Current Liver disease News and Events

Current Liver disease News and Events, Liver disease News Articles.
Sort By: Most Relevant | Most Viewed
Page 1 of 25 | 1000 Results
Liver cancer ten times more likely in men with common genetic disorder haemochromatosis
Men who have the Western world's most common genetic disorder, haemochromatosis, are ten times more likely to develop liver cancer, according to a major new study. (2020-11-24)

Study: gut hormones' regulation of fat production abnormal in obesity, fatty liver disease
Gut hormones play an important role in regulating fat production in the body. One key hormone, released a few hours after eating, turns off fat production by regulating gene expression in the liver, but this regulation is abnormal in obesity, researchers at the University of Illinois Urbana-Champaign found in a new study. (2020-11-24)

Breakthrough in studying the enzyme that ultimately produces fish odour syndrome
Fish odour syndrome (trimethylaminuria) is a debilitating disease, in which the liver cannot break down the smelly chemical trimethylamine which is produced by enzymes from bacteria residing in the gut leaving people with a fish like odour. Researchers from the University of Warwick are paving the way to prevent the syndrome after a breakthrough in studying the enzyme in the gut which produces trimethylamine. (2020-11-23)

Antimicrobial soap additive worsens fatty liver disease in mice
Triclosan, an antimicrobial found in many soaps and other household items, worsens fatty liver disease in mice fed a high-fat diet. (2020-11-23)

A gene mutation that protects against disease
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer. (2020-11-19)

Maraxilibat reduces debilitating itching in children with Alagille syndrome
On behalf of Childhood Liver Disease Research Network (ChiLDReN), Texas Children's Hospital and Baylor College of Medicine researchers report that prolonged treatment with Maraxilibat resulted in clinically meaningful improvements in debilitating itching (pruritus) and related quality of life outcomes in children with Alagille syndrome. The novel pharmacological approach addresses a major unfulfilled therapeutic need to control severe and relentless itching in pediatric patients with Alagille syndrome. (2020-11-19)

Algae breathe life into 3D engineered tissues
3D bioprinted algae can be harnessed as a sustainable source of oxygen for human cells in engineered vascularized tissues, researchers report November 18 in the journal Matter. They embedded the bioprinted photosynthetic algae, along with human liver-derived cells, in a 3D hydrogel matrix to create honeycomb-shaped tissues with lobules, similar to the human liver. (2020-11-18)

Promising results from in vitro combination therapy against COVID-19
Researchers at Karolinska Institutet in Sweden report promising results from an in vitro combination therapy against COVID-19. In a study published in EMBO Molecular Medicine, the researchers show that a combination of remdesivir, an approved drug against COVID-19, and hrsACE2, a medicine currently in phase II trials for COVID-19 treatment, reduced the viral load of SARS-CoV-2 and inhibited viral replication in cell cultures and organoids. (2020-11-17)

Normothermic Machine Perfusion (NMP) in rat livers extended from 6 to 24 hours
In a paper published in TECHNOLOGY, a team of researchers from Massachusetts General Hospital (MGH) have demonstrated 24-hour rat liver viability in a normothermic machine perfusion (NMP) system. Rat liver perfusion is an efficient and cost-effective method to study how various pharmacologic agents impact liver parenchyma. (2020-11-17)

Liver condition identified in patients using urine samples: new research
Fifty fragments of proteins, termed peptides, have been identified in the urine of liver fibrosis patients in a new study that could pave the way for a potential diagnostic urine test for the condition if further validated. (2020-11-16)

Approved JAK inhibitor baricitinib shows promise against cytokine storm in COVID-19 clinical study
A clinical study involving 601 patients in Italy and Spain suggests that the JAK inhibitor drug baricitinib may enhance survival rates of patients (2020-11-13)

New source of lymphatic system leak discovered in children with rare open heart surgery complication
Interventional radiologists with Nemours Children's Health System have identified a new source of abnormal lymphatic flow between the liver and the lungs that may be responsible for some cases of plastic bronchitis. Plastic bronchitis is a rare but serious late complication in patients with congenital heart disease who had Fontan surgery. A report detailing the discovery of this fluid leak, and successful treatment of two cases was published in European Heart Journal. (2020-11-11)

Induced liver regeneration enhances CRISPR/Cas9-mediated gene repair
Use of thyroid hormone to boost hepatocyte proliferation enhanced the efficiency of CRISPR/Cas9-mediated gene correction in the mouse liver. This dietary induction of hepatocyte regeneration may be a viable clinical strategy to enhance gene repair in the liver. (2020-11-10)

Liver scarring relatively common among middle-aged adults
A substantial minority of participants from the Framingham Heart Study, (nearly nine percent), had potentially clinically significant liver fibrosis (scarring). This the first study of this size and scale done in the United States. (2020-11-09)

When malaria parasites trick liver cells to let themselves in
A new study led by Maria Manuel Mota, group leader at Instituto de Medicina Molecular, now shows that malaria parasites secrete the protein EXP2 that is required for their entry into hepatocytes. These findings, published today in the scientific journal Nature Communications, open a new avenue for prophylactic anti-malarial strategies, since blocking or decreasing the infection of the liver can prevent the disease. (2020-11-06)

Dietary supplement may help in the treatment of fatty liver
A recent study by researchers at the University of Jyväskylä was successful in partially preventing fatty liver disease in rats. Rats with fatty liver disease were fed with a dietary supplement that is known to increase the growth of good bacteria in the gut. Simultaneous with the increased abundance of the bacteria, the liver fat content decreased significantly. In addition, preliminary results from a human study seem promising. (2020-11-04)

Promising therapeutic approach against COPD
Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide. Until today, COPD is not curable. Researchers at Helmholtz Zentrum München and at the German Cancer Research Center (DKFZ) have now succeeded in curing COPD in mice exposed to chronic cigarette smoke. Their goal is to test the novel therapeutic approach in human clinical trials over the next few years. (2020-11-04)

Vitamin E from palm oil useful in boosting immune response based on studies on liver cells
Palm oil is an economical source of vitamin E, and several studies have shown the beneficial effects on the immune system, which include anti-oxidant and anti-cancer activity as well has cytoprotective actions. Researchers hope that these findings pave the way for easily available remedies for a variety of diseases. The current study is published in Current Pharmaceutical Biotechnology. (2020-11-03)

Eating less suppresses liver cancer due to fatty liver
Liver cancer from too much fat accumulation in the liver has been increasing in many countries including Japan. In order to change this unfortunate state of affairs, it is important to improve the prognosis of non-alcoholic fatty liver disease. Fatty liver is often improved through eating less, getting more exercise, and reducing body weight. The research group posed the question, ''Can eating less also suppress liver cancer caused by fatty liver?'' (2020-10-29)

Langerhans cells are up to the job, they just need a chance
Researchers from the University of Tsukuba found that Langerhans cells (LCs) play a crucial role in mucocutaneous acute guest-versus-host disease (aGVHD). Their experiments in mice showed that when the LCs of a recipient were depleted, the formation of mucocutaneous lesions was enhanced because the infiltration of CD8+ T cells was inhibited. Their findings have significant implications for improving blood stem cell transplantation treatments and clinical outcomes for patients. (2020-10-27)

Surprising players in acute liver failure point to potential treatment
Gut microbes and host cells jointly contribute to the progression of this mostly incurable disease. (2020-10-27)

Ontario should vaccinate newborns for hepatitis B, study suggests
Not all pregnant women are universally screened for hepatitis B virus (HBV) in Ontario, even though this screening is recommended, and the majority of those who test positive do not receive follow-up testing or interventions, leading to infections of newborns, found new research in CMAJ (Canadian Medical Association Journal). (2020-10-26)

Liver cancer diagnoses and deaths impacted by geography and household income
An analysis of information from a large U.S. cancer database indicates that patients with liver cancer from rural regions and lower income households often have more advanced cancer at the time of diagnosis and face a higher risk of death compared with other patients. The findings are published early online in CANCER, a peer-reviewed journal of the American Cancer Society (ACS). (2020-10-26)

Cell-Free DNA provides a dynamic window into health
A new study presented at the ASHG 2020 Virtual Meeting shows how cfDNA testing can be used to provide insight into a patient's health. (2020-10-26)

Gut bacteria associated with animal-based diet may mitigate risk of cardiovascular disease
Researchers have found that a type of common gut bacteria sometimes associated with inflammation, abscesses, bowel disease and cancer has a major silver lining: It seems to help prevent cardiovascular disease. (2020-10-26)

The road to uncovering a novel mechanism for disposing of misfolded proteins
The discovery of the cause of a rare liver disease in babies led to uncovering a novel cellular mechanism for disposing of misfolded proteins that has implications for neurodegenerative conditions of older age (2020-10-20)

Natural killer cells also have a memory function
Good news for the human immune system: researchers from MedUni Vienna's Departments of Dermatology and Surgery have managed to ascribe an immunological memory function to a subset of cytotoxic NK cells, which have hitherto been regarded as antigen-non-specific. (2020-10-19)

Immune activation in the liver illuminated with new glycan-tagging strategy
A signaling system implicated in liver fibrosis and immune activation is better understood thanks to this creative chemical fishing lure. (2020-10-19)

Study shows main cell type in the liver has key role in defending against some viruses
Scientists at Scripps Research have uncovered an important disease-fighting role for cells called hepatocytes, which constitute most of the liver. The discovery could potentially be harnessed to develop new medicines for viral illnesses. (2020-10-16)

Study shows proof of concept of BioIVT HEPATOPAC cultures with targeted assay to evaluate bioactivation potential and drug-induced liver injury (DILI) risk
New in vitro Bioactivation Liver Response Assay used HEPATOPAC model to demonstrate utility of in vitro transcriptomic signature-based strategy in preclinical DILI risk assessment. (2020-10-12)

Even mild fatty liver disease is linked to increased mortality
Non-alcoholic fatty liver disease, NAFLD, affects nearly one in four adults in Europe and the U.S. Earlier research has demonstrated an increased risk of death in patients with NAFLD and advanced fibrosis or cirrhosis. Now, researchers at Karolinska Institutet in Sweden and Massachusetts General Hospital in the U.S. show that mortality increases with disease severity, but even mild fatty liver disease is linked to higher mortality. The findings have been published in the journal Gut. (2020-10-12)

The world's first successful identification and characterization of in vivo senescent cells
A research team led by Professor Makoto Nakanishi of the Institute of Medical Science, the University of Tokyo, generated a p16-Cre ERT2 -tdTomato mouse model to characterize in vivo p16 high cells at the single-cell level. They found tdTomato-positive p16 high cells detectable in all organs, which were enriched with age. They also found that these cells failed to proliferate and had half-lives ranging from 2.6 to 4.2 months, depending on the tissue examined. (2020-10-07)

Nanoparticles can turn off genes in bone marrow cells
Using specialized nanoparticles, MIT engineers have developed a way to turn off specific genes in cells of the bone marrow, which play an important role in producing blood cells. (2020-10-05)

Cancer immunotherapy 'uniquely suppressed' by liver tumors
Though cancer immunotherapy has become a promising standard-of-care treatment--and in some cases, perhaps a cure--for a wide variety of different cancers, it doesn't work for everyone, and researchers have increasingly turned their attention to understanding why. (2020-10-02)

Skoltech scientists discovered a new biomarker for liver cancer diagnosis
A group of Skoltech scientists led by a Skoltech and MSU professor Olga Dontsova discovered a novel liver-specific non-coding RNA. The researchers tracked the RNA amounts in a healthy liver and that affected by carcinogenesis and suggested using the RNA as a biomarker, thus creating a new panel of potential biomarkers for postoperative diagnosis of various liver cancers. (2020-09-30)

The heat is on for building 3D artificial organ tissues
Bioengineers have devised a technology that uses heat to remotely control the positioning and timing of cell functions to build 3-dimensional, artificial, living tissues. They designed 3-D printed fluid systems to supply penetrating heat, which allows them to manipulate the genetic wiring of cells deep in artificial tissues. Their vision for the future is to try to find ways to direct cells to form complex artificial organs that assume some functions of damaged livers. (2020-09-30)

Senescent cells may be good when it comes to a bad injury
It's called senescence, when stressed cells can no longer divide to make new cells, and it's considered a factor in aging and in some diseases. Now scientists have some of the first evidence that at a younger age at least, senescent cells show up quickly after a major injury and are protective. (2020-09-29)

Unconventional T cell subset enriched in airways of some patients with severe COVID-19
Unconventional T cells called mucosa-associated invariant T (MAIT) cells are recruited to the airways and strongly activated in some patients with severe COVID-19, a new study has found, suggesting the cells' possible involvement in the development of disease. (2020-09-28)

URI grad student finds PFAS in seabirds from Narragansett Bay, Massachusetts Bay, Cape Fear
A recent study by a University of Rhode Island graduate student researching PFAS exposure found high levels of the compounds in seabirds from offshore Massachusetts and coastal Rhode Island and North Carolina adding to the accumulating pile of evidence related to human and animal exposure to these chemical compounds. (2020-09-23)

Predicting the future of liver-safe drugs
Researchers at Tokyo Medical and Dental University (TMDU) working with an international team have developed a Polygenic Risk Score using previous genomic studies that may help predict drug-induced liver injury. This score was validated on genomic data, cell cultures and organoids for several potentially hepatotoxic drugs, and may inform a screening test that can predict adverse responses both to approved medications in clinical practice as well as to drug candidates in preliminary experimental trials. (2020-09-18)

Page 1 of 25 | 1000 Results
   First   Previous   Next      Last   
Brightsurf.com is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to Amazon.com.