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Probiotics could help millions of patients suffering from bipolar disorder
About 3 million people in the US are diagnosed every year with bipolar disorder, a psychiatric condition characterized by dramatic shifts in mood from depression to mania. (2018-12-13)
The Lancet Neurology: Cannabis-based drug in combination with other anti-spasticity
Oral spray containing two compounds derived from the cannabis plant reduced spasticity compared with placebo in patients already taking anti-spasticity drugs. (2018-12-13)
Oxybutynin decreased frequency of hot flashes, improved QOL for breast cancer survivors
Treatment with oxybutynin helped reduce the frequency and intensity of hot flashes for women who could not take hormone replacement, including breast cancer survivors, according to results of a trial presented at the 2018 San Antonio Breast Cancer Symposium. (2018-12-07)
Mayo-led study: Drug reduces hot flashes, improves breast cancer survivor quality of life
Research led by oncologists Roberto Leon-Ferre, M.D. and Charles Loprinzi, M.D. of Mayo Clinic has found that the drug oxybutynin helps to reduce the frequency and intensity of hot flashes in women who are unable to take hormone replacement therapy, including breast cancer survivors. (2018-12-07)
Low-dose tamoxifen reduced recurrence and new disease for patients with DCIS, LCIS, and ADH
Treatment with a low dose of tamoxifen (5 mg per day) halved the risk of disease recurrence and new disease for women who had been treated with surgery following a diagnosis of breast intraepithelial neoplasia compared with placebo, and it did not cause more serious adverse events, according to data from the randomized, phase III TAM-01 clinical trial presented at the 2018 San Antonio Breast Cancer Symposium. (2018-12-06)
Liquid biopsies in SOLAR-1 trial predict benefit of Alpelisib in PIK3CA-mutant breast cancer
Liquid biopsy-based assessment of PIK3CA mutational status served as a better indicator of progression-free survival compared with analysis of tissue biopsy in breast cancer patients enrolled in the phase III clinical trial SOLAR-1, according to data presented at the 2018 San Antonio Breast Cancer Symposium. (2018-12-06)
Pot withdrawal eased for dependent users
A new drug can help people diagnosed with cannabis use disorder reduce withdrawal symptoms and marijuana use, a new Yale-led study published Dec. (2018-12-06)
Cannabis-based compound may reduce seizures in children with epilepsy
Interest has been growing in the use of cannabinoids--the active chemicals in cannabis or marijuana-- for the treatment of epilepsy in children. (2018-12-05)
Common antidepressant does not aid stroke recovery, study finds
Stroke patients prescribed a common antidepressant show no improvement compared with those given a dummy drug, a study led by the University of Edinburgh has found. (2018-12-05)
Cleveland Clinic-led study: Rivaroxaban reduced blood clots and related death in cancer patients
Cleveland Clinic medical oncologist and researcher, Alok Khorana, M.D., is the primary investigator on a study that concluded rivaroxaban for venous thromboembolism (VTE), a blood clot in the venous system, significantly reduced VTE and VTE-related death for outpatient, at-risk cancer patients while they were taking the oral blood thinner. (2018-12-04)
Sex-specific effects of DHEA on bone mineral density and body composition
Women 55 and older have an increased risk of bone and muscle loss but therapy with the hormone Dehydroepiandrosterone (DHEA) may help prevent bone loss and increase muscle mass in older women, according to a new study led by Catherine M. (2018-12-04)
A new drug to prevent life-threatening swelling attacks
Patients with hereditary angioedema experience recurrent and sometimes life-threatening swelling attacks. (2018-11-28)
Phase 3 trial shows lanadelumab to be effective in reducing hereditary angioedema attacks
A phase 3 clinical trial led by a Massachusetts General Hospital physician, finds that injections of the monoclonal antibody drug lanadelumab reduced attacks of hereditary angioedema -- a rare, potentially life-threatening disorder. (2018-11-27)
New study reveals probiotics do not help children with intestinal infections
Probiotics are a multibillion-dollar industry with marketing claims of being an effective treatment for a multitude of ailments, including diarrhea. (2018-11-21)
Probiotic no better than placebo for acute gastroenteritis in children
While probiotics are often used to treat acute gastroenteritis (also known as infectious diarrhea) in children, the latest evidence shows no significant differences in outcomes, compared to a placebo. (2018-11-21)
Researchers find promise in new treatment for peanut allergy
Controlled ingestion of peanut protein could help build tolerance in peanut allergy sufferers. (2018-11-19)
MDMA makes people cooperative, but not gullible
New research from King's College London has found that MDMA, the main ingredient in ecstasy, causes people to cooperate better -- but only with trustworthy people. (2018-11-19)
Aspirin and omega-3 reduce pre-cancerous bowel polyps
Both aspirin and a purified omega-3, called EPA, reduce the number of pre-cancerous polyps in patients found to be at high risk of developing bowel cancer, according to new research. (2018-11-19)
VITAL study: How vitamin D and fish oil affect risk of heart attack, stroke and cancer
Brigham and Women's Hospital investigators leading the VITamin D and OmegA-3 TriaL (VITAL) conducted a rigorous placebo-controlled trial over the course of 5.3 years, gleaning a treasure trove of information on the effects of both supplements. (2018-11-10)
Compound derived from marijuana may benefit children with epilepsy
In recent years, cannabinoids -- the active chemicals in medical marijuana -- have been increasingly touted as a potential treatment for a range of neurological and psychiatric disorders. (2018-11-07)
Among heart attack survivors, drug reduces chances of second heart attack or stroke
In a clinical trial involving 18,924 patients from 57 countries who had suffered a recent heart attack or threatened heart attack, researchers at the University of Colorado Anschutz Medical Campus and fellow scientists around the world have found that the cholesterol-lowering drug alirocumab reduced the chance of having additional heart problems or stroke. (2018-11-07)
Study finds tennis elbow treatments provide little to no benefit
In the largest analysis to date, researchers and clinicians at Beth Israel Deaconess Medical Center (BIDMC) have compared the efficacy and safety of non-surgical treatment options for tennis elbow -- also called enthesopathy of the extensor carpi radialis brevis (eECRB). (2018-11-01)
Drug combination for treatment resistant depression no more effective than single
A large clinical trial published in the British Medical Journal today, looked at the effectiveness of adding mirtazapine to an SSRI or SNRI in patients who remain depressed after at least six weeks of conventional (SSRI or SNRI) antidepressant treatment. (2018-11-01)
Study: Denosumab effective in treating osteoporosis in transfusion dependent thalassemia
For patients with osteoporosis caused by transfusion-dependent thalassemia (TDT), a twice-yearly injection appears to improve spinal bone mineral density, according to a new study. (2018-10-31)
Combination drug targeting opioid system may help relieve symptoms of major depression
Two clinical trials of an investigational drug that targets the opioid system support its safety and effectiveness in reducing symptoms of major depression, when added to standard antidepressant treatment. (2018-10-29)
Sensitive tests suggest low risk of drug resistance with dapivirine ring
If approved, a monthly vaginal ring containing an antiretroviral (ARV) called dapivirine would be the first biomedical HIV prevention method specifically for women. (2018-10-24)
Epigenetic therapy worth pursuing in hormone receptor positive advanced breast cancer
Epigenetic therapy with histone deacetylase (HDAC) inhibitors is worth pursuing in hormone receptor positive advanced breast cancer, suggests a phase III trial reported today at the ESMO 2018 Congress in Munich. (2018-10-22)
Antipsychotics ineffective for treating ICU delirium
A large multi-site study has found that critically ill patients are not benefiting from antipsychotic medications that have been used to treat delirium in intensive care units (ICUs) for more than four decades. (2018-10-22)
Cannabis improves symptoms of Crohn's disease despite having no effect on gut inflammation
In a randomized, placebo-controlled study, researchers from Israel have shown that cannabis can produce clinical remission in up to 65 percent of individuals after eight weeks of treatment, but that this improvement does not appear to result from a dampening down of the underlying inflammatory process. (2018-10-21)
Immune therapy generates promising results in hard-to-treat ankylosing spondylitis
Results from a phase 3 clinical trial indicate that patients who have not benefited from standard therapy for ankylosing spondylitis (AS), a chronic inflammatory disease characterized by back pain and sacroiliac-joint damage, may have another treatment option in the biologic drug ixekizumab. (2018-10-20)
Chewing gum may be effective for delivering vitamins
Nearly 15 percent of all chewing gum varieties sold promise to provide health-enhancing supplements to users, so Penn State researchers studied whether two vitamin-supplemented products were effective at delivering vitamins to the body. (2018-10-09)
Weight loss drug shows positive effect on diabetes
'Now we report that, when added to lifestyle interventions, lorcaserin significantly reduced incidence of diabetes, increased rates of diabetes remission, and reduced the risk of diabetic microvascular complications.' (2018-10-04)
Study shows how lixisenatide slows or prevents damage to the kidneys in patients with type 2 diabetes and cardiovascular disease
New research presented at the annual meeting of the European Association for the Study of Diabetes (EASD) and published simultaneously in The Lancet Diabetes & Endocrinology shows how the glucose-lowering drug lixisenatide can slow or prevent damage to the kidneys in macro-albuminuric patients with type 2 diabetes mellitus (T2DM) and cardiovascular disease. (2018-10-03)
Study finds albiglutide reduces cardiovascular events in patients with type 2 diabetes and existing cardiovascular disease
New research presented at this year's annual meeting of the European Association for the Study of Diabetes (EASD) and published in The Lancet shows that treatment with albiglutide (a type of drug called a glucagon-like peptide 1 receptor agonist) results in fewer cardiovascular events in people with type 2 diabetes and existing cardiovascular disease than treatment with placebo. (2018-10-02)
Non-small cell lung cancer patients see improved survival with durvalumab
Non-small cell lung cancer patients survive longer when their treatment includes durvalumab following platinum-based chemoradiotherapy, according to research led by Moffitt Cancer Center. (2018-09-27)
Study finds that a lifestyle intervention may mitigate PFAS-related weight gain
A new study finds that perfluoroalkyl and polyfluoroalkyl substances (PFASs) are associated with increases in weight, but exercise and diet may reduce the obesogenic effects of these environmental contaminants. (2018-09-25)
Common painkiller not effective for chronic pain after traumatic nerve injury
A new study out today in the Journal of Neurology finds that pregabalin is not effective in controlling the chronic pain that sometimes develops following traumatic nerve injury. (2018-09-24)
Aspirin found not to prolong healthy aging
Taking a low-dose aspirin daily does not prolong healthy living in older adults, according to findings from the ASPirin in Reducing Events in the Elderly (ASPREE) trial published online Sept. (2018-09-17)
Daily low-dose aspirin found to have no effect on healthy life span in older people
In a clinical trial to determine the effects of daily low-dose aspirin in healthy older adults without previous cardiovascular events, aspirin did not prolong healthy, independent living free of dementia or physical disability. (2018-09-16)
Scientific analysis shows probiotic use is associated with fewer antibiotic prescriptions
New analysis shows that infants and children who receive probiotics as a preventative measure are less likely to receive antibiotic prescriptions. (2018-09-14)
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