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Current Leukemia News and Events

Current Leukemia News and Events, Leukemia News Articles.
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Scientists kill cancer cells by 'shutting the door' to the nucleus
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes--large channels that control the flow of materials in and out of the cell nucleus--shrank aggressive tumors in mice while leaving healthy cells unharmed. (2020-09-28)
New way to halt leukemia relapse shown promising in mice
Drugs tackling chronic myelogenous leukemia have completely transformed prognoses of patients over the last couple of decades, with most cases going into remission. (2020-09-18)
New study estimates nearly 90,000 cancer cases diagnosed in adolescents and young adults
A new report examining cancer in adolescents and young adults (AYAs), defined as diagnoses occurring during ages 15 to 39, provides updated estimates of the contemporary cancer burden in this age group, predicting that 89,500 cases and 9,270 deaths will occur in 2020 in the United States. (2020-09-17)
The Josep Carreras Institute identifies a marker of poor evolution in Hodgkin's lymphoma
Dr. Manel Esteller, director of the Josep Carreras Leukemia Research Institute, published today in Blood journal, the discovery of a marker that allows predicting which patient with Hodgkin's lymphoma will present the aggressive clinical course, and will therefore be a case of special risk. (2020-09-15)
Inherited genetic variant influences response to leukemia treatment for some children
St. Jude researchers showed that an inherited variant of the GATA3 gene is tied to minimal residual disease levels and response to therapy for acute lymphoblastic leukemia. (2020-09-11)
New insights into why people with down syndrome are at higher risk for leukemia
Scientists from Stanley Manne Children's Research Institute at Ann & Robert H. (2020-09-08)
Scientists develop first drug-like compounds to inhibit elusive cancer-linked enzymes
Structural biology techniques helped researchers target the nuclear receptor-binding SET domain family for the first time; its malfunction is associated with several types of cancer. (2020-08-31)
NUS research breakthrough: CircASXL1-1 regulates BAP1 deubiquitinase activity in leukemia
Researchers from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) have identified covalently closed circular RNAs (circRNAs) from key genes involved in leukemia development and provided greater understanding of their roles in haematological malignancies. (2020-08-13)
Combination therapy improves survival outcomes for patients with acute myeloid leukemia
A combination regimen of venetoclax and azacitidine was safe and improved overall survival (OS) over azacitidine alone in certain patients with acute myeloid leukemia (AML), according to the Phase III VIALE-A trial led by The University of Texas MD Anderson Cancer Center. (2020-08-12)
ASH releases new clinical practice guidelines on acute myeloid leukemia in older adults
Today, ASH published new guidelines to help older adults with acute myeloid leukemia (AML) and their health care providers make critical care decisions, including if and how to proceed with cancer treatment and the need for blood transfusions for those in hospice care. (2020-08-06)
New study may refine predicted survival outcomes and treatment in younger adults with acute leukemia
The findings of a new study led by researchers at The Ohio State University Comprehensive Cancer Center - Arthur G. (2020-08-05)
Huntsman Cancer Institute illuminates potential new treatment in acute myeloid leukemia
In a study published in the journal Leukemia, lead author Ami Patel, MD, Huntsman Cancer Institute researcher and assistant professor in the Division of Hematology and Hematologic Malignancies at the University of Utah, showed that factors produced by bone marrow support cells allowed leukemia cells to survive treatment with quizartinib, a type of TKI. (2020-07-31)
New model by CHOP researchers identifies noncoding mutations across five pediatric cancers
Researchers at Children's Hospital of Philadelphia (CHOP) have developed a new computational algorithm that has, for the first time, identified a spectrum of mutations in the noncoding portion of the human genome across five major pediatric cancers. (2020-07-24)
2 immunotherapies merged into single, more effective treatment
Researchers at Washington University School of Medicine in St. Louis have combined two immunotherapy strategies into a single therapy and found, in studies in human cells and in mice, that the two together are more effective than either alone in treating certain blood cancers, such as leukemia. (2020-07-23)
City of Hope scientists leverage interference between signaling pathways for cancer treatment
In order for cancer to form in the human body, normal cells must acquire multiple mutations before they develop toward the disease. (2020-07-22)
Leukemia drug shows the potential to treat aggressive pediatric brain câncer
When tested in vitro, arsenic trioxide killed tumor cells and prevented the formation of new colonies. (2020-07-21)
Sylvester researchers identify protein target that might ease graft versus host disease
Researchers at Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine publish findings on how inhibiting the STING protein pathway can help protect against a complication from stem cell transplants. (2020-07-15)
A rapid finger-stick blood test quickly estimates radiation exposure in mice
A new finger-stick test can use a single drop of blood to quickly estimate how much harmful radiation mice have been exposed to, according to a study. (2020-07-15)
Moffitt researchers find dual inhibitor may be safer for CLL patients
Moffitt Cancer Center researchers want to learn more about how PI3K inhibitor therapy works with the body's immune system to determine if there are ways to predict or mitigate associated adverse effects. (2020-07-14)
A new nanoconjugate blocks acute myeloid leukemia tumor cells without harming healthy ones
The nanoparticle targets only leukemic cells and therefore would reduce the severe adverse effects of current treatments. (2020-07-09)
St. Jude researchers create an analytic tool that opens a new frontier of cancer discovery
St. Jude Children's Research Hospital scientists have developed software to identify cancer-causing mutations lurking in vast regions of the human genome. (2020-07-06)
Identified the genetic landscape of myelodysplastic/myeloproliferative neoplasms
Researchers from the MDS Group of the Josep Carreras Leukaemia Research Institute and the Munich Leukemia Laboratory map the mutations that can ease and accelerate the diagnosis of Myelodysplastic/Myeloproliferative Neoplasms rare malignancies. (2020-07-01)
Blood cell mutations linked to leukemias are inevitable as we age
A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. (2020-06-24)
CAR T cell therapy: potential for considerable savings
Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer. (2020-06-23)
Oncotarget: RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation
The cover for issue 25 of Oncotarget features Figure 8, 'BI-D1870 in combination with vincristine increase metaphase arrest and apoptosis synergistically,' by Chae, et al. (2020-06-23)
Researchers attempt new treatment approach for blood cancer
In an effort to improve the survival of patients with myeloproliferative neoplasms, a type of leukemia, researchers inhibited a specific protein (alpha5beta1 integrin) to decrease the number of large bone marrow cells (megakaryocytes) in an experimental model. (2020-06-19)
Nanoparticle for overcoming leukemia treatment resistance
One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. (2020-06-18)
Call for caution for using a CAR-T immunotherapy against acute myeloid leukemia
Researchers from the Josep Carreras Leukaemia Research Institute prove that the preclinical implementation of Acute Myeloid Leukaemia immunotherapy, based on CD123-redirected CAR T-cells, affects hematopoiesis, blood cells production, and reconstitution. (2020-06-17)
Team led by Children's Hospital LA researcher generates developmental map of human T-cells
Chintan Parekh, MD, of the The Saban Research Institute of Children's Hospital Los Angeles, has led a team of investigators that generated a comprehensive roadmap for how T-cells develop in the human thymus. (2020-06-16)
The novel mechanisms for inflammation and cancer induced by HTLV-1
A Japanese research group has clarified the mechanism by which human T-cell leukemia virus type 1 (HTLV-1) causes inflammation and oncogenesis. (2020-06-16)
Cytokine implicated in HLH treatment resistance
Research sheds light on cytokine storm syndromes and how ruxolitinib may benefit patients with hemophagocytic lymphohistiocytosis. (2020-06-12)
Putting 'super' in natural killer cells
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells -- a type of immune cell -- with measurably stronger activity against a form of leukemia, both in vivo and in vitro. (2020-06-11)
For acute myeloid leukemia, genetic testing is often worth the wait
New tailored therapies offer exciting prospects for treating acute myeloid leukemia (AML), but taking advantage of them may require waiting a week or more for genetic testing before starting treatment, posing a dilemma for doctors and patients facing this deadly and often fast-moving disease. (2020-06-04)
Leukemia immune profiles predict drug resistance and benefits of immunotherapy
By analyzing 442 samples from three groups of children and adults with acute myeloid leukemia (AML), researchers have identified new immune classes of the disease that predict the likelihood of drug resistance and positive responses to immunotherapy. (2020-06-04)
Key gene in leukemia discovered
Acute myeloid leukemia (AML) is one of the most common forms of blood cancer among adults and is associated with a low survival rate, and leads to the inhibition of normal blood formation. (2020-06-03)
Discovery in human acute myeloid leukemia could provide novel pathway to new treatments
Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited. (2020-06-02)
Combination therapy well-tolerated and highly effective for patients with IDH1-mutated AML
A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center. (2020-05-28)
At the crossroads
In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (2020-05-20)
Assassin cells armed with anticancer drugs kill cancer masses
POSTECH Professor Won Jong Kim's team uses immunological synapse formation of natural killer cells to treat cancer. (2020-05-13)
More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. (2020-05-08)
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