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Current Fibroblasts News and Events, Fibroblasts News Articles.
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Interactions between cancer cells and fibroblasts promote metastasis
In order to colonize other organs and grow into metastases, tumor cells that detach from the parent tumor need to manipulate their new microenvironment and create a 'metastatic niche'. (2020-03-23)
Study finds molecule in lymphatic system implicated in autoimmune diseases
A study by investigators at Hospital for Special Surgery (HSS) has discovered a molecule in the lymphatic system that has the potential to play a role in autoimmune disease. (2020-03-20)
Possible treatment for breast cancer patients could roll out to clinical trial immediately
A worldwide collaborative study involving scientists at the University of Sussex has proposed a new treatment strategy for patients with a rare but aggressive subtype of cancer known as triple negative breast cancer. (2020-03-10)
'Primitive' stem cells shown to regenerate blood vessels in the eye
Johns Hopkins Medicine scientists say they have successfully turned back the biological hands of time, coaxing adult human cells in the laboratory to revert to a primitive state, and unlocking their potential to replace and repair damage to blood vessels in the retina caused by diabetes. (2020-03-09)
Scientists show drug may greatly improve cancer immunotherapy success
A study led by the University of Southampton, funded by Cancer Research UK, has shown a new drug -- originally developed to tackle the scarring of organ tissue -- could help to significantly improve the success rate of cancer immunotherapy treatment. (2020-03-02)
A molecular atlas of skin cells
Our skin protects us from physical injury, radiation and microbes, and at the same time produces hair and facilitates perspiration. (2020-02-27)
Structural framework for tumors also provides immune protection
Aggressive colorectal cancers set up an interactive network of checkpoints to keep the immune system at bay, scientists report. (2020-02-26)
New light shed on damaging impact of infrared and visible rays on skin
New research reveals for the first time that UV combined with visible and infrared light cause damage to the skin and we need to protect our skin against all three to prevent aging. (2020-01-23)
New radiotracer offers opportunities for earlier intervention after heart attack
A new radiotracer can effectively image fibroblast activation after a heart attack, identifying a window of time during which cardiac fibrosis can be prevented and the disease course altered. (2020-01-02)
Fibroblasts involved in healing spur tumor growth in cancer
The connective tissue cells known as fibroblasts are vitally important for our recovery from injury. (2019-12-19)
Study finds common cold virus can infect the placenta
For the first time, researchers have shown that a common cold virus can infect cells derived from human placentas, suggesting that it may be possible for the infection to pass from expectant mothers to their unborn children. (2019-12-02)
How do scars form? Fascia function as a repository of mobile scar tissue
In the riddle about the origin of scar tissue, researchers have reached an important next step. (2019-11-27)
Researchers identify a molecular mechanism involved in Huntington's disease
Researchers from the Institute of Neurosciences of the University of Barcelona (UBNeuro) and the August Pi i Sunyer Biomedical Research Institute (IDIBAPS) described a mechanism, the increase of proteinaceous synthesis, which takes part in the degeneration of the type of neurons that are affected in Huntington's disease, a genetic neurodegenerative disease. (2019-11-20)
New advances in the treatment of advanced lung cancer
The University of Barcelona (UB) and Hospital Clínic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer. (2019-11-19)
Master regulator in mitochondria is critical for muscle function and repair
New study identifies how loss of mitochondrial protein MICU1 disrupts calcium balance and causes muscle atrophy and weakness. (2019-11-14)
Mechanical signaling cascade central to fibrotic scar tissue development defined
In a new study published in Science Signaling, Cleveland Clinic researchers have identified a novel target for new therapies that may help to treat or prevent a host of fibrotic conditions, which contribute to nearly half of overall mortality in the United States. (2019-11-13)
Kidney cancer study uncovers new subtypes and clues to better diagnosis and treatment
In what is believed to be the most comprehensive molecular characterization to date of the most common -- and often treatment-resistant -- form of kidney cancer, researchers at Johns Hopkins' departments of pathology and oncology, Johns Hopkins Kimmel Cancer Center, and the Johns Hopkins University School of Medicine report evidence for at least three distinct subtypes of clear cell renal cell carcinoma (ccRCC), along with new revelations about the proteins that define them. (2019-10-31)
New insights could help block the path of cancer 'super-highways'
A key mechanism controlling tissue structure, which could help identify drugs that make it harder for cancer cells to spread, has been identified by researchers at the Francis Crick Institute. (2019-10-28)
Protective mediators can help heal injured tendon cells by attacking inflammation
Tendon tears, both to the rotator cuff and Achilles heel, are common injuries, especially in aged individuals. (2019-10-10)
Scientists have identified the presence of cancer-suppressing cells in pancreatic cancer
Researchers have identified cells containing a protein called Meflin that has a role in restraining the progression of pancreatic cancer. (2019-10-07)
Temple scientists ID new targets to treat fibrosis -- a feature of many chronic diseases
When it comes to repairing injured tissue, specialized cells in the body known as fibroblasts are called into action. (2019-10-04)
Stanford scientists find potential diagnostic tool, treatment for Parkinson's disease
Investigators at the Stanford University School of Medicine have pinpointed a molecular defect that seems almost universal among patients with Parkinson's disease and those at a high risk of acquiring it. (2019-09-26)
Smoothing wrinkles in mice -- without needles
In the quest for a more youthful appearance, many people slather ointments on their skin or undergo injections of dermal fillers. (2019-09-25)
A protein essential for chikungunya virus replication identified
Chikungunya is an infectious disease caused by a mosquito-borne virus transmitted to humans. (2019-09-25)
Promising steps towards a treatment for pulmonary fibrosis
Research published in the journal Science Translational Medicine on 25 September by members of the Cardiovascular Disease Mechanisms group at the MRC LMS in collaboration with Duke-NUS Medical School, National Heart Centre Singapore & National Heart and Lung Institute, Imperial College London, showed that blocking a protein called interleukin-11 (IL-11) using therapeutic antibodies can reverse the fibrosis in the lung. (2019-09-25)
New insights into the healing capacity of the heart
Researchers report that the Hippo pathway is important for maintaining adult murine cardiac fibroblasts in their resting state. (2019-09-25)
CU researchers identify potential target for cardiac fibrosis treatment
A research team led by scientists at the University of Colorado School of Medicine has identified a potential target for treating heart failure related to fibrosis. (2019-09-17)
New cardiac fibrosis study identifies key proteins that translate into heart disease
The formation of excess fibrous tissue in the heart, which underlies several heart diseases, could be prevented by inhibiting specific proteins that bind to RNA while its code is being translated. (2019-09-12)
CAR T-cell therapy may be harnessed to treat heart disease
CAR T-cell therapy, a rapidly emerging form of immunotherapy using patients' own cells to treat certain types of cancers, may be a viable treatment option for another life-threatening condition: heart disease. (2019-09-11)
Bioengineers explore cardiac tissue remodeling after aortic valve replacement procedures
Researchers have developed biomaterial-based 'mimics' of heart tissues to measure patients' responses to an aortic valve replacement procedure, offering new insight into the ways that cardiac tissue re-shapes itself post-surgery. (2019-09-11)
Key to targeting the spread of pancreatic cancer
Targeting the tissue around pancreatic cancer cells may be the key to stopping their spread and improving chemotherapy outcomes. (2019-08-12)
How cigarette smoke makes head and neck cancer more aggressive
A change in the tumor metabolism due to tobacco exposure could open new treatment avenues in head and neck cancer. (2019-08-08)
'Promising' antibody therapy extends survival in mice with pancreatic cancer
Scientists have found a way to target and knock out a single protein that they have discovered is widely involved in pancreatic cancer cell growth, survival and invasion. (2019-07-31)
Signals from skin cells control fat cell specialization
When cells change to a more specialized type, we call this process cellular differentiation. (2019-07-25)
Disrupting immune cell behavior may contribute to heart disease and failure, study shows
A new study, led by researchers at Johns Hopkins Medicine, provides evidence that when circulating anti-inflammatory white blood cells known as monocytes fail to properly differentiate into macrophages -- the cells that engulf and digest cellular debris, bacteria and viruses -- certain forms of heart disease may result. (2019-07-24)
Rare inherited enzyme disorder yields insight into fibrosis
St. Jude investigators have discovered an association between a deficiency in the enzyme neuraminidase 1 and the build-up of connective tissue in organs, suck as the muscle, kidney, liver, heart and lungs. (2019-07-17)
Scientists make single-cell map to reprogram scar tissue into healthy heart cells
Annually, about 790,000 Americans suffer a heart attack, which leaves damaged scar tissue on the heart and limits its ability to beat efficiently. (2019-06-20)
Repurposing existing drugs or combining therapies could help in the treatment of autoimmune diseases
Research has found that re-purposing already existing drugs or combining therapies could be used to treat patients who have difficult to treat autoimmune diseases. (2019-06-17)
Special fibroblasts help pancreatic cancer cells evade immune detection
A subpopulation of fibroblasts called apCAFs can interact with the immune system to help pancreatic cancer cells avoid detection. (2019-06-13)
New radiotracer can identify nearly 30 types of cancer
A novel class of radiopharmaceuticals has proven effective in non-invasively identifying nearly 30 types of malignant tumors. (2019-06-07)
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