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Current Methylation News and Events

Current Methylation News and Events, Methylation News Articles.
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NSD2 enzyme appears to prevent cellular senescence
Using comprehensive genetic analysis, Kumamoto University researchers have found, for the first time, that the NSD2 enzyme blocks cell aging. (2020-08-07)
Lead poisoning could reduce gene expression in humans
Scientists have unveiled a correlation between high blood lead levels in children and methylation of genes involved in haem synthesis and carcinogenesis, indicating a previously unknown mechanism for lead poisoning. (2020-08-07)
Algorithm created by deep learning finds potential therapeutic targets throughout genome
A team of researchers have developed an algorithm through machine learning that helps predict sites of DNA methylation - a process that can change the activity of DNA without changing its overall structure - and could identify disease-causing mechanisms that would otherwise be missed by conventional screening methods. (2020-08-06)
Epigenetic changes in ADNP syndrome, a cause of autism, do not indicate profound presentation of the disorder
Study Finds Epigenetic Signatures Show Little Correlation to Severity of Symptoms (2020-08-05)
New maps of chemical marks on DNA pinpoint regions relevant to many developmental diseases
In research that aims to illuminate the causes of human developmental disorders, Salk scientists have generated 168 new maps of chemical marks on strands of DNA -- called methylation -- in developing mice. (2020-07-29)
Fine-tuning adoptive cell therapy for advanced cancers
Researchers identified a discordant phenomenon in which a subset of patients displayed profoundly decreased expression of the transgenic TCR over time, despite the transgenic TCR being present at the DNA level. (2020-07-22)
Non-invasive blood test can detect cancer four years before conventional diagnosis methods
An international team of researchers has developed a non-invasive blood test that can detect whether an individual has one of five common types of cancers, four years before the condition can be diagnosed with conventional methods. (2020-07-21)
Identification of distinct loci for de novo DNA methylation by DNMT3A and DNMT3B during mammalian development
A research team working at The University of Tokyo and Kyoto University in Japan has announced that they have successfully identified specific target sites for the DNA methylases DNMT3A and DNMT3B . (2020-07-21)
City of Hope: Mechanism that may lead to metabolic memory/sustained diabetes complications
For people with diabetes, vascular complications like kidney disease and atherosclerosis, which can lead to poor health and even death, are seen at increased rates. (2020-07-20)
Scientists achieve first complete assembly of human X chromosome
Although the current human reference genome is the most accurate and complete vertebrate genome ever produced, there are still gaps in the DNA sequence, even after two decades of improvements. (2020-07-14)
Amygdala changes in male patients with schizophrenia and bipolar disorder
Researchers in Japan have revealed that DNA methylation occurs in the serotonin transporter gene that regulates neurotransmitter transmission in schizophrenia and bipolar patients. (2020-07-09)
Mapping the immune landscape of haematological cancers may help to enhance therapies
Activating the immune system of the body is a promising form of treatment for cancer. (2020-07-09)
How old is your dog in human years? Scientists develop better method than 'multiply by 7'
By mapping molecular changes in the genome over time, UC San Diego researchers developed a formula to more accurately compare dog age to human age -- a tool that could also help them evaluate how well anti-aging products work. (2020-07-02)
A scientific measure of dog years
How old is your tail-wagging bundle of joy in human years? (2020-07-02)
Breaking the silence: scientists investigate epigenetic impact across whole genome
Researchers from the Okinawa Institute of Science and Technology Graduate University (OIST) have uncovered a clue to the mystery of how epigenetic regulation impacts the entire plant genome, by looking at how plant cells suppress transcription - the first stage of how genes manufacture their products. (2020-06-30)
Novel software reveals molecular barcodes that distinguish different cell types
A new set of computational methods developed at Baylor College of Medicine allows researchers to identify cell-type specific methylation patterns -- molecular barcodes -- in complex cell mixtures. (2020-06-30)
Hackensack Meridian CDI scientists uncover signposts in DNA for cancer, disease risk
The most strongly disease-relevant genetic variants can be hard to localize in widespread scanning of the genome -- but by zooming in on key genetic locations associated with DNA methylation imbalances in multiple normal and cancer tissues, the scientists report they have uncovered promising new leads beneath the broader statistical signals. (2020-06-29)
Effects from low-level concentrations of harmful chemicals preserved in three generations of fish
Fish exposed to very low levels of chemicals commonly found in waterways can pass the impacts on to future generations that were never directly exposed to the chemicals, according to Oregon State University researchers. (2020-06-24)
NIH-funded study links endometriosis to DNA changes
DNA from uterine cells of women with endometriosis has different chemical modifications, compared to the DNA of women who do not have the condition, according to researchers funded by the National Institutes of Health. (2020-06-17)
From bacteria to you: The biological reactions that sustain our rhythms
Methylation and the circadian clock are both conserved mechanisms found in all organisms. (2020-06-11)
New insights into epigenetic modifications
Scientists at the European Molecular Biology Laboratory in Rome, in collaboration with Tim Bestor at Columbia University in New York and John Edwards at Washington University in St. (2020-06-11)
Strahl lab decodes another piece of the histone code puzzle
Published in the journal Cell Reports, this research reinforces the notion that the multiple chemical modifications placed on histones by a single enzyme ensures multiple and distinct functions -- an idea that was postulated by Strahl and his former mentor, David Allis, Ph.D., and was called the Histone Code hypothesis. (2020-06-09)
Large-scale analysis of protein arginine methylation by mass spectrometry
In this research, the researchers offer an overview on state-of-the-art approaches for the high-confidence identification and accurate quantification of protein arginine methylation by high-resolution mass spectrometry methods, which comprise the development of both biochemical and bioinformatics methods. (2020-05-22)
A new epigenetic editing tool is developed to activate silenced genes
The research project is based on the CRISPR genetic editing technique and uses a plant protein to control gene expression in in-vitro cells. (2020-05-18)
Lighting up cells with genetically-encoded X-ray-sensitive probes
Synchrotron-based X-ray microscopy provides a unique approach for direct imaging a whole cell with its intrinsic nanoscale resolution. (2020-05-18)
First epigenetic study in 3D human cancer cells
The researcher Manel Esteller performs the first massive epigenetic characterization in organoids or 3D cancer cultures and makes the data available to the research community to facilitate new findings on tumor development and progression. (2020-05-13)
Dock and harbor: A novel mechanism for controlling genes
In a recent study published in Molecular Cell, researchers at Kanazawa University report the role of cellular structures called PML bodies in regulating gene function. (2020-05-12)
Epidemiologists develop new tool for measuring the pace of aging across the life course
A study just released by Columbia University Mailman School of Public Health is reporting a blood-DNA-methylation measure that is sensitive to variation in the pace of biological aging among individuals born the same year. (2020-05-05)
Novel method produces life-saving T cells from mesenchymal stromal cells
A new study released today in STEM CELLS suggests for the first time that regulatory T-cells (Treg) induced by mesenchymal stromal cells can yield an abundant replacement for naturally occurring T-cells, which are vital in protecting the body from infection. (2020-04-30)
Skoltech research shows how a 'Swiss Army knife' protein helps phages disarm their victims
Researchers from the Severinov Laboratory at Skoltech, along with their colleagues from Switzerland and Israel, have investigated a poorly studied bacterial BREX defense mechanism to show that it can be ''turned off'' by a multipurpose viral protein that successfully impersonates DNA. (2020-04-27)
NEI researchers link age-related DNA modifications to susceptibility to eye disease
National Eye Institute (NEI) researchers profiling epigenomic changes in light-sensing mouse photoreceptors have a clearer picture of how age-related eye diseases may be linked to age-related changes in the regulation of gene expression. (2020-04-21)
Physical force alone spurs gene expression, study reveals
Cells will ramp up gene expression in response to physical forces alone, a new study finds. (2020-04-01)
Biological 'atlas' shows dual personality for immune cells that cause Type 1 diabetes
Scientists at St. Jude Children's Research Hospital mapped the epigenetic controls on T cells, which could aid Type 1 diabetes diagnosis and treatment, as well as cancer immunotherapy. (2020-03-30)
Blood test accurately detects over 50 types of cancer, often before symptoms show
Researchers have developed the first blood test that can accurately detect more than 50 types of cancer and identify in which tissue the cancer originated, often before there are any signs of the disease. (2020-03-30)
Blood test detects wide range of cancers, available to at risk individuals in clinical study
In a study involving thousands of participants, a new blood test detected more than 50 types of cancer as well as their location within the body with a high degree of accuracy, according to an international team of researchers led by Dana-Farber Cancer Institute. (2020-03-30)
Elucidation of mechanisms that coordinate cell memory inheritance with DNA replication
Why normal cells turn into cancer cells? One of the factors is deeply related to the failure of the cell differentiation mechanism called DNA methylation. (2020-03-16)
Prostate cancer 'fingerprint' detected in blood sample
Scientists at UCL have invented a new test to identify the earliest genetic changes of prostate cancer in blood: a process which could allow doctors to see if cancers have spread, monitor tumor behavior and enable better treatment selection. (2020-03-09)
Urine test could reduce unnecessary prostate cancer biopsies
Unnecessary prostate cancer biopsies could be reduced by 60% thanks to new research from the University of East Anglia. (2020-03-09)
Biomarker in saliva predicts childhood obesity risk
The intriguing discovery, reported in the journal BMC Medical Genetics, supports ongoing efforts to identify biomarkers associated with the emergence of childhood obesity before body mass index (BMI) is designated as obese, said Shari Barkin, MD, MSHS, director of Pediatric Obesity Research at Monroe Carell Jr. (2020-03-06)
Intestinal microbes reprogram genetic activity of gut mucosa
Scientists from the German Cancer Research Center and the Hebrew University in Jerusalem demonstrated in mice that intestinal bacteria reprogram DNA activity in cells of the gut mucosa and thus have a considerable impact on the development of the healthy gut. (2020-03-05)
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