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Current Immunotherapy News and Events

Current Immunotherapy News and Events, Immunotherapy News Articles.
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Immunotherapy for bowel cancer could change clinical practice
A large international trial involving UCL and University College London Hospitals NHS Foundation Trust (UCLH) has found that pembrolizumab, a form of immunotherapy, more than doubled the 'progression free survival' time of patients with a specific subtype of advanced bowel cancer, when compared with chemotherapy. (2020-05-29)
Study reveals factors influencing outcomes in kidney cancer treated with immunotherapy
By analyzing tumors from patients treated with immunotherapy for advanced kidney cancer in three clinical trials, Dana-Farber Cancer Institute scientists have identified several features of the tumors that influence their response to immune checkpoint inhibitor drugs. (2020-05-29)
Mapping immune cells in brain tumors
It is not always possible to completely remove malignant brain tumors by surgery so that further treatment is necessary. (2020-05-28)
New drug combinations help overcome resistance to immunotherapy
A new study from researchers at the UCLA Jonsson Comprehensive Cancer Center helps explain how disruptions in genes can lead to the resistance to one of the leading immunotherapies, PD-1 blockade, and how new drug combinations could help overcome resistance to the anti-PD-1 therapy in a mechanistically-based way. (2020-05-28)
Immunotherapy improves survival in patients with advanced bladder cancer
An immunotherapy drug called 'avelumab' has been shown to significantly improve survival in patients with the most common type of bladder cancer, according to results from a phase III clinical trial led by Queen Mary University of London and Barts Cancer Centre, UK. (2020-05-28)
New cancer immunotherapy targeting myeloid cells slows tumor growth
Checkpoint inhibitors, a type of immunotherapy, that target myeloid immune cells and slow tumor growth were discovered by a team from the Perelman School of Medicine at the University of Pennsylvania and other institutions. (2020-05-27)
Treatment shows promise in treating deadly brain cancer
In this study, researchers investigated if specific targeting of CD133+ glioblastoma with cutting-edge immunotherapy drugs could eradicate the most aggressive subpopulation of cells in the tumor. (2020-05-27)
Fine-tuning treatment for triple-negative breast cancer
Researchers at the University of Queensland may have found a way to improve treatment of triple-negative breast cancer. (2020-05-26)
PD-1/PD-L1 inhibitors treatment in lung cancer: Brightness and challenge
Immune-checkpoint inhibitors (ICIs) have made a significant impact on the outcomes of lung cancer patients. (2020-05-18)
Scientists identify promising immunotherapy combination for pediatric brain cancer
Scientists at Sanford Burnham Prebys have discovered that combining immunotherapy with a drug called tumor necrosis factor (TNF) eradicated a deadly type of pediatric brain tumor in mice. (2020-05-18)
Moffitt Cancer Center study suggests more could benefit from CAR T-cell therapy
Moffitt Cancer Center organized a consortium of 16 cancer treatment facilities across the US that offer Yescarta as a standard-of-care therapy for patients with relapsed/refractory large B cell lymphoma. (2020-05-14)
Immunoscore guided cold tumors acquire temperature through integrating methods
In this review article the authors Jing Liu, Mengze Xu and Zhen Yuan from University of Macau, Macau SAR, China consider immunotherapy for the treatment of tumors. (2020-05-12)
Researchers ID target for colorectal cancer immunotherapy
Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have identified a target for colorectal cancer immunotherapy. (2020-05-11)
A new plant-based system for the mass production of allergens for immunotherapy
Researchers from the University of Tsukuba developed a novel system for the mass production of allergens. (2020-05-10)
Clinically-applicable math model predicts patient outcomes to cancer immunotherapy
A group of our cancer and mathematics researchers at Houston Methodist have developed a clinically-applicable mathematical model to predict patient outcomes to cancer immunotherapy. (2020-04-30)
Study shows immunotherapy prior to surgery may help destroy high-risk breast cancer
A new study led by Yale Cancer Center (YCC) researchers shows women with high-risk HER2-negative breast cancer treated before surgery with immunotherapy, plus a PARP inhibitor with chemotherapy, have a higher rate of complete eradication of cancer from the breast and lymph nodes compared to chemotherapy alone. (2020-04-28)
Immunotherapy before surgery could advance care of an aggressive form of skin cancer
In what is believed to be a first-of-its-kind study to evaluate the safety of a type of immunotherapy before surgery in patients with an aggressive form of skin cancer, researchers report that the treatment eliminated pathologic evidence of cancer in nearly half of the study participants undergoing surgery. (2020-04-27)
SU2C-funded research to be presented during the AACR Virtual Meeting -- April 27-28, 2020
Stand Up To Cancer®-supported research will be presented will be presented during the American Association for Cancer Research Annual (AACR) Virtual Meeting 1. (2020-04-27)
A promising new treatment for recurrent pediatric brain cancer
Researchers developed a novel approach that delivers appropriately-targeted chimeric antigen receptor (CAR) T cell therapy directly into the cerebrospinal fluid that surrounds recurrent pediatric brain tumors. (2020-04-27)
A new therapeutic target turns the immune system against lymphoma
EPFL scientists have identified a key mechanism that tumor cells use to take advantage of and avoid detection from the immune system. (2020-04-23)
Pancreatic cancer cells hijack basic cell mechanism to evade immunotherapy
Pancreatic cancer cells use a normal waste removal process to hide tags on their surfaces that would otherwise let the immune system destroy them, a new study finds. (2020-04-22)
Scientists explore using 'own' immune cells to target infectious diseases including COVID-19
The engineering of specific virus-targeting receptors onto a patient's own immune cells is now being explored by scientists from Duke-NUS Medical School, as a potential therapy for controlling infectious diseases, including the COVID-19-causing virus, SARS-CoV-2. (2020-04-21)
Comprehensive tumour immunity map opens up immunotherapy to more patients
Scientists have developed a new way to map the molecules on tumour cells that flag their presence to the immune system, according to a study published today in eLife. (2020-04-21)
Study reveals how 'hypermutated' malignant brain tumors escape chemotherapy and immunotherapy
An analysis of more than 10,000 gliomas and clinical outcomes reported in Nature by scientists in Boston and Paris found that glioma patients whose tumors were hypermutated actually had no significant benefit when treated with checkpoint blockers. (2020-04-15)
Moffitt researchers identify molecular pathway that controls immunosuppression in tumors
In a new article published in the journal Immunity, Moffitt Cancer Center researchers reveas how protein-signaling pathways associated with cellular stress processes turn myeloid cells into tumor-promoting players. (2020-04-14)
Turning cold tumors hot: Drug delivery system makes immunotherapy more effective
A new drug delivery system from PME researchers turns 'cold' tumors hot, letting the body's immune system attack hard-to-treat cancers. (2020-04-14)
Missing BAP1 gene associated with immunosuppressive molecules in uveal melanoma
New study from researchers in Finland and the United Kingdom reveals that tumors lacking a protein called BAP1 have an ineffective immune reaction against cancer, thus rendering immunotherapies ineffectual, particularly in uveal melanomas (UM). (2020-04-09)
Immunotherapy treatment after chemotherapy significantly slows metastatic bladder cancer
Using immunotherapy immediately after chemotherapy treatment in patients with metastatic bladder cancer significantly slowed the progression of the cancer, according to results of a clinical trial led by Mount Sinai researchers published in the Journal of Clinical Oncology in April, 2020. (2020-04-09)
Immunotherapy prior to surgery is effective in colon cancer
Patients with colon cancer, but no distant metastases, can benefit from a short course of immunotherapy while waiting for their surgery, as it can cause tumours to shrink substantially or clear up in a very short time. (2020-04-06)
Immunotherapy effective in metastatic prostate cancers with specific markers of immune activation
A subset of patients with metastatic prostate cancer and specific markers of immune activity responded well to treatment with immune checkpoint inhibitors, according to results of a Phase II trial. (2020-04-01)
Researchers discover potential boost to immunotherapy
Mount Sinai researchers have discovered a pathway that regulates special immune system cells in lung cancer tumors, suppressing them and allowing tumors to grow. (2020-03-30)
New type of immunotherapy hinders the spread of ovarian cancer
Malignant ovarian cancer is insidious: Known and feared for vague and uncharacteristic symptoms that often mean the disease is discovered so late that on average only four out of six patients are still alive after five years. (2020-03-26)
CAR T-cell therapy for solid tumors may advance cancer treatments
The full title of the research is 'The study of the mechanisms of effectiveness of T-cells CAR-T towards solid tumors'; it was supported by nonprofit RakFond (Cancer Fund) and CyStoreLab (a resident of Skolkovo). (2020-03-25)
Immunotherapy using 'young cells' offers promising option against cancer
A new study from Washington University School of Medicine in St. (2020-03-23)
Cancer: The immune system attacks tumors remotely
How does the immune system act to limit tumor development? (2020-03-12)
Arming the body's immune cells
Researchers at UC have discovered a previously unknown mechanism that could explain the reason behind decreased immune function in cancer patients and could be a new therapeutic target for immunotherapy for those with head and neck cancers. (2020-03-10)
Gut bacteria can penetrate tumors and aid cancer therapy, study suggests
Researchers at the University of Texas Southwestern Medical Center and University of Chicago have discovered that bacteria that usually live in the gut can accumulate in tumors and improve the effectiveness of immunotherapy in mice. (2020-03-06)
Could cancer immunotherapy success depend on gut bacteria?
Gut bacteria can penetrate tumor cells and boost the effectiveness of an experimental immunotherapy that targets the CD47 protein. (2020-03-06)
Severe peanut allergy may be a 'gut reaction'
A new study of 19 people who suffer from peanut allergy found an abundance of allergy-causing immunoglobulin E (IgE) antibodies in the gut, providing valuable insights into the mechanisms of severe allergies to peanuts and other foods, which together affect as much as 6% of the US population. (2020-03-05)
Study suggests blocking immune T-cell regulator may help eliminate tumours
Immune system T-cells are more able to destroy skin cancer cells when a T-cell regulator called SLAMF6 is missing, a new study in eLife shows. (2020-03-03)
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