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Current Leukemia News and Events

Current Leukemia News and Events, Leukemia News Articles.
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A new nanoconjugate blocks acute myeloid leukemia tumor cells without harming healthy ones
The nanoparticle targets only leukemic cells and therefore would reduce the severe adverse effects of current treatments. (2020-07-09)
St. Jude researchers create an analytic tool that opens a new frontier of cancer discovery
St. Jude Children's Research Hospital scientists have developed software to identify cancer-causing mutations lurking in vast regions of the human genome. (2020-07-06)
Identified the genetic landscape of myelodysplastic/myeloproliferative neoplasms
Researchers from the MDS Group of the Josep Carreras Leukaemia Research Institute and the Munich Leukemia Laboratory map the mutations that can ease and accelerate the diagnosis of Myelodysplastic/Myeloproliferative Neoplasms rare malignancies. (2020-07-01)
Blood cell mutations linked to leukemias are inevitable as we age
A new study by researchers at the RIKEN Center for Integrative Medical Science in Japan reports differences in blood cell mutations between Japanese and European populations. (2020-06-24)
CAR T cell therapy: potential for considerable savings
Chimeric antigen receptor (CAR) T cell therapy is a new and in some cases highly effective form of immunotherapy to treat certain types of cancer. (2020-06-23)
Oncotarget: RSK inhibitor BI-D1870 inhibits acute myeloid leukemia cell proliferation
The cover for issue 25 of Oncotarget features Figure 8, 'BI-D1870 in combination with vincristine increase metaphase arrest and apoptosis synergistically,' by Chae, et al. (2020-06-23)
Researchers attempt new treatment approach for blood cancer
In an effort to improve the survival of patients with myeloproliferative neoplasms, a type of leukemia, researchers inhibited a specific protein (alpha5beta1 integrin) to decrease the number of large bone marrow cells (megakaryocytes) in an experimental model. (2020-06-19)
Nanoparticle for overcoming leukemia treatment resistance
One of the largest problems with cancer treatment is the development of resistance to anticancer therapies. (2020-06-18)
Call for caution for using a CAR-T immunotherapy against acute myeloid leukemia
Researchers from the Josep Carreras Leukaemia Research Institute prove that the preclinical implementation of Acute Myeloid Leukaemia immunotherapy, based on CD123-redirected CAR T-cells, affects hematopoiesis, blood cells production, and reconstitution. (2020-06-17)
Team led by Children's Hospital LA researcher generates developmental map of human T-cells
Chintan Parekh, MD, of the The Saban Research Institute of Children's Hospital Los Angeles, has led a team of investigators that generated a comprehensive roadmap for how T-cells develop in the human thymus. (2020-06-16)
The novel mechanisms for inflammation and cancer induced by HTLV-1
A Japanese research group has clarified the mechanism by which human T-cell leukemia virus type 1 (HTLV-1) causes inflammation and oncogenesis. (2020-06-16)
Cytokine implicated in HLH treatment resistance
Research sheds light on cytokine storm syndromes and how ruxolitinib may benefit patients with hemophagocytic lymphohistiocytosis. (2020-06-12)
Putting 'super' in natural killer cells
Using induced pluripotent stem cells (iPSCs) and deleting a key gene, researchers at University of California San Diego School of Medicine have created natural killer cells -- a type of immune cell -- with measurably stronger activity against a form of leukemia, both in vivo and in vitro. (2020-06-11)
For acute myeloid leukemia, genetic testing is often worth the wait
New tailored therapies offer exciting prospects for treating acute myeloid leukemia (AML), but taking advantage of them may require waiting a week or more for genetic testing before starting treatment, posing a dilemma for doctors and patients facing this deadly and often fast-moving disease. (2020-06-04)
Leukemia immune profiles predict drug resistance and benefits of immunotherapy
By analyzing 442 samples from three groups of children and adults with acute myeloid leukemia (AML), researchers have identified new immune classes of the disease that predict the likelihood of drug resistance and positive responses to immunotherapy. (2020-06-04)
Key gene in leukemia discovered
Acute myeloid leukemia (AML) is one of the most common forms of blood cancer among adults and is associated with a low survival rate, and leads to the inhibition of normal blood formation. (2020-06-03)
Discovery in human acute myeloid leukemia could provide novel pathway to new treatments
Researchers at Mount Sinai have discovered that human acute myeloid leukemia (AML) stem cells are dependent on a transcription factor known as RUNX1, potentially providing a new therapeutic target to achieve lasting remissions or even cures for a disease in which medical advances have been limited. (2020-06-02)
Combination therapy well-tolerated and highly effective for patients with IDH1-mutated AML
A combination therapy of ivosenidib (IVO) plus venetoclax (VEN) with or without azacitidine (AZA) was found to be effective against a specific genetic subtype of acute myeloid leukemia (AML) in a Phase Ib/II trial led by researchers at The University of Texas MD Anderson Cancer Center. (2020-05-28)
At the crossroads
In the bone marrow, blood stem cells via precursor cells give rise to a variety of blood cell types with various functions: white blood cells, red blood cells, or blood platelets. (2020-05-20)
Assassin cells armed with anticancer drugs kill cancer masses
POSTECH Professor Won Jong Kim's team uses immunological synapse formation of natural killer cells to treat cancer. (2020-05-13)
More selective elimination of leukemia stem cells and blood stem cells
Hematopoietic stem cells from a healthy donor can help patients suffering from acute leukemia. (2020-05-08)
E1912 trial leads to FDA approval of ibrutinib-rituximab combo for untreated CLL
Patients aged 70 or younger with untreated chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma have a new treatment option -- a combination of the targeted agent ibrutinib with the immunologic agent rituximab. (2020-04-29)
Discovered the physiological mechanisms underlying the most common pediatric Leukemia
Researchers from the Josep Carreras Leukaemia Research Institute unveil the mechanisms that lead to hyperdiploid Acute Lymphoblastic Leukemia, Hyper D-ALL, the most common pediatric B-cell Leukaemia. (2020-04-23)
Finding leukemia's weakness using genome-wide CRISPR technology
Researchers at University of California San Diego School of Medicine and Moores Cancer Center used CRISPR technology to identify key regulators of aggressive chronic myeloid leukemia. (2020-04-20)
What's old is new again
Drug resistance is a major obstacle in cancer treatment--leading to relapse for many patients. (2020-04-20)
Impact of donor lymphocyte infusion and intensified conditioning for relapsed/refractory leukemia
Leukemia relapse is still a major problem that impedes the success of hematopoietic cell transplant (HCT). (2020-04-15)
Cancer mutation in dual role
Researchers show that an oncogenic mutation in leukemia cells also promotes inflammations in the body (2020-04-08)
Scientists modify CAR-T cells to target multiple sites on leukemia cells
In a preclinical study, scientists engineer new CAR-T cells to attack three sites on leukemia cells, instead of one. (2020-03-31)
Oncotarget Roscovitine enhances all-trans retinoic acid (ATRA)-induced nuclear enrichment
Oncotarget Volume 11, Issue 12 reported that using the HL-60 human non-APL AML model where ATRA causes nuclear enrichment of c-Raf that drives differentiation/G0-arrest, the research team now observe that roscovitine enhanced nuclear enrichment of certain traditionally cytoplasmic signaling molecules and enhanced differentiation and cell cycle arrest. (2020-03-26)
Engineers model mutations causing drug resistance
Whether it is a drug-resistant strain of bacteria, or cancer cells that no longer react to the drugs intended to kill them, diverse mutations make cells resistant to chemicals, and 'second generation' approaches are needed. (2020-03-24)
3D genetic structure in blood cancer important beyond DNA code changes
Children with aggressive blood cancers have differences -- not just in the DNA code of their blood cells -- but also in the heavily twisted protein superstructure that controls access to genes. (2020-03-23)
Oncotarget Quizartinib, a selective FLT3 inhibitor, maintains antileukemic activity
Oncotarget Volume 11, Issue 11 reported that in this preclinical study, we characterized the binding affinity and selectivity of quizartinib, a small-molecule inhibitor of FLT3, and AC886, the active metabolite of quizartinib, compared with those of other FLT3 inhibitors. (2020-03-20)
Oncotarget Acute promyelocytic leukemia (APL): a review of the literature
Oncotarget Volume 11, Issue 11 reported that relapsed APL, particularly in the high-risk subset of patients, remains an important clinical problem. (2020-03-20)
St. Jude finds cancer drug resistance genes and possibly how to limit their effects
Drug resistance is a leading cause of cancer death in children and adults with leukemia. (2020-03-09)
New genetic signatures in childhood leukemia create paths for precision medicine
Researchers with Nemours Children's Health System utilized Next Generation Sequencing (NGS) to more precisely identify genomic characteristics of leukemias in children, the most common childhood cancer. (2020-03-05)
Cancer survival rates improve for young adults
A new study in the Journal of the National Cancer Institute finds improvements in five-year survival rates for all cancers in young adults. (2020-03-03)
Five-year survival improves for certain cancers in adolescent and young adults
The five-year survival rate for adolescents and young adults with cancer has significantly improved from 1975 to 2005 in the United States overall, but this was not the case for all cancers, according to a report in the Journal of the National Cancer Institute. (2020-03-03)
Study reveals properties of cells fated to relapse in acute lymphoblastic leukemia
Researchers have found that genetically defined subpopulations of leukemia cells present at diagnosis have distinct characteristics that lead to relapse. (2020-03-03)
A randomized, double-blind trial of F14512, a polyamine-vectorized anticancer drug, compared...
The objective of this study was to compare the safety and antitumor activity of F14512 and etoposide phosphate in dogs with spontaneous non-Hodgkin lymphoma and to investigate the potential benefit of F14512 in P-glycoprotein overexpressing lymphomas. (2020-02-19)
Mutation's role in blood cancers revealed by ideal team-up
Researchers from CSHL and MSKCC have determined that a mutation affecting the important process of RNA splicing can manipulate the 'quality control' in your cell. (2020-01-31)
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