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Current Fibrosis News and Events, Fibrosis News Articles.
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New 3D cultured cells mimic the progress of NASH
A research team led by scientists from Tokyo University of Agriculture and Technology (TUAT), Japan, has successfully established 3D cultured tissue that mimics liver fibrosis, a key characteristic of non-alcoholic steatohepatitis (NASH). (2020-04-01)
Researchers reverse muscle fibrosis from overuse injury in animals, hope for human trials
High-force, high-repetition movements create microinjuries in muscle fibers. Muscle tissue responds by making repairs. (2020-03-30)
Cells must age for muscles to regenerate in muscle-degenerating diseases
Exercise can only improve strength in muscle-degenerating diseases when a specific type of muscle cell ages, report a Hokkaido University researcher and colleagues with Sapporo Medical University in Japan. (2020-03-30)
Study compares funding, research productivity for 2 diseases
This study compared federal and foundation research funding for sickle cell disease and cystic fibrosis and investigated whether funding was associated with differences in drug development and research productivity. (2020-03-27)
How tissues harm themselves during wound healing
Researchers from Osaka University discovered that increased expression of Rbm7 in apoptotic tissue cells results in the recruitment of segregated-nucleus-containing atypical monocytes, leading to tissue fibrosis. (2020-03-25)
Bacterial protein fragment kills lung cells in pulmonary fibrosis, study finds
A bacterial protein fragment instigates lung tissue death in pulmonary fibrosis, a mysterious disease affecting millions of people worldwide, according to a new study from researchers at the University of Illinois at Urbana-Champaign and Mie University in Japan. (2020-03-24)
Closing in on liver fibrosis: Detailing the fibrosis process at unprecedented resolution
Today, there is no effective way to treat liver fibrosis. (2020-03-09)
Liver fibrosis tied to specific heart failure, regardless of HIV or hepatitis C status
While there is an association between liver fibrosis and heart failure, the mechanisms for this association are currently unclear but may be of particular importance for people living with human immunodeficiency virus (HIV) and/or hepatitis C, both of which are chronic infections that affect the liver and heart. (2020-03-06)
Inhalation therapy shows promise against pulmonary fibrosis in mice, rats
A new study shows that lung stem cell secretions -- specifically exosomes and secretomes -- delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats. (2020-02-28)
Scientists discover three genes associated with fatal lung disease
Researchers at the Universities of Leicester and Nottingham have discovered parts of the DNA that put some people at higher risk of an incurable lung disease called idiopathic pulmonary fibrosis (IPF). (2020-02-28)
Plant-based relatives of cholesterol could give boost to gene therapy
Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells. (2020-02-20)
Research team tackles superbug infections with novel therapy
Superbug infections kill 35,000 people in the US annually. A team of researchers has found that a treatment known as AB569 kills pseudomonas aeruginosa in humanized cells in mouse models. (2020-02-20)
Curing genetic disease in human cells
Scientists from the groups of Hans Clevers (Hubrecht Institute) and Jeffrey Beekman (UMC Utrecht) show for the first time that a newer type of CRISPR, called base-editing, can safely cure cystic fibrosis in stem cells derived from patients. (2020-02-20)
Second wind: New technology to help diagnose and manage respiratory diseases
Researchers at Australia's Monash University have developed radical non-invasive technology that can be used to diagnose respiratory lung diseases, such as cystic fibrosis and lung cancer, and potentially fast-track treatments for patients. (2020-02-12)
Researchers find test to ID children at higher risk for cystic fibrosis liver disease
A major multi-center investigation of children with cystic fibrosis has identified a test that allows earlier identification of those at risk for cystic fibrosis liver disease. (2020-02-12)
Eternygen presents data demonstrating INDY inhibition as novel therapeutic option in NASH
Study to be presented at 3rd Global NASH Congress in London, U.K., February 10, 11. (2020-02-10)
Yale studies suggest new path for reversing type-2 diabetes and liver fibrosis
In a pair of related studies, a team of Yale researchers has found a way to reverse type-2 diabetes and liver fibrosis in mice, and has shown that the underlying processes are conserved in humans. (2020-02-04)
Researchers describe unique genetic identity of primordial lung progenitors
For the first time, researchers describe the genetic program behind primordial lung progenitors -- embryonic cells that give rise to all the cells that form the lining of the respiratory system after birth. (2020-01-31)
New target identified for repairing the heart after heart attack
An immune cell is shown for the first time to be involved in creating the scar that repairs the heart after damage. (2020-01-30)
Researchers build a better lung model
Using a combination of pluripotent stem cells (cells that can potentially produce any cell or tissue type) and machine learning (artificial intelligence that allows computers to learn automatically), researchers have improved how they generate lung cells. (2020-01-30)
New treatment kills off infection that can be deadly to cystic fibrosis patients
The findings, which are published in the journal Scientific Reports, show that scientists from Aston University, Mycobacterial Research Group, combined doses of three antibiotics -- amoxicillin and imipenem-relebactam and found it was 100% effective in killing off the infection which is usually extremely difficult to treat in patients with cystic fibrosis. (2020-01-27)
Liver fibrosis 'off switch' discovered in mice
UC San Diego School of Medicine researchers identified several genetic switches, or transcription factors, that determine whether or not liver cells produce collagen -- providing a new therapeutic target for liver fibrosis. (2020-01-23)
Magnetic nanomaterials become an effective treatment against liver fibrosis
Fibrosis may affect different body organs. It develops as a reaction to long-time inflammation and is supposed to isolate the inflammation site from surrounding tissues. (2020-01-20)
Obesity crisis blamed for a rise in fatty liver disease amongst young adults
One in five young people have fatty liver disease (steatosis), with one in 40 having already developed liver scarring (fibrosis), research published today has found. (2020-01-15)
Researchers develop new protocol to generate intestinal organoids in vitro
Boston researchers have developed a new way to generate groups of intestinal cells that can be used, among others, to make disease models in the lab to test treatments for diseases affecting the gastrointestinal system. (2020-01-10)
Cystic fibrosis carriers are at increased risk for cystic fibrosis-related conditions
A University of Iowa study challenges the conventional wisdom that having just one mutated copy of the cystic fibrosis (CF) gene has no effects on a person's health. (2020-01-08)
Cell 'hands' to unlock doors in health research, drug design, and bioengineering
A previously overlooked cell membrane protein could help to further cancer research, drug design, and bioengineering, according to new research. (2020-01-06)
New radiotracer offers opportunities for earlier intervention after heart attack
A new radiotracer can effectively image fibroblast activation after a heart attack, identifying a window of time during which cardiac fibrosis can be prevented and the disease course altered. (2020-01-02)
Short or long sleep associated with Pulmonary Fibrosis
Scientists have discovered that people who regularly sleep for more than 11 hours or less than 4 hours are 2-3 times more likely to have the incurable disease, pulmonary fibrosis, compared to those that sleep for 7 hours in a day. (2019-12-30)
NTM infections on the rise nationally; women and elderly most affected
The number of people newly infected each year and the number of people living with nontuberculous mycobacterial lung disease appears to be increasing, especially among women and those 65 and older, according to new research published online in the Annals of the American Thoracic Society. (2019-12-13)
A study demonstrates the efficiency of a screening strategy to detect liver diseases
Miquel Serra-Burriel, a researcher at the Centre for Research in Health Economics (CRES-UPF), co-author of the article together with researchers from the Hepatology Unit of Hospital Clínic de Barcelona and a team of international experts, have published the study in Journal of Hepatology in the framework of the LiverScreen project. (2019-12-10)
Modifier gene may explain why some with cystic fibrosis are less prone to infection
People with cystic fibrosis who carry genetic variants that lower RNF5 gene expression have more mutant CFTR protein on cell surfaces. (2019-12-10)
Researchers create accurate model of organ scarring using stem cells in a lab
A team led by Dr. Brigitte Gomperts at UCLA has developed a 'scar in a dish' model that uses multiple types of cells derived from human stem cells to closely mimic the progressive scarring that occurs in human organs. (2019-12-10)
New approach to treating cystic fibrosis could lower risk of lung transplants and death
A new approach to treating people with cystic fibrosis (CF) has been shown to reduce inflammation, which has the potential to reduce the need for lung transplants and lower the risk of death. (2019-12-03)
Dangerous bacteria communicate to avoid antibiotics
Researchers at the University of Copenhagen have found a new survival mechanism for a commonly known type of bacteria. (2019-11-22)
Ammonia levels do not aid management of hepatic encephalopathy in cirrhotic patients
Hepatic encephalopathy (HE) is a reversible complication of liver cirrhosis thought to be caused by ammonia and is typically treated with lactulose. (2019-11-19)
New advances in the treatment of advanced lung cancer
The University of Barcelona (UB) and Hospital Clínic de Barcelona collaborate with Boehringer Ingelheim Inc. to improve the efficiency of nintedanib, an antiangiogenic and antifibrotic drug, for the treatment of lung cancer. (2019-11-19)
Yale study provides insights into how fibrosis progresses in the human lung
A Yale-led collaborative study boosts scientific understanding of how the lung disease idiopathic pulmonary fibrosis (IPF) progresses, providing a roadmap for researchers to discover new treatment targets for the disease. (2019-11-15)
Study reveals 'bug wars' that take place in cystic fibrosis
Scientists have revealed how common respiratory bugs that cause serious infections in people with cystic fibrosis interact together, according to a new study in eLife. (2019-11-12)
Research points to possible target to treat idiopathic pulmonary fibrosis, or IPF
In a study of idiopathic pulmonary fibrosis, or IPF, recruited monocyte-derived macrophages with increased flux in their mevalonate pathway were able induce lung fibrosis in a mouse model without prior lung injury. (2019-11-12)
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