Current Micrornas News and Events

Current Micrornas News and Events, Micrornas News Articles.
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NYUAD researchers discover immune evasion strategy used by Malaria-causing parasite
A team of researchers at NYU Abu Dhabi (NYUAD) has found that the Plasmodium parasite, which transmits malaria to humans through infected mosquitos, triggers changes in human genes that alter the body's adaptive immune response to malarial infections. (2020-10-09)

Exosome treatment improves recovery from heart attacks in a preclinical study
Research in pigs shows that using the exosomes naturally produced from a mixture of heart muscle cells, endothelial cells and smooth muscle cells -- which were all derived from human induced pluripotent stem cells -- yields regenerative benefits equivalent to the injected human induced pluripotent stem cell-cardiac cells. (2020-09-29)

Blood marker may reduce cancer burden
Researchers at Flinders University are expanding work on a promising blood test model to help predict or diagnose head and neck cancer, a difficult cancer to pick up early and treat. With cancer accounting for almost 10 million a year, the Global Burden of Disease report (2017) attributed more than 380,000 deaths to head and neck cancer. (2020-09-01)

Protein influences regeneration of vascular cells
Through their basic research, physicians at the Heart Center of the University Hospital Bonn have discovered how the communication between individual cells can be influenced with the help of a specific protein. These findings are an important approach to improving the treatment of diseases such as arteriosclerosis (calcified blood vessels), which causes heart attacks. The study was published online in advance in the ''Journal of Extracellular Vesicles'', the printed version will be published shortly. (2020-08-19)

Stomach SIDT1 mediates dietary microRNA absorption: ending of the 10-year debate
In a new study published in Cell Research, Chen-Yu Zhang's group at Nanjing University School of Life Sciences, China, reports that SIDT1 in the mammalian stomach mediates host uptake of dietary and orally administered microRNAs (miRNAs), thus exerting biological functions in the host. (2020-08-17)

Exercise induces secretion of biomarkers into sweat
The aim was to reveal the potential of microRNAs in sweat extracellular vesicles in monitoring exercise performance. (2020-08-12)

Scientists found genes that help cancer cells to penetrate the brain
An international team of scientists, including a researcher from Sechenov University, reviewed scientific articles on proteins (and genes encoding them) that help cancer cells enter the brain. An understanding of the processes that facilitate the formation of metastases in the brain will allow scientists to create new methods for cancer diagnosis and treatment. Details of the study can be found in the journal Trends in Cancer. (2020-08-11)

Silver-plated gold nanostars detect early cancer biomarkers
Biomedical engineers at Duke University have engineered a method for simultaneously detecting the presence of multiple specific microRNAs in RNA extracted from tissue samples without the need for labeling or target amplification. The technique could be used to identify early biomarkers of cancer and other diseases without the need for the elaborate, time-consuming, expensive processes and special laboratory equipment required by current technologies. (2020-07-21)

A rapid finger-stick blood test quickly estimates radiation exposure in mice
A new finger-stick test can use a single drop of blood to quickly estimate how much harmful radiation mice have been exposed to, according to a study. (2020-07-15)

International study discovers three potential new targets for treating epilepsy
A major international study has uncovered three molecules that have the potential to be developed into new drugs to treat epilepsy. The findings are an important step towards discovering new drugs for people with epilepsy whose seizures cannot be controlled with current treatments. (2020-06-25)

Direct reprogramming: Defying the contemporary limitations in cardiac regeneration
Repair and regeneration of myocardium are the best possible therapy for the end-stage heart failure patients because the current therapies that can help restore the lost cardiomyocytes are limited to heart transplantation only. Emerging interests to directly reprogram a mammalian heart with minimal regenerative capacity holds a promising future in the field of cardiovascular regenerative medicine. (2020-06-22)

Researchers study a novel type of extracellular vesicles
Researchers from Sechenov University and the University of Pittsburgh compared the properties of two groups of extracellular vesicles. Either present in a liquid phase or attached to the fibres of the extracellular matrix, these vesicles facilitate metabolism and cell-cell communication. A better understanding of their structure, production and movement can help create new bioengineered materials and repair damaged tissues more quickly. Findings are published in Science Advances. (2020-06-18)

Intracellular biopsy technique for fast microRNAs profiling in living cells
MicroRNAs (miRNAs) are gaining more attention in researches. To achieve fast and highly sensitive profiling of miRNAs, a research team from City University of Hong Kong (CityU) has developed a novel high-throughput intracellular biopsy technique that isolates targeted miRNAs from living cells within around 10 minutes by using diamond nanoneedles. The technique is simple and can be applied to other aspects, from the nucleic acid testing of viruses (e.g. COVID-19) to early cancer diagnosis. (2020-06-10)

Oncotarget: Anticancer effect of physical activity is mediated
Volume 11, Issue 22 of Oncotarget reported that the goal of this study was to explore the involvement of mi RNAs in beneficial effects exerted by physical activity in breast cancer prevention. (2020-06-03)

New understanding of RNA movements can be used to treat cancer
Research from Karolinska Institutet published today in Nature shows that an RNA molecule involved in preventing tumour formation can change its structure and thereby control protein production in the cell. The finding can have important clinical implications as it opens for new strategies to treat different types of cancer. (2020-05-27)

Releasing molecular 'brake' kick-starts immune cell function
The immune system's ability to marshal specialized cells to fight off infection relies in part on tiny molecules called microRNAs, which act as a release for the 'brakes' that keep cells dormant until needed, according to a new study published in the journal Cell Reports. (2020-05-18)

University of Minnesota researchers study radiation resistance in brain cancer cells
In a vertical climb to avoid collision with a towering mountain, a plane ejects cargo to gain altitude. Investigators at the University of Minnesota showed that cancer cells perform similar feats in escaping the killing effects of radiation. (2020-05-14)

Tiny RNA that should attack coronavirus diminish with age, disease
A group of tiny RNA that should attack the virus causing COVID-19 when it tries to infect the body are diminished with age and chronic health problems, a decrease that likely helps explain why older individuals and those with preexisting medical conditions are vulnerable populations, investigators report. (2020-05-13)

A study by TalTech geneticists revealed new potential causes of female infertility
Over the last six years a group of Estonian geneticists led by Associate Professor Agne Velthut-Meikas and a PhD student Ilmatar Rooda from TalTech Department of Chemistry and Biotechnology have studied genes previously associated primarily with female hormone synthesis and ovarian follicle development. The findings suggest that these genes may play a far more complex role in oocyte maturation than previously assumed. (2020-05-06)

Moffitt identifies novel therapeutic targets in cutaneous squamous cell carcinoma
Researchers at Moffitt Cancer Center want to devise better therapeutic strategies for patients with cutaneous squamous cell carcinoma (cuSCC) by improving their understanding of how the disease develops. In a new article published online ahead of print in the journal Cancer Research, Moffitt scientists report on their identification of potential therapeutic targets for cuSCC. (2020-03-30)

Taking a break helps drosophila germline cells reach their destination
Quiescence, or breaks during cell cycling, are common during germ cell development in many animals but the mechanisms regulating these periods are unclear. In a recent study from the University of Tsukuba, researchers identified a microRNA, miR-10404, and subsequently the entire pathway, governing the first of two quiescence periods in Drosophila germ-cell cycling. Understanding this mechanism furthers our understanding of the significance of quiescence in germline development. (2020-03-23)

MicroRNA exhibit unexpected function in driving cancer
New research shows that both strands of microRNA cooperate to drive growth and aggressiveness across cancer types, suggesting that these molecules may be more central in deadly cancers than previously thought. (2020-02-20)

Unraveling mechanisms of ventricular enlargement linked to schizophrenia
Scientists at St. Jude Children's Research Hospital have implicated two microRNAs in the biological processes that underlie the ventricle enlargement observed in models of schizophrenia. (2020-02-14)

Single-molecule detection of cancer markers brings liquid biopsy closer to clinic
A fast, inexpensive yet sensitive technique to detect cancer markers is bringing researchers closer to a 'liquid biopsy' -- a test using a small sample of blood or serum to detect cancer, rather than the invasive tissue sampling routinely used for diagnosis. The method captures and counts cancer-associated microRNAs, or tiny bits of messenger molecules that are exuded from cells and can be detected in blood or serum, with single-molecule resolution. (2019-12-18)

Agricultural parasite avoids evolutionary arms race, shuts down genes of host plants
A parasitic plant has found a way to circumvent an evolutionary arms race with its hosts, allowing the parasite to thrive on a variety of agriculturally important plants. (2019-12-17)

The function of new microRNAs are identified in Salmonella and Shigella infections
The research, published in Nature Microbiology, could help the search for more effective medicine and delves deeper into understanding the role of microRNAs in gene expression. (2019-12-16)

Ancient worm reveals way to destroy toxic cells in Huntington's disease
Research led by a Monash University scientist has identified a highly conserved mechanism in worms and humans that controls the removal of toxic protein aggregates -- hallmarks of neurodegenerative diseases. (2019-12-07)

Biochemical model enhances power to predict MicroRNA targeting
Through millions of affinity measurements, researchers have developed a biochemical model that reveals novel insights into microRNAs, which function in part to silence gene expression, but other biological functions of which are unknown. (2019-12-05)

Investigators narrow in on a microRNA for treating multiple sclerosis
Investigators from Brigham and Women's Hospital have discovered a microRNA -- a small RNA molecule -- that increases during peak disease in a mouse model of MS and in untreated MS patients. (2019-11-26)

Adolescent drinking increases anxiety, alcohol abuse later in life
Adolescent binge drinking modifies gene expression in a fashion that increases susceptibility to anxiety and alcohol use disorders in adulthood, according to research in rats recently published in eNeuro. Targeting the microRNAs responsible could be a new route for undoing the damage of alcohol use caused during adolescence. (2019-11-18)

MicroRNA comprehensively analyzed
Messenger RNA transmits genetic information to the proteins, and microRNA plays a key role in the regulation of gene expression. Scientists from the Moscow Institute of Physics and Technology and the Research Centre for Medical Genetics have described the complex interactions between these two and other kinds of human RNA. (2019-11-14)

Small RNAs link immune system and brain cells
A collaborative study carried out by the Institute of Pharmacology and Clinical Pharmacy at Goethe University (Professor Jochen Klein) and the Institute of Neurosciences at the Hebrew University of Jerusalem (Professor Hermona Soreq) shows sex-specific biases in disease-specific changes in brain cells, as well as in cellular control mechanisms based on endogenous short ribonucleic acid (RNA) chains. (2019-11-12)

Researchers discover how left-right information is integrated to correct organ positioning
Scientists from the Instituto de Neurociencias CSIC-UMH in Alicante, Spain, under the supervision of Professor Angela Nieto, have discovered the molecular mechanism that ensures the right equilibrium needed in left-right signaling cascade during development for the correct leftward positioning of the heart. (2019-10-17)

Cheap, quick test identifies pneumonia patients at risk of respiratory failure or sepsis
Spanish researchers in Valencia have identified specific fragments of genetic material that play a role in the development of respiratory failure and sepsis in pneumonia patients, according to research presented at the European Respiratory Society International Congress. The findings could enable doctors to test quickly for these biological markers when a patient is admitted to hospital with pneumonia, so that they could anticipate complications and provide more intensive support and monitoring. (2019-10-01)

New mechanisms that regulate pluripotency in embryonic stem cells are discovered
A study by researchers at the Center for Cell-Based Therapy, which is supported by FAPESP, identified microRNAs involved in pluripotency maintenance and cell differentiation. (2019-09-24)

To grow or to flower: Genes IDed in early land plant descendant also found in modern crops
Since they first arrived on land, plants have likely been using the same genetic tools to regulate whether they grow bigger or reproduce. The discovery was made using liverwort, one descendant of the first plants to move out of the ancient oceans and onto land. 'Liverworts have the maximum power with the least structure,' said Professor Yuichiro Watanabe from the University of Tokyo's Department of Life Sciences, an expert in plant molecular biology. (2019-09-19)

UTSW researchers identify new pathway that controls fat formation
In work suggesting new therapeutic targets to fight obesity, UT Southwestern researchers have identified a novel mechanism that regulates the creation of fat in mammals. (2019-09-17)

Methylation of microRNA may be a new powerful biomarker for cancer
Researchers from Osaka University found that levels of methylated microRNA were significantly higher in tissue and serum from cancer patients compared with that from normal controls. Specifically, methylation levels in serum samples distinguished patients with early pancreatic cancer from healthy controls with extremely high sensitivity and specificity. These findings provide a basis for new diagnostic strategies for early-stage cancer and represent a new perspective for understanding microRNA biology. (2019-09-02)

Tiny RNA provides big protection after a heart attack
Heart muscle can continue to die even after restoring blood following a heart attack, and scientists have new evidence that one way to help it live is by boosting levels of a tiny RNA that helped the heart form. (2019-08-26)

Rapid evolution: New findings on its molecular mechanisms
Evolutionary biologists from Konstanz analyze the role of microRNAs in the evolution of new species. (2019-08-14)

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