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Current Fibrosis News and Events

Current Fibrosis News and Events, Fibrosis News Articles.
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New insights into wound healing
Research from a multidisciplinary team led by Washington University may provide new insights into wound healing, scarring and how cancer spreads (2020-07-29)
Mix and match: New 3D cell culture model replicates fibrotic elements of pancreatic cancer
Pancreatic cancer is a deadly cancer characterized by prominent fibrosis, which plays a crucial role in disease progression and therapeutic resistance. (2020-07-22)
Cystic fibrosis: why so many respiratory complications?
Cystic fibrosis, one of the most common genetic diseases in Switzerland, causes severe respiratory and digestive disorders. (2020-07-13)
Yale, Baylor study reveals new cell types in lethal lung disease
A research team from Yale and Baylor College of Medicine has completed the largest single-cell analysis to date of lungs affected by Idiopathic Pulmonary Fibrosis (IPF), revealing how cells change in response to the disease and identifying previously unknown cell types. (2020-07-12)
World-first technology breathes new life into cystic fibrosis detection and treatment
World-first research, led by Monash University, has developed radical non-invasive X-ray technology aimed at helping diagnose, treat and manage people with cystic fibrosis. (2020-07-12)
Researchers find promising therapy to fight epidemic of liver disease
In an effort to combat a growing worldwide epidemic of Nonalcoholic Fatty Liver Disease (NAFLD), scientists have discovered a new target and a new therapy that has shown promising results in preclinical mouse models, according to researchers at the University of Colorado Anschutz Medical Campus. (2020-07-08)
New clues to lung-scarring disease may aid treatment
Scientists at Vanderbilt University Medical Center (VUMC) and the Translational Genomics Research Institute (TGen) in Phoenix, Arizona, have discovered previously unreported genetic and cellular changes that occur in the lungs of people with pulmonary fibrosis (PF). (2020-07-08)
TGen-led study identifies unique cells that may drive lung fibrosis
This is one of the first comprehensive looks at lung cells using a technology called single-cell RNA sequencing. (2020-07-08)
Giant leap in diagnosing liver disease
A collaborative team of Salk Institute and UC San Diego scientists have created a novel microbiome-based diagnostic tool that, with the accuracy of the best physicians, quickly and inexpensively identifies liver fibrosis and cirrhosis over 90 percent of the time in human patients. (2020-07-01)
Silicosis: Ominous resurgence of an occupational lung condition reported
A new study appearing in the journal CHEST®, published by Elsevier, documents an increased incidence of silicosis, which progressed rapidly to massive pulmonary fibrosis in a significant proportion of patients who had previously worked artificial stone (AS), also called artificial quartz agglomerate or conglomerate, a popular new countertop material, despite cessation of exposure after diagnosis. (2020-06-18)
Researchers identify key steps in development of kidneys
The discovery of how certain key structures in the kidneys are formed could have important implications for treating renal fibrosis (or scarring), a feature of chronic kidney disease (CKD). (2020-06-18)
CAR T cells beyond cancer: Targeting senescence-related diseases
Scientists at Memorial Sloan Kettering have genetically engineered immune cells to find and kill cells that contribute to diseases caused by a tissue-damaging process called senescence. (2020-06-17)
Seeing corneal degeneration in a new light
The molecular changes that lead to Fuchs' endothelial corneal dystrophy (FECD) occur decades before the disease causes blurry vision and other noticeable symptoms in patients, new research by UT Southwestern scientists shows. (2020-06-17)
Off-the-shelf tool for making mouse models of COVID-19
Researchers at the University of Iowa and Medical University, Guangzhou, in China, have created a gene therapy vector that is essentially an off-the-shelf tool that allows labs to create their own COVID-19 mouse model within a matter of days. (2020-06-16)
A rare heart bone is discovered in chimpanzees
Experts from the University of Nottingham have discovered that some chimpanzees have a bone in their heart, which could be vital in managing their health and conservation. (2020-06-10)
A newly discovered disease may lead to better treatment of cystic fibrosis
Cystic fibrosis is the most frequent severe inherited disorder worldwide. (2020-06-05)
Uncuffing nitric oxide production: Beta-arrestin2 complexes regulate NO levels
In a new report, researchers at the Medical University of South Carolina have uncovered one of the mechanisms regulating the production of nitric oxide (NO) in liver endothelial cells. (2020-06-04)
Researchers identify secretion mechanisms for a protein necessary for maintaining healthy connective
Researchers have discovered that a defective form of the protein aortic carboxypeptidase-like protein (ACLP) from patients with Ehlers-Danlos syndrome (EDS) is retained in cells and induces cellular stress. (2020-06-03)
Atomic blueprint of 'molecular machine' reveals role in membrane protein installation
Van Andel Institute scientists have revealed the first known atomic structure of a 'molecular machine' responsible for installing critical signaling proteins into cellular membranes. (2020-06-03)
Stem cells from placental amniotic membrane slow lung scarring in pulmonary fibrosis
In a study released today in STEM CELLS Translational Medicine (SCTM), researchers show for the first time how stem cells collected from human amniotic membrane can slow the progression of scarring in pulmonary fibrosis. (2020-05-26)
ACMG updates seminal laboratory standard on CFTR variant testing
This technical standard includes revised information about CF and the CFTR gene, new testing considerations and methodologies, and updated recommendations for the interpretation and reporting of test results. (2020-05-14)
Global spread of the multi-resistant pathogen Stenotrophomonas maltophilia
An international consortium found a remarkable global spread of strains of a multi-resistant bacterium that can cause severe infections - Stenotrophomonas maltophilia. (2020-05-14)
Can vaping scar your lungs? New insights and a possible remedy
Researchers report evidence that the compounds in e-cigarette liquid could potentially cause the body's tissue repair process to go haywire and lead to scarring inside the lungs. (2020-04-27)
Researchers identify key mechanisms involved in pulmonary fibrosis development
Working alongside research groups from Heidelberg, researchers from Charité - Universitätsmedizin Berlin have elucidated the novel disease processes involved in the development of pulmonary fibrosis. (2020-04-27)
TGF-β-driven reduction of CYGB is associated with oxidative DNA damage of HSCs in NASH
This study shows that the molecular regulatory mechanism of TGF-β-induced downregulation of CYGB expression in human HSCs, leading to the loss of cellular tolerance to exogenous oxidative stress and oxidative DNA damage in activated HSCs in human NASH with advanced fibrosis. (2020-04-21)
Keep children from hospital during crisis
With stressed hospital services, and concerns about the spread of COVID-19, experts are reminding carers of children and young people of the importance of safely adhering to their supported chronic condition self-management plans from the safety of their home. (2020-04-21)
Simulations show how to make gene therapy more effective
Diseases with a genetic cause could be treated by supplying a correct version of the faulty gene. (2020-04-17)
COPD as a lung stem cell disease
Two internationally renowned stem cell researchers at the University of Houston have found an abundance of abnormal stem cells in the lungs of patients who suffer from Chronic Obstructive Pulmonary Disease (COPD), a leading cause of death worldwide. (2020-04-15)
New 3D cultured cells mimic the progress of NASH
A research team led by scientists from Tokyo University of Agriculture and Technology (TUAT), Japan, has successfully established 3D cultured tissue that mimics liver fibrosis, a key characteristic of non-alcoholic steatohepatitis (NASH). (2020-04-01)
Researchers reverse muscle fibrosis from overuse injury in animals, hope for human trials
High-force, high-repetition movements create microinjuries in muscle fibers. Muscle tissue responds by making repairs. (2020-03-30)
Cells must age for muscles to regenerate in muscle-degenerating diseases
Exercise can only improve strength in muscle-degenerating diseases when a specific type of muscle cell ages, report a Hokkaido University researcher and colleagues with Sapporo Medical University in Japan. (2020-03-30)
Study compares funding, research productivity for 2 diseases
This study compared federal and foundation research funding for sickle cell disease and cystic fibrosis and investigated whether funding was associated with differences in drug development and research productivity. (2020-03-27)
How tissues harm themselves during wound healing
Researchers from Osaka University discovered that increased expression of Rbm7 in apoptotic tissue cells results in the recruitment of segregated-nucleus-containing atypical monocytes, leading to tissue fibrosis. (2020-03-25)
Bacterial protein fragment kills lung cells in pulmonary fibrosis, study finds
A bacterial protein fragment instigates lung tissue death in pulmonary fibrosis, a mysterious disease affecting millions of people worldwide, according to a new study from researchers at the University of Illinois at Urbana-Champaign and Mie University in Japan. (2020-03-24)
Closing in on liver fibrosis: Detailing the fibrosis process at unprecedented resolution
Today, there is no effective way to treat liver fibrosis. (2020-03-09)
Liver fibrosis tied to specific heart failure, regardless of HIV or hepatitis C status
While there is an association between liver fibrosis and heart failure, the mechanisms for this association are currently unclear but may be of particular importance for people living with human immunodeficiency virus (HIV) and/or hepatitis C, both of which are chronic infections that affect the liver and heart. (2020-03-06)
Inhalation therapy shows promise against pulmonary fibrosis in mice, rats
A new study shows that lung stem cell secretions -- specifically exosomes and secretomes -- delivered via nebulizer, can help repair lung injuries due to multiple types of pulmonary fibrosis in mice and rats. (2020-02-28)
Scientists discover three genes associated with fatal lung disease
Researchers at the Universities of Leicester and Nottingham have discovered parts of the DNA that put some people at higher risk of an incurable lung disease called idiopathic pulmonary fibrosis (IPF). (2020-02-28)
Plant-based relatives of cholesterol could give boost to gene therapy
Gene-infused nanoparticles used for combating disease work better when they include plant-based relatives of cholesterol because their shape and structure help the genes get where they need to be inside cells. (2020-02-20)
Research team tackles superbug infections with novel therapy
Superbug infections kill 35,000 people in the US annually. A team of researchers has found that a treatment known as AB569 kills pseudomonas aeruginosa in humanized cells in mouse models. (2020-02-20)
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