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For teens with migraine, sleeping in (a bit) may help
Research indicates that starting school later in the morning yields health and academic benefits for high schoolers, whose natural body clock tends toward late-to-bed, late-to-rise habits. While parents raise concerns about drowsy driving, irritation and impaired school performance, a new study led by researchers at UC San Francisco suggests another reason to push back the start time. (2020-11-25)

New breakthrough in the treatment of rheumatoid arthritis
People with Rheumatoid Arthritis (RA) could soon benefit from a new drug treatment, otilimab, that not only suppresses inflammation but also significantly reduces patient reported pain scores. (2020-11-25)

Rhythm and bleughs: changes in our stomach's rhythms steer us away from disgusting sights
Does the sight of maggots squirming in rotten food make you look away in disgust? The phrase 'makes my stomach turn' takes on a new meaning today as researchers at the University of Cambridge reveal that changes in the rhythm of our stomachs prompt us to look away from disgusting images. (2020-11-24)

Drug eases recovery for those with severe alcohol withdrawal
Yale scientists say a drug originally developed to treat high blood pressure can reduce severe withdrawal symptoms for patients diagnosed with alcohol use disorder. (2020-11-19)

Vitamin D supplements may reduce risk of developing advanced cancer
In a secondary analysis of VITAL, a team led by investigators at Brigham and Women's Hospital has narrowed in on the connection between taking vitamin D supplements and risk of metastatic or fatal cancer. In a paper published in JAMA Network Open, the team reports that vitamin D was associated with an overall 17 percent risk reduction for advanced cancer. (2020-11-18)

Low levels of choline in pregnant Black American women associated with higher levels of stress
Researchers at the University of Colorado Anschutz Medical Campus have found that many pregnant Black Americans have low levels of choline, an essential nutrient that aids in prenatal brain development. Stress caused by institutional racism may play a role. (2020-11-16)

Trifarotene in moderate acne: No study data for the assessment of the added benefit
Trifarotene in moderate acne: no study data for the assessment of the added benefit. Although acne affects many people and there are treatment alternatives, the new drug was only compared with placebo in the approval studies. (2020-11-16)

Cleveland Clinic led trial shows drug effective in 96% of patients with recurrent pericarditis
Cleveland: Cleveland Clinic researchers leading a global clinical trial have found that rilonacept, an FDA approved drug for other inflammatory diseases, resolved acute pericarditis episodes and reduced risk of pericarditis recurrence. The study was published today in the New England Journal of Medicine and presented at the American Heart Association's Scientific Sessions. (2020-11-16)

Patients taking statins experience similar side effects from dummy pills
People taking dummy pills and statins experienced similar side effects in a new study. (2020-11-15)

Omega-3s did not reduce cardiac events in recent heart attack survivors
Omega-3 supplements in commonly available forms appear to be ineffective in preventing further cardiovascular events among elderly people with recent heart attacks. When compared to a placebo, an omega-3 fatty acids supplement in addition to statin therapy and/or a blood thinner did not reduce the number of cardiac events in a study of more than 1,000 patients in Norway. (2020-11-15)

Side effects often attributed to statins were the same for those taking a placebo
Study participants who reported side effects from cholesterol-lowering medications known as statins also reported the same side effects when they unknowingly took placebo pills. These side effects are real, and it appears may be mostly due to the psychological rather than the pharmacological effects of statins since symptoms were consistent when taking the placebo. (2020-11-15)

Hydroxychloroquine does not help patients hospitalized with COVID-19: Study
Findings from a national study published today in the Journal of the American Medical Association (JAMA) ''do not support'' the use of hydroxychloroquine for the treatment of adult patients hospitalized with COVID-19. (2020-11-13)

The future's uncertain - but noradrenaline can help us adapt
A brain chemical called noradrenaline is responsible for our responses to uncertain situations - helping us to learn quickly and adapt our behaviour, a new study has found. (2020-11-13)

Diabetes drug can treat and reverse heart failure and reduce
Mount Sinai clinical trial results could help lead to FDA approval (2020-11-13)

Fluvoxamine may prevent serious illness in COVID-19 patients
Researchers at Washington University School of Medicine in St. Louis have completed a clinical trial suggesting that the antidepressant drug fluvoxamine may help prevent deterioration in COVID-19 patients, making hospitalization less likely. (2020-11-12)

JAMA reports fluvoxamine as potential early treatment for COVID-19
The COVID-19 Early Treatment Fund (CETF) announced that JAMA, The Journal of the American Medical Association, published the results of a Washington University School of Medicine in St. Louis double-blind, randomized controlled clinical trial that investigated whether the antidepressant medication fluvoxamine can reduce the risk for respiratory deterioration. (2020-11-12)

Vitamin D lessens symptoms of severe eczema in children
Vitamin D supplementation eased the symptoms experienced by children with severe atopic dermatitis, or eczema, in a recent randomized controlled trial published in Pharmacology Research & Perspectives. (2020-11-04)

Intensive urate lowering reduces urine albumin excretion
Phase 2 trial of verinurad with febuxostat vs. placebo shows 49% reduction in albuminuria (2020-10-29)

NEJM: clinical trial indicates monoclonal antibody lowered hospitalizations and emergency visits
COVID-19 (coronavirus) patients who were administered a novel antibody had fewer symptoms and were less likely to require hospitalization or emergency medical care than those who did not receive the antibody, according to a new study published in the The New England Journal of Medicine. (2020-10-29)

Keck Medicine of USC enrolling individuals in phase 3 clinical trial to treat mild Alzheimer's disease using deep brain stimulation
Keck Medicine of USC is enrolling individuals in an international phase 3 clinical trial to examine the safety and effectiveness of deep brain stimulation to treat Alzheimer's. The study uses electrical impulses to stimulate the region of the brain known as the fornix, which is associated with memory and learning. (2020-10-21)

U of M trial shows hydroxychloroquine does not prevent COVID-19 in health care workers
University of Minnesota Medical School researchers found that taking hydroxychloroquine once or twice weekly did not prevent the development of COVID-19 in health care workers better than the placebo. (2020-10-21)

Tocilizumab doesn't ease symptoms or prevent death in moderately ill COVID-19 inpatients
The drug tocilizumab (Actemra) does not reduce the need for breathing assistance with mechanical ventilation or prevent death in moderately ill hospitalized patients with COVID-19, according to a study by researchers at Massachusetts General Hospital. The study, published in the New England Journal of Medicine, casts doubt on earlier research suggesting that tocilizumab, which is commonly prescribed for rheumatoid arthritis and other conditions, might be an effective treatment for patients with worsening cases of COVID-19. (2020-10-21)

Cannabis reduces OCD symptoms by half in the short-term
People with obsessive-compulsive disorder (OCD) report that the severity of symptoms was reduced by about half within four hours of smoking cannabis. After smoking cannabis, users with OCD reported it reduced their compulsions by 60%, intrusions, or unwanted thoughts, by 49% and anxiety by 52%. The study also found that higher doses and cannabis with higher concentrations of CBD were associated with larger reductions in compulsions. (2020-10-20)

Exercise and nutrition regimen benefits physical, cognitive health
Researchers studied the effects of a 12-week exercise regimen on 148 active-duty Air Force airmen, half of whom also received a twice-daily nutrient beverage that included protein; the omega-3 fatty acid, DHA; lutein; phospholipids; vitamin D; B vitamins and other micronutrients; along with a muscle-promoting compound known as HMB. Both groups improved in physical and cognitive function, with added gains among those who regularly consumed the nutritional beverage, the team reports. (2020-10-19)

The Lancet Infectious Diseases: Preliminary results find vaccine candidate based on inactivated SARS-CoV-2 virus is safe and induces an immune response in healthy volunteers
A Chinese COVID-19 vaccine candidate based on the inactivated whole SARS-CoV-2 virus (BBIBP-CorV) is safe and elicits an antibody response, findings from a small early-phase randomised clinical trial published today in The Lancet Infectious Diseases journal have found. (2020-10-15)

Can an antibody 'cocktail' prevent COVID-19 infection?
In a new COVID-19 clinical trial, Stuart Cohen at UC Davis Health tests monoclonal antibody combination to prevent COVID-19 in adults exposed to infected patients. (2020-10-12)

Study explores link between methamphetamine use and risky sexual behavior
Recreational use of the illicit drug methamphetamine has long been associated with increases in overall impatient and risky behavior. Now, a new study by Johns Hopkins Medicine researchers affirms that meth use increases not only sexual desire but also, specifically and measurably, the risk of casual sex without a condom for those who have an increase in sexual desire. (2020-09-30)

Prostate cancer: immunotherapy offers hope
An antibody for treating advanced prostate cancer improves progression-free survival in patients with metastasised, castration-resistant prostate cancer. This is the finding of the long-term analyses of an international phase 3 clinical trial, recently published in the leading journal ''European Urology''. The study showed that overall survival was 2 - 3 times higher than in the placebo arm. (2020-09-29)

How hormone therapy slows progression of atherosclerosis
As one of the most common treatments for effectively managing menopause symptoms, hormone therapy (HT) is also known to provide multiple health benefits, including slowing the progression of atherosclerosis. A study based on Early Versus Late Intervention Trial With Estradiol (ELITE) data evaluated the underlying mechanism of such benefit and will be presented during the 2020 Virtual Annual Meeting of The North American Menopause Society (NAMS), opening on September 28. (2020-09-28)

Study provides additional support for use of new class of diabetes drugs
A new study led by a cardiologist from Brigham and Women's Hospital has assessed the cardiovascular and renal outcomes for ertugliflozin, an SGLT2 inhibitor prescribed for patients with type 2 diabetes to help them control blood sugar levels. (2020-09-24)

Reduction in insomnia symptoms associated with non-invasive neurotechnology
For people with chronic insomnia, a good night's sleep is elusive. But what if insomnia symptoms could be alleviated by simply listening to one's own brainwaves? (2020-09-17)

Gut microbiota not involved in the incidence of gestational diabetes mellitus
Consuming the combination of fish oil and probiotic food supplements modulate the composition of gut microbiota in overweight and obese pregnant women, reveals a new study conducted at the University of Turku, Finland. The same study shows that gut microbiota composition and function is not related to gestational diabetes. (2020-09-09)

A pain reliever that alters perceptions of risk
While acetaminophen is helping you deal with your headache, it may also be making you more willing to take risks, a new study suggests. People who took acetaminophen rated activities like ''bungee jumping off a tall bridge'' and ''speaking your mind about an unpopular issue in a meeting at work'' as less risky than people who took a placebo, researchers found. (2020-09-08)

Probiotics may help manage childhood obesity
Probiotics may help children and adolescents with obesity lose weight when taken alongside a calorie-controlled diet, according to a study being presented at e-ECE 2020. The study found that obese children who were put on a calorie-restricted diet and given probiotics Bifidobacterium breve BR03 and Bifidobacterium breve B632, lost more weight and had improved insulin sensitivity compared with children on a diet only. (2020-09-07)

New drug shown to improve bone growth in children with achondroplasia
A phase three global clinical trial led by the Murdoch Children's Research Institute (MCRI) has shown that the drug vosoritide restores close-to-average bone growth rates of children with achondroplasia, the most common form of dwarfism. The study, published in The Lancet, enrolled 121 children aged five to 18. The 60 children who received vosoritide grew an average 1.57 cm more per year. Regulatory authorities are reviewing applications to license treatment. (2020-09-05)

Elderly people protected against respiratory infections by BCG vaccine
The BCG vaccine has a broad, stimulating effect on the immune system. This gives it an effective preventive action against various infections - possibly also against COVID-19. New studies are investigating that. BCG is frequently given to children, but a double-blind randomized clinical study, a collaboration between Radboud university medical center and the National and Kapodistrian University of Athens shows that elderly people also benefit from it. The results are published in Cell. (2020-09-01)

Trial supports first specific treatment for obstructive hypertrophic cardiomyopathy
Mavacamten improves heart function and symptoms in patients with obstructive hypertrophic cardiomyopathy, according to results of the EXPLORER-HCM trial presented in a Hot Line session today at ESC Congress 2020. (2020-08-31)

EMPEROR-Reduced meets primary endpoint in heart failure with reduced ejection fraction
Empagliflozin reduces the risk of cardiovascular death or hospitalisation for heart failure in patients with heart failure and a reduced ejection fraction. That's the finding of the EMPEROR-Reduced trial presented in a Hot Line session today at ESC Congress 2020. (2020-08-31)

Gout drug repurposed to fight heart disease
Colchicine reduces the risk of major cardiovascular events in patients with chronic coronary disease, according to results of the LoDoCo2 trial presented in a Hot Line session today at ESC Congress 2020.1 ''Over a decade, more than one in three heart patients will have another heart attack or stroke, or die from heart disease, despite taking preventive medication,'' said study author Dr. Mark Nidorf of GenesisCare, Australia. (2020-08-31)

DAPA-CKD trial meets primary endpoint in patients with chronic kidney disease
Dapagliflozin reduces the risk of kidney failure, death from cardiovascular causes or heart failure hospitalisation and all-cause mortality in chronic kidney disease patients with or without type 2 diabetes. That's the main result of the DAPA-CKD trial presented in a Hot Line session today at ESC Congress 2020. (2020-08-31)

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