Current Side effects News and Events

Current Side effects News and Events, Side effects News Articles.
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Survival protein may prevent collateral damage during cancer therapy
Australian researchers have identified a protein that could protect the kidneys from 'bystander' damage caused by cancer therapies. The 'cell survival protein', called BCL-XL, was required in laboratory models to keep kidney cells alive and functioning during exposure to chemotherapy or radiotherapy. Kidney damage is a common side effect of these widely used cancer therapies, and the discovery has shed light on how this damage occurs at the molecular level. (2020-11-25)

Early trial hints CAR T cells may combat solid tumors in children with neuroblastoma
A phase 1 trial involving 12 children with relapsed neuroblastoma - a hard-to-treat pediatric cancer - shows that anticancer CAR T cells displayed signs of efficacy against these tumors while avoiding damage to nerve tissue. (2020-11-25)

NSF's National Solar observatory predicts a large sunspot for Thanksgiving
On November 18 scientists from the US National Science Foundation's National Solar Observatory predicted the arrival of a large sunspot just in time for Thanksgiving. Using a special technique called helioseismology, the team has been ''listening'' to changing sound waves from the Sun's interior which beckon the arrival of a large sunspot. (2020-11-24)

A DNA-based nanogel for targeted chemotherapy
Current chemotherapy regimens slow cancer progression and save lives, but these powerful drugs affect both healthy and cancerous cells. Now, researchers reporting in ACS' Nano Letters have designed DNA-based nanogels that only break down and release their chemotherapeutic contents within cancer cells, minimizing the impacts on normal ones and potentially eliminating painful and uncomfortable side effects. (2020-11-18)

Dentists from RUDN University found a reason for early deterioration of dental implants
A team of dentists from RUDN University confirmed that a change in the dominant side of chewing is a reason for the early deterioration of dental implants. Such a change makes it more difficult for a patient to get accustomed to an implant and can lead to bone tissue abnormalities. The discovery can help dentists plan the recovery process after implantation surgeries. (2020-11-18)

Scientists reduce levels of molecules that kill neurons in elderly mice with Alzheimer's
Researchers at the Universitat Autònoma de Barcelona have developed an antibody fragment that reduces beta-amyloid peptide and tau protein levels, the ultimate cause of neuronal death in Alzheimer's, ameliorating the hallmarks of the disease at its most advanced stage. The research, published in the International Journal of Molecular Sciences, paves the way for a new pharmacological approach to treat Alzheimer's disease. (2020-11-16)

Patients taking statins experience similar side effects from dummy pills
People taking dummy pills and statins experienced similar side effects in a new study. (2020-11-15)

Side effects often attributed to statins were the same for those taking a placebo
Study participants who reported side effects from cholesterol-lowering medications known as statins also reported the same side effects when they unknowingly took placebo pills. These side effects are real, and it appears may be mostly due to the psychological rather than the pharmacological effects of statins since symptoms were consistent when taking the placebo. (2020-11-15)

Predicting the risk of severe side effects of cancer treatment
The risk of serious adverse effects on the blood status and bone marrow of patients during chemotherapy can be predicted by a model developed at Linköping University, Sweden. This research may make it possible to use genetic analysis to identify patients with a high probability of side effects. The study has been published in npj Systems Biology and Applications. (2020-11-12)

A molecule from gut bacteria reduces effect of diabetes medication
The action of metformin, the classic drug used to treat diabetes by stabilizing blood sugar, can be blocked by a molecule from the bacteria in our intestines, a University of Gothenburg study shows. (2020-11-11)

Is proton therapy the silver bullet for children with brain cancer?
How safe is proton therapy for children with brain cancer compared to the conventional x-ray radiation delivered post-surgery? (2020-11-11)

Smart devices to schedule electricity use may prevent blackouts
Power plants generate electricity and send it into power lines that distribute energy to nodes where it can be used. But if the electricity load is more than the system's capacity, transmission can fail, leading to a cascade of failures throughout the electric grid. In the journal Chaos, researchers show demand side control may be an effective solution to stabilizing the reliability of power grids that use a mix of energy generation sources. (2020-11-10)

Boosting treatments for metastatic melanoma
University of Cincinnati clinician-scientist Soma Sengupta, MD, PhD, says that new findings from her and Daniel Pomeranz Krummel's, PhD, team might have identified a treatment-boosting drug to enhance effectiveness of therapies for metastatic cancer and make them less toxic, giving patients a fighting chance at survival and improved quality of life. (2020-11-05)

Safety of HPV vaccines in males
A new analysis published in the British Journal of Clinical Pharmacology shows that HPV vaccines are safe and well tolerated in the male population, and the side effects that may occur after immunization are similar in both sexes. (2020-11-04)

Active surveillance safe for African Americans with low-risk prostate cancer
Researchers with UC San Diego School of Medicine and Moores Cancer Center say active surveillance is safe for African American men with low-risk prostate cancer. (2020-11-03)

Do octopuses' arms have a mind of their own?
Octopuses are strange creatures, with three hearts, eight arms and a nervous system distinct from any other animal. These fiercely intelligent creatures are jam-packed with over 500 million neurons, but over two thirds of these neurons are located within their arms and body. Many scientists therefore think that octopuses' arms act independently from the brain, but a study in Current Biology suggests that an octopus' arms and brain are more connected than previously thought. (2020-11-02)

Trial targets deadly lung cancer
With more than 650 Australians diagnosed with malignant mesothelioma last year, Flinders University is leading new research to discover alternatives to chemotherapy and even prevent deaths by early detection in future. One novel approach, using natural therapeutic benefits of curcumin, a key component of the spice turmeric, will be put to the test in a clinical trial in 2021 as part of world-leading research at Flinders University. (2020-10-30)

Microbes in the gut could be protective against hazardous radiation exposure
A study by scientists at UNC Lineberger Comprehensive Cancer Center and colleagues showed that mice exposed to potentially lethal levels of total body radiation were protected from radiation damage if they had specific types of bacteria in their gut. They demonstrated that the bacteria mitigated radiation exposure and enhanced the recovery of blood cell production as well as repair of the gastrointestinal tract. (2020-10-30)

Sexual health often overlooked in cancer survivorship care, especially for female patients
A new study points to a need for oncologists to ask their patients about sexual health after chemotherapy, radiation and other cancer treatments. In a survey of nearly 400 cancer survivors, 87% said they experienced sexual side effects, but most also said their oncologist had not formally asked about them. Female patients were especially unlikely to be asked about sexual dysfunction. Findings will be presented at the American Society for Radiation Oncology (ASTRO) Annual Meeting. (2020-10-30)

Muscle pain and energy-rich blood: Cholesterol medicine affects the organs differently
Contrary to expectation, treatment with statins has a different effect on blood cells than on muscle cells, a new study from the University of Copenhagen reveals. Today, statins are mainly used in the treatment of elevated cholesterol, but the new results may help design drugs for a number of conditions. (2020-10-29)

Stronger treatments could cure Chagas disease
Researchers in the University of Georgia's Center for Tropical and Emerging Global Diseases have found that a more intensive, less frequent drug regimen with currently available therapeutics could cure the infection that causes Chagas disease (2020-10-29)

Cancer treatment without side effects?
Treating cancer without debilitating side effects has long been the holy grail of oncologists, and researchers at the University of California, Irvine and Switzerland's Lausanne University Hospital may have found it. (2020-10-27)

Taking the itch out of cancer immunotherapy
Researchers from the University of Tsukuba have determined that PD-1 expression on CD8 T cells is the biological pathway that leads to psoriasis-like dermatitis, an unfavorable side effect of cancer immunotherapy with PD-1 inhibitors. This finding offers hope that blocking this pathway can prevent or reduce the undesirable side effect and help cancer patients continue their treatment with improved quality-of-life. (2020-10-26)

Targeted inhibitor of mutated KRAS gene shows promise in lung, bowel, & other solid tumors
A novel agent that targets a mutated form of the KRAS gene - the most commonly altered oncogene in human cancers and one long considered ''undruggable'' - shrank tumors in most patients in a clinical trial with manageable side effects, researchers reported today at the 32nd EORTC-NCI-AACR Symposium on Molecular Targets and Therapeutic, which is taking place online. (2020-10-25)

Researchers develop a simplified method to modify disease signaling with light
Cellular optogenetics is a technique that allows researchers to use light to precisely control cell signaling and function in space and time enabling the investigation of mechanisms involved in disease processes. A research team from the University of Turku have developed a novel way to make cellular optogenetic tools much easier to monitor and apply, and showed how they can be used to investigate the cellular side effects of medicines used to treat cancer. (2020-10-22)

Vaccine to treat and prevent lung, bowel and pancreatic cancer shows promise in the lab
An experimental vaccine, designed to enlist the body's own immune system to target cancer cells, has shown promise for treating and preventing cancer in mice. The vaccine was created to target a gene called KRAS that is involved in the development of many types of cancer, including lung, bowel and pancreatic cancer. (2020-10-22)

U of M trial shows hydroxychloroquine does not prevent COVID-19 in health care workers
University of Minnesota Medical School researchers found that taking hydroxychloroquine once or twice weekly did not prevent the development of COVID-19 in health care workers better than the placebo. (2020-10-21)

Researchers identify genetic variants linked to toxic side effects from bevacizumab
In the largest study of its kind, researchers have found two common genetic variants that can be used to predict whether or not cancer patients might suffer severe adverse side-effects, such as high blood pressure, from the drug bevacizumab. The genome-wide association study is the largest such study in patients being treated with bevacizumab and it is to be presented at the 32th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics. (2020-10-21)

New approach to fighting cancer could reduce costs and side effects
CAR-T biotherapeutics company Carina Biotech and researchers at the University of South Australia have developed a novel approach based on microfluidic technology to ''purify'' the immune cells of patients in the fight against cancer. (2020-10-20)

Boron nitride nanofilms for protection from bacterial and fungal infections
NUST MISIS material scientists have presented antibacterial nano-coatings based on boron nitride, which are highly effective against microbial pathogens (up to 99.99%). They can become a safe alternative to the usual antibiotics in implantology since they do not have typical negative side effects. The results of the work are published in the international scientific journal ACS Applied Materials & Interfaces. (2020-10-20)

Efficacy, politics influence public trust in COVID-19 vaccine
If an initial COVID-19 vaccine is about as effective as a flu shot, uptake by the American public may fall far short of the 70% level needed to achieve herd immunity, new Cornell research suggests. (2020-10-20)

Study: There's work to be done before people feel ready for COVID-19 vaccine
A new study in the journal Vaccines indicates some significant public messaging should be communicated before any COVID-19 vaccines are made available in the US. And with vaccines potentially being approved by the end of the year or early next year, the clock is ticking. (2020-10-13)

Mysterious molecular phenomenon could boost precision of targeted drug delivery
Scientists have shown how a type of cellular binding could help pave the way for highly targeted therapies against diseases like cancer. (2020-10-06)

Study identifies characteristics of infused CAR T cells associated with efficacy and toxicity in in patients with large B-cell lymphoma
Researchers at The University of Texas MD Anderson Cancer Center have identified molecular and cellular characteristics of anti-CD19 CAR T cell infusion products associated with how patients with large B-cell lymphoma (LBCL) respond to treatment and develop side effects. (2020-10-05)

Risk of heart disease in breast cancer patients can be predicted from routine scans
Automated analysis of breast cancer patients' routine scans can predict which women have a greater than one in four risk of going on to develop cardiovascular disease, according to research presented at the 12th European Breast Cancer Conference. (2020-10-01)

Cannabinoids associated with negative respiratory health effects in older adults with COPD
Cannabinoids, a class of prescription pills that contain synthetically-made chemicals found in marijuana, are associated with a 64 per cent increase in death among older adults with chronic obstructive pulmonary disease (COPD), according to the first published data on the impact of cannabinoids on the respiratory health of individuals with the lung disease. (2020-09-30)

Mussels connect antibodies to treat cancer
POSTECH research team develops innovative local anticancer immunotherapy technology using mussel protein. (2020-09-29)

Clinical trial of selpercatinib shows strong response for patients with non-small cell lung cancer
Drug shown to precisely target non-small cell lung cancer driven by mutations to gene RET. Majority of patients on trial experience shrinking tumours and live for more than a year without disease progression. National Cancer Centre Singapore, one of a handful of three Asian centres to participate in the trial, has implemented routine testing of the gene RET for all lung cancer patients. Findings published in high impact factor journal, New England Journal of Medicine. (2020-09-28)

Antacid monotherapy more effective in relieving epigastric pain than in combination with lidocain
Antacid monotherapy is more effective in relieving epigastric pain than in combination with lidocaine. That is the conclusion of a study to be published in the September 2020 issue of Academic Emergency Medicine (AEM), a journal of the Society for Academic Emergency Medicine (SAEM). (2020-09-28)

New Duchenne muscular dystrophy drug shows benefit in Duke trial
A new drug offers hope for young boys with the progressive neuromuscular disease Duchenne muscular dystrophy (DMD) by potentially offering an alternative to high-dose glucocorticoids that have significant side effects. (2020-09-25)

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