Current Glioblastoma News and Events

Current Glioblastoma News and Events, Glioblastoma News Articles.
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Immune checkpoint inhibitor efficacy against glioblastoma may decrease with dexamethasone
Among patients with glioblastoma receiving an immune checkpoint inhibitor, those who received the corticosteroid dexamethasone at baseline for cerebral edema had significantly worse overall survival. (2020-11-25)

Revolutionary CRISPR-based genome editing system treatment destroys cancer cells
Researchers at Tel Aviv University (TAU) have demonstrated that the CRISPR/Cas9 system is very effective in treating metastatic cancers, a significant step on the way to finding a cure for cancer. The researchers developed a novel lipid nanoparticle-based delivery system that specifically targets cancer cells and destroys them by genetic manipulation. The system, called CRISPR-LNPs, carries a genetic messenger (messenger RNA), which encodes for the CRISPR enzyme Cas9 that acts as molecular scissors that cut the cells' DNA. (2020-11-18)

A therapeutic option for glioblastoma using pH-sensitive nanomicelles
A polymeric nanomicelle that effectively delivers to glioblastoma (GBM) was developed. (2020-11-12)

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. (2020-11-10)

Photon IMRT treatment group displays no significant survival difference between arms
A preliminary analysis of photon therapy treatment group 1 from the phase II NRG Oncology clinical trial NRG-BN001 indicates that there is no statistically significant overall survival (OS) or toxicity differences between dose-intensification radiation therapy (DI-RT) using intensity-modulated radiation therapy (IMRT) and standard-dose radiation therapy (SD-RT) with temozolomide treatments for patients with newly diagnosed glioblastoma (GBM). (2020-10-26)

UCalgary researchers discover new tactic to stop the growth of a deadly brain cancer
UCalgary scientists and members of the Clark H. Smith Brain Tumour Centre at the Arnie Charbonneau Cancer Institute at the Cumming School of Medicine have discovered a way to stop the growth of glioblastoma, the deadliest form of brain cancer. The finding, published in Nature Communications, provides a new tactic in the war against cancer that involves reprogramming the immune system to do what it does best - fight the tumour instead of fueling it. (2020-10-26)

New test can target and capture most lethal cells in fatal brain cancer
A laboratory test developed by a research team led by Johns Hopkins University bioengineers can accurately pinpoint, capture and analyze the deadliest cells in the most common and aggressive brain cancer in adults. (2020-10-15)

Experimental glioblastoma therapy shows curative powers in mice models
Houston Methodist researchers used a second-generation prodrug called MP-Pt(IV) to target the deadly cells of glioblastoma tumors and found mice harboring human glioblastoma tumors in their brains had greatly enhanced survival and weight gain when given the newly developed prodrug. This mitochondrial-targeted prodrug also greatly improves outcomes when coupled with standard therapies of radiation and/or chemotherapy. The study was published Oct. 8 in Molecular Cancer Therapeutics. (2020-10-08)

Molecules responsible for radio-resistant glioblastoma identified
Scientists have identified key molecules that mediate radioresistance in glioblastoma multiforme; these molecules are a potential target for the treatment of this brain cancer. (2020-09-30)

Researchers identify mechanism underlying cancer cells' immune evasion
Researchers in China have discovered how brain cancer cells increase production of a key protein that allows them to evade the body's immune system. The study, which will be published August 27 in the Journal of Experimental Medicine (JEM), suggests that targeting this cellular pathway could help treat the deadly brain cancer glioblastoma, as well as other cancers that are resistant to current forms of immunotherapy. (2020-08-27)

Blocking copper uptake in tumor cells may be clue to boosting immune system
Australian researchers have discovered that removing copper from the blood can destroy some of the deadliest cancers that are resistant to immunotherapy using models of the disease. (2020-08-18)

Extrachromosomal DNA is common in human cancer and drives poor patients outcomes
The multiplication of genes located in extrachromosomal DNA that have the potential to cause cancer drives poor patient outcomes across many cancer types, according to a Nature Genetics study published Aug. 17, 2020 by a Nature Genetics by a team of researchers including Professors Vineet Bafna and Dr.Paul Mischel of the University of California San Diego and Professor Roel Verhaak of Jackson Laboratories. (2020-08-17)

Gene targeting helps overcome the resistance of brain cancer to therapy
New insight into a gene that controls energy production in cancer stem cells could help in the search for a more effective treatment for glioblastoma. A McGill-led study published in Nature Communication reveals that suppressing the OSMR gene can improve the effectiveness of radiation therapy. (2020-08-17)

TLK protein inhibition activates the innate immune system
These proteins are a potential therapeutic target for enhancing the effect of some cancer treatments. Inhibition of TLK proteins triggers the Alternative Lengthening of Telomeres pathway, a common process in some of the most aggressive types of cancer, such as glioblastoma. The study, performed by the Genomic Instability and Cancer Laboratory at IRB Barcelona, has been published in the journal Cell Reports. (2020-08-05)

Study suggests new approach to improve radiation therapy resistance in glioblastoma
Laboratory research paves the way for a clinical trial to see if an FDA-approved drug used to prevent organ transplant rejection can work against glioblastoma, an aggressive type of brain tumor. (2020-07-30)

New drug targets for lethal brain cancer discovered
More than 200 genes with novel and known roles in glioblastoma - the most aggressive type of brain cancer - offer promising new drug targets. Researchers from the Sanger Institute and their collaborators engineered a new mouse model to show for the first time how a mutation in the well-known cancer gene, EGFR initiates glioblastoma, and works with a selection from more than 200 other genes to drive the cancer. (2020-07-29)

New study: Brain tumors may be seeded from distant site
A mouse model of glioblastoma, an aggressive type of cancer that can occur in the brain, suggests that this recalcitrant cancer originates from a pool of stem cells that can be a significant distance away from the resulting tumors. The findings of a new study, led by Children's National Hospital researchers and published July 22 in the journal Nature Communications, suggest new ways to fight this deadly disease. (2020-07-22)

MU advances chemotherapy-free treatment for cancer in animals and humans
Osteosarcoma, a common bone cancer in dogs, affects more than 10,000 dogs in the US each year. While chemotherapy is generally effective at killing some of the cancer cells, the numerous side effects can be painful and often a subset of cancer cells exist that are resistant to chemotherapy. (2020-07-17)

Reprogramming of immune cells enhances effects of radiotherapy in preclinical models of brain cancer
A Ludwig Cancer Research study has dissected how radiotherapy alters the behavior of immune cells known as macrophages found in glioblastoma (GBM) tumors and shown how these cells might be reprogrammed with an existing drug to suppress the invariable recurrence of the aggressive brain cancer (2020-07-15)

Scientists ID gene responsible for deadly glioblastoma
The discovery of the oncogene responsible for glioblastoma could be the brain cancer's Achilles' heel, one researcher says. (2020-07-14)

Unexpected associations found between drug response and cell changes in brain cancer
Therapies for treating glioblastoma brain cancer can be delivered with greater precision and existing drugs can be used in new ways. These are the conclusions from a study from Uppsala University investigating a large number of cell samples from patients with brain tumours. The researchers have characterised how changes in glioblastoma cells influence the effect of different drugs. Their findings are published in the journal Cell Reports. (2020-07-14)

New PET radiotracer proven safe and effective in imaging malignant brain tumors
A first-in-human study presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Annual Meeting has demonstrated the safety, favorable pharmacokinetic and dosimetry profile of 64Cu-EBRGD, a new, relatively long-lived PET tracer, in patients with glioblastomas. The radiotracer proved to be a superior, high-contrast imaging diagnostic in patients, visualizing tumors that express low or moderate levels of αvβ3 integrin with high sensitivity. (2020-07-13)

Breakthrough with cancer vaccine
Scientists have developed a new cancer vaccine with the potential to activate the body's immune system to fight a range of cancers, including leukaemia, breast cancer, lung cancer and pancreatic cancers. (2020-07-09)

Deconstructing glioblastoma complexity reveals its pattern of development
Brain cancers have long been thought of as being resistant to treatments because of the presence of multiple types of cancer cells within each tumor. A new study uncovers a cancer cell hierarchy that originates from a single cancer cell type, which can be targeted to slow cancer growth. (2020-07-08)

Focused ultrasound shows promise against deadliest brain tumor
Focused sound waves create tiny bubbles inside cancer cells, causing them to die. (2020-06-22)

New method to identify genes that can drive development of brain tumors
Researchers at Uppsala University have developed a method for identifying functional mutations and their effect on genes relevant to the development of glioblastoma. The results show that a specific, evolutionarily conserved, mutation in the vicinity of SEMA3C disrupts the binding of certain proteins whose task is to bind genes and regulate their activity. (2020-06-09)

Tulane scientists find a switch to flip and turn off breast cancer growth and metastasis
Researchers at Tulane University School of Medicine identified a gene that causes an aggressive form of breast cancer to rapidly grow. More importantly, they have also discovered a way to ''turn it off'' and inhibit cancer from occurring. The animal study results have been so compelling that the team is now working on FDA approval to begin clinical trials and has published details in the journal Scientific Reports. (2020-06-02)

How preserve the properties of polyphenols and flavonoids in oncological treatments?
A new technique preserves the anti-carcinogenic properties of polyphenols and flavonoids in oncological treatments. The research opens the door to developing more natural drugs that are less toxic for patients with cancer. The results of this study led by researchers from the URV have been published in the journal Scientific Reports. (2020-05-27)

Treatment shows promise in treating deadly brain cancer
In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumor. They also looked at the safety of CD133-targeting therapies on normal, non-cancerous human stem cells including hematopoietic stem cells which create blood cells and progenitor cells which can form one or more kinds of cells. (2020-05-27)

Anti-malarial drug shows promise for brain cancer treatment
Glioblastoma multiforme (GBM) is an aggressive form of cancer in the brain that is typically fatal. But new findings by VCU Massey Cancer Center and VCU Institute of Molecular Medicine (VIMM) researchers could help increase the effectiveness of the most common current treatments with the addition of lumefantrine, an FDA-approved drug used to treat malaria. (2020-05-26)

Genome-wide pattern found in tumors from brain cancer patients predicts life expectancy
For the past 70 years, the best indicator of life expectancy for a patient with glioblastoma -- the most common and the most aggressive brain cancer -- has been age at diagnosis. Now, an international team of scientists has experimentally validated a predictor that is not only more accurate but also more clinically relevant: a pattern of co-occurring changes in DNA abundance levels, or copy numbers, at hundreds of thousands of sites across the whole tumor genome. (2020-05-15)

University of Minnesota researchers study radiation resistance in brain cancer cells
In a vertical climb to avoid collision with a towering mountain, a plane ejects cargo to gain altitude. Investigators at the University of Minnesota showed that cancer cells perform similar feats in escaping the killing effects of radiation. (2020-05-14)

Researchers develop 'piggyback' method to improve drug delivery of RNA therapeutics
A group of researchers from University of Toronto Engineering and SickKids Hospital have developed a new way to deliver molecules that target specific genes within cells. Their platform has been shown to down-regulate critical genes in cancer cells, and could be used for other genetic diseases as well. (2020-05-01)

Schizophrenia drug combined with radiation shows promise in treating deadly brain tumors
UCLA researchers found adding a drug once commonly used to treat schizophrenia to traditional radiation therapy helped improve overall survival in mice with glioblastoma. (2020-05-01)

CBD shows promise for fighting aggressive brain cancer
Findings from a new study examining human and canine brain cancer cells suggest that cannabidiol, or CBD, could be a useful therapy for a difficult-to-treat brain cancer. (2020-04-27)

Boosting the immune system's appetite for cancer
A combination of immunotherapy agents that encourages some immune cells to eat cancer cells and alert others to attack tumors put mice with a deadly type of brain cancer called glioblastoma into long-term remission. (2020-04-23)

Potential therapy for rare neurologic disease
A targeted therapy, currently being studied for treatment of certain cancers including glioblastoma, may also be beneficial in treating other neurologic diseases, a study at the University of Cincinnati shows. (2020-04-06)

Oncotarget Targeting PI3Kβ alone and in combination with chemotherapy or immunotherapy
The cover for issue 11 of Oncotarget features Figure 6, 'Effects of AZD8186 in combination with anti-PD1 on syngeneic models,' by Owusu-Brackett, et al. In vitro cell viability assay and immunoblotting demonstrated that PTEN loss was significantly correlated with AZD8186 sensitivity in triple-negative breast cancer cell lines. (2020-03-18)

New imaging technique enables the study of 3D printed brain tumors
In research published in Science Advances, Xavier Intes, a professor of biomedical engineering at Rensselaer, joined a multidisciplinary team from Northeastern University and the Icahn School of Medicine at Mount Sinai to demonstrate a methodology that combines the bioprinting and imaging of glioblastoma cells in a cost-effective way that more closely models what happens inside the human body. (2020-03-06)

Engineered bone marrow cells slow growth of prostate and pancreatic cancer cells
In experiments with mice, researchers at the Johns Hopkins Kimmel Cancer Center say they have slowed the growth of transplanted human prostate and pancreatic cancer cells by introducing bone marrow cells with a specific gene deletion to induce a novel immune response. (2020-03-05)

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