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Current Gene therapy News and Events

Current Gene therapy News and Events, Gene therapy News Articles.
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Groundbreaking gene therapy trial set to cure hemophilia
A 'cure' for hemophilia is one step closer, following results of a groundbreaking gene therapy trial led by Queen Mary University of London and the NHS in London. (2017-12-14)
Frequent sun exposure may cue gene fusion found in skin cancer
Researchers from Kumamoto University, Japan have determined that a particular fusion gene has a tendency to be found in cutaneous squamous cell carcinoma (cSCC) lesions on skin exposed frequently to the sun. (2017-12-14)
Even smokers may benefit from targeted lung cancer treatments
No matter a patient's smoking history, when a targetable genetic alteration is present, matching the alteration with the appropriate targeted therapy is associated with a survival benefit of 1.5 years. (2017-12-13)
The toxic sugar tree: Mapping the evolutionary history of a cancerous sugar gene
The gene CMAH, that allows for the synthesis of a sugar called Neu5Gc, is missing from humans. (2017-12-13)
Searching for the CRISPR swiss-army knife
Scientists at the University of Copenhagen, led by the Spanish Professor Guillermo Montoya, are investigating the molecular features of different molecular scissors of the CRISPR-Cas system to shed light on the so-called 'Swiss-army knives' of genome editing. (2017-12-12)
Hormone therapy not recommended for prevention of chronic conditions in postmenopausal women
The US Preventive Services Task Force (USPSTF) recommends against the use of combined estrogen and progestin in postmenopausal women, or estrogen alone in postmenopausal women who have had a hysterectomy, to prevent chronic conditions such as heart disease, dementia and stroke. (2017-12-12)
Searching for the CRISPR Swiss-army knife
Scientists at the University of Copenhagen, led by the Spanish Professor Guillermo Montoya, are investigating the molecular features of different molecular scissors of the CRISPR-Cas system to shed light on the so-called 'Swiss-army knives' of genome editing. (2017-12-11)
AML study reports high response rates with combination targeted therapy
Initial findings from a multi-national open-label phase Ib study of inhibitory drug therapy for relapsed or refractory acute myeloid leukemia (AML) have demonstrated a complete response in up to 50 percent patients say researchers at The University of Texas MD Anderson Cancer Center. (2017-12-11)
Patients' individual genomes may affect efficacy, safety of gene editing
Gene editing has begun to be tested in clinical trials, using CRISPR-Cas9 and other technologies to directly edit DNA inside people's cells, and multiple trials are recruiting or in planning. (2017-12-11)
Researchers invent novel RNA nanotech to decorate exosomes for effective cancer therapy
A new study shows that attaching antibody-like RNA nanoparticles to microvesicles can deliver effective RNA therapeutics specifically to cancer cells. (2017-12-11)
Landmark CAR-T cancer study published in the New England Journal of Medicine
Loyola University Medical Center is the only Chicago center that participated in the pivotal clinical trial of a groundbreaking cancer treatment that genetically engineers a patient's immune system to attack cancer cells. (2017-12-10)
St. Jude gene therapy improves immunity in babies with 'bubble boy' disease
Preliminary findings indicate gene therapy pioneered at St. Jude Children's Research Hospital is safe and effective for babies with a devastating inherited disorder that leaves them with little or no immune protection. (2017-12-09)
Inflammatory factors linked to inhibition of factor VIII gene therapy in hemophilia A
As a gene therapy cure for hemophilia A moves closer to reality, a new study sheds light on a challenging complication in which a host autoimmune response inhibits the production of normal clotting factor VIII from the transferred FVIII gene. (2017-12-07)
A risk factor for drug-induced skin disease identified
Researchers have identified a type of human leukocyte antigen (HLA) that is associated with the skin disease bullous pemphigoid (BP) in diabetic patients administered with DPP-4 inhibitory drugs. (2017-12-06)
Study examines safety and effectiveness of infliximab biosimilar in patients with inflammatory bowel
Biosimilars are biologic agents that highly similar to original biomedical medications (oringinators), but are much cheaper. (2017-12-06)
Breakthroughs in understanding the genetic basis of aggressive prostate cancer
New research shows how losing a ubiquitous gene opens genetic floodgates that make prostate cancer deadly, a finding that could apply to many cancers. (2017-12-06)
A new gene therapy transplantation technique could improve treatment of neurodegenerative diseases
A study published today in Science Advances shows for the first time the efficacy of a new gene therapy transplantation technique which aims at repopulating the brain with new, genetically engineered immune cells. (2017-12-06)
Routing gene therapy directly into the brain
The technique, which could be used to transplant donor-matched hematopoietic stem cells (HSCs) or a patient's own genetically-engineered HSCs into the brain, was reported in Science Advances today by researchers from the Dana-Farber/Boston Children's Cancer and Blood Disorders Center and the San Raffaele Telethon Institute for Gene Therapy. (2017-12-06)
Gene experts set to tackle pest control
Experts at the University of Edinburgh's Roslin Institute are to investigate how genetic techniques could be applied to help control pest species. (2017-12-05)
Researchers examine role of gene variation linked to Major Depressive Disorder
A new study assessed the effects of a SLC6A15 gene variant on resting-state brain function in patients with major depressive disorder (MDD), comparing the results with those in healthy individuals. (2017-12-05)
Successful implantation of heart pump with power cable behind the ear, a Japan first!
In March 2017, the Cardiovascular Surgery Group at Osaka University successfully implanted a left ventricular assist device with an internal power cable tunneled through the neck to the head in a patient who was ineligible for a cardiac transplantation, destination therapy (DT) trial, a Japan first. (2017-12-04)
Thyroid hormone therapy heals lung fibrosis in animal study
Thyroid hormone therapy significantly resolves fibrosis, or scarring, in the lungs of mice, increasing their survival from disease, a Yale-led study shows. (2017-12-04)
Gene regulation: Risk-free gene reactivation
Chemical modification of DNA subunits contribute to the regulation of gene expression. (2017-12-01)
Two-drug combination may boost immunotherapy responses in lung cancer patients
Johns Hopkins Kimmel Cancer Center researchers and colleagues have identified a novel drug combination therapy that could prime nonsmall cell lung cancers to respond better to immunotherapy. (2017-11-30)
New in the Hastings Center report, November-December 2017
Standard-of-care sprawl and clinician self-interest, health implications of ending DACA, questions about CAR-T gene therapy, and more in the (November-December 2017 issue. (2017-11-30)
How having too much or too little of CHRNA7 can lead to neuropsychiatric disorders
Using new pluripotent stem cell technology, researchers have discovered unexpected effects on calcium flux on neurons from patients with neuropsychiatric disorders carrying either fewer or extra copies of the CHRNA7 gene. (2017-11-28)
Tracking down genetic influences on brain disorders
New findings will help to identify the genetic causes of brain disorders: researchers at the Universities of Basel, Bonn and Cologne have presented a systematic catalog of specific variable locations in the genome that influence gene activity in the human hippocampus, as they report in the journal Nature Communications. (2017-11-27)
New strategy for multiple myeloma immunotherapy
Cancer-specific proteins have been identified for the development of monoclonal antibody (mA)-based therapies, but there remains a need to uncover new targets, especially in cancers that are prone to relapses, such as multiple myeloma (MM). (2017-11-27)
Drug-delivering nanoparticles seek and destroy elusive cancer stem cells
University of Illinois researchers are sending tiny drug-laden nanoparticles on a mission to seek and destroy cancer stem cells, the elusive and rare cells that can cause cancer to come back even when years have passed since the initial tumor was treated. (2017-11-27)
Small but distinct differences among species mark evolution of human brain
The most dramatic divergence between humans and other primates can be found in the brain, the primary organ that gives our species its identity. (2017-11-23)
Hormone therapy in the menopause transition does not increase risk of stroke
Postmenopausal hormone therapy is not associated with increased risk of stroke, provided that it is started early, according to a report from Karolinska Institutet in Sweden published in the journal PLOS Medicine. (2017-11-23)
High yield, protein with soybean gene
Soybean growers face a challenge. It has proved difficult to develop soybean varieties with both high protein levels and high yields. (2017-11-22)
The HLF-gene controls the generation of our long-term immune system
A research group at Lund University in Sweden has found that when the HLF (hepatic leukemia factor) gene -- which is expressed in immature blood cells -- does not shut down on time, we are unable to develop a functional long-term immune system. (2017-11-22)
One-size treatment for blood cancer probably doesn't fit all, USC researchers say
Though African-American men are three times more likely to be diagnosed with a blood cancer called multiple myeloma, most scientific research on the disease has been based on people of European descent. (2017-11-22)
Corn genetics research exposes mechanism behind traits becoming silent
For more than a century, plant geneticists have been studying maize as a model system to understand the rules governing the inheritance of traits, and a team of researchers recently unveiled a previously unknown mechanism that triggers gene silencing in corn. (2017-11-21)
New study points the way to therapy for rare cancer that targets the young
Scientists have engineered a mouse model to study a rare and often-fatal form of liver cancer. (2017-11-21)
Clinical trial suggests new cell therapy for relapsed leukemia patients
A significant proportion of children and young adults with treatment-resistant B-cell leukemia who participated in a small study achieved remission with the help of a new form of gene therapy, according to researchers at the Stanford University School of Medicine and the National Cancer Institute. (2017-11-20)
Gene drive technologies for ecosystem conservation: Use with care!
Scientists working in the vanguard of new genetic technologies have issued a cautionary call to ensure that possible applications in conservation will only affect local populations. (2017-11-16)
Direct evidence of the GC-NSF(a) hypothesis on creation of an entirely new gene/protein
The hypothesis assumes that an entirely new gene is produced from the non-stop frame on the antisense strand of a GC-rich gene after gene duplication, followed by the accumulation of base substitutions to produce a mature novel GC-rich gene. (2017-11-15)
Targeting cancer without destroying healthy T-cells
A unique approach to targeting the abnormal T-cells that cause T-cell lymphomas could offer hope to patients with the aggressive and difficult-to-treat family of cancers, finds a study involving researchers from Cardiff University. (2017-11-15)
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