Current Macular degeneration News and Events

Current Macular degeneration News and Events, Macular degeneration News Articles.
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UB study identifies new functions in the Machado-Joseph genetic disease
Ataxia is a minority disease with genetic origins, known for its neuromuscular alterations due to the selective loss of neurons in the cerebellum. University of Barcelona researchers have identified new functions in the ataxin 3 gene (ATXN3) -which causes Machado-Joseph disease, the most common type of ataxia- in the development of retina photoreceptors. These results are relevant also to understand other diseases, such as macular degenerations. (2020-11-25)

Stem cell-based screen identifies potential new treatments
In a recent study published in Stem Cell Reports, Seba Almedawar, PhD, and colleagues with the Center for Regenerative Therapies TU Dresden, Germany, used induced pluripotent stem cells (iPSCs) derived from the skin of healthy donors and of patients with retinitis pigmentosa to find drugs with the potential to enhance RPE phagocytosis. (2020-11-25)

Study: Early, late stages of degenerative diseases are distinct
Rice University biochemists have proposed that degenerative diseases as varied as Alzheimer's, Parkinson's and muscle atrophy occur in two distinct phases marked by protein signaling changes that could result in patients responding differently to the same treatment. (2020-11-23)

Racket sports may worsen knee arthritis
Racket sports like tennis and racquetball appear to accelerate knee joint degeneration in overweight people with osteoarthritis, according to a study being presented at the annual meeting of the Radiological Society of North America (RSNA). (2020-11-17)

An acebuchin-oil-enriched diet helps to reduce hypertension
The acebuche, also know as the wild olive tree, is a variety of tree widely found throughout Spain and covering almost nine million hectares in Andalusia. However, little data is available on the composition and therapeutic potential of acebuchin oil. The studies mainly focus on the composition and pharmacological effects of olive tree leaves and extra virgin olive oil. (2020-11-17)

Chronic inflammation causes a reduction in NAD+
NAD+, a metabolite central to metabolism, declines with age. This previously unexplained phenomena is associated with numerous age-related diseases and has spawned the development of supplements aimed at restoring NAD+ to youthful levels. Researchers have identified chronic inflammation as a driver of NAD+ decline. They show an increasing burden of senescent cells causes NAD+ to degrade, via the activation of CD38, a protein found both inside and on the surface of many immune cells. (2020-11-16)

One step for fibrosis, one giant leap for scleroderma
At the Medical University of South Carolina, a team of researchers has demonstrated a ''moonlighting'' role for lysyl oxidase (LOX) in scleroderma. It was previously known that LOX crosslinked the connective tissue. However, this research showed that, independent of its crosslinking function, LOX plays multiple additional roles in promoting fibrosis in scleroderma, known as ''moonlighting.'' Furthermore, these researchers demonstrated that LOX could be a potential biomarker and target for antifibrotic therapy. (2020-11-16)

Novel deep learning method enables clinic-ready automated screening for diabetes-related eye disease
Researchers at Helmholtz Zentrum M√ľnchen together with LMU University Eye Hospital Munich and the Technical University of Munich (TUM) created a novel deep learning method that makes automated screenings for eye diseases such as diabetic retinopathy more efficient. (2020-11-12)

New strategy for treating common retinal diseases shows promise
Scientists at Scripps Research have uncovered a potential new strategy for treating eye diseases that affect millions of people around the world, often resulting in blindness. (2020-10-27)

Coronaviruses are masters of mimicry, new study finds
Coronaviruses are adept at imitating human immune proteins that have been implicated in severe COVID-19 disease, a study from researchers at Columbia University has found. (2020-10-27)

Common treatment for diabetic macular edema not effective in Black individuals
A medication frequently used to treat diabetic macular edema, which is the most common cause of blindness in people with diabetes, is less effective when used to treat the condition in Black patients, new study results show. (2020-10-22)

Scientists use gene therapy and a novel light-sensing protein to restore vision in mice
A newly developed light-sensing protein called the MCO1 opsin restores vision in blind mice when attached to retina bipolar cells using gene therapy. The National Eye Institute, part of the National Institutes of Health, provided a Small Business Innovation Research grant to Nanoscope, LLC for development of MCO1. The company is planning a U.S. clinical trial for later this year. (2020-10-21)

Six-Year MiSight contact lens study: 23% of eyes showed no additional myopia progression
The latest findings from the long-running CooperVision MiSight 1 day clinical study provide new insights about myopia management and the proven efficacy of the specially designed contact lens. Nearly one in four children's eyes originally fit with MiSight 1 day remain stable for myopia after six years. (2020-10-09)

Blocking immune system pathway may stop COVID-19 infection, prevent severe organ damage
While the world waits eagerly for a safe and effective vaccine to prevent infections from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the virus behind the COVID-19 pandemic, researchers also are focusing on better understanding how SARS-CoV-2 attacks the body in the search for other means of stopping its devastating impact. (2020-10-08)

New class of highly effective inhibitors protects against neurodegeneration
Heidelberg University neurobiologists have uncovered how a special receptor can lead to cell death. Their fundamental findings on neurodegenerative processes simultaneously led the researchers to a completely new principle for therapeutic agents. In their experiments on mouse models, they discovered a new class of highly effective inhibitors for protecting nerve cells. This novel class of drugs opens up perspectives to combat currently untreatable diseases of the nervous system. (2020-10-08)

Researchers demonstrate how deep learning can advance study of neural degeneration
Researchers have demonstrated the utility of artificial intelligence (AI) in identifying and categorizing neural degeneration in the model organism C. elegans. The tool uses deep learning, a form of AI, and should facilitate and expedite research into neural degeneration. (2020-09-24)

HIV drugs could prevent diabetes, study suggests
Patients taking drugs called NRTIs to treat HIV and hepatitis B had a 33% lower risk of developing diabetes. (2020-09-23)

How night vision is maintained during retinal degenerative disease
New insight on how people with retinal degenerative disease can maintain their night vision for a relatively long period of time has been published today in the open-access eLife journal. (2020-09-22)

New gene implicated in neuron diseases
Healthy NEMF helps the cell recycle garbled protein fragments. But several mutant forms resulted in neuromuscular, neurodegenerative or other ALS-like disease, the scientists found. (2020-09-16)

New molecule to repair and restore brain and spinal cord function
A molecule created by researchers can restore lost connections in the spinal cord and brain of mice with neurological disorders including cerebellar ataxia, Alzheimer's disease and spinal cord injury. The research, involving scientists in the Medical Research Council Laboratory of Molecular Biology (MRC LMB), in Cambridge, and collaborators from Japan and Germany, describes how the molecule repaired function in cells and in mouse models of diseases and injury. (2020-09-11)

Seeing the eye like never before
In a big step for ophthalmology, scientists created a method to view the inner workings of the eye and its diseases at the cellular level. Currently, researchers can only see a broad section of the retina. This new technology allows them to zoom into just one part of a cell. In their words, they have accelerated the process for vision restoration. (2020-09-10)

Levodopa may improve vision in patients with macular degeneration
Investigators have determined that treating patients with an advanced form of age-related macular degeneration (AMD) with levodopa, a safe and readily available drug commonly used to treat Parkinson's disease, stabilized and improved their vision. It reduced the number of treatments necessary to maintain vision, and as such, will potentially reduce the burden of treating the disease, financially and otherwise. Their findings appear in The American Journal of Medicine, published by Elsevier. (2020-09-10)

Unlocking the mystery of tau for treatment of neurodegenerative diseases
A team of researchers from various collaborating universities and hospitals in Japan has uncovered crucial molecular details regarding the activity of the ''tau'' protein, promising to revolutionize the therapy of tau-induced neurodegenerative diseases. (2020-09-09)

USTC deciphers transcriptomic atlas of aging human and macaque retina
The work which provides valuable basic for the molecular regulation of aging progression and related diseases, was published in National Science Review on Aug. 25, 2020. (2020-09-06)

Seeing progress
As we get older, many of our body's processes start slowing down. For instance, a cut on the hand will take longer to heal after middle age than in youth. That said, it still heals. (2020-09-03)

Nerve cells with energy saving program
Thanks to a metabolic adjustment, the cells can remain functional despite damage to the mitochondria. (2020-08-31)

A healthy lifestyle for cardiovascular health also promotes good eye health
In a new study, investigators found that ideal cardiovascular health, which is indicative of a healthy lifestyle, was associated with lower odds for ocular diseases especially diabetic retinopathy. These findings appearing in The American Journal of Medicine, published by Elsevier, suggest that interventions to prevent cardiovascular diseases may also hold promise in preventing ocular diseases. (2020-08-20)

OCT-based technique captures subtle details of photoreceptor function
Researchers have developed a new instrument that has, for the first time, measured tiny light-evoked deformations in individual rods and cones in a living human eye. The new approach could one day improve detection of retinal diseases such as age-related macular degeneration, a leading cause of blindness in people over 55 worldwide. (2020-08-18)

Artificial intelligence recognizes deteriorating photoreceptors
A software based on artificial intelligence (AI), which was developed by researchers at the Eye Clinic of the University Hospital Bonn, Stanford University and University of Utah, enables the precise assessment of the progression of geographic atrophy (GA), a disease of the light sensitive retina caused by age-related macular degeneration (AMD). (2020-08-13)

Researchers develop cell injection technique that could help reverse vision loss
University of Toronto Engineering researchers have developed a new method of injecting healthy cells into damaged eyes. The technique could point the way toward new treatments with the potential to reverse forms of vision loss that are currently incurable. (2020-08-13)

Flipping a metabolic switch to slow tumor growth
The enzyme serine palmitoyl-transferase can be used as a metabolically responsive ''switch'' that decreases tumor growth, according to a new study by a team of San Diego scientists, who published their findings Aug. 12 in the journal Nature. By restricting the dietary amino acids serine and glycine, or pharmacologically targeting the serine synthesis enzyme phosphoglycerate dehydrogenase, the team induced tumor cells to produce a toxic lipid that slows cancer progression in mice. (2020-08-12)

KIST finds clue to improve artificial vision for patients with retinitis pigmentosa
A Korean research team has reported important findings that could potentially improve the performance of retinal prostheses creating artificial vision for blind individuals. The Korea Institute of Science and Technology (KIST) had found retinal neural signals arising from electric stimulation are altered depending on disease progression in mice affected by outer retinal degeneration. This research was done in collaboration with Harvard Medical School, Massachusetts General Hospital. (2020-08-10)

New treatment targets found for blinding retinal disease
When the eye isn't getting enough oxygen in the face of common conditions like premature birth or diabetes, it sets in motion a state of frenzied energy production that can ultimately result in blindness, and now scientists have identified new points where they may be able to calm the frenzy and instead enable recovery. (2020-08-10)

Ancient part of immune system may underpin severe COVID
New genetic and patient analyses suggest severe COVID is linked to overactive complement, one of the immune system's oldest branches, and excess blood clotting. (2020-08-03)

Study reveals less connectivity between hey brain regions in people with FXTAS premutation
Investigators from the University of Kansas were able to identify brain processes specifically linked to sensorimotor issues in aging people with the FMR1 premutation. (2020-08-03)

Scientists identify a new drug target for dry age-related macular degeneration
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that the blood protein vitronectin is a promising drug target for dry age-related macular degeneration (AMD), a leading cause of vision loss in Americans 60 years of age and older. The study, published in the Proceedings of the National Academy of Sciences (PNAS), also holds implications for Alzheimer's and heart disease, which are linked to vitronectin. (2020-07-20)

Combating drug resistance in age-related macular degeneration
An international team of researchers led by Baylor College of Medicine and Houston Methodist has discovered a strategy that can potentially address a major challenge to the current treatment for age-related macular degeneration, (2020-07-16)

Novel bone imaging approach provides insights into the progression of knee osteoarthritis
A new approach to functional bone imaging has established that bone metabolism is abnormally elevated in patients with knee osteoarthritis. This physiological information provides a new functional measure to help assess degeneration of the knee joint. The research was presented at the Society of Nuclear Medicine and Molecular Imaging 2020 Virtual Annual Meeting, July 11-14, 2020. (2020-07-13)

Gene yields insights into the causes of neurodegeneration
Cornell researchers including Fenghua Hu, associate professor in the Department of Molecular Biology and Genetics and member of the Weill Institute for Cell and Molecular Biology, are taking a closer look at the factors that cause Alzheimer's, FTLD and similar diseases. Hu's latest study, ''A role of the frontotemporal lobar degeneration risk factor TMEM106B in myelination,'' was published June 23 in the journal Brain. (2020-07-09)

Scientists use nanoparticle-delivered gene therapy to inhibit blinding eye disease in rodents
In experiments in rats and mice, two Johns Hopkins scientists -- an engineer and an ophthalmologist -- report the successful use of nanoparticles to deliver gene therapy for blinding eye disease. A uniquely engineered large molecule allows researchers to compact large bundles of therapeutic DNA to be delivered into the cells of the eye. (2020-07-07)

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