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Current Scleroderma News and Events

Current Scleroderma News and Events, Scleroderma News Articles.
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Regulatory and effector B cells control scleroderma
A Japan-based research team led by Kanazawa University have found reciprocal regulation of B cells on bleomycin-induced scleroderma model. (2018-08-30)
Light device is effective ulcer treatment
University of Manchester and Salford Royal NHS Trust scientists have developed a lamp which could treat chronic ulcers with light. (2018-07-25)
Why internal scars won't stop growing
A study has newly identified an immune trigger of some fibrotic diseases and an experimental compound to treat it. (2018-07-12)
New treatment lenebasum shows promise for diffuse cutaneous systemic sclerosis (dcSSc)
The results of an open label extension of a phase II study presented today at the Annual European Congress of Rheumatology (EULAR 2018) demonstrate that lenabasum continues to have acceptable safety and tolerability in diffuse cutaneous systemic sclerosis (dcSSc) with no severe or serious adverse events (AE). (2018-06-15)
Uncovering a mechanism causing chronic graft-vs-host disease after bone marrow transplant
MicroRNA-17-92 is required for the T-cell and B-cell pathogenicity that drives chronic graft-versus-host disease (cGVHD) after allogeneic bone marrow transplant (BMT), report investigators at The Medical University of South Carolina in an article prepublished online March 12, 2018 by Blood. (2018-04-02)
Genomics reveals key macrophages' involvement in systemic sclerosis
A new international study has made an important discovery about the key role of macrophages, a type of immune cell, in systemic sclerosis (SSc), a chronic autoimmune disease which currently has no cure. (2018-01-18)
LJI researchers discover key driver of atopic dermatitis
Severe eczema, also known as atopic dermatitis, is a chronic inflammatory skin condition that is driven by an allergic reaction. (2018-01-16)
Scleroderma study: Hope for a longer life for patients with rare autoimmune disorder
The approach could represent the first new treatment to improve survival in patients with severe scleroderma in more than four decades. (2018-01-12)
New HSS study finds hope in understanding and better treating scleroderma
Researchers at HSS find a potential cause and treatment lead for scleroderma. (2018-01-10)
Study shows stem cell transplant is better than drug therapy for scleroderma
Scleroderma with internal organ involvement is a debilitating and lethal autoimmune disorder with few effective treatments. (2018-01-03)
Stem cell transplant for severe scleroderma improves survival, quality of life
Clinical trial findings show that a regimen involving transplantation of a person's own blood-forming stem cells can improve survival for people with severe scleroderma, a life-threatening autoimmune disease. (2018-01-03)
Study shows increased risk of uterine fibroids in African-American women with a common form of hair
In a study of medical records gathered on hundreds of thousands of African-American women, Johns Hopkins researchers say they have evidence that women with a common form of hair loss have an increased chance of developing uterine leiomyomas, or fibroids (2017-12-28)
Autoimmune disease discovery could spark new treatments
University of Colorado Boulder researchers have discovered a potent, drug-like compound that could someday revolutionize treatment of rheumatoid arthritis and other autoimmune diseases. (2017-11-20)
Molecular pathway offers treatment targets for pulmonary fibrosis, related conditions
A study led by investigators at Massachusetts General Hospital and University Health Network in Toronto has identified a molecular pathway that appears to be critical to the development of fibrosis -- scarring and excessive tissue deposition that result from abnormal healing responses and can compromise the function of vital organs. (2017-11-15)
Shock-wave therapy successfully treats finger ulcers in scleroderma patients
Extracorporeal shock-wave therapy at low energy levels showed promise as a new treatment for digital ulcers in patients with systemic sclerosis, or scleroderma, according to new research findings presented this week at the 2017 ACR/ARHP Annual Meeting in San Diego. (2017-11-04)
EULAR and ACR present SLE classification criteria at the 2017 ACR/ARHP Annual Meeting
The European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR) will present the draft of new classification criteria for systemic lupus erythematosus (SLE) during a session at the 2017 ACR/ARHP Annual Meeting this week in San Diego, Calif., at the San Diego Convention Center. (2017-11-04)
Scientists discover novel treatment target for pulmonary fibrosis
Scientists have demonstrated that a unique population of immune cells plays a key role in the development of pulmonary fibrosis, and showed that targeting such cells could lead to new treatments for the disease. (2017-07-12)
Research suggests link between imbalanced gut microbiome and systemic sclerosis
Americans and Norwegians with systemic sclerosis had higher levels of bacteria that can cause inflammation and lower levels of bacteria that are believed to protect against inflammation compared with healthy people. (2017-05-11)
Peptide reverses cardiac fibrosis in a preclinical model of congestive heart failure
Cardiac fibrosis, an abnormal thickening of the heart wall leading to congestive heart failure, was not only halted but also reversed by a caveolin-1 surrogate peptide (CSD) in a preclinical model, report researchers at the Medical University of South Carolina in an article published online on Jan. (2017-02-21)
Promising new drug stops spread of melanoma by 90 percent
Michigan State University researchers have discovered that a chemical compound, and potential new drug, reduces the spread of melanoma cells by up to 90 percent. (2017-01-04)
Gene activity predicts progression of autoimmune disease, Stanford researchers find
Researchers at the Stanford University School of Medicine and six other institutions have designed a new diagnostic tool for a rare and deadly autoimmune disease that affects the skin and internal organs. (2016-12-22)
Samumed selected for 7 presentations in 5 therapeutic areas at ACR 2016
Samumed, a leader in tissue regeneration, has been selected to feature seven presentations in five different therapeutic areas at the 2016 American College of Rheumatology (ACR) Annual Meeting from Nov. (2016-11-01)
New study suggests way to slow skin fibrosis in scleroderma
New and ongoing research at Hospital for Special Surgery in New York City has identified a possible mechanism behind the fibrosis that occurs in scleroderma -- a mechanism that may one day lead to a treatment for the disease. (2016-10-31)
Female sex hormone clue to fighting serious immune disease
Female sex hormone clue to fighting serious immune disease (2016-06-10)
Drug does not reduce digital ulcers in patients with systemic sclerosis
In an article appearing in the May 10, 2016 issue of JAMA, Dinesh Khanna, M.D., of the University of Michigan Scleroderma Program, Ann Arbor, and colleagues evaluated the efficacy of the drug macitentan in reducing the number of new digital ulcers in patients with systemic sclerosis. (2016-05-10)
Anti-fibrotic peptide shows early promise against interstitial lung disease
Investigators at the Medical University of South Carolina report preclinical findings showing that the M10 peptide reduces collagen production and reverses fibrotic damage due to systemic sclerosis (SSc)-related interstitial lung disease (ILD) in the April 2016 issue of Translational Research. (2016-04-13)
Connective tissue disease increases risk for cardiovascular problems
African-American patients with connective tissue diseases such as lupus or rheumatoid arthritis are twice as likely as white patients to suffer from atherosclerotic blood vessels, which increase the risk of a heart attack, stroke or death. (2016-02-04)
New paste prevents scarring caused by radiation therapy for cancer
An antiscarring paste when applied to the skin of mice halts fibrosis caused by the radiation used in cancer therapy. (2016-01-04)
Stem cell transplantation does not provide significant improvement for Crohn's disease
A clinical trial to test the effectiveness of a stem cell therapy among adults with difficult to treat Crohn's disease has found it is not significantly better than conventional treatment in producing sustained disease remission after one year. (2015-12-17)
Childhood cancer survivors at heightened risk of several autoimmune diseases
Childhood cancer survivors are at heightened risk of a wide range of autoimmune diseases, reveals research published online in the Annals of the Rheumatic Diseases. (2015-11-10)
Researchers identify a new culprit behind fibrosis
An international team of researchers has identified a new molecule involved in skin fibrosis, a life-threatening disease characterized by the inflammation and hardening of skin tissue. (2015-10-15)
Women's immune system genes operate differently from men's, Stanford study finds
A new technology for studying the human body's vast system for toggling genes on and off reveals that genes associated with the immune system toggle more frequently, and those same genes operate differently in women and men. (2015-07-29)
Rapid skin improvement seen after treating systemic sclerosis patients with fresolimumab
A major treatment breakthrough for total body scarring of the skin that occurs in patients with systemic sclerosis, also known as scleroderma, may soon be available for the estimated 300,000 Americans who suffer with this condition. (2015-06-22)
Antifreeze protein from ticks fights frostbite in mice
A protein that protects ticks from freezing temperatures also prevents frostbite when introduced in mice, a Yale-led study has found. (2015-02-25)
SPARC consortium provides $1.9 million for autoimmune disease research
The first grants from the Strategic Pharma-Academic Research Consortium for Translational Medicine will provide over $1.9 million to advance research on autoimmune disease at several medical research universities across the Midwest. (2015-02-12)
New targets for treating pulmonary hypertension found
Two new potential therapeutic targets for the treatment of pulmonary arterial hypertension, a deadly disease marked by high blood pressure in the lungs, have been identified by researchers at the University of Illinois at Chicago. (2014-09-08)
Two case reports of rare stiff person syndrome
Two female patients achieved clinical remission from the rare, debilitating neurological disease called stiff person syndrome (SPS, which can be marked by a 'tin soldier' gait) after an autologous -- from your own body -- stem cell transplant that eventually allowed them to return to work and regain their previous functioning. (2014-08-25)
New drugs to combat asthma and the like
Science and industry are collaborating to develop future pharmaceuticals for treating chronic inflammatory diseases. (2014-07-24)
The American College of Chest Physicians releases updated PAH guidelines
The American College of Chest Physicians announced today the online first publication of Pharmacological Therapy for Pulmonary Arterial Hypertension in Adults: CHEST Guideline in the journal CHEST. (2014-06-17)
Dentists' knowledge, confidence tied to care for scleroderma patients
A survey of dentists in Massachusetts suggests that their confidence in treating patients with scleroderma may be related to their familiarity with the autoimmune disease. (2014-05-29)
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