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Current Gene therapy News and Events

Current Gene therapy News and Events, Gene therapy News Articles.
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Artery hardening and thickness not affected by stopping hormone therapy
Heart disease is still the number one killer of US women, and hormone therapy remains a top treatment for menopause symptoms. (2018-07-18)
Genome damage from CRISPR/Cas9 gene editing higher than thought
Scientists at the Wellcome Sanger Institute have discovered that CRISPR/Cas9 gene editing can cause greater genetic damage in cells than was previously thought. (2018-07-16)
Fetal gene therapy prevents fatal neurodegenerative disease
A fatal neurodegenerative condition known as Gaucher disease can be prevented in mice following fetal gene therapy, finds a new study led by UCL, the KK Women's and Children's Hospital and National University Health System in Singapore. (2018-07-16)
Early treatment with nusinersen can mean better outcomes for babies
Spinal muscular atrophy (SMA) is a genetic disease that affects motor neurons in the spinal cord, resulting in muscle atrophy and widespread weakness that eventually impair swallowing and breathing. (2018-07-16)
Homology Medicines announces publication of in vivo gene editing data with nuclease-free technology
Homology Medicines, Inc., a genetic medicines company, announced today a peer-reviewed publication demonstrating that Homology's technology induces efficient and precise in vivo gene editing. (2018-07-16)
Rice plants evolve to adapt to flooding
Although water is essential for plant growth, excessive amounts can waterlog and kill a plant. (2018-07-12)
Tablet computers can be of use in speech therapy for kids
Thus, computer games have been established to be a potential benefit for speech therapy and for children's motivation and satisfaction from classes. (2018-07-10)
Mapping the genetic controllers in heart disease
Researchers have developed a 3D map of the gene interactions that play a key role in cardiovascular disease, a study in eLife reports. (2018-07-10)
UAB researchers cure type 2 diabetes and obesity in mice using gene therapy
A single administration of a therapeutic vector in mouse models cures type 2 diabetes and obesity in the absence of long-term side effects. (2018-07-09)
Genome editing reduces cholesterol in large animal model, laying human trial groundwork
Using genome editing to inactivate a protein called PCSK9 effectively reduced cholesterol levels in rhesus macaques. (2018-07-09)
Researchers develop a new method for turning skin cells into pluripotent stem cells
Researchers at the University of Helsinki, Finland, and Karolinska Institutet, Sweden, have for the first time succeeded in converting human skin cells into pluripotent stem cells by activating the cell's own genes. (2018-07-06)
Extended tamoxifen therapy may increase risk of endometrial cancer
There is clear evidence that extended adjuvant tamoxifen therapy for 10 years reduces local recurrence and improves breast cancer-free survival in women with oestrogen receptor-positive breast cancer. (2018-07-05)
Progress in addressing a severe skin disease that affects dogs and humans
Both dogs and humans can suffer from ichthyosis, a disorder in which the skin becomes very dry, scaly, and prone to secondary infections. (2018-07-05)
Gene therapy method developed to target damaged kidney cells
Research led by Washington University School of Medicine in St. (2018-07-05)
Chronic pain remains the same or gets better after stopping opioid treatment
Stopping long-term opioid treatment does not make chronic, non-cancer-related pain worse and, in some cases, makes it better, Washington State University researchers have found. (2018-07-02)
Study: Zika could cause more miscarriages than we realize
More women could be losing their pregnancies to the Zika virus without knowing they're infected, suggests a collaborative study published in Nature Medicine.The study found 26 percent of nonhuman primates infected with Zika during early stages of pregnancy experienced miscarriage or stillbirth even though the animals showed few signs of infection. (2018-07-02)
CRISPR genome editing technology can correct alpha-1 antitrypsin deficiency
Groundbreaking research demonstrates proof-of-concept for using CRISPR-Cas9 genome editing technology to correct the gene mutation responsible for alpha-1 antitrypsin (AAT) deficiency, successfully making a targeted gene correction in the livers of affected mice that restored at least low levels of normal AAT. (2018-07-02)
Gene discovery unlocks mysteries to our immunity
Australia's national science agency CSIRO has identified a new gene that plays a critical role in regulating the body's immune response to infection and disease. (2018-07-01)
DBS treatment may slow the progression of Parkinson's tremor in early-stage patients
Deep brain stimulation (DBS) may slow the progression of tremor for early-stage Parkinson's disease patients, according to a Vanderbilt University Medical Center study released in the June 29 online issue of Neurology®, the medical journal of the American Academy of Neurology. (2018-06-29)
Novel genetic method improves efficiency of enzyme
Researchers at the US Department of Energy's (DOE's) National Renewable Energy Laboratory (NREL) and the University of Georgia developed a new genetic engineering technique to dramatically improve an enzyme's ability to break down biomass. (2018-06-26)
New nuclear medicine technique could help tackle brain disease
A new molecular imaging method can monitor the success of gene therapy in all areas of the brain, potentially allowing physicians to more effectively tackle brain conditions such as Parkinson's disease, Alzheimer's disease and multiple sclerosis. (2018-06-25)
Lipid-based nanoparticles enable improved therapy for cystic fibrosis patients
Researchers are working on a nanotechnology-based treatment that holds great promise for improving the lives of cystic fibrosis patients. (2018-06-22)
The psychobiology of online gaming
When researchers looked at expression of a particular gene complex that is activated by chronic stress, they found differences depending on whether someone was positively engaging in video games or were problematic gamers. (2018-06-21)
University of Michigan researchers use gene silencing to alleviate common ataxia
In what researchers are calling a game changer for future ataxia treatments, a new study showed the ability to turn down the disease progression of the most common dominantly inherited ataxia, Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease. (2018-06-20)
Long-term estrogen therapy changes microbial activity in the gut, study finds
Long-term therapy with estrogen and bazedoxifene alters the microbial composition and activity in the gut, affecting how estrogen is metabolized, a new study in mice found. (2018-06-19)
Sensitive new assay finds abnormalities in tumor cells that other techniques may miss
RNA-Seq, a new next-generation assay, can detect gene fusions in solid tumor cells with high accuracy and excellent reproducibility. (2018-06-18)
Rare mutation of gene carried by Quebec family gives insight into how the brain is wired
The study of a Quebec family with an unusual gene provides novel insight into how our brain is built and, according to the McGill led team of scientists, offers a better understanding of psychiatric disorders such as depression, addictions and schizophrenia. (2018-06-18)
Blue gene regulation helps plants respond properly to light
Researchers at the RIKEN Center for Sustainable Resource Science (CSRS) have discovered a process through which gene expression in plants is regulated by light. (2018-06-18)
JAK inhibitors associated with aggressive lymphoma
Austrian researchers have discovered that a small number of patients taking targeted drugs known as Janus kinase (JAK) inhibitors to treat myelofibrosis may develop aggressive lymphomas. (2018-06-15)
Gene therapy restores hand function after spinal cord injury in rats
Researchers at King's College London have shown that rats with spinal cord injuries can re-learn skilled hand movements after being treated with a gene therapy that could be switched on and off using a common antibiotic. (2018-06-14)
The neurons that rewrite traumatic memories
Neuroscientists at EPFL have located the cells that help reprogram long-lasting memories of traumatic experiences towards safety, a first in neuroscience. (2018-06-14)
Non-coding DNA changes sex determination
Scientists have identified a key enhancer of Sox9 -- a gene critical for male sex development -- and demonstrated that deleting this non-coding DNA results in male-to-female sex reversal. (2018-06-14)
Study looks at differences between African-Americans, whites in statin therapy
African-American patients were less likely to receive guideline-appropriate statin therapy than white patients and the difference can be explained by a combination of demographic and clinical characteristics, socioeconomic status, patient beliefs and clinician factors. (2018-06-13)
Stem cell-derived organoids for testing gene delivery to retinal & photoreceptor cells
A new study that compared six of the most promising adeno-associated viral (AAV) gene therapy vectors in human retinal organoid models showed clear distinctions in the efficiency of gene transfer to both retinal pigment epithelial (RPE) and photoreceptor cells. (2018-06-13)
Genome-editing tool could increase cancer risk
Therapeutic use of gene editing with the so-called CRISPR-Cas9 technique may inadvertently increase the risk of cancer, according to a new study from Karolinska Institutet, Sweden, and the University of Helsinki, Finland, published in Nature Medicine. (2018-06-11)
Combination drug therapy effectively treats male infertility
Two drugs that are commonly used off-label in the treatment of male infertility are clomiphene citrate (CC) and anastrozole (AZ); however, data are lacking on the use of combination CC+AZ therapy. (2018-06-06)
Upgrading the toolbox for Duchenne muscular dystrophy research with a new rabbit model
Research to improve our understanding of Duchenne muscular dystrophy (DMD), and the development of new therapies, has previously relied on mouse models. (2018-06-04)
Gene linked to intellectual ability affects memory replay in mice
Researchers at the RIKEN Center for Brain Science in Japan have discovered that a gene associated with human intellectual ability is necessary for normal memory formation in mice. (2018-06-04)
Landmark study finds more breast cancer patients can safely forgo chemotherapy
A 21-gene test performed on tumors could enable most patients with the most common type of early breast cancer to safely forgo chemotherapy, according to a landmark study published in the New England Journal of Medicine. (2018-06-03)
Neuroscientists discover roles of gene linked to Alzheimer's
MIT researchers found that the gene APOE4 promotes the aggregation of beta amyloid proteins that cause plaques seen in Alzheimer's patients. (2018-05-31)
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