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Current Melanoma News and Events, Melanoma News Articles.
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Cancer's hidden vulnerabilities
To fight cancer more effectively, a Caltech researcher probes its inner workings for metabolic weaknesses. (2020-09-28)
Scientists kill cancer cells by 'shutting the door' to the nucleus
Scientists at Sanford Burnham Prebys Medical Discovery Institute have shown that blocking the construction of nuclear pores complexes--large channels that control the flow of materials in and out of the cell nucleus--shrank aggressive tumors in mice while leaving healthy cells unharmed. (2020-09-28)
Pale melanomas masked by albino gene
People with pale coloured melanomas are more likely to have a gene mutation associated with albinism, University of Queensland research has found. (2020-09-23)
Increasing the effectiveness of immunotherapy against skin cancer
Researchers at the University of Bern have discovered a mechanism in the body's own immune system which is responsible for the maturation and activation of immune cells. (2020-09-18)
New targets for melanoma treatment
A collaborative study led by Monash University's Biomedicine Discovery Institute and the Olivia Newton-John Cancer Research Institute (ONJCRI) has uncovered new markers (HLA-associated peptides) that are uniquely present on melanoma tumours and could pave the way for therapeutic vaccines to be developed in the fight against melanoma. (2020-09-16)
UCLA study shows how interferon-gamma guides response to cancer immunotherapy
UCLA researchers shed light on how interferon-gamma (IFN-y) guides the treatment response in people with advanced melanoma who are treated with one of the leading immunotherapies -- immune checkpoint blockade. (2020-09-10)
DNA-based nanotechnology stimulates potent antitumor immune responses
Combining their expertise in protein engineering and synthetic DNA technology, Wistar scientists successfully delivered nanoparticle antitumor vaccines that stimulated robust CD8 T cell immunity and controlled melanoma growth in preclinical models. (2020-09-10)
New nanosystem from Tel Aviv university enhances treatment for melanoma in animal models
Researchers at Tel Aviv University, led by Prof. Ronit Satchi-Fainaro of TAU's Department of Physiology and Pharmacology at the Sackler School of Medicine, have developed an innovative nanotechnological drug delivery system that significantly enhances the effectiveness of treatment for the aggressive skin cancer melanoma. (2020-09-08)
Moffitt researchers identify metastasis driver in BRAF inhibitor resistant melanoma
In a new article published in the Journal of Investigative Dermatology, Moffitt researchers identify erythropoietin-producing hepatocellular receptor A2 (EphA2) as a driver of metastasis and BRAF-MEK inhibitor resistance in melanoma. (2020-09-02)
Effective cancer immunotherapy further linked to regulating a cell 'suicide' gene
Johns Hopkins Medicine researchers have added to evidence that a gene responsible for turning off a cell's natural ''suicide'' signals may also be the culprit in making breast cancer and melanoma cells resistant to therapies that use the immune system to fight cancer. (2020-09-01)
Finding a way to STING tumor growth
The immune protein STING has long been noted for helping protect against viruses and tumors by signaling a well-known immune molecule. (2020-08-24)
New, pharmacologically available STING agonists promote antitumor immunity in mice
In a pair of studies, researchers report the discovery and molecular pharmacology of stable, synthetic STING (stimulator of interferon genes) agonists that induce anticancer immune responses in mice. (2020-08-20)
Unleashing the immune system's 'STING' against cancer
Scientists at Scripps Research have discovered a molecule that can activate a natural immune-boosting protein called STING. (2020-08-20)
The secret of lymph: How lymph nodes help cancer cells spread
For decades, physicians have known that many kinds of cancer cells often spread first to lymph nodes before traveling to distant organs through the bloodstream. (2020-08-19)
Study finds cancer mapping may solve puzzle of regional disease links
New statistical analysis finds cancer mapping may help question regional disease links. (2020-08-13)
UCalgary researchers discover the microbiome's role in attacking cancerous tumours
University of Calgary researchers have discovered which gut bacteria help our immune system battle cancerous tumours and how they do it. (2020-08-13)
Molecules in urine allow doctors to monitor skin cancer
What if you could simply provide a urine sample rather than undergo a painful surgical procedure to find out if your cancer was responding to treatment? (2020-08-11)
Scientists found genes that help cancer cells to penetrate the brain
An international team of scientists, including a researcher from Sechenov University, reviewed scientific articles on proteins (and genes encoding them) that help cancer cells enter the brain. (2020-08-11)
How tumor cells evade the immune defense
Scientists are increasingly trying to use the body's own immune system to fight cancer. (2020-08-05)
HDAC6 can control tumor growth and halt metastasis in triple-negative breast cancer
Genetic modifier HDAC6 was found to control tumor growth and halt metastasis in triple-negative breast cancer in vivo, according to a new study published in the journal Cancer Research by investigators at the GW Cancer Center. (2020-08-05)
Researchers outline need for evaluation of gene expression profiling in melanoma
A consensus statement published today in JAMA Dermatology cautions against routine use of currently available GEP tests for patients with cutaneous melanoma. (2020-07-29)
A helping hand for cancer immunotherapy
Scientists at Sanford Burnham Prebys Medical Discovery Institute have demonstrated the therapeutic potential of PRMT5 inhibitors to sensitize unresponsive melanoma to immune checkpoint therapy. (2020-07-08)
A 3D biofabricated cutaneous squamous cell carcinoma tissue model
The cover for issue 27 of Oncotarget features Figure 4, ''(A) Bimodal imaging examples of control and treated tumors (red) before and after the treatment period,'' by Browning, et al. and reported that the authors developed a 3-dimensional bioprinted skin model of cutaneous squamous cell carcinoma (cSCC) tumors together with a microscopy assay to test chemotherapeutic effects in tissue. (2020-07-07)
Protein derived from tick saliva proves effective in the treatment of equine skin cancer
Experiments were conducted by scientists affiliated with the Center of Excellence in New Target Discovery, a research center supported by FAPESP, involving five animals with spontaneous skin tumors. (2020-06-29)
Study reveals key finding about microbiome of anticancer compound-producing marine invertebrate
Could the cure for melanoma - the most dangerous type of skin cancer -- be a compound derived from a marine invertebrate that lives at the bottom of the ocean? (2020-06-25)
Oncotarget: Mutation profile of primary subungual melanomas in Caucasians
Volume 11 Issue 25 of @Oncotarget reported that this study aimed to define the mutation profile of SUM in Caucasians. (2020-06-23)
Patient-personalized sequencing pipeline steps up sensitivity of tumor DNA monitoring
A sequencing pipeline that integrates a patient's specific tumor genetic data boosts the sensitivity of tests that detect cancer cell DNA circulating in the blood, according to a newly published study. (2020-06-17)
Wearable patch may provide new treatment option for skin cancer
Purdue University innovators have created a novel wearable patch to provide an improved treatment experience for people with melanoma. (2020-06-16)
Photodynamic therapy used to treat ovarian cancer
Photodynamic therapy (PDT) is one of the most promising methods of treating localized tumors. (2020-06-08)
A comprehensive survey reveals bacteria are widespread in human tumors and differ by tumor type
Different human tumor types each harbor their own unique bacterial communities, researchers report in a new study that profiled the microbiomes of more than 1,500 individual tumors across seven types of human cancer - the most comprehensive tumor microbiome study to date. (2020-05-28)
Blocking tumor signals can hinder cancer's spread
A University of Pennsylvania-led team used an inhibitor of an enzyme called p38α kinase to suppress the spread of melanoma to the lungs in a mouse model. (2020-05-28)
A new method for predicting the evolution of melanoma emerges
Research led by the UPV/EHU-University of the Basque Country estimates that determining the mutational load of the mutation of the BRAF (BRAF-V600E) gene could predict whether the melanoma will progress to metastasis (2020-05-27)
Study reveals first evidence inherited genetics can drive cancer's spread
Scientists have long struggled to understand what drives a tumor to seed itself elsewhere in the body. (2020-05-25)
Examining melanoma risk in patients treated with biologics for common inflammatory diseases
This study combined the results of seven studies and compared the risk of melanoma among 34,000 patients treated with biologics and 135,000 patients treated with conventional systemic therapy for rheumatoid arthritis, psoriasis or inflammatory bowel disease. (2020-05-20)
Genetic origins of hybrid dysfunction
Evolutionary biologists studying populations of hybrid fish have found two genes that contribute to melanoma - only the second time people have identified specific genes associated with dysfunction in hybrid vertebrates. (2020-05-14)
Antihistamines may help patients with malignant melanoma
Can a very common allergy medicine improve survival among patients suffering from the serious skin cancer, malignant melanoma? (2020-05-11)
Interleukin-12 electroporation may sensitize 'cold' melanomas to immunotherapies
Combining intratumoral electroporation of interleukin-12 (IL-12) DNA (tavokinogene telseplasmid, or TAVO) with the immune checkpoint inhibitor pembrolizumab (Keytruda) led to clinical responses in patients with immunologically quiescent advanced melanoma, according to results from a phase II trial. (2020-05-06)
Activating an estrogen receptor can stop pancreatic cancer cells from growing
Activating a receptor found on the surface of many normal and cancer tissues can not only stop pancreatic cancer from growing but may also make tumors more visible to the immune system and thus more susceptible to modern immunotherapy (2020-05-04)
Continuous dosing improves progression-free survival for melanoma patients with common mutations
A first-of-its-kind randomized clinical trial offers strong and perhaps surprising evidence that a combination of two targeted melanoma drugs when given continuously keeps patients' cancer from growing or spreading longer when compared with intermittent treatment, according to study results to be presented at the 2020 virtual annual meeting of the American Association for Cancer Research. (2020-04-27)
Scientists double understanding of genetic risk of melanoma
A global collaboration of scientists has more than doubled the known number of regions on the human genome that influence the risk of developing melanoma. (2020-04-27)
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