Current Psilocybin News and Events

Current Psilocybin News and Events, Psilocybin News Articles.
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Psychedelic treatment with psilocybin relieves major depression, study shows
A compound found in so-called magic mushrooms, psilocybin produces visual and auditory hallucinations and profound changes in consciousness over a few hours after ingestion. In 2016, Johns Hopkins Medicine researchers first reported that treatment with psilocybin under psychologically supported conditions significantly relieved existential anxiety and depression in people with a life-threatening cancer diagnosis. (2020-11-04)

A scientific first: How psychedelics bind to key brain cell receptor
For the first time, scientists at UNC-Chapel Hill and Stanford solved the high-resolution structure of these compounds when they are actively bound to the 5-HT2A serotonin receptor on the surface of brain cells. This discovery is already leading to the exploration of more precise compounds that could eliminate hallucinations but still have strong therapeutic effects. Psilocybin - the psychedelic compound in mushrooms - has already been granted breakthrough status by the FDA to treat depression. (2020-09-17)

Research news tip sheet: Story ideas from Johns Hopkins Medicine
We want you to continue having access to the latest Johns Hopkins Medicine research achievements and clinical advances, so we are issuing a second tip sheet every Thursday, covering topics not related to COVID-19 or the SARS-CoV-2 virus. (2020-06-18)

Psychedelic drug psilocybin tamps down brain's ego center
Perhaps no region of the brain is more fittingly named than the claustrum, taken from the Latin word for 'hidden or shut away.' The claustrum is an extremely thin sheet of neurons deep within the cortex, yet it reaches out to every other region of the brain. Its true purpose remains 'hidden away' as well, with researchers speculating about many functions. For example, Francis Crick of DNA-discovery fame believed that the claustrum is the seat of consciousness, responsible for awareness and sense of self. (2020-06-05)

Psychedelic compound from magic mushrooms produced in yeast
Scientists from DTU Biosustain prove that psilocybin, a potential drug for treating depression and other psychological conditions can be produced in yeast. (2020-04-16)

Neuronal and neurotransmitter systems dynamic coupling explains the effects of psilocybin
Interest in research into the effects of psilocybin, a psychedelic drug, has increased significantly in recent years due to its promising therapeutic effects in neuropsychiatric disorders such as depression, anxiety and addiction. (2020-04-16)

Revisiting the potential of using psychedelic drugs in psychiatry
Before they were banned about a half century ago, psychedelic drugs like LSD and psilocybin showed promise for treating conditions including alcoholism and some psychiatric disorders. In a commentary publishing April 2 in the journal Cell, researchers say it's time for regulators, scientists, and the public to 'revisit drugs that were once used but fell out of use because of political machinations, especially the war on drugs.' (2020-04-02)

Antianxiety and antidepressant effects from a single dose of psychedelic drug persist years later in cancer patients
Following up on their landmark 2016 study, researchers at NYU Grossman School of Medicine found that a one-time, single-dose treatment of psilocybin, a compound found in psychedelic mushrooms, combined with psychotherapy appears to be associated with significant improvements in emotional and existential distress in cancer patients. (2020-01-28)

New research confirms lingering mood benefit of psychedelics
People who had recently used psychedelics such as psilocybin report a sustained improvement in mood and feeling closer to others after the high has worn off, shows a new Yale study published the week of Jan. 20 in the journal Proceedings of the National Academy of Sciences. (2020-01-20)

Psychedelic drugs could help treat PTSD
Clinical trials suggest treatment that involves psychedelics can be more effective than psychotherapy alone. More than three million people in the United States are diagnosed each year with post-traumatic stress disorder, whose symptoms include nightmares or unwanted memories of trauma, heightened reactions, anxieties, and depression--and can last months, or even years. (2020-01-17)

Ayahuasca compound changes brainwaves to vivid 'waking-dream' state
Scientists have peered inside the brain to show how taking DMT affects human consciousness by significantly altering the brain's electrical activity. (2019-11-19)

Mindfulness meditation enhances positive effects of psilocybin
Recent years have seen a renewed interest in the clinical application of classic psychedelics in the treatment of depression and anxiety disorders. Researchers of the University of Zurich have now shown that mindfulness meditation can enhance the positive long-term effects of a single dose of psilocybin, which is found in certain mushrooms. (2019-10-24)

Science of microdosing psychedelics remains patchy and anecdotal, say researchers
The practice of taking small, regular doses of psychedelic drugs to enhance mood, creativity, or productivity lacks robust scientific evidence, say scientists. (2019-07-15)

Experiences of 'ultimate reality' or 'God' confer lasting benefits to mental health
In a survey of thousands of people who reported having experienced personal encounters with God, Johns Hopkins researchers report that more than two-thirds of self-identified atheists shed that label after their encounter, regardless of whether it was spontaneous or while taking a psychedelic. (2019-04-23)

Mouse study examines the underpinnings of hallucinations
In a study publishing March 26 in the journal Cell Reports, researchers looked at how a hallucinogenic drug impacts the brains of mice at the level of individual neurons. They found that visual hallucinations may be triggered by a reduction in signaling within the visual cortex, rather than an increase, and by altered timing of when the neurons fire. (2019-03-26)

Fast-acting psychedelic associated with improvements in depression/anxiety
Johns Hopkins researchers have discovered that use of the synthetic psychedelic 5-methocy-N,-N-dimethyltryptamine (5-MeO-DMT) appears to be associated with unintended improvements in self-reported depression and anxiety when given in a ceremonial group setting. 5-MeO-DMT is a psychedelic that is found in the venom of Bufo Alvarius toads, in a variety of plants species, and can be produced synthetically. (2019-03-18)

Psychedelic microdosing in rats shows beneficial effects
Microdosing -- taking tiny amounts of psychedelic drugs to boost mood and mental acuity -- is based on anecdotal reports of its benefits. Now, a study in rats by researchers at UC Davis suggests microdosing can provide relief for symptoms of depression and anxiety, but also has potential negative effects.  (2019-03-04)

Reclassification recommendations for drug in 'magic mushrooms'
In an evaluation of the safety and abuse research on the drug in hallucinogenic mushrooms, Johns Hopkins researchers suggest that if it clears phase III clinical trials, psilocybin should be re-categorized from a schedule I drug -- one with no known medical potential -- to a schedule IV drug such as prescription sleep aids, but with tighter control. (2018-09-26)

Can psychedelic drugs heal?
Many people think of psychedelics as relics from the hippie generation or something taken by ravers and music festival-goers, but they may one day be used to treat disorders ranging from social anxiety to depression, according to research presented at the annual convention of the American Psychological Association. (2018-08-09)

Psychedelic drug use associated with reduced partner violence in men
In a new study published in the Journal of Psychopharmacology, researchers from UBC's Okanagan campus have discovered that men who have used psychedelic drugs in the past have a lower likelihood of engaging in violence against their intimate partners. (2018-06-05)

Why are some mushrooms 'magic?'
Psychedelic mushrooms likely developed their (2018-02-27)

New study suggests psychedelic drugs may reduce criminal behaviour
Newly published research suggests that common psychedelic drugs -- such as magic mushrooms, LSD and mescaline (a substance derived from the peyote cactus) -- may reduce criminal offences. The new study, co-authored by UBC Okanagan's Associate Professor of Psychology Zach Walsh, found that psychedelic drugs are associated with a decreased likelihood of antisocial criminal behaviour. (2017-10-23)

Magic mushrooms may 'reset' the brains of depressed patients
Patients taking psilocybin to treat depression show reduced symptoms weeks after treatment following a 'reset' of their brain activity. (2017-10-13)

Rethinking serotonin could lead to a shift in psychiatric care
A better understanding of how a key chemical messenger acts in the brain could lead to a radical shift in psychiatric care, according to a new research paper. (2017-09-04)

Magic enzymes
Little fungi pack a punch: 'Magic mushrooms' of the Psilocybe species produce psychoactive compounds that alter perception when ingested. Recently, the effects on the neuronal system caused by their ingredient psilocybin have attracted the interest of pharmacologists. German scientists have now identified four of the enzymes responsible for the biosynthesis of psilocybin. In the journal Angewandte Chemie, they describe the biosynthetic pathway and introduce a synthetic route that could form the basis of biotechnological production. (2017-08-25)

First evidence for higher state of consciousness found
Scientific evidence of a 'higher' state of consciousness has been found in a study led by the University of Sussex. (2017-04-19)

Researchers urge caution around psilocybin use
In a survey of almost 2,000 people who said they had had a past negative experience when taking psilocybin-containing 'magic mushrooms,' Johns Hopkins researchers say that more than 10 percent believed their worst 'bad trip' had put themselves or others in harm's way, and a substantial majority called their most distressing episode one of the top 10 biggest challenges of their lives. (2016-12-30)

Hallucinogenic drug psilocybin eases existential anxiety in people with life-threatening cancer
In a small double-blind study, Johns Hopkins researchers report that a substantial majority of people suffering cancer-related anxiety or depression found considerable relief for up to six months from a single large dose of psilocybin -- the active compound in hallucinogenic 'magic mushrooms.' (2016-12-01)

Single dose of hallucinogenic drug psilocybin relieves anxiety and depression in patients with advanced cancer
When combined with psychological counseling, a single dose of a mind-altering compound contained in psychedelic mushrooms significantly lessens mental anguish in distressed cancer patients for months at a time, according to results of a clinical trial led by researchers at NYU Langone Medical Center. (2016-12-01)

The Lancet Psychiatry: Magic mushroom compound psilocybin could provide new avenue for antidepressant research
Psilocybin -- a hallucinogenic compound derived from magic mushrooms -- may offer a possible new avenue for antidepressant research, according to a new study published in The Lancet Psychiatry today. (2016-05-17)

UBC study finds psychedelic drugs may reduce domestic violence
Psychedelic drugs may help curb domestic violence committed by men with substance abuse problems, according to a new UBC study. The UBC Okanagan study found that 42 percent of US adult male inmates who did not take psychedelic drugs were arrested within six years for domestic battery after their release, compared to a rate of 27 percent for those who had taken drugs such as LSD, psilocybin (commonly known as magic mushrooms) and MDMA (ecstasy). (2016-04-26)

Psilocybin reduces psychological pain after social exclusion
Social problems are key characteristics in psychiatric disorders and are insufficiently targeted by current treatment approaches. By applying brain imaging methods, researchers at the University of Zurich now show that a small amount of psilocybin changes the processing of social conflicts in the brain. As a result, participants experienced social exclusion and social pain as less stressful. This could help to improve therapy of social problems. (2016-04-18)

Active ingredient in magic mushrooms reduces anxiety and depression in cancer patients
Psilocybin, found in magic mushrooms, decreased anxiety and depression in patients diagnosed with life-threatening cancer. In a study presented at the annual meeting of the American College of Neuropsychopharmacology by Roland Griffiths of the Johns Hopkins School of Medicine, patients who received a psilocybin dose that altered perception and produced mystical-type experiences, reported significantly less anxiety and depression compared with patients who received a low dose of the drug. The positive effects lasted 6 months. (2015-12-10)

Psychedelic therapy re-emerging for anxiety, PTSD and addiction
Renewed medical interest in the use of psychedelic drugs for anxiety, posttraumatic stress disorder and addiction has resulted in small research studies that show some success with the controlled use of these drugs, according to an analysis published in CMAJ. (2015-09-08)

Psychedelic drugs should be legally reclassified as they may benefit patients
Legal restrictions imposed on medical use of psychedelic drugs, such as LSD and psilocybin (the compound found in 'magic' mushrooms), are making trials almost impossible and authorities should 'downgrade their unnecessarily restrictive class A, schedule 1 classification,' writes a psychiatrist in The BMJ this week. (2015-05-26)

Psychedelic drug use could reduce psychological distress, suicidal thinking
A history of psychedelic drug use is associated with less psychological distress and fewer suicidal thoughts, planning and attempts, according to new research from Johns Hopkins and the University of Alabama at Birmingham. (2015-03-09)

No link between psychedelics and mental health problems
The use of psychedelics, such as LSD and magic mushrooms, does not increase a person's risk of developing mental health problems, according to an analysis of information from more than 135,000 randomly chosen people, including 19,000 people who had used psychedelics. The results are published today in Journal of Psychopharmacology. (2015-03-05)

Classic psychedelic use protective with regard to psychological distress and suicidality
Classic psychedelics, such as LSD, psilocybin mushrooms and mescaline, previously have been shown to occasion lasting improvements in mental health. (2015-01-21)

New study discovers biological basis for magic mushroom 'mind expansion'
New research shows that our brain displays a similar pattern of activity during dreams as it does during a mind-expanding drug trip. (2014-07-03)

Psilocybin inhibits the processing of negative emotions in the brain
When emotions are processed in a negatively biased manner in the brain, an individual is at risk to develop depression. Psilocybin, the bioactive component of the Mexican magic mushroom, seems to intervene positively in the emotion-processing mechanism. Even a small amount of the natural substance attenuates the processing of negative emotions and brightens mood as shown by UZH researchers using imaging methods. (2014-05-07)

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