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Current Pharmaceuticals News and Events

Current Pharmaceuticals News and Events, Pharmaceuticals News Articles.
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Study finds micronutrient deficiencies common at time of celiac disease diagnosis
Micronutrient deficiencies, including vitamins B12 and D, as well as folate, iron, zinc and copper, are common in adults at the time of diagnosis with celiac disease. (2019-06-24)
When sand behaves like oil
Sand, coffee grounds and rice behave very differently than water or oil, but under certain conditions they will suddenly exhibit astonishing similarities. (2019-05-08)
Cell architects: 'Smart cells' improve production of pharmaceutical raw materials
Researchers in Japan have developed an integrated synthetic biology system to construct new metabolic pathways and enzymes within microbes. (2019-05-07)
A simple solution to a complex problem
Freiburg researchers use a novel approach to identify a transport protein in mycobacteria. (2019-04-29)
PSU researchers develop blockchain protocol to prevent counterfeit pharmaceutical sales
Portland State University researcher Nirupama Bulusu wants to prevent counterfeit pharmaceuticals from flooding the market. (2019-04-15)
Metal-free catalyst to convert aldehyde into ketone, a basic structure of pharmaceuticals
We succeeded in synthesizing a ketone, a basic structure of many pharmaceuticals, from an aldehyde and a carboxylic acid using N-heterocyclic carbene catalyst under mild conditions. (2019-04-03)
Gilteritinib improved survival for patients with acute myeloid leukemia
Treatment with the FLT3-targeted therapeutic gilteritinib (Xospata) improved survival for patients with relapsed or refractory acute myeloid leukemia (AML) harboring a FLT3 mutation compared with standard chemotherapy regimens, according to results from the ADMIRAL phase III clinical trial presented at the AACR Annual Meeting 2019, March 29-April 3. (2019-04-01)
Fluorine: Toxic and aggressive, but widely used
In toothpaste, Teflon, LEDs and medications, it shows its sunny side - but elemental fluorine is extremely aggressive and highly toxic. (2019-03-27)
Medicine and personal care products may lead to new pollutants in waterways
When you flush the toilet, you probably don't think about the traces of the medicine and personal care products in your body that are winding up in sewage treatment plants, streams, rivers, lakes, bays and the ocean. (2019-03-21)
Fast-acting agent shows promise in reversing effects of ticagrelor
PB2452 provides immediate and sustained reversal of ticagrelor's antiplatelet effects (2019-03-17)
Over half of ED visits for nonmedical prescription drug use are patients under 35
Using nationally representative public health surveillance data to characterize US ED visits for harm caused by nonmedical prescription drug use, investigators at CDC and FDA report in the American Journal of Preventive Medicine that over half these visits are by young adults under 35, and over 40 percent of patients arrive unconscious or after cardiorespiratory failure. (2019-03-06)
Copper catalyst distinguishing two different carbonyl compounds -- synthesis of 1,2-diols
Reductive coupling of two different carbonyl compounds A and B was known to yield three kinds of 1,2-diol, i.e. (2019-03-05)
When changing one atom makes molecules better
The group of Nuno Maulide, recently named the Scientist of the Year 2018 in Austria, in collaboration with the group of Harald Sitte, has now reported a facile method for the replacement of hydrogen with fluorine in important drug molecules. (2019-03-05)
How celastrol sensitizes brains to leptin, curbing hunger and obesity
Celastrol's potent anti-obesity effects were widely reported in 2015. Derived from the roots of the thunder god vine, the drug curbed food intake in obese mice by nearly 80 percent, producing up to a 45 percent weight loss. (2019-03-04)
Pharmaceutical residues in fresh water pose a growing environmental risk
Over the past 20 years, concentrations of pharmaceuticals have increased in freshwater sources all over the world, as research by environmental experts at Radboud University has revealed. (2019-02-22)
Drug 'librarian' discovers new compound that may thwart common surgery complication
In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke. (2019-02-20)
Light-based production of drug-discovery molecules
EPFL chemists have developed a light-based chemical method for cheap and simple production of chemical molecules used in drug discovery, such as muscle relaxants and antimicrobials. (2019-02-18)
Cystic fibrosis drug combo found safe and effective for 2- to 5-year-olds
An open label Phase 3 study conducted at Ann & Robert H. (2019-01-24)
Chemists develop new synthesis method for producing fluorinated piperidines
A team of chemists at the University of Münster led by Professor Frank Glorius have developed a new, simple synthetic method for producing fluorinated piperidines -- which had previously been very difficult. (2019-01-22)
Flavonoids as P-gp inhibitors: A systematic review of SARs
This review concerned the recent updates on the structure-activity relationships of flavonoids as P-gp inhibitors, the molecular mechanisms of their action and their ability to overcome P-gp-mediated MDR in preclinical studies. (2018-12-26)
Researchers investigate how vial sizes can be optimized to reduce pharmaceutical wastage
Pharmaceuticals are often dosed according to patient weight or body size which means that a dose must be individually measured. (2018-12-05)
The Center for the Study of Itch reviews what causes chronic itching and scratching
Relentless itch is a feature of many skin disorders, such as eczema and psoriasis, but the cause of this itch -- and what drives us to scratch -- is somewhat mysterious. (2018-11-21)
Human pharmaceuticals change cricket personality
Crickets that are exposed to human drugs that alter serotonin levels in the brain are less active and less aggressive than crickets that have had no drug exposure, according to a new study led by researchers from Linköping University. (2018-11-16)
DNA-encoded PCSK9 inhibitors may provide alternative for treating high cholesterol
Wistar researchers have developed novel synthetic DNA-encoded monoclonal antibodies (DMAbs) directed against PCSK9, a protein key to regulating cholesterol levels in the bloodstream. (2018-11-15)
Drug pollution concentrates in stream bugs, passes to predators in water and on land
Sixty-nine pharmaceutical compounds have been detected in stream insects, some at concentrations that may threaten animals that feed on them, such as trout and platypus. (2018-11-06)
Scientists find a 'switch' to increase starch accumulation in algae
Results from a collaborative study by Tokyo Institute of Technology and Tohoku University, Japan, raise prospects for large-scale production of algae-derived starch, a valuable bioresource for biofuels and other renewable materials. (2018-11-02)
New tools for creating mirrored forms of molecules
Chemists have developed an easier way to make libraries of candidate drugs with a specific 'handedness.' (2018-10-25)
DNA vaccine against Ebola virus shows potent & long-term efficacy in preclinical studies
A novel synthetic DNA vaccine developed based on technology pioneered by scientists at The Wistar Institute Vaccine & Immunotherapy Center offers complete protection from Zaire Ebolavirus (EBOV) infection in promising preclinical research. (2018-10-10)
New biomarker for Alzheimer's disease found thanks to the CRISPR technique
The scientists have found a deficiency in the protein STIM1 in brain tissue from patients with Alzheimer's disease. (2018-10-09)
New algorithm efficiently finds antibiotic candidates
In an article published today in the journal Nature Communications, researchers from Carnegie Mellon University; the University of California, San Diego; and St. (2018-10-02)
New method promises fewer side effects from cancer drugs
A recent achievement in the field of protein research allows for better tailored pharmaceuticals with fewer side effects. (2018-09-14)
Male birds sing less to females on antidepressants
Female starlings who have ingested dilute concentrations of antidepressants while feeding on worms, maggots and flies at sewage treatment plants appear to be less attractive to the opposite sex. (2018-08-06)
Small amounts of pharmaceuticals found in north central Pa. rural well water
Drinking water from wells in rural north central Pennsylvania had low levels of pharmaceuticals, according to a study led by Penn State researchers. (2018-07-31)
A ruthenium-based catalyst with highly active, flat surfaces outperforms metal-based competitors
Scientists in Japan and India have developed a reusable, high-performance catalyst based on flat-shaped ruthenium nanoparticles (Ru-NP) for the production of valuable chemicals. (2018-07-02)
University of Michigan researchers use gene silencing to alleviate common ataxia
In what researchers are calling a game changer for future ataxia treatments, a new study showed the ability to turn down the disease progression of the most common dominantly inherited ataxia, Spinocerebellar ataxia type 3 (SCA3), also known as Machado-Joseph disease. (2018-06-20)
Manipulated enzymes
TU Graz researchers managed for the first time ever to 'retrain' an enzyme to build ring-shaped molecular structures instead of performing its natural task of reducing double bonds. (2018-06-11)
Study of acute myeloid leukemia patients shows protein inhibitor drug safe and effective with durable remissions
Ivosidenib, an experimental drug that inhibits a protein often mutated in several cancers has been shown to be safe, resulting in durable remissions, in a study of acute myeloid leukemia (AML) with relapsed or refractory disease. (2018-06-02)
Cannabidiol significantly reduces seizures in patients with severe form of epilepsy
Cannabidiol (CBD), a compound derived from the cannabis plant that does not produce a 'high,' was shown in a new large-scale, randomized, controlled trial to significantly reduce the number of dangerous seizures in patients with a severe form of epilepsy called Lennox-Gastaut syndrome. (2018-05-16)
Therapeutic RNA corrects splicing defect that causes familial dysautonomia
Researchers at CSHL have published a proof of concept for a therapeutic RNA drug to correct the error in RNA splicing that causes familial dysautonomia (FD), a rare inherited neurodegenerative disorder. (2018-04-30)
Key drivers of high US healthcare spending identified
The major drivers of high healthcare costs in the US appear to be higher prices for nearly everything -- from physician and hospital services to diagnostic tests to pharmaceuticals -- and administrative complexity. (2018-03-13)
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