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Current Pharmaceuticals News and Events

Current Pharmaceuticals News and Events, Pharmaceuticals News Articles.
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Turning wood into pharmaceutical ingredients 
Production of hazardous waste during drug manufacturing is a serious concern for the pharmaceutical industry. (2019-10-23)
Nitrogen-embedded polycyclic compound with strong antiaromaticity and stability
Nitrogen-embedded polycyclic compounds with strong antiaromaticity and stability were synthesized and isolated for the first time using pyrrole as a key unit. (2019-10-18)
Long-term dupilumab benefits adolescents with eczema
Results from a phase IIa open-label trial and a subsequent phase III open-label extension trial reinforce findings from an earlier short-term trial that adolescents with moderate-to-severe atopic dermatitis, or eczema, can experience significant improvements with dupilumab. (2019-10-09)
Mason scientists invent new technology to streamline drug discovery
George Mason University researchers have discovered the exact location where two proteins responsible for hiding cancer cells from the immune system bind using a transformative protein painting technology. (2019-10-07)
Chemicals for pharmaceuticals could be made cheaper and greener by new catalysts
High value chemicals used to make pharmaceuticals could be made much cheaper and quicker thanks to a series of new catalysts made by scientists at the University of Warwick in collaboration with GoldenKeys High-Tech Co., Ltd. in China. (2019-10-01)
Better methods needed for predicting risk of liver disease
While blood samples can reliably identify people with a low risk of developing severe liver disease, better methods are needed in primary care for identifying people in most need of care. (2019-09-27)
Scientists create a nanomaterial that is both twisted and untwisted at the same time
A new nanomaterial developed by scientists at the University of Bath could solve a conundrum faced by scientists probing some of the most promising types of future pharmaceuticals. (2019-09-13)
A new way to make valuable chemicals
A new discovery has advanced the field of carbon capture and utilization. (2019-08-26)
Urban stormwater could release contaminants to ground, surface waters
A good rainstorm can make a city feel clean and revitalized. (2019-08-21)
When naproxen breaks down, toads croak
A new study in Environmental Toxicology and Chemistry takes a harder look at the effects a common anti-inflammatory medication and its degradation products have on amphibians. (2019-08-12)
Promising clinical trial results for drug for rare disease in which patients can't eat fat
In a Phase III clinical trial, the drug volanesorsen significantly reduced blood fat (triglyceride) levels in participants with a rare disease called familial chylomicronemia syndrome; finding could also help inform better prevention methods and treatments for many types of heart disease. (2019-08-08)
Shrinking brain tumours and opening the door for targeted cancer therapies
A new drug, known as IP1867B, could be used for future treatments of brain tumours. (2019-08-05)
Should polycystic kidney disease patients be screened for brain aneurysms?
Brain aneurysms were detected by pre-symptomatic screening in 9% of patients with autosomal dominant polycystic kidney disease, more frequently in those with a history of hypertension and smoking. (2019-07-30)
Expert panel in macular degeneration recommends paradigm shift for future directions
A panel of investigators assembled by the National Advisory Eye Council (NAEC) calls for large-scale collaborative research to address dry macular degeneration -- the leading cause of blindness among the elderly -- for which there is currently no effective treatment. (2019-07-26)
Study finds micronutrient deficiencies common at time of celiac disease diagnosis
Micronutrient deficiencies, including vitamins B12 and D, as well as folate, iron, zinc and copper, are common in adults at the time of diagnosis with celiac disease. (2019-06-24)
When sand behaves like oil
Sand, coffee grounds and rice behave very differently than water or oil, but under certain conditions they will suddenly exhibit astonishing similarities. (2019-05-08)
Cell architects: 'Smart cells' improve production of pharmaceutical raw materials
Researchers in Japan have developed an integrated synthetic biology system to construct new metabolic pathways and enzymes within microbes. (2019-05-07)
A simple solution to a complex problem
Freiburg researchers use a novel approach to identify a transport protein in mycobacteria. (2019-04-29)
PSU researchers develop blockchain protocol to prevent counterfeit pharmaceutical sales
Portland State University researcher Nirupama Bulusu wants to prevent counterfeit pharmaceuticals from flooding the market. (2019-04-15)
Metal-free catalyst to convert aldehyde into ketone, a basic structure of pharmaceuticals
We succeeded in synthesizing a ketone, a basic structure of many pharmaceuticals, from an aldehyde and a carboxylic acid using N-heterocyclic carbene catalyst under mild conditions. (2019-04-03)
Gilteritinib improved survival for patients with acute myeloid leukemia
Treatment with the FLT3-targeted therapeutic gilteritinib (Xospata) improved survival for patients with relapsed or refractory acute myeloid leukemia (AML) harboring a FLT3 mutation compared with standard chemotherapy regimens, according to results from the ADMIRAL phase III clinical trial presented at the AACR Annual Meeting 2019, March 29-April 3. (2019-04-01)
Fluorine: Toxic and aggressive, but widely used
In toothpaste, Teflon, LEDs and medications, it shows its sunny side - but elemental fluorine is extremely aggressive and highly toxic. (2019-03-27)
Medicine and personal care products may lead to new pollutants in waterways
When you flush the toilet, you probably don't think about the traces of the medicine and personal care products in your body that are winding up in sewage treatment plants, streams, rivers, lakes, bays and the ocean. (2019-03-21)
Fast-acting agent shows promise in reversing effects of ticagrelor
PB2452 provides immediate and sustained reversal of ticagrelor's antiplatelet effects (2019-03-17)
Over half of ED visits for nonmedical prescription drug use are patients under 35
Using nationally representative public health surveillance data to characterize US ED visits for harm caused by nonmedical prescription drug use, investigators at CDC and FDA report in the American Journal of Preventive Medicine that over half these visits are by young adults under 35, and over 40 percent of patients arrive unconscious or after cardiorespiratory failure. (2019-03-06)
Copper catalyst distinguishing two different carbonyl compounds -- synthesis of 1,2-diols
Reductive coupling of two different carbonyl compounds A and B was known to yield three kinds of 1,2-diol, i.e. (2019-03-05)
When changing one atom makes molecules better
The group of Nuno Maulide, recently named the Scientist of the Year 2018 in Austria, in collaboration with the group of Harald Sitte, has now reported a facile method for the replacement of hydrogen with fluorine in important drug molecules. (2019-03-05)
How celastrol sensitizes brains to leptin, curbing hunger and obesity
Celastrol's potent anti-obesity effects were widely reported in 2015. Derived from the roots of the thunder god vine, the drug curbed food intake in obese mice by nearly 80 percent, producing up to a 45 percent weight loss. (2019-03-04)
Pharmaceutical residues in fresh water pose a growing environmental risk
Over the past 20 years, concentrations of pharmaceuticals have increased in freshwater sources all over the world, as research by environmental experts at Radboud University has revealed. (2019-02-22)
Drug 'librarian' discovers new compound that may thwart common surgery complication
In a strategic search, Johns Hopkins scientists created and screened a library of 45,000 new compounds containing chemical elements of widely used immune system suppressants, and say they found one that may prevent reperfusion injury, a tissue-damaging and common complication of surgery, heart attack and stroke. (2019-02-20)
Light-based production of drug-discovery molecules
EPFL chemists have developed a light-based chemical method for cheap and simple production of chemical molecules used in drug discovery, such as muscle relaxants and antimicrobials. (2019-02-18)
Cystic fibrosis drug combo found safe and effective for 2- to 5-year-olds
An open label Phase 3 study conducted at Ann & Robert H. (2019-01-24)
Chemists develop new synthesis method for producing fluorinated piperidines
A team of chemists at the University of Münster led by Professor Frank Glorius have developed a new, simple synthetic method for producing fluorinated piperidines -- which had previously been very difficult. (2019-01-22)
Flavonoids as P-gp inhibitors: A systematic review of SARs
This review concerned the recent updates on the structure-activity relationships of flavonoids as P-gp inhibitors, the molecular mechanisms of their action and their ability to overcome P-gp-mediated MDR in preclinical studies. (2018-12-26)
Researchers investigate how vial sizes can be optimized to reduce pharmaceutical wastage
Pharmaceuticals are often dosed according to patient weight or body size which means that a dose must be individually measured. (2018-12-05)
The Center for the Study of Itch reviews what causes chronic itching and scratching
Relentless itch is a feature of many skin disorders, such as eczema and psoriasis, but the cause of this itch -- and what drives us to scratch -- is somewhat mysterious. (2018-11-21)
Human pharmaceuticals change cricket personality
Crickets that are exposed to human drugs that alter serotonin levels in the brain are less active and less aggressive than crickets that have had no drug exposure, according to a new study led by researchers from Linköping University. (2018-11-16)
DNA-encoded PCSK9 inhibitors may provide alternative for treating high cholesterol
Wistar researchers have developed novel synthetic DNA-encoded monoclonal antibodies (DMAbs) directed against PCSK9, a protein key to regulating cholesterol levels in the bloodstream. (2018-11-15)
Drug pollution concentrates in stream bugs, passes to predators in water and on land
Sixty-nine pharmaceutical compounds have been detected in stream insects, some at concentrations that may threaten animals that feed on them, such as trout and platypus. (2018-11-06)
Scientists find a 'switch' to increase starch accumulation in algae
Results from a collaborative study by Tokyo Institute of Technology and Tohoku University, Japan, raise prospects for large-scale production of algae-derived starch, a valuable bioresource for biofuels and other renewable materials. (2018-11-02)
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