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Current Immunotherapy News and Events

Current Immunotherapy News and Events, Immunotherapy News Articles.
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Favorable five-year survival reported for patients with advanced cancer treated with the immunotherapy
A research team led by experts at the Bloomberg~Kimmel Institute for Cancer Immunotherapy at the Johns Hopkins Kimmel Cancer Center reports favorable five-year survival rates from the first multidose clinical trial of the immunotherapy drug nivolumab (anti-PD-1) as a treatment for patients whose previous therapies failed to stem their advanced melanoma, renal cell carcinoma (RCC) or non-small-cell lung cancer (NSCLC). (2019-07-25)
Immune therapy takes a 'BiTE' out of brain cancer
Massachusetts General Hospital investigators have created a new method that could make immune therapy more effective again brain tumors and expand its use against other types of solid tumors. (2019-07-24)
Targeted therapy erdafitinib effective for patients with advanced bladder cancer and specific gene mutations
A Phase II clinical trial led by MD Anderson found that treatment with the FGFR inhibitor erdafitinib was effective in 40% of patients with metastatic bladder cancers marked by FGFR3 mutations. (2019-07-24)
Expanding the limits of personalized medicine with high-performance computing
Imagine that you have a serious medical condition. Then imagine that when you visit a team of doctors, they could build an identical virtual 'twin' of the condition and simulate millions of ways to treat it until they develop an effective treatment. (2019-07-24)
New technique helps create more personalized therapies for people with advanced cancers
Using an ultra-sensitive and high-throughput isolation technology, UCLA researchers were able to characterize and identify the neoantigens driving the antitumor responses in a patient. (2019-07-22)
Scientists develop promising drug for treating ovarian, pancreatic cancers
Cancer scientists at Houston Methodist have been looking for more effective late-stage treatments for ovarian and pancreatic cancers and may have found one. (2019-07-22)
New research identifies gene that hides cancer cells from immunotherapy
A team at Fred Hutchinson Cancer Research Center has identified a gene that could make immunotherapy treatments, specifically checkpoint inhibitors, work for a wider variety of cancer patients. (2019-07-18)
Discovery shows how difficult-to-treat prostate cancer evades immune system
Researchers at The University of Texas MD Anderson Cancer Center have discovered how an aggressive form of prostate cancer called double-negative prostate cancer (DNPC) metastasizes by evading the the immune system. (2019-07-18)
A genomic barcode tracker for immune cells
A new research method to pinpoint the immune cells that recognise cancer could significantly change how we treat the disease. (2019-07-16)
Australian bee sting vaccine trial holds promise against allergic reactions
Most people have probably been stung by a bee and while it can be painful, it's especially dangerous for those at risk of suffering a life threatening allergic reaction. (2019-07-16)
New biomarker-guided strategy has potential for liver cancer treatment
A study at The University of Texas MD Anderson Cancer Center discovered a cellular pathway tied to cancer that may be beneficial in reducing side effects and extending duration of immunotherapy in some patients with hepatocellular carcinoma, the most common form of liver cancer. (2019-07-15)
Tightening the tumor-targeting abilities of checkpoint blockade immunotherapy
Seeking to improve upon existing checkpoint inhibitor therapies, scientists have developed a common checkpoint inhibitor (anti-PD-L1) in a nanoparticle formulation, which were activated specifically at tumor sites in mouse models of cancer. (2019-07-12)
Elegant antibody nanoparticles override immunological tolerance of tumors
Scientists from the Shanghai Institute of Materia Medica (SIMM) of the Chinese Academy of Sciences have developed a tumor enzymatic microenvironment-activatable antibody nanoparticle for robust cancer immunotherapy. (2019-07-12)
Adding immunotherapy after initial treatment can benefit metastatic lung cancer patients
Treating metastatic non-small cell lung cancer (NSCLC) patients with the immunotherapy drug pembrolizumab after they've completed locally ablative therapy almost tripled the median progression-free survival (PFS) compared to the historical average. (2019-07-11)
Immunotherapy could work against bowel cancers resistant to important targeted treatment
Patients with bowel cancer who have stopped responding to a widely used targeted drug could benefit from immunotherapy, a major new study reveals. (2019-07-08)
Immune-boosting compound makes immunotherapy effective against pancreatic cancer
Researchers at Washington University School of Medicine in St. Louis and Rush University in Chicago have found a compound that promotes a vigorous immune assault on pancreatic cancer. (2019-07-03)
Reprogramming pancreatic cancer
A type of white blood cell that has been especially susceptible to being deceived by pancreatic cancer cells into not attacking them can be 're-programmed' via a specially designed molecule that activates a protein found on their surfaces. (2019-07-03)
Reversing t cells' misunderstood rep in responding to a pediatric leukemia
A study of pediatric patients with leukemia demonstrates that they were able to generate T cells against tumor-associated mutations, contradicting previous assumptions that T cells cannot be effectively unleashed on pediatric tumors. (2019-06-26)
Immunotherapy and HDAC inhibition are anti-cancer besties
Colorado study shows that adding HDAC inhibitor sensitized cancers to anti-PD1 therapy. (2019-06-24)
Signature of an ineffective immune response to cancer revealed
Our immune system is programmed to destroy cancer cells. Sometimes it has trouble slowing disease progression because it doesn't act quickly or strongly enough. (2019-06-20)
Redundancies in T cells
Researchers at ETH Zurich have discovered redundancies in the biochemical signalling pathways of immune cells. (2019-06-18)
Novel agent reactivates an immune call by LIF blockade
Promising new therapy with a dual mechanism of action to eliminate cancer stem cells and activate the immune system now in clinical development. (2019-06-11)
Study drug delays type 1 diabetes in high risk children and adults
A drug that targets the immune system can delay the onset of type 1 diabetes an average of two years in children and adults at high risk, according to findings from TrialNet's Teplizumab (anti-CD3) Prevention Study published in the New England Journal of Medicine. (2019-06-10)
Molecular chatter makes for a 'hot tumor'
A Ludwig Cancer Research study has deciphered a complex molecular conversation between cancer and immune cells that is key to orchestrating the successful invasion of tumors by T cells that kill cancer cells. (2019-06-10)
Three-drug combination helps curb the growth of deadly type of skin cancer
A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma. (2019-06-06)
Combination checkpoint blockade effective in pre-surgical setting for early-stage lung cancers
Neoadjuvant, or pre-surgical, treatment with nivolumab plus ipilimumab resulted in an overall major pathologic response (MPR) rate of 33 percent of treated patients with early-stage, resectable non-small cell lung cancers, meaning these patients had less than or equal to 10 percent viable tumor remaining at surgery. (2019-06-03)
UT Southwestern develops test to predict immunotherapy response in kidney cancer
A novel imaging test shows promise for identifying kidney cancer patients most likely to benefit from immunotherapy. (2019-06-03)
Immunotherapy drug found safe in treating cancer patients with HIV
The results of a study led by physicians at Fred Hutchinson Cancer Research Center showed that patients living with HIV and one of a variety of potentially deadly cancers could be safely treated with the immunotherapy drug pembrolizumab, also known by its brand name, KEYTRUDA. (2019-06-03)
Immunotherapy better than aggressive chemo as first-line treatment in head and neck cancer
Immunotherapy used with chemotherapy or on its own is a better first-line treatment for people with head and neck cancer that has returned than standard aggressive chemotherapy, new clinical trial results show. (2019-06-03)
Discovery may lead to natural ent-kaurane diterpenoid for NK-based tumor immunotherapy
Research groups led by Prof. LI Yan and Prof. Puno Pematenzin from the Kunming Institute of Botany of the Chinese Academy of Sciences found that ent-kaurane diterpenoids, which show a wide range of bioactivity, especially antitumor activity, are good candidates as sensitizer agents for NK cells. (2019-05-30)
Stand up to cancer-funded research to be presented at ASCO May 31-June 4 in Chicago
SU2C supported researchers will present work on pediatric brain tumors, cfDNA for early cancer detection, dual blockade of CTLA-4 and PD-1 in mCRC, cancer interception of pancreatic and lung cancers, machine learning RECIST in RWE study of lung cancer, and molecular markers of response to neoadjuvant nivolumab in resectable NSCLC. (2019-05-30)
De-TOXing exhausted T cells may bolster CAR T immunotherapy against solid tumors
A decade ago researchers announced development of a cancer immunotherapy called CAR (for chimeric antigen receptor)-T, in which a patient is re-infused with their own genetically modified T cells equipped to mount a potent anti-tumor attack. (2019-05-27)
Skin patch shows promise for children with milk-induced eosinophilic esophagitis
A new study from Children's Hospital of Philadelphia finds that a skin patch may be useful in treating children with a painful, chronic condition called eosinophilic esophagitis (EoE) triggered by milk. (2019-05-22)
New investigational therapy shows promise for asthma patients in Phase 2 trial
In a Phase 2 trial, RTB101, which belongs to a class of drugs known as TORC1 inhibitors, was observed to be well tolerated and to reduce the incidence of respiratory tract infections in adults age 65 and older when given once daily for 16 weeks during winter cold and flu season. (2019-05-20)
Tumor mutations may predict response to immunotherapy
Center say they have found a potential explanation for the failures. (2019-05-07)
Prostate cancer patients with gene mutation at three times the risk of dying
Scientists have identified a gene mutation in the tumours of men with prostate cancer that is linked to very poor survival -- and which could be used to pick out patients for more intensive treatment. (2019-05-06)
Pretreatment with TNF inhibitors may improve outcomes of combination cancer immunotherapy
This study proposes a new therapeutic approach against cancer that dissociates efficacy and toxicity in the use of combined immunotherapy in animal models. (2019-05-02)
Biomarker may predict if immunotherapy is right choice for colorectal cancer patients
Foundational research could help metastatic colorectal cancer patients decide whether to choose immunotherapy or chemotherapy as a first treatment option. (2019-05-02)
Mutational intensity influences a tumor's response to PD-1 immunotherapy
Following FDA approval last year of PD-1 immune checkpoint inhibitors for tumors with mismatch repair deficiency, a new study reveals more about why responses of these tumors to this immunotherapy vary, specifically implicating mutation intensity. (2019-05-02)
Researchers find new target to improve response to cancer immunotherapy
Researchers at the University of Michigan Rogel Cancer Center looked at a little-understood type of cell death called ferroptosis. (2019-05-01)
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