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Current Epithelial cells News and Events, Epithelial cells News Articles.
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Research team discovers molecular processes in kidney cells that attract and feed COVID-19
What about the kidneys make them a hotspot for COVID-19's cytokine storm? (2020-10-23)
Molecular processes in kidney cells may 'prime' diabetics for COVID-19 infection
People with diabetes -- especially those with diabetic kidney disease -- are among the most at risk for COVID-19. (2020-10-23)
Thymoquinone induces apoptosis & DNA damage in 5-Fluorouracil-resistant colorectal cancer
Volume 11, Issue 31 from @Oncotarget reported that TQ decreased the expression levels of colorectal stem cell markers CD44 and Epithelial Cell Adhesion Molecule Ep CAM and proliferation marker Ki67 in colonospheres derived from both cell lines and reduced cellular migration and invasion. (2020-10-22)
Lab-grown mini-lungs mimic the real thing - right down to covid infection
A team of Duke researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place. (2020-10-22)
Oncotarget: Inhibition of HAS2 and hyaluronic acid production by 1,25-Dihydroxyvitamin D3 in breast
Oncotarget Volume 11, Issue 30 reported that genomic profiling of murine mammary tumor cells with differential VDR expression identified 35 transcripts that were altered by the 1,25D3-VDR complex including Hyaluronan Synthase-2. (2020-10-20)
Two studies point to an unrecognized avenue for anti-viral therapies against COVID-19
Helping to explain what makes SARS-CoV-2 so capable of infecting human cells, researchers in two independent studies discovered that the virus's spike protein recognizes and binds a protein on the human cell surface called neuropilin-1. (2020-10-20)
Oncotarget: Induction of phenotypic changes in HER2-postive breast cancer cells
The cover for issue 30 of Oncotarget features Figure 4, ''RNAseq results demonstrating differences between normal, cancer, and redirected cells,'' by Frank-Kamenetskii, et al. which reported that the influence of breast cancer cells on normal cells of the microenvironment, such as fibroblasts and macrophages, has been heavily studied but the influence of normal epithelial cells on breast cancer cells has not. (2020-10-17)
Small RNA as a central player in infections
The most important pathogenicity factors of the gastric pathogen Helicobacter pylori are centrally regulated by a small RNA molecule, NikS. (2020-10-15)
Vanderbilt researchers make counterintuitive discoveries about immune-like characteristics of cells
Biologists reveal that tissue perturbations by chemotherapy agents promote stem cell expansion and that fibroblast cells exhibit unexpected, immune-like behavior. (2020-10-15)
Oncotarget: Efavirenz induces DNA damage response pathway in lung cancer
The cover for Issue 41 of Oncotarget features Figure 7, ''IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells,'' recently published in ''Efavirenz induces DNA damage response pathway in lung cancer'' by Marima, et al. which reported that the cell-cycle related genes are potential gene targets in understanding the effects of efavirenz in lung cancer. (2020-10-14)
An alternative to animal experiments
Researchers of the Technical University of Munich (TUM) have cultured so-called intestinal organoids from human intestinal tissue, which is a common byproduct when performing bowel surgery. (2020-10-14)
Urine-based liquid biopsy test outperforms urine cytology in detecting bladder cancer
Analysis of DNA copy number variants (CNVs) in the cells exfoliated in urine showed better sensitivity and similar specificity in detecting urothelial carcinoma compared with urine cytology (2020-10-09)
Mechanical forces of biofilms could play role in infections
Studying bacterial biofilms, EPFL scientists have discovered that mechanical forces within them are sufficient to deform the soft material they grow on, e.g. biological tissues, suggesting a ''mechanical'' mode of bacterial infection. (2020-10-08)
Treating cystic fibrosis with mRNA therapy or CRISPR
The potential for treating cystic fibrosis (CF) using mRNA therapies or CRISPR gene editing is possible regardless of the causative mutation. (2020-10-08)
Watch how cells squeeze through channels
Observations of cells moving through small channels shed new light on cell migration in 3D environments, researchers report October 6 in Biophysical Journal. (2020-10-06)
Biomedical sciences researchers find new way to prevent and cure rotavirus, other viral infections
A combination of two substances secreted by the immune system can cure and prevent rotavirus infection, as well as potentially treat other viral infections that target epithelial cells, which cover body surfaces such as skin, blood vessels, organs and the urinary tract, according to researchers in the Institute for Biomedical Sciences at Georgia State University. (2020-10-02)
Tumor progression depends on the tumor microenvironment
Researchers from Tokyo Medical and Dental University (TMDU) and Niigata University identified a novel mechanism by which tumors progress. (2020-10-01)
Latent lineage potential in neural stem cells enables spinal cord repair in mice
Spinal stem cells in mice can be reprogrammed to generate protective oligodendrocytes after spinal cord injury, enhancing neural repair, according to a new study. (2020-10-01)
UC researchers uncover clues for COVID-19 treatment
By examining preexisting research for other conditions, researchers at the University of Cincinnati have found a potential treatment that could be applied to COVID-19. (2020-09-29)
Drug found to correct gene defect that causes immune-driven gut leakiness
A team of researchers led by biomedical scientist Declan McCole at the University of California, Riverside, has found that the drug tofacitinib, also called Xeljanz and approved by the FDA to treat rheumatoid arthritis and ulcerative colitis, can repair permeability defects in the intestine. (2020-09-29)
Researchers identify 'druggable' signaling pathway that stimulates lung tissue repair
Researchers at Children's Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania have identified a cellular pathway that can be targeted with a naturally occurring drug to stimulate lung tissue regeneration, which is necessary for recovery from multiple lung injuries. (2020-09-28)
Unconventional T cell subset enriched in airways of some patients with severe COVID-19
Unconventional T cells called mucosa-associated invariant T (MAIT) cells are recruited to the airways and strongly activated in some patients with severe COVID-19, a new study has found, suggesting the cells' possible involvement in the development of disease. (2020-09-28)
Trends in treatment, survival among women with advanced ovarian cancer
This observational study examined survival rates and the use of chemotherapy before surgery among women with advanced-stage epithelial ovarian cancer in the United States from 2004 to 2016. (2020-09-25)
Study suggests older Western Europeans could already have systemic 'profile' that makes them susceptible to severe COVID-19
New research presented the ESCMID Conference on Coronavirus Disease (ECCVID, online 23-25 September) shows that the severe COVID-19 immunological profile, represented by changes in cell populations and circulating inflammatory proteins, is already partly present in older healthy individuals (2020-09-24)
Study reveals higher COVID-19 mortality in men could be explained by differences in circulating proteins and immune system cells
New research presented at the ESCMID Conference on Coronavirus Diseases (ECCVID, online 23-25 September) suggests that the higher risk of poor COVID-19 outcomes in men could be explained by differences in circulating proteins and immune system cells compared with women. (2020-09-24)
New insights into colorectal cancer: Growth factor R-spondin suppresses tumor growth
R-spondin, which enhances the growth of healthy cells in the gut, suppresses the growth of intestinal adenoma cells, thus reducing the formation of intestinal tumors. (2020-09-23)
Likely molecular mechanisms of SARS-CoV-2 pathogenesis are revealed by network biology
Researchers have built an interactome that includes the lung-epithelial cell host interactome integrated with a SARS-CoV-2 interactome. (2020-09-23)
New vaccine strategy harnesses 'foot soldier' T-cells to protect against influenza
As Americans begin pulling up their sleeves for an annual flu vaccine, researchers at the University of Wisconsin-Madison have provided new insights into an alternative vaccine approach that provides broader protection against seasonal influenza. (2020-09-22)
BU researchers discover how COVID-19 may trigger fatal levels of lung inflammation
Responding to the COVID-19 pandemic caused by the novel coronavirus, SARS-CoV-2, requires models that can duplicate disease development in humans, identify potential targets and enable drug testing. (2020-09-21)
Super-potent blood stem cells discovered in human embryos
In research recently published in Stem Cell Reports, Andrejs Ivanovs, Alexander Medvinsky (a.medvinsky@ed.ac.uk) and colleagues from the University of Edinburgh discovered that HSCs from early human embryos, when HSCs are just starting to form, are more robust at expanding than those from the cord blood. (2020-09-17)
A 'cell-less' therapy may regenerate heart tissue without cell transplant risks
Ling Gao and colleagues have developed a strategy that uses exosomes - tiny membrane-bound sacs secreted by cells - to mimic the heart-regenerating effects of cardiac cell transplants, while potentially avoiding risks associated with whole-cell transplants. (2020-09-16)
A scientific advance in studying early-stage lung cancer
Lung cancer is the leading cancer killer in the US. (2020-09-15)
Veterinary college team IDs gene that drives ovarian cancer
scientists at the College of Veterinary Medicine have collaborated on a study that pinpoints which specific genes drive - or delay - high-grade serious ovarian carcinoma. (2020-09-11)
Stem cell function may explain higher colon cancer rate in males
In research recently published in Stem Cell Reports, Jingxin Li (ljingxin@sdu.edu.cn), Dawei Chen (dawei.chen@uliege.be) and colleagues found that androgen levels can regulate intestinal stem cell proliferation, a new potential link between androgen levels and colon cancer. (2020-09-10)
UNC researchers publish striking images of SARS-CoV-2 infected cells
The UNC School of Medicine laboratory of Camille Ehre, PhD, Assistant Professor of Pediatrics, produced striking images in respiratory tract cultures of the infectious form of the SARS-CoV-2 virus produced by infected respiratory epithelial cells. (2020-09-10)
Cancer drug can rebalance kidney function in a devastating genetic disease
Researchers at the University of Cambridge and the University of Zurich have discovered that a drug newly approved for cancer improves kidney dysfunction in a mouse model of Dent disease 2 and Lowe syndrome (2020-09-09)
Common cold combats influenza
As the flu season approaches, a strained public health system may have a surprising ally -- the common cold virus. (2020-09-04)
Seeing progress
As we get older, many of our body's processes start slowing down. (2020-09-03)
How do tumor cells divide in the crowd?
Scientists led by Dr. Elisabeth Fischer-Friedrich, group leader at the Excellence Cluster Physics of Life (PoL) and the Biotechnology Center TU Dresden (BIOTEC) studied how cancer cells are able to divide in a crowded tumor tissue and connected it to the hallmark of cancer progression and metastasis, the epithelial-mesenchymal transition (EMT). (2020-09-02)
Ultraviolet B exposure expands proenkephalin+ regulatory T cells with a healing function
Skin exposure to ultraviolet B (UVB) induces expansion of regulatory T (Treg) cells with immunosuppressive activity. (2020-09-01)
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