Current Heparin News and Events

Current Heparin News and Events, Heparin News Articles.
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Results of an individual patient data pooled analysis reported at RCT Connect
An individual patient data pooled analysis comparing the use of bivalirudin versus heparin in heart attack patients undergoing percutaneous coronary intervention (PCI) found that bivalirudin use was associated with similar overall rates of 30-day mortality across all heart attack patients, but lower rates of serious bleeding events. Moreover, mortality was reduced in patients with ST-segment elevation myocardial infarction (STEMI) who were treated with a post-PCI bivalirudin infusion. (2020-10-14)

New mouse model of tau propagation
Accumulation of assembled tau protein in the central nervous system is characteristic of Alzheimer's disease and several other neurodegenerative diseases, called tauopathies. Researchers at Tokyo Metropolitan Institute of Medical Science (TMIMS) established a new mouse model of tau accumulation and propagation in brain. Single intracerebral injection of synthetic tau filaments induced by dextran sulphate into wild-type mice caused seeding of endogenous tau, followed by spreading to distinct areas in a time-dependent manner. (2020-09-23)

COVID-19 virus uses heparan sulfate to get inside cells
UC San Diego researchers discovered that the SARS-CoV-2 virus can't grab hold of cell receptor ACE2 without a carbohydrate called heparan sulfate, which is also found on lung cell surfaces -- disrupting that interaction with a repurposed drug may help treat COVID-19. (2020-09-15)

Excessive lung release of neutrophil DNA traps may explain severe complications in Covid-19 patients
Researchers from the University of Liège (Belgium) has detected significant amounts of DNA traps in distinct compartments of the lungs of patients who died from Covid-19. These traps, called NETs, are released massively into the airways, the lung tissue and the blood vessels. Such excessive release could be a major contributor to severe disease complications leading to in-hospital death. These results are published this week in the Journal of Experimental Medicine. (2020-09-14)

New hydrogels for T-cell growth to be used in cancer immunotherapy
A team with the participation of researchers from the Spanish National Research Council (CSIC) has designed new hydrogels that allow the culture of T-cells or T-lymphocytes, cells of the immune system that are used in cancer immunotherapy since they have the capacity to destroy tumor cells. These hydrogels can mimic lymph nodes, where T-cells reproduce and, therefore, provide high rates of cell proliferation. (2020-08-31)

Additional data on blood thinner efficacy for COVID-19 and insight on best possible regimens
Mount Sinai study is the basis of a new international clinical trial. (2020-08-26)

In cell studies, seaweed extract outperforms remdesivir in blocking COVID-19 virus
In a test of antiviral effectiveness against the virus that causes COVID-19, an extract from edible seaweeds substantially outperformed remdesivir, the current standard antiviral used to combat the disease. (2020-07-24)

Peer mentorship can be more effective, accessible than traditional mentorship in academic medicine
Peer mentorship is a critical and more accessible option for professional and personal growth than traditional mentor-mentee relationships, according to a new paper from the University of Colorado Anschutz Medical Campus. (2020-07-23)

Common FDA-approved drug may effectively neutralize virus that causes COVID-19
A common drug, already approved by the Food and Drug Administration (FDA), may also be a powerful tool in fighting COVID-19, according to research published this week in Antiviral Research. (2020-07-15)

Implants: Can special coatings reduce complications after implant surgery?
New coatings on implants could help make them more compatible. Researchers at the Martin Luther University Halle-Wittenberg (MLU) have developed a new method of applying anti-inflammatory substances to implants in order to inhibit undesirable inflammatory reactions in the body. Their study was recently published in the ''International Journal of Molecular Sciences''. (2020-06-30)

COVID-19 should be treated as a thrombotic disease, Brazilian pulmonologist argues
Dr. Elnara Negri, who works in São Paulo City at the largest hospital complex in Latin America, advocates the use of the anti-coagulant drug heparin to treat complications caused by novel coronavirus. (2020-05-25)

Lyin' eyes: Butterfly, moth eyespots may look the same, but likely evolved separately
The iconic eyespots that some moths and butterflies use to ward off predators likely evolved in distinct ways, providing insights into how these insects became so diverse. (2020-05-06)

Blood thinners may improve survival among hospitalized COVID-19 patients
Research could change standard of care protocols to prevent clotting associated with coronavirus. (2020-05-06)

UC San Diego researchers move closer to producing heparin in the lab
In a new study published in PNAS, UC San Diego researchers moved one step closer to the ability to make heparin in cultured cells. Heparin is a potent anti-coagulant and the most prescribed drug in hospitals, yet cell-culture-based production of heparin is currently not possible. Heparin is now produced by extracting the drug from pig intestines, which is a concern for safety, sustainability, and security reasons. (2020-04-10)

Rivaroxaban superior to heparin in preventing blood clots after common orthopedic surgeries
The direct oral anticoagulant rivaroxaban dramatically cut the likelihood of serious venous thromboembolism (VTE) in people recovering from lower limb orthopedic surgery requiring immobilization in comparison with enoxaparin, another anticoagulant agent, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)

Oral apixaban as good as dalteparin for treating cancer-associated clots
For people with cancer, the oral blood thinner apixaban is at least as effective as dalteparin, a low molecular weight heparin given by injection, in preventing a repeat venous thromboembolism (VTE), or blood clot, with no excess in major bleeding events, according to Phase 3 trial results presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)

Researchers invent method to unlock potential of widely used drug
The blood-thinning drug heparin is used all over the world. But, the underlying sugar structures of heparin and the wider family of heparan sulfate sugars in cells have not been fully mapped. Now, a research group headed by a recent recruit from the UK, Dr Rebecca Miller at the University of Copenhagen has invented a method to map this type of sugar structure in detail. This method has vast potential to reveal important biological functions and allow new drugs to be developed. (2020-03-20)

What interventional radiologists need to know about frostbite and amputation
An ahead-of-print article in the April issue of the American Journal of Roentgenology (AJR) reviewing various techniques and clinical management paradigms to treat severe frostbite injuries -- relevant for interventional radiology, especially--showed promising results using both intraarterial and intravenous tissue plasminogen activator to reduce amputation. AJR's meta-analysis of thrombolytic therapy updates the guidelines for all interventional radiologists, including a suggested protocol, inclusion and exclusion criteria, and potential complications. (2020-02-06)

Deciphering the sugar code
Like animals and humans, plants possess a kind of immune system. It can e.g. recognize pathogenic fungi by the chitin in their cell walls, triggering disease resistance. Some fungi hide from the immune system by modifying some of the chitin building blocks, converting chitin into chitosan. Researchers of the University of Münster now found that plants can react to a certain pattern in this chitosan, stimulating their immune system. (2020-01-24)

Oregon scientist shows possible path to improved bone-repair procedures
Researchers are closer to improved spinal fusion procedures and repairing broken or defective bones. In a preclinical study, researchers reduced undesired bone growth outside of targeted repair areas in rat femurs by delivering bone morphogenetic protein combined with a new biomaterial made from heparin. (2020-01-03)

Hitting HIT: Heparin therapy
Heparin is widely used as an anticoagulant, but evokes in some patients a potentially life-threatening condition called HIT. Clinical scientists at Ludwig-Maximilians-Universitaet (LMU) in Munich have now shown that inhibition of a single enzyme may markedly reduce this risk. (2019-12-20)

New spray gel could help take the bite out of frostbite
Mountaineers and winter sports enthusiasts know the dangers of frostbite -- the tissue damage that can occur when extremities, such as the nose, ears, fingers and toes, are exposed to very cold temperatures. However, it can be difficult to get treated quickly in remote, snowbound areas. Now, researchers reporting in ACS Biomaterials Science & Engineering have developed a convenient gel that could be sprayed onto frostbite injuries when they occur, helping wounds heal. (2019-12-11)

Sweet! How C. difficile toxin A enters intestinal cells
Clostridiodes difficile infection has become a leading cause of severe, sometimes fatal diarrheal illness, with the bacterium's toxins causing the damage. New work cements our knowledge of how C. diff's two primary toxins, A and B, slip into intestinal cells, the first step toward a possible treatment that doesn't involve antibiotics. This latest study, on toxin A, shows its activity can be blocked with molecules already being developed for various medical indications. (2019-06-03)

Side-by-side comparison on point of care tests for blood's ability to clot
During big procedures like open heart surgery, patients need anticoagulants to prevent dangerous blood clot formation and regular bedside monitoring to make sure the drugs aren't also causing problems like excessive bleeding. (2019-05-07)

Lack of standard dosage for blood thinners can lead to bleeding during bariatric surgery
Rutgers researchers have found a way to reduce bleeding in patients following bariatric surgery. (2019-01-09)

Mayo researchers say oral apixaban safe and effective for treating blood clots in cancer patients
Mayo Clinic researchers have found that an oral drug, apixaban, used to treat blood clots in patients undergoing cancer therapy, is safe and effective. The drug was associated with fewer major bleeding events and fewer recurrent blood clots, compared to low-molecular- weight heparin. Their findings were presented at the annual meeting of the American Society of Hematology by Robert McBane II M.D., a Mayo Clinic cardiologist. (2018-12-03)

New magnetically controlled thrombolytic successfully passed preclinical testing
New anti-thrombosis drug based on magnetite nanoparticles developed at ITMO University was successfully tested on animals. Preclinical studies showed drug's high efficacy and safety. Clot dissolution time of the new drug is 20 times shorter than the one of traditional medications. The range of permissible concentrations is very high, and the minimum dose of the active substance was a hundred times smaller than usual. The results are published in Applied Materials and Interfaces. (2018-11-08)

Aspirin alone a good clot buster after knee surgery
When it comes to preventing blood clots after a knee replacement, good old aspirin may be just as effective as newer, more expensive drugs, such as rivaroxaban (Xarelto), according to a University of Michigan orthopedics study. (2018-10-22)

Use of bivalirudin for anticoagulation in interventional cardiovascular procedures
In the current issue of Cardiovascular Innovations and Applications (Volume3, Number 2, 2018, pp. 149-162(14); DOI: 10.15212/CVIA.2017.0045 Zhen Ge, Jaya Chandrasekhar and Roxana Mehran from the Zena and Michael A. Wiener Cardiovascular Institute, Icahn School of Medicine at Mount Sinai, New York, N.Y., USA consider the use of bivalirudin for anticoagulation in interventional cardiovascular procedures. (2018-09-10)

URI chemistry professor develops contaminant detection technique for heparin
In 2008, a contaminant eluded the quality safeguards in the pharmaceutical industry and infiltrated a large portion of the supply of the popular blood thinner heparin, sickening hundreds and killing about 100 in the US. (2018-08-17)

Oral drug treatment helps protect cancer patients from potentially deadly blood clots
Research from the University of Warwick indicates that taking a tablet a day can help treat cancer patients of a potentially deadly condition. (2018-05-11)

Growth factor gradients in migration-permissive hydrogels for salivary gland assembly
At the 47th Annual Meeting of the American Association for Dental Research (AADR), held in conjunction with the 42nd Annual Meeting of the Canadian Association for Dental Research (CADR), Kelsea Marie Hubka, a Rice University graduate student and visiting student at University of Texas Health Science Center School of Dentistry, Houston, Texas, presented a poster titled 'Growth Factor Gradients in Migration-Permissive Hydrogels for Salivary Gland Assembly.' (2018-03-22)

Penn engineers test drug transfer using placenta-on-a-chip
Researchers at the University of Pennsylvania's School of Engineering and Applied Science have demonstrated the feasibility of their 'organ-on-a-chip' platform in studying how drugs are transported across the human placental barrier. (2018-02-16)

Protamine neutralizes CSPG-mediated inhibition of oligodendrocyte differentiation
The research group of researcher Akihiro Fujikawa and Professor Masaharu Noda of the National Institute for Basic Biology developed a screening method to obtain neutralizing agents for canceling the inhibitory effects of CSPGs on oligodendrocyte differentiation. The group found that the inhibitory activity of a representative extracellular matrix CSPG molecule, aggrecan, was neutralized by a polycationic peptide, protamine, that is clinically used to stop the anticoagulant effect of heparin. (2017-12-07)

Understanding a therapeutic paradox for treating thrombo-vascular complications in kidney disease
Researchers at Boston University School of Medicine (BUSM) have discovered a potential treatment target to prevent chronic kidney disease patients from developing blood clots without causing bleeding complications - an unwanted and perplexing side effect. They say the strategy offers a much-needed therapeutic alternative to standard-of-care heparin, which throws off the finely-tuned balance between pro-clotting and anticoagulant factors in blood vessels that work to keep fluid flowing while protecting against excessive bleeding after injuries. (2017-11-28)

Acute kidney failure with VTE proves difficult to treat
Researchers from the Walter Reed National Military Medical Center conducted a prospective, observational study to assess the impact that weight and renal function have on venous thromboembolism (VTE) rates among in-patients receiving prophylaxis with low-molecular-weight or unfractionated heparin. (2017-10-23)

Study shows modified blood thinner reduces the impact of traumatic brain injury in mice
A chemically modified version of the common blood thinner heparin may be the first promising method of preventing the harmful cascade of destruction to brain tissue that commonly follows traumatic brain injury (TBI), according to new research findings. (2017-09-13)

Synthetic version of popular anticoagulant poised for clinical trials
A synthetic version of low molecular weight heparin is poised for clinical trials and development as a drug for patients with clotting disorders, and those undergoing procedures such as kidney dialysis, heart bypass surgery, stent implantation, and knee and hip replacement. (2017-09-06)

Heparin stimulates food intake and body weight gain in mice
Research shows that heparin, which is well known for its role as an anticoagulant, can also promote food intake and body weight increase in animal models. (2017-09-05)

Apixaban lowers stroke risk in AF patients undergoing cardioversion (EMANATE)
Apixaban lowers the risk of stroke compared to warfarin in anticoagulation-naïve patients with atrial fibrillation scheduled for elective cardioversion, according to late-breaking results from the EMANATE trial presented today in a Hot Line LBCT Session at ESC Congress. Rates of bleeding were similar between the two groups. (2017-08-28)

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