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Current Placebo News and Events, Placebo News Articles.
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Researchers offer hope for an oral, noninjectable treatment of acromegaly
Adults who need medical maintenance treatment of the growth hormone disorder acromegaly respond well to an investigational oral form of the drug octreotide, investigators of the Chiasma OPTIMAL study reported. (2020-03-31)
First FDA-approved drug for thyroid eye disease effective regardless of age, gender
Teprotumumab, the first FDA-approved medicine for thyroid eye disease, provides significant improvement in eye bulging, regardless of patient gender, age or smoking status, according to a study accepted for presentation at ENDO 2020, the Endocrine Society's annual meeting, and publication in a special supplemental section of the Journal of the Endocrine Society. (2020-03-31)
Liraglutide can help adolescents with obesity manage their weight
Liraglutide 3.0 mg, approved by the United States Food and Drug Administration (FDA) as an adjunct to a reduced-calorie diet and increased physical activity to help adults with obesity manage their weight, appears to help adolescents too, according to an industry-sponsored randomized controlled trial. (2020-03-31)
Vericiguat improves outcomes in patients with worsening heart failure
Patients with worsening heart failure and reduced ejection fraction who received the investigational drug vericiguat had a significantly lower rate of cardiovascular death or heart failure hospitalization compared with those receiving a placebo, based on research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)
Intravenous sodium nitrite ineffective for out-of-hospital cardiac arrest
Among patients who had an out-of-hospital cardiac arrest, intravenous sodium nitrite given by paramedics during resuscitation did not significantly improve their chances of being admitted to or discharged from the hospital alive, according to research presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)
Alirocumab substantially reduces cholesterol in adult patients with HoFH
The cholesterol drug alirocumab reduced low-density lipoprotein (LDL) cholesterol by 35.6% compared to placebo in adult patients with homozygous familial hypercholesterolemia (HoFH), according to a phase three clinical trial presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)
Evinacumab cuts cholesterol levels by half in patients with HoFH
The investigational drug evinacumab reduced low-density lipoprotein (LDL) cholesterol to near-normal levels among patients with a rare cholesterol disorder, meeting the primary endpoint in the first randomized placebo-controlled trial of the drug, which is being presented at the American College of Cardiology's Annual Scientific Session Together with World Congress of Cardiology (ACC.20/WCC). (2020-03-30)
The placebo effect and psychedelic drugs: tripping on nothing?
A new study from McGill suggests that, in the right context, some people may experience psychedelic-like effects from placebos alone. (2020-03-30)
Study: An aspirin a day does not keep dementia at bay
Taking a low-dose aspirin once a day does not reduce the risk of thinking and memory problems caused by mild cognitive impairment or probable Alzheimer's disease, nor does it slow the rate of cognitive decline, according to a large study published in the March 25, 2020, online issue of Neurology®, the medical journal of the American Academy of Neurology. (2020-03-25)
Acupuncture can reduce migraine headaches
Acupuncture can reduce migraine headaches compared to both sham (placebo) acupuncture and usual care, finds a new trial from China published by The BMJ today. (2020-03-25)
Using cannabinoids to treat acute pain
A new systematic review and meta-analysis showed a small but significant reduction in subjective pain scores for cannabinoid treatment compared to placebo in patients experiencing acute pain. (2020-03-23)
Clinicians should consider screening for TSH-R-Abs before pregnancy in patients with history of autoimmune thyroid disorders
Clinicians should consider screening for thyroid-stimulating hormone receptor antibodies (TSH-R-Abs) before pregnancy when the patient has a history of autoimmune thyroid disease or a history of radioactive iodine treatment or thyroidectomy. (2020-03-23)
Antioxidant supplements do not improve male fertility, NIH study suggests
Antioxidant supplements do not improve semen quality among men with infertility, according to a new study supported by the Eunice Kennedy Shriver National Institute of Child Health and Human Development . (2020-02-28)
Anti-psychotic medication linked to adverse change in brain structure
In a first-of-its-kind study using advanced brain imaging techniques, a commonly used anti-psychotic medication was associated with potentially adverse changes in brain structure. (2020-02-26)
Potential new heartburn drug studied at VUMC
An investigational drug that binds bile acids in the stomach can reduce the severity of heartburn symptoms in patients with treatment-resistant gastroesophageal reflux disease (GERD) when combined with a proton pump inhibitor (PPI), a new study suggests. (2020-02-26)
The Lancet Respiratory Medicine: New therapy could help relieve persistent cough
A new treatment - called gefapixant - may reduce the frequency of coughing, including in patients who have suffered from a chronic cough for more than 15 years, according to results from a phase 2b clinical trial which lasted 12 weeks and included 253 people, published in The Lancet Respiratory Medicine journal. (2020-02-25)
Study investigates rates of adverse events for common rheumatoid arthritis drug
Investigators have been able to far more accurately determine rates of adverse events for people taking methotrexate, finding small-to-moderate elevations in risks for skin cancer, gastrointestinal, infectious, lung, and blood adverse events. (2020-02-17)
Insufficient evidence backing herbal medicines for weight loss
Researchers from the University of Sydney have conducted the first global review of herbal medicines for weight loss in 19 years, finding insufficient evidence to recommend any current treatments. (2020-02-17)
Kisspeptin hormone injection can boost brain activity associated with attraction
The hormone kisspeptin can enhance brain activity associated with attraction, according to a new study. (2020-02-13)
Pharmacological migraine prophylaxis shows almost no effect in children
Migraines affect not only adults but frequently also children and adolescents. (2020-02-10)
New treatment discovered for rare eye disease may prevent blindness
Patients with thyroid eye disease who used the minimally invasive insulin-like growth factor I blocking antibody, teprotumumab, experienced improvement in their symptoms, appearance and quality of life, according to a study recently published in the New England Journal of Medicine. (2020-02-09)
Botanical drug is shown to help patients with head and neck cancers
In a UCLA-led phase I clinical trial, a new plant-based drug called APG-157 showed signs of helping patients fight oral and oropharyngeal cancers. (2020-02-06)
Zinc lozenges did not shorten the duration of colds
Administration of zinc acetate lozenges to common cold patients did not shorten colds in a randomized trial published in BMJ Open. (2020-01-28)
New insight into how cannabidiol takes effect in the brains of people with psychosis
Researchers from King's College London have shown that cannabidiol (CBD) alters the brain activity in people with psychosis during memory tasks, making it more similar to the activation seen in people without psychosis during the same tasks. (2020-01-28)
Oral hormone-blocking drug may help with heavy menstrual bleeding
In women with uterine fibroids, the drug elagolix suppresses ovarian hormone production and prevents heavy menstrual bleeding. (2020-01-23)
Low-dose aspirin may reduce preterm birth risk among first-time mothers
Daily low-dose aspirin, from as early as the sixth week of pregnancy through the 36th week, may lower the risk for preterm birth among first-time mothers, suggests a study funded by the National Institutes of Health. (2020-01-23)
Medicinal cannabis may not ease sleep problems in the long run
Medicinal cannabis might not ease sleep problems in people with chronic pain over the long term, because frequent users might build up tolerance to its sleep-inducing effects, suggests preliminary research published online in BMJ Supportive & Palliative Care. (2020-01-20)
Rich rewards: Scientists reveal ADHD medication's effect on the brain
Researchers at the Okinawa Institute of Science and Technology Graduate University (OIST) have identified how certain areas of the human brain respond to methylphenidate -- a stimulant drug which is used to treat symptoms of ADHD. (2020-01-17)
Zinc, folic acid supplements fail to enhance male fertility
Zinc and folic acid, a pair of dietary supplements long touted as an effective treatment for male infertility, failed to improve pregnancy rates, sperm counts, and sperm potency in a new study conducted at University of Utah Health and other medical centers in conjunction with the National Institutes of Health. (2020-01-07)
Nerve stimulation may benefit women with fibromyalgia
Published in Arthritis & Rheumatology, a treatment involving electrical nerve stimulation helped women with fibromyalgia in a recent clinical trial. (2020-01-06)
MIV-711 not associated with pain reduction, but may reduce disease progression in osteoarthritis
MIV-711, a novel selective cathepsin K inhibitor, was not more effective than placebo for reducing pain related to knee osteoarthritis. (2019-12-30)
Breakthrough science provides hope for disease that affects 1.5 million people in US
Today the prestigious New England Journal of Medicine (NEJM) publishes research led by Monash University that offers the first real hope for the treatment of lupus, a disease which affects 1.5 million people in the US and more than 5 million globally, 90% women and for which there is no cure. (2019-12-18)
Old drug offers new hope for children with devastating disorder
A drug that once helped obese adults lose weight, withdrawn from the market due to heart risks, may be safe and effective for children with a seizure disorder called Dravet syndrome, say researchers from UCSF Benioff Children's treatment centers. (2019-12-17)
Nilotinib appears safe in Parkinson's trial; drug thought to allow dopamine replenishment
A clinical trial investigating the repurposed cancer drug nilotinib in people with Parkinson's disease finds that it is reasonably safe and well tolerated. (2019-12-16)
10-year results of NRG Oncology/NSABP B-42 trial
In the updated results from NRG Oncology/NSABP B-42 trial through 10 years of observation, extending letrozole therapy for additional five years after five years of adjuvant endocrine therapy resulted in a statistically significant improvement in the 10-year disease-free survival (DFS) of postmenopausal women with hormone-receptor-positive breast cancer. (2019-12-12)
Migraine prevention in children and adolescents
Two medicines already used to prevent migraine in adults also showed efficacy in adolescents with migraine. (2019-12-10)
Acupuncture reduces radiation-induced dry mouth for cancer patients
After receiving acupuncture treatment three days a week during the course of radiation treatment, head and neck cancer patients experienced less dry mouth, according to study results from researchers at The University of Texas MD Anderson Cancer Center. (2019-12-06)
First of its kind study seeks to answer whether effects of 'abortion pill' can be reversed
Women who initiate medical abortion but opt to stop in the middle of treatment may be at risk for serious blood loss, a UC Davis Health study finds. (2019-12-05)
Australian GPs widely offering placebos, new study finds
Most Australian GPs have used a placebo in practice at least once, with active placebos (active treatments used primarily to generate positive expectations) more commonly used than inert placebos, according to a new study from University of Sydney. (2019-12-02)
Cannabis reduces headache and migraine pain by nearly half
Inhaled cannabis reduces self-reported headache severity by 47.3% and migraine severity by 49.6%, according to a recent study by Washington State University researchers published in the Journal of Pain. (2019-11-25)
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