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Current Muscular dystrophy News and Events, Muscular dystrophy News Articles.
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COVID-19 anxiety linked to body image issues
A new study has found that anxiety and stress directly linked to COVID-19 could be causing a number of body image issues. (2020-10-22)
Scientists identify compound that stimulates muscle cells in mice
UCLA researchers have identified a compound that can reproduce the effect of exercise in muscle cells in mice. (2020-10-21)
Skeletal muscle development and regeneration mechanisms vary by gender
Researchers at Kumamoto University, Japan generated mice lacking the estrogen receptor beta (ERβ) gene, both fiber-specific and muscle stem cell-specific, which resulted in abnormalities in the growth and regeneration of skeletal muscle in female mice. (2020-10-12)
Damaged muscles don't just die, they regenerate themselves
Researchers building a model of muscle damage in a cultured system found that components leaking from broken muscle fibers activate ''satellite cells,'' which are muscle stem cells. (2020-10-12)
Terahertz zaps alter gene activity in stem cells
Terahertz light pulses change gene expression in stem cells, report researchers from Kyoto University's Institute for Integrated Cell-Material Sciences (iCeMS) and Tokai University in Japan in the journal Optics Letters. (2020-10-08)
Microneedles for therapeutic gene delivery
Researchers develop a minimally invasive biodegradable microneedle patch as a novel delivery mode for gene therapy applications (2020-10-07)
New Duchenne muscular dystrophy drug shows benefit in Duke trial
A new drug offers hope for young boys with the progressive neuromuscular disease Duchenne muscular dystrophy (DMD) by potentially offering an alternative to high-dose glucocorticoids that have significant side effects. (2020-09-25)
Scientists uncover a novel approach to treating Duchenne muscular dystrophy
Scientists at Sanford Burnham Prebys, Fondazione Santa Lucia IRCCS, and Università Cattolica del Sacro Cuore have shown that pharmacological (drug) correction of the content of extracellular vesicles released within dystrophic muscles can restore their ability to regenerate muscle and prevent muscle scarring. (2020-09-15)
Twist on CRISPR gene editing treats adult-onset muscular dystrophy in mice
UC San Diego researchers demonstrate that one dose of their version of CRISR gene editing can chew up toxic RNA and almost completely reverse symptoms in a mouse model of myotonic dystrophy, a type of adult-onset muscular dystrophy. (2020-09-14)
Drugging the undruggable: Yale finds treatment path for muscular dystrophy
Researchers at Yale have identified a possible treatment for Duchenne muscular dystrophy (DMD), a rare genetic disease for which there is currently no cure or treatment, by targeting an enzyme that had been considered ''undruggable.'' The finding appears in the Aug. (2020-09-11)
African wild dogs have vestigial first digit and muscular adaptations for life on the run
African wild dogs (Lycaon pictus) are known for their unique hunting style, often referred to as ''exhaustive predation'', in which they chase their prey to exhaustion, rather than hunting using speed, strength, or stealth. (2020-09-07)
Handgrip strength shown to identify people at high risk of type 2 diabetes
A simple test such as the strength of your handgrip could be used as a quick, low-cost screening tool to help healthcare professionals identify patients at risk of type 2 diabetes. (2020-09-02)
Duchenne: "Crosstalk" between muscle and spleen
Duchenne muscular dystrophy (DMD) is the most common muscle disease in children and is passed on by X-linked recessive inheritance. (2020-08-27)
A multicenter look at gene therapy for spinal muscular atrophy
A new study confirms the safety and efficacy of gene therapy in children with spinal muscular atrophy under two years old. (2020-08-25)
Researchers characterize important regulators of tissue inflammation, fibrosis and regeneration
Although macrophages (cells involved in the detection and destruction of bacteria and other harmful organisms as well as dead cells) are classified as immune cells functioning in the activation and resolution of tissue inflammation, it is now clear that they are critically involved in a variety of disease processes, such as chronic inflammatory diseases, tumor growth and metastasis and tissue fibrosis. (2020-08-10)
European Heart Journal: Cell infusions benefit heart patients
Three years after the ALLSTAR clinical trial ended prematurely, the study's data shows that treatments of cardiosphere-derived cells -- the same cells used as an experimental therapy tested in COVID-19 patients -- demonstrated unexpected promise in heart attack survivors. (2020-08-04)
Erectile dysfunction drugs can help cells destroy misfolded proteins
PDE5 inhibitors -- which include the erectile dysfunction drugs sildenafil and tadalafil -- can activate the cell's protein quality-control systems and improve its ability to dispose of misfolded proteins. (2020-07-22)
NHGRI researchers generate complete human X chromosome sequence
Researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health (NIH) have produced the first end-to-end DNA sequence of a human chromosome. (2020-07-14)
Study: RNA repair shows promise in reversing mutations underlying a neurological disorder
Scientists successfully edited RNA in a living animal in such a way that the repaired RNA then corrected a mutation in a protein that gives rise to a debilitating neurological disorder in people known as Rett syndrome. (2020-07-14)
Glowing worms provide live-action movies of the body's internal scaffolding
Duke researchers have made the first time-lapse movies of the sheet-like mesh that surrounds and supports most animal tissues. (2020-07-08)
Experimental drug shows early promise against inherited form of ALS, trial indicates
A clinical trial conducted at Washington University School of Medicine in St. (2020-07-08)
New Human Gene Therapy editorial: Concern following gene therapy adverse events
Response to the recent report of the deaths of two children receiving high doses of a gene therapy vector (AAV8) in a Phase I trial for X-linked myotubular myopathy (MTM). (2020-07-02)
Traditional strength training vs jump training for physically inactive young adults
The aim of this study was to compare the effects of 4-weeks of Traditional Resistance Training versus Plyometric Jump Training programs on the muscular fitness of sedentary and physically inactive participants. (2020-06-30)
New treatment for common form of muscular dystrophy shows promise in cells, animals
Researchers have designed a potential new treatment for one of the most common forms of muscular dystrophy, according to a new study published today in the Proceedings of the National Academy of Sciences. (2020-06-29)
New treatment method for Alport Syndrome uses antisense oligonucleotides
A multi-institutional research group including Kobe University researchers has succeeded in developing an exon-skipping therapy using nucleic-acid therapeutics for Alport syndrome, an incurable kidney disease that can progress to renal failure. (2020-06-24)
New structural 'map' solves mysteries of gigantic gene regulator
Structural biology has been used to 'map' part of a protein called SMCHD1, explaining how some changes in SMCHD1 cause certain developmental and degenerative conditions. (2020-06-17)
First report of systemic delivery of micro-dystrophin gene therapy in children with DMD
Researchers from Nationwide Children's Hospital have published in JAMA Neurology results from the first four patients treated in the first clinical trial of systemic delivery of micro-dystrophin gene therapy in children with Duchenne muscular dystrophy (DMD) -- and initial findings suggest that the therapy can provide functional improvement that is greater than that observed under the standard of care. (2020-06-15)
Treat early or wait? Experts ponder best way to manage milder forms of spinal muscular atrophy
The advent of therapeutic interventions for spinal muscular atrophy (SMA) has increased the importance of presymptomatic diagnosis and treatment. (2020-06-11)
The death marker protein cleans up your muscles after exercise
Researchers at the University of Copenhagen's Department of Nutrition, Exercise and Sports have demonstrated that physical activity prompts a clean-up of muscles as the protein Ubiquitin tags onto worn-out proteins, causing them to be degraded. (2020-05-28)
Restoring nerve-muscle communication in ALS
A new study finds that restoring the protein SV2 in a genetic form of ALS can correct abnormalities in transmission and even prevent cells from dying, providing a new target for future therapies. (2020-05-28)
A natural amino acid could be a novel treatment for polyglutamine diseases
Researchers from Osaka University, National Center of Neurology and Psychiatry, and Niigata University identified the amino acid arginine as a potential disease-modifying drug for polyglutamine diseases, including familial spinocerebellar ataxia and Huntington disease. (2020-05-25)
Researchers identify therapeutic targets to prevent cancer-associated muscle loss
Researchers at the University of Nebraska Medical Center have identified a key cell signaling pathway that drives the devastating muscle loss, or cachexia, suffered by many cancer patients. (2020-05-22)
Gene therapy in mice builds muscle, reduces fat
Researchers at Washington University School of Medicine in St. Louis found that gene therapy in mice helped build strength and significant muscle mass quickly, while reducing the severity of osteoarthritis. (2020-05-08)
Scientists edge closer to treatment for myotonic dystrophy
Scientists at the University of Nottingham have taken a step closer towards developing a treatment for the long-term genetic disorder, myotonic dystrophy. (2020-04-29)
Substituting the next-best protein
Children born with Duchenne muscular dystrophy have a mutation in the X-chromosome gene that would normally code for dystrophin, a protein that provides structural integrity to skeletal muscles. (2020-04-24)
Russian scientists has developed and introduced new laser method for cataract surgery
Scientists from ITMO and the S.N. Fyodorov Eye Microsurgery Complex came up with a technology where a laser is used both to destroy the clouded eye lens and to stimulate the regeneration of adjacent tissue. (2020-04-07)
One size does not fit all: Not all men idolize Western ideals of muscularity
UK researchers reported that men in Uganda and Nicaragua were generally less hung up about their body image and cared less about pursuing a muscular physique than British men. (2020-04-03)
Researchers reverse muscle fibrosis from overuse injury in animals, hope for human trials
High-force, high-repetition movements create microinjuries in muscle fibers. Muscle tissue responds by making repairs. (2020-03-30)
Experimental model mimics early-stage myogenic deficit in boys with DMD
An experimental model of severe Duchenne muscular dystrophy that experiences a large spike in TGFβ activity after muscle injury shows that high TGFβ activity suppresses muscle regeneration and promotes fibroadipogenic progenitors, Children's National Hospital researchers find. (2020-03-26)
For clogged and hardened hearts, a mussel is the solution
Prof. Hyung Joon Cha and his research team developed a stem cell therapy on myocardial infarction, using proteins that can be found in mussels, mussel adhesive proteins. (2020-03-25)
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