Current Lung function News and Events

Current Lung function News and Events, Lung function News Articles.
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Cooking with wood may cause lung damage
Advanced imaging with CT shows that people who cook with biomass fuels like wood are at risk of suffering considerable damage to their lungs from breathing in dangerous concentrations of pollutants and bacterial toxins, according to a study being presented at the annual meeting of the Radiological Society of North America (RSNA). (2020-11-25)

Warwick scientists design model to predict cellular drug targets against COVID-19
A computational model of a human lung cell has been used to understand how SARS-CoV-2 draws on human host cell metabolism to reproduce by researchers at the University of Warwick. This study helps understand how the virus uses the host to survive, and enable drug predictions for treating the virus to be made. (2020-11-25)

Radboud university medical center research: Most lungs recover well after COVID-19
Lung tissue of patients who suffered severely from COVID-19 shows good recovery in most cases. This was revealed by a study carried out by the Radboud university medical center that has now been published in Clinical Infectious Diseases. A striking conclusion is that the group who was referred by a GP did not recover as well as patients who were admitted to the hospital's Intensive Care Unit (ICU). (2020-11-25)

Doctors use existing treatment earlier to save the lives of Covid-19 patients
The lives of patients hospitalised with COVID-19 are being saved by doctors who are using an existing medical treatment at an earlier stage. Continuous Positive Airway Pressure (CPAP) in the first days of hospitalisation seems to save between 10% to 20% of patients. The researchers also found that the early use of CPAP potentially reduces lung damage during the worst of the COVID-19 infection and allows the patient to recover from the inflammatory effects. (2020-11-25)

Lung-on-chip provides new insight on body's response to early tuberculosis infection
Scientists have developed a lung-on-chip model to study how the body responds to early tuberculosis (TB) infection, according to findings published today in eLife. (2020-11-24)

Animal-free method predicts nanoparticle toxicity for safer industrial materials
Researchers at Helmholtz Zentrum München together with scientists across Europe developed a novel animal-free method to predict the toxic effect of nanoparticles to the human lung. The method aims to enable the safety-by-design development of safer industrial materials. (2020-11-24)

Better survival among women after lung cancer surgery
There are known differences in the survival rates of women and men with lung cancer. Researchers at Karolinska Institutet in Sweden set out to investigate potential reasons behind this disparity, such as the presence of other underlying diseases and smoking status. The study, which was published in Chest, shows that women have better survival rates after lung cancer surgery than men, independent of other factors. (2020-11-23)

Gut microbiome link to deadly lung disease
Research led by the Centenary Institute, the University of Technology Sydney and the University of Queensland has shown for the first time a link between chronic obstructive pulmonary disease (COPD), an often fatal lung condition, and the gut microbiome. (2020-11-19)

Understanding lung infections in patients with cystic fibrosis
For young people with cystic fibrosis, lung infection with Staphylococcus aureus, MRSA, is common and is treated with antibiotics in the hope that this will prevent a decline in lung function. However there has recently been debate over the role S. aureus plays in CF lung disease. Researchers from the University of Warwick have used a new model of CF lungs which could be used to make better decisions about future use of antibiotics. (2020-11-19)

Three reasons why COVID-19 can cause silent hypoxia
To crack the mystery of what causes silent hypoxia, a condition when oxygen levels in the body are abnormally low, BU biomedical engineers used computer modeling to test out three different scenarios that help explain how and why the lungs stop providing oxygen to the bloodstream. (2020-11-19)

Study reveals how smoking worsens COVID-19 infection in the airways
UCLA researchers using a model of airway tissue created from human stem cells have pinpointed how smoking cigarettes causes more severe infection by SARS-CoV-2, the virus that causes COVID-19, in the airways of the lungs. (2020-11-17)

Study identifies patients with lung cancer most likely to respond to immunotherapy
In a new study, researchers at UCLA found patients with a particular type of HLA, a protein scaffold involved in presenting pieces of proteins described as peptides to the immune system, were particularly likely to benefit from immunotherapy. (2020-11-16)

Exercised over nothing: Masks don't impair lung function during physical activity
A team of American and Canadian researchers report that while they may feel uncomfortable, there is little empirical evidence that wearing a facemask significantly diminishes lung function, even when worn during heavy exercise. (2020-11-16)

One step for fibrosis, one giant leap for scleroderma
At the Medical University of South Carolina, a team of researchers has demonstrated a ''moonlighting'' role for lysyl oxidase (LOX) in scleroderma. It was previously known that LOX crosslinked the connective tissue. However, this research showed that, independent of its crosslinking function, LOX plays multiple additional roles in promoting fibrosis in scleroderma, known as ''moonlighting.'' Furthermore, these researchers demonstrated that LOX could be a potential biomarker and target for antifibrotic therapy. (2020-11-16)

Why does COVID-19 seem to spare children?
Researchers at Vanderbilt University Medical Center (VUMC) and their colleagues have determined a key factor as to why COVID-19 appears to infect and sicken adults and older people preferentially while seeming to spare younger children. (2020-11-13)

Early-life events linked to lung health in young adulthood
Early-life events, such as the exposure to air pollutants, increases the risk of chronic lung disease in young adulthood, according to new results by researchers at Karolinska Institutet, Sweden, published in the European Respiratory Journal and Thorax. The studies add to the growing evidence that chronic lung disease in adulthood can be traced back to childhood. (2020-11-12)

State-level lung cancer screening rates not aligned with lung cancer burden in the US
A new study reports that state-level lung cancer screening rates were not aligned with lung cancer burden. (2020-11-12)

Are the movements of tiny hairlike structures a key to our health?
New research from USC scholars identifies the mechanisms in play for cilia to work effectively and productively to push particles and fluid along, which is especially important given their critical role in health and in even ensuring reproduction. (2020-11-12)

The lung microbiome may affect lung cancer pathogenesis and prognosis
Enrichment of the lungs with oral commensal microbes was associated with advanced stage disease, worse prognosis, and tumor progression in patients with lung cancer, according to results from a study published in Cancer Discovery, a journal of the American Association for Cancer Research. (2020-11-11)

As cancer has evolved, it is time for cancer research to do the same
Marking Lung Cancer Awareness month, a new study investigates the extent to which human-based, non-animal approaches are supplanting animal models in cancer research - comparing number of publications, funding, and publications associated with clinical trials between xenograft models and human organoids. The analysis reveals limited support for human biology-based methods and the authors recommend encouraging efforts to reduce reliance on animal testing in order to accelerate discovery and development of new, effective and affordable medicines. (2020-11-10)

New analysis finds lung cancer screening reduces rates of lung cancer-specific death
Low-dose CT screening methods may prevent one death per 250 at-risk adults screened, according to a meta-analysis of eight randomized controlled clinical trials of lung cancer screening. Researchers at the University of Georgia analyzed the health outcomes of 90,275 patients, comparing those who were screened versus those who received usual medical care or chest x-rays. (2020-11-10)

New opportunities for detecting osteoporosis
Osteoporosis can be detected through low dose computed tomography (LDCT) imaging tests performed for lung cancer screening or other purposes. A study published in the Journal of Bone and Mineral Research found that such tests can identify large numbers of adults with low bone mineral density. (2020-11-04)

Promising therapeutic approach against COPD
Chronic obstructive pulmonary disease (COPD) is one of the most common and deadliest diseases worldwide. Until today, COPD is not curable. Researchers at Helmholtz Zentrum München and at the German Cancer Research Center (DKFZ) have now succeeded in curing COPD in mice exposed to chronic cigarette smoke. Their goal is to test the novel therapeutic approach in human clinical trials over the next few years. (2020-11-04)

New insights on a common protein could lead to novel cancer treatments
A new University of Colorado Boulder-led study sheds light on a protein key to controlling how cells grow, proliferate and function and long implicated in tumor development. (2020-11-04)

COVID-19 lung damage caused by persistence of 'abnormal cells'
Investigations of deceased COVID-19 patients have shed light on possible lung damage caused by the virus. (2020-11-03)

Study shows COVID-19 risk to firefighters and emergency medical workers in New York City
Firefighters and emergency medical workers in New York City were 15 times more likely to be infected during the first wave of the COVID-19 pandemic compared to the general public, according to a study published in ERJ Open Research. (2020-10-29)

Racial disparities in treatment for common lung cancer persist despite gains
African American patients with lung cancer are still less likely to receive the most effective treatment for a common type of early stage lung cancer. (2020-10-28)

Racial, socioeconomic disparities in extensive-stage small cell lung cancer treatment
A new study shows that Black individuals with extensive-stage small cell lung cancer are less likely to receive chemotherapy for their disease compared to white and other racial groups. Led by researchers at Boston Medical Center, the results indicate that individuals who are Black, elderly, uninsured, or have non-private health insurance and lower education levels, were less likely to be treated with chemotherapy for this type of lung cancer. (2020-10-26)

ASTRO: Proton therapy for lung cancer may help reduce risk of heart diseases
Treating lung cancer patients with proton therapy may help reduce the risk of radiation-induced heart diseases. (2020-10-23)

Lab-grown mini-lungs mimic the real thing - right down to covid infection
A team of Duke researchers has developed a lab-grown living lung model that mimics the tiny air sacs of the lungs where coronavirus infection and serious lung damage take place. This advance has enabled Duke and UNC virologists to watch the battle between the SARS-CoV-2 coronavirus and lung cells at the finest molecular scale. In experiments so far, the mini lungs respond just like the real thing. (2020-10-22)

'Mini-lungs' reveal early stages of SARS-CoV-2 infection
'Mini-lungs' grown from tissue donated to Cambridge hospitals has provided a team of scientists from South Korea and the UK with important insights into how COVID-19 damages the lungs. Writing in the journal Cell Stem Cell, the researchers detail the mechanisms underlying SARS-CoV-2 infection and the early innate immune response in the lungs. (2020-10-22)

Vaccine to treat and prevent lung, bowel and pancreatic cancer shows promise in the lab
An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (2020-10-22)

Spectral CT improves detection of early-stage coronavirus disease (COVID-19)
According to an open-access article in ARRS' American Journal of Roentgenology (AJR), the use of spectral CT with electron density imaging could improve the assessment of lung lesion extent in patients with early-stage coronavirus disease (COVID-19). (2020-10-21)

Aging alone does not explain kidney pathology
Histopathology in non-neoplastic kidney tissue from 1,347 nephrectomy specimens showed very limited histopathologic changes in subset of older individuals. (2020-10-21)

CBD helps reduce lung damage from COVID by increasing levels of protective peptide
One way CBD appears to reduce the 'cytokine storm' that damages the lungs and kills many patients with COVID-19 is by enabling an increase in levels of a natural peptide called apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this storm. (2020-10-19)

LSU Health New Orleans review suggests HNB tobacco products may threaten health
A review of heat-not-burn (HNB) tobacco products from LSU Health New Orleans School of Medicine, reports an association with elevated blood pressure, increased heart rate, cell death, and circulatory dysfunction shown by early studies. Additionally, chemicals found in the vapor produced by HNB devices have previously been shown to impair lung function, put users at risk of heart attack and stroke, cause cancers, increase circulating low-density lipoprotein (''bad cholesterol'') and more. (2020-10-19)

Moffitt researchers develop tool to better predict treatment course for lung cancer
In a new article published in Nature Communications, Moffitt Cancer Center researchers demonstrate how a deep learning model using positron emission tomography/computerized tomography radiomics can identify which non-small cell lung cancer patients may be sensitive to tyrosine kinase inhibitor treatment and those who would benefit from immune checkpoint inhibitor therapy. (2020-10-16)

Oncotarget: Exosomal lncRNA PCAT-1 promotes Kras-associated chemoresistance
Oncotarget Volume 11, Issue 29 reported that Immunosuppressive chemoresistance is a major burden in lung cancer. (2020-10-15)

Ultrasound technique offers more precise, quantified assessments of lung health
Researchers have developed a technique that uses ultrasound to provide non-invasive assessments of pulmonary fibrosis and pulmonary edema. The technique has been shown to both quantify lung scarring and detect lung fluid in rats. A study on pulmonary edema in humans is under way. (2020-10-15)

Oncotarget: Efavirenz induces DNA damage response pathway in lung cancer
The cover for Issue 41 of Oncotarget features Figure 7, ''IPA ATM-signaling pathway in (A) EFV treated MRC-5 and (B) A549 cells,'' recently published in ''Efavirenz induces DNA damage response pathway in lung cancer'' by Marima, et al. which reported that the cell-cycle related genes are potential gene targets in understanding the effects of efavirenz in lung cancer. (2020-10-14)

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