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Hypertension drug may hold promise for Alzheimer's disease
The blood pressure drug nilvadipine increased blood flow to the brain's memory and learning center, without affecting other brain regions among people with Alzheimer's disease. (2019-06-17)
Tildrakizumab shows promising efficacy and safety in psoriatic arthritis
The results of a phase 2B study presented today at the Annual European Congress of Rheumatology (EULAR 2019) demonstrate superior efficacy and comparable safety of tildrakizumab versus placebo in patients with psoriatic arthritis. (2019-06-14)
Linagliptin improved albuminuria but effect on eGFR and CV risk in patients with diabetes
In the CARMELINA trial nearly 10% of all patients with diabetes had nephrotic-range proteinuria at baseline. (2019-06-14)
Tart cherry shown to decrease joint pain, sore muscles in some breast cancer patients
Tart cherry reduces the musculoskeletal effects of aromatase inhibitors in patients with non-metastatic breast cancer, according to new findings from a clinical trial by researchers at Marshall University Joan C. (2019-06-10)
Large international study finds diabetes drug cuts cardiovascular and kidney problems
A clinical trial that followed more than 9,900 people in 24 countries has found that the drug dulaglutide reduced cardiovascular events and kidney problems in middle-aged and older people with type 2 diabetes. (2019-06-09)
The Lancet journals: Papers at American Diabetes Association (ADA) 2019
The following papers will be presented at the ADA conference in San Francisco and published simultaneously in either The Lancet or The Lancet Diabetes & Endocrinology journals. (2019-06-09)
Three-drug combination helps curb the growth of deadly type of skin cancer
A UCLA-led research team has pinpointed a three-drug combination that could prove to be an effective new therapy for people with a specific type of advanced melanoma. (2019-06-06)
Alzheimer's therapy may help overcome opioid addiction
Clinical trial results reveal that a medication used to treat Alzheimer's disease may also be an effective therapy for individuals addicted to opioids. (2019-06-05)
POLO trial for advanced pancreatic cancer: a new standard of care
Treatment with the drug olaparib significantly reduced the risk of disease progression or death from metastatic pancreatic cancer, according to findings from the recently completed, international, phase-III POLO (Pancreas cancer OLaparib Ongoing) trial. (2019-06-03)
Vitamin D could help cancer patients live longer
Michigan State University physicians have found that vitamin D, if taken for at least three years, could help cancer patients live longer. (2019-06-03)
Ribociclib plus hormone therapy extends survival for patients with premenopausal advanced hormone receptor-positive breast cancer
Adding the targeted therapy ribociclib to hormone therapy significantly improved overall survival (OS) in premenopausal patients with advanced hormone receptor-positive (HR+) breast cancer, according to results of the MONALEESA-7 Phase III clinical trial led by researchers at The University of Texas MD Anderson Cancer Center. (2019-06-01)
Energy drinks may increase risk of heart function abnormalities and blood pressure changes
Three to four hours after drinking 32 ounces of energy drinks, the heart's electrical activity was abnormal compared to drinking a placebo drink. (2019-05-29)
Short-term use of opioids increases subjective pleasure
As indicated by a recently published study, short-term opioid use shifts a range of emotional responses to the positive direction. (2019-05-24)
CBD clinical trial results on seizure frequency in dogs 'encouraging'
Dr. Stephanie McGrath found in a small study that 89 percent of dogs who received CBD in the clinical trial had a reduction in the frequency of seizures. (2019-05-21)
New opioid speeds up recovery without increasing pain sensitivity or risk of chronic pain
A new type of non-addictive opioid developed by researchers at Tulane University and the Southeast Louisiana Veterans Health Care System accelerates recovery time from pain compared to morphine without increasing pain sensitivity, according to a new study published in the Journal of Neuroinflammation. (2019-05-21)
rTMS improves memory in younger and older adults
Magnetic stimulation of the brain improves working memory, offering a new potential avenue of therapy for individuals living with Alzheimer's disease and other forms of dementia, according to new research from the Duke University School of Medicine. (2019-05-15)
The Lancet: Preventative antibiotics after assisted childbirth almost halve maternal infection rate and reduce overall antibiotic use
Giving a single dose of preventative antibiotics to all women after childbirth involving forceps or vacuum extraction could prevent almost half of maternal infections including sepsis--equivalent to over 7,000 maternal infections every year in the UK, and around 5,000 in the USA. (2019-05-13)
Progesterone could increase births in women with early pregnancy bleeding and previous miscarriage
Research led by the University of Birmingham suggests that giving progesterone to pregnant women with early pregnancy bleeding and a history of miscarriage could increase their chances of having a baby. (2019-05-08)
New treatment for severe dry eye disease promising in early clinical trials
Participants in a phase I/II clinical trial of a new enzyme-based treatment for severe dry eye disease experienced reduced signs of disease and discomfort, according to a paper in Translational Vision Science and Technology. (2019-05-07)
Montmorency tart cherries may provide benefits for adults with metabolic syndrome
Montmorency tart cherries reduced systolic blood pressure, insulin levels and insulin concentrations in adults with metabolic syndrome participating in a small pilot study published in the Journal of Functional Foods. (2019-05-07)
Azithromycin appears to reduce treatment failure in severe, acute COPD exacerbations
The antibiotic azithromycin may reduce treatment failure in patients hospitalized for an acute exacerbation of chronic obstructive pulmonary disease (COPD), according to a randomized, controlled trial published online in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. (2019-05-03)
Study shows drug reduces risk of relapse with neuromyelitis optica
The drug eculizumab, a synthetic antibody that inhibits the inflammatory response, significantly reduced the risk of relapse with neuromyelitis optica spectrum disorder (NMOSD). (2019-05-03)
Blood pressure drug shows no benefit in Parkinson's disease
A study of a blood pressure drug does not show any benefit for people with Parkinson's disease, according to findings released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4-10, 2019. (2019-05-02)
Modulating a hormonal pathway improves social function in 2 clinical trials of adults and children with autism spectrum disorder
Results from two clinical trials reveal that modulating the hormone vasopressin's biological pathway safely enhanced social functioning in 223 adult men and 30 children with autism spectrum disorder (ASD). (2019-05-01)
Experimental drug shows promise for genetic form of ALS
An early stage trial of an investigational therapy for amyotrophic lateral sclerosis (ALS) suggests that people could tolerate the experimental drug and, in exploratory results, the experimental drug was linked to possible slower progression in people with a genetic form of the disease caused by mutations in a gene called superoxide dismutase 1 (SOD1). (2019-05-01)
Cannabis-based medicine may reduce seizures for children with difficult-to-treat epilepsy
Taking a pharmaceutical formulation of cannabidiol, a cannabis-based medicine, cut seizures nearly in half for children with a rare and severe type of epilepsy called Dravet syndrome, according to a phase 3 study released today that will be presented at the American Academy of Neurology's 71st Annual Meeting in Philadelphia, May 4-10, 2019. (2019-04-30)
Drug treats Type 2 diabetes in children, team announces
Jane Lynch, M.D., FAAP, professor of pediatrics at UT Health San Antonio, said the drug liraglutide, in combination with an existing medication, metformin, showed robust effect in treating children with type 2 diabetes who were studied in the Ellipse trial. (2019-04-29)
When designing clinical trials for huntington's disease, first ask the experts
Progress in understanding the genetic mutation responsible for Huntington's disease (HD) and at least some molecular underpinnings of the disease has resulted in a new era of clinical testing of potential treatments. (2019-04-23)
Magic mouthwash effective treatment for mouth sore pain caused by radiation therapy
'Magic mouthwash,' an oral rinse containing diphenhydramine, lidocaine and antacids, significantly reduced pain from oral mucositis, mouth sores, in patients receiving radiation therapy for cancers of the head and neck when compared to plaecbo. (2019-04-16)
Diabetic drug shown to reduce the risk of heart disease in non-diabetic patients
Metformin could reverse the harmful thickening of heart muscle that leads to cardiovascular disease, according to researchers at the University of Dundee. (2019-04-16)
Statins safe for preventing cardiovascular events in rheumatoid arthritis patients
Results from a large clinical trial indicate that patients with rheumatoid arthritis are likely to experience the same level of cardiovascular benefits from statins as other individuals, without additional risks. (2019-04-15)
Train your brain, change your brain
Less than one hour of brain training with neurofeedback leads to a strengthening of neural connections and communication among brain areas. (2019-04-14)
Zinc oxide reduces body odor caused by bacteria and aids wound healing
New research presented at this week's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Amsterdam, Netherlands (April 13-16) shows that a formulation containing zinc oxide is effective at reducing armpit odour through killing the responsible bacteria, and assists in wound healing. (2019-04-12)
Obeticholic acid improves liver fibrosis and other histological features of NASH
A prespecified interim analysis of the ongoing Phase 3 REGENERATE study has confirmed that obeticholic acid (OCA) is effective in the treatment of nonalcoholic steatohepatitis (NASH) with liver fibrosis. (2019-04-10)
OHIO study: Acetaminophen can reduce positive empathy for others
A new study by an Ohio University faculty member showed that acetaminophen limited positive empathy a person has for others while taking it. (2019-04-08)
Experimental therapy completely clears HPV in one-third of cervical cancer precursors
A potential new immune-based therapy to treat precancers in the cervix completely eliminated both the lesion and the underlying HPV infection in a third of women enrolled in a clinical trial. (2019-04-04)
Well-known drug has less risk for preterm delivery in PCOS
Metformin significantly reduces the risk of late miscarriages and preterm births for women with PCOS. (2019-04-01)
Common medication used in pregnancy may lead to obesity in children
Metformin, a common drug used for type 2 diabetes, has several benefits when the mother has PCOS. (2019-03-27)
Second potential male birth control pill passes human safety tests
A new male birth control pill passed tests of safety and tolerability when healthy men used it daily for a month, and it produced hormone responses consistent with effective contraception, according to researchers at two institutions testing the drug. (2019-03-25)
Automated drug delivery system combats low blood sugar after weight-loss surgery
A new automated drug delivery system can help prevent dangerously low blood sugar in patients who have undergone weight-loss surgery, according to a study to be presented Monday, March 25, at ENDO 2019, the Endocrine Society's annual meeting in New Orleans, La. (2019-03-25)
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