have found that azithromycin by itself is not associated with an increase in cardiac events; however, if the drug is taken with certain other drugs that affect the electrical functioning of the heart, then cardiac events increased. (2020-09-16)

Drugs bill warning over US/UK trade deal
The NHS would spend billions of pounds more on drugs if it had to pay US prices following a US/UK trade deal. According to a new study by researchers at Brigham and Women's Hospital in Boston, Harvard Medical School, and the University of Oxford, NHS England would have spent over £5 billion more on 50 brand-name prescription drugs widely used in primary care if it had paid US prices in 2018. (2020-09-10)

'One size fits all' medication approach doesn't work in pregnancy
New research led by the University of South Australia shows that a blanket approach to prescribing medication during pregnancy may put low birth weight babies at risk for the rest of their lives. (2020-09-08)

Common drugs tied to increased risk of cognitive decline
A class of drugs used for many conditions, including allergies, colds, high blood pressure and depression, may be associated with an increased risk of developing mild thinking and memory problems, particularly in people who have genetic risk factors for Alzheimer's disease or markers of this condition, according to a study published in the Sept. 2, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-09-02)

One quarter of prescription drugs in Canada may be in short supply
Research from the Centre for Health Evaluation and Outcome Sciences (CHÉOS) sheds new light on the factors behind drug shortages in Canada, a common problem across the country. (2020-09-01)

There's a shortage of info on drugs for children in Canada
The research team manually reviewed monographs of all new drugs approved by Health Canada between 2007 and 2016. During this time, Health Canada approved 281 drugs, 270 of which had clear benefit for children. However, only 75 (28 per cent) of the drug monographs were approved for children and there were only 10 (4 per cent) drugs approved for use in newborns. (2020-09-01)

Fresh tumor biopsies in world-first technique for cancer treatments
An innovative technique to improve cancer treatments using tumour biopsies less than 30 minutes after they're taken has been developed at The University of Queensland. (2020-08-24)

Synthetic drug ebselen could be repurposed to treat SARS-CoV-2 by targeting main protease at distant
The synthetic drug ebselen can bind to both the catalytic region and a previously unknown distant site on the SARS-CoV-2 virus' main protease, according to a molecular simulation analysis of the drug's interactions with this enzyme. (2020-08-14)

Unexpected associations found between drug response and cell changes in brain cancer
Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. These are the conclusions from a study from Uppsala University investigating a large number of cell samples from patients with brain tumours. The researchers have characterised how changes in glioblastoma cells influence the effect of different drugs. Their findings are published in the journal Cell Reports. (2020-07-14)

Malaria's secret to surviving in the blood uncovered
New research from the Francis Crick Institute has found how the malaria parasite protects itself from toxic compounds in red blood cells. (2020-06-30)

Virtually screening antiviral compounds against SARS-CoV-2 structure may speed up drug and vaccine D
Virtually screening antiviral compounds to model their interactions with the SARS-CoV-2 virus may enable scientists to more easily identify antiviral drugs that work against the virus while informing the search for viable vaccine candidates, according to a new study. By screening for interactions with certain (2020-06-24)

Existing drugs may limit damage caused by HIV
Yale researchers have identified four drugs that may help minimize the long-term health effects of HIV infection, they report June 23 in the Journal of Clinical Investigation. (2020-06-23)

Old drug standards delay new drug approvals
The more information the FDA has about existing drugs, the longer it takes to OK new ones for the same conditions. (2020-06-19)

Researchers flush out worrying trend of designer drug use
In a sign that designer drugs are becoming more prevalent in Australia, synthetic cathinones -- commonly known as 'bath salts' -- have been detected in the nation's wastewater in the largest study of its kind in the country. (2020-06-15)

Antiepileptic drugs are associated with a higher risk of mortality in persons with Alzheimer's
The use of antiepileptic drugs is associated with a higher risk of death among persons with Alzheimer's disease, according to a new study from the University of Eastern Finland. The results were published in Neurology. (2020-06-03)

Colorado tool, My-DST, may pick best multiple myeloma treatment
Response of liquid biopsies to approved drugs can help show resistance, predict response. (2020-05-28)

What if we could design powerful drugs without unwanted side effects?
The paper describes how to minimize or eliminate side effects in drugs that target G protein-coupled receptors. GPCRs are proteins found in all human cells. LSD and other psychedelics are molecules that attach to GPCRs, as are about a third of prescription drugs, including antihistamines, beta blockers and opioids. 'Armed with our results, researchers can begin to imagine new and better ways to design drugs that retain their effectiveness while posing fewer dangers.' (2020-05-19)

Perspective: Rapid repurposing of drugs for COVID-19
Given the rapid spread of COVID-19 and its relatively high mortality, filling the gap for coronavirus-specific drugs is urgent. (2020-05-08)

MU researcher identifies four possible treatments for COVID-19
While COVID-19 has infected millions of people worldwide and killed hundreds of thousands, there is currently no vaccine. In response, researchers have been evaluating the effectiveness of various antiviral drugs as possible COVID-19 treatments. (2020-05-04)

High cost of cancer drugs not always justified
Do high prices of some cancer medicines have a higher benefit than those drugs with lower prices? An international UZH study has concluded that, in general, there is no correlation between costs of a cancer drugs and their clinical benefit. The researchers are therefore calling for the clinical benefit of drugs to be better reflected in pricing. (2020-04-30)

New drug formulation could treat Candida infections
With antimicrobial resistance (AMR) increasing around the world, new research led by the University of Bristol has shown a new drug formulation could possibly be used in antifungal treatments against Candida infections. (2020-04-28)

New nanocarrier drug delivery technology crosses the blood-brain barrier
The blood-brain barrier (BBB) makes it more difficult for substances to be delivered from the blood to the brain compared to peripheral organs. Japanese researchers have developed a cyclic peptide that enhances BBB penetration. By putting drugs into nanoparticles that have the cyclic peptide on their surface, new drug nanocarriers may be developed for the delivery to the brain. (2020-04-16)

Potential harms of chloroquine, hydroxychloroquine and azithromycin for treating COVID-19
Chloroquine, hydroxychloroquine and azithromycin are being used to treat and prevent COVID-19 despite weak evidence for effectiveness, and physicians and patients should be aware of the drugs' potentially serious adverse events, states a review in CMAJ (Canadian Medical Association Journal). (2020-04-08)

Limited supply may scupper proposals to use antimalarials to ward off Covid-19
Limited global supplies may scupper proposals to use the antimalarial drugs, chloroquine and hydroxychloroquine, to lessen the symptoms of Covid-19 infection or ward it off altogether, say Italian doctors in a letter published online today in the Annals of the Rheumatic Diseases. (2020-04-02)

Study helps to identify medications which are safe to use in treatment of COVID-19
A recent study has found that there is no evidence for or against the use of non-steroidal anti-inflammatory drugs such as ibuprofen for patients with COVID-19. (2020-03-30)

Bristol pioneers use of VR for designing new drugs
Researchers at the University of Bristol are pioneering the use of virtual reality (VR) as a tool to design the next generation of drug treatments. (2020-03-11)

Popular painkiller ibuprofen affects liver enzymes in mice
The popular painkiller ibuprofen may have more significant effects on the liver than previously thought, according to new research from UC Davis. The study in laboratory mice also shows marked differences between males and females. (2020-03-11)

The inactivated human receptor will help to create effective drugs
Scientists from China and Russia found a new way of searching for new drug candidates by inactivating the molecular structure of the human muscarinic receptor and applying screening to find drugs that it responds to. (2020-03-11)

Drug development for rare diseases affecting children is increasing
The number of treatments for rare diseases affecting children has increased, a new study suggests. But federal incentives intended to encourage drug development for rare conditions are being used more often to expand the use of existing drugs rather than for creating new ones. (2020-03-03)

Drug interactions with cannabinoids: 5 things to know
A practice article provides 5 things to know on how drugs can interact with cannabinoids in CMAJ (Canadian Medical Association Journal). (2020-03-02)

Study shows rising age of first drug use in teens, young adults
The average age at which teens and young adults start using drugs has been rising, according to a study published in JAMA Pediatrics. The study examined changes in the average age of first drug use for 18 different drugs--including alcohol and tobacco products--between 2004 and 2017 and found that average ages had increased for the majority of those drugs. (2020-03-02)

After free lunch from drug firms, doctors increase prescriptions
Doctors prescribe more branded medications after marketing visits by the makers of those drugs, new research co-authored by a Cornell University economist confirms. (2020-02-17)

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