Current Spinal cord injury News and Events

Current Spinal cord injury News and Events, Spinal cord injury News Articles.
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Spinal/epidural anesthesia associated with increased survival in leg artery bypass surgery
A new study published in The BMJ shows that people who had surgery to improve blood flow in their legs under spinal or epidural anesthesia were less likely to die than those who were given general anesthesia. (2020-11-25)

New mechanism of pain control revealed
Researchers have identified a unique population of astrocytes in the dorsal horn of the spinal cord of mice that produces pain hypersensitivity when activated by neurons carrying signals down from the brain. The findings indicate that the role of descending neurons in controlling spinal pain transmission is not limited to suppression and point to this group of astrocytes as a new target for enhancing the effect of chronic pain treatments. (2020-11-25)

Central trafficking compartment in neurons malfunctions in majority of Alzheimer's patients
A new Columbia study suggests that malfunctioning endosomes--a central trafficking station inside neurons--are commonly involved in the appearance of Alzheimer's disease. (2020-11-25)

World's first: Drug guides stem cells to desired location, improving their ability to heal
Scientists at Sanford Burnham Prebys Medical Discovery Institute have created a drug that can lure stem cells to damaged tissue and improve treatment efficacy--a scientific first and major advance for the field of regenerative medicine. (2020-11-24)

Trinity researchers discover how the brain 're-wires' after disease
Trinity College researchers are studying how the brain re-wires itself in neurological disease. The team is building treatments for today's more common global conditions like Motor Neurone Disease (MND/ALS) and Spinal Muscular Atrophy and their findings could impact rehabilitation for patients, the discovery of effective drugs and quantifying the potential efficacy of new therapies. (2020-11-24)

Tarantula toxin attacks with molecular stinger
A bird-catching Chinese tarantula bite contains a stinger-like poison that plunges into a molecular target in the electrical signaling system of their prey's nerve cells. New cryo-electron microscopy studies show how this venom traps the voltage sensors of sodium channels in a resting state so they can't be activated. Such research may suggest designs for better drugs for chronic pain. (2020-11-23)

New non-invasive technology could spot early signs of motor disorders in babies
Imperial College London scientists have created the world's first non-invasive way to map how baby movements are generated on a neuronal level. (2020-11-20)

Simple measurement could transform injury rehabilitation
Researchers from Edith Cowan University in Western Australia have found a simple way to analyse the effectiveness of exercise training that could one day be conducted easily at a local gym or physio. Using vertical jumps as a test activity, the researchers could predict detailed information regarding technique and muscle activation patterns just through a relatively simple analysis of forces produced against the ground during the jump. (2020-11-19)

A gene mutation that protects against disease
Called PCSK9Q152H, the mutation of the PCSK9 gene was initially thought to protect against cardiovascular diseases. Recent studies reveal that it may protect against other human illnesses, mainly liver diseases. It may allow the PCSK9Q152H mutant subjects to stay in good health and live longer. (2020-11-19)

Lovestruck by oxytocin! Novel roles of the hormone in controlling male sexual function
Hormones are the master regulators of sexual functions in mammals. The hormone oxytocin has a well-established role in social bonding, sexual function, maternal instinct, nursing, and lactation. Researchers from Okayama University have now explored the roles of oxytocin in male sexual function for the first time. Findings from the study suggest that oxytocin-mediated control of male sexual function via the spinal cord may in fact be instrumental in treating erectile dysfunction. (2020-11-18)

Cellular pathway of genetic heart disease similar to neurodegenerative disease
Research on a genetic heart disease has uncovered a new and unexpected mechanism for heart failure. This landmark discovery found a correlation between the clumping of RNA-binding proteins long linked to neurodegenerative disease and the aggregates of protein found in the heart tissue of patients with RBM20 dilated cardiomyopathy. (2020-11-18)

Blood biomarkers for detecting brain injury in COVID-19 patients
COVID-19 can directly cause neurologic symptoms and long-term neurological disease. Elevations of blood biomarkers indicative of brain injury have been reported in the blood and cerebrospinal fluid of COVID-19 patients. Clinical application of blood biomarkers to improve medical management of COVID-19 patients (2020-11-17)

New ALS guideline establishes national standard for managing neurodegenerative disease
The first Canadian guideline for the care and management of patients with amyotrophic lateral sclerosis (ALS) -- Lou Gehrig's disease -- recommends a patient-focused approach, with attention to holistic and emotional aspects of well-being. The guideline, published in CMAJ (Canadian Medical Association Journal) http://www.cmaj.ca/lookup/doi/10.1503/cmaj.191721, is intended for ALS clinicians, allied health professionals and primary care providers, and contains an easy-to-reference table with comprehensive recommendations. (2020-11-16)

Reversal of glial scar tissue back to neuronal tissue through neuroregenerative gene therapy
Brain or spinal cord injury often results in glial scar tissue that is correlated to neural functional loss. Glial scar is a well-known obstacle for neural regeneration. A research team led by Prof. Gong Chen at Jinan University, Guangzhou, published an article in the current issue of Frontiers in Cellular Neuroscience, demonstrating that glial scar tissue can be reversed back to neuronal tissue through NeuroD1-based neuroregenerative gene therapy. (2020-11-16)

Promising MS drug may worsen disease, research suggests
The drug has not yet made it to human trials for multiple sclerosis, but scientists at the University of Virginia School of Medicine are urging their colleagues to move cautiously. (2020-11-13)

Repeated small blasts put military, law enforcement at risk for brain injury
Military and law-enforcement personnel repeatedly exposed to low-level blasts have significant brain changes - including an increased level of brain injury and inflammation -- compared with a control group, a new study has found. (2020-11-12)

Exoskeleton-assisted walking improves mobility in individuals with spinal cord injury
''Participants showed improvement regardless of level of injury, completeness, or duration of injury,'' noted Dr. Forrest, ''indicating that exoskeletons can be used to improve mobility across a broad spectrum of individuals with neurological deficits caused by spinal cord injury. Our results can be used to guide the application of exoskeletons to spinal cord injury rehabilitation, and the timely acquisition of skills for the safe use of these devices for rehabilitation and community use.'' (2020-11-12)

University of Pittsburgh neuroscientists advance understanding of pain from light touch
Researchers from the Pittsburgh Center for Pain Research uncovered additional complexities behind mechanical allodynia - the sensation of pain from innocuous stimuli, such as light touch. (2020-11-11)

Balance dysfunction after traumatic brain injury linked to diminished sensory acuity
Compared with the control group, the TBI group had higher perturbation perception thresholds (PPT) and lower functional scores on balance - findings with important implications. 'As a means of detecting and quantifying sensory acuity PPT may serve as a novel marker for sensory integration deficits that underlie balance impairments after traumatic brain injury,' said Dr. Pilkar. 'This line of research will provide the information we need to develop new rehabilitative treatments that restore balance and reduce the risk for falls, and improve long-term outcomes.' (2020-11-11)

Penn researchers develop approach to prevent toxicity tied to neurological gene therapy
Penn Medicine researchers have developed a new targeted approach to prevent a toxicity seen in the sensory neurons of dorsal root ganglia after gene therapy to treat neurological disorders. It's an important hurdle to clear, as the field works toward more safe and effective gene therapies for patients with disorders like spinal muscular atrophy. (2020-11-11)

Protein in blood may predict prognosis, recovery from stroke
Researchers at Mayo Clinic in Florida and collaborators have found that a biomarker in the blood may determine the extent of brain injury from different types of strokes and predict prognosis in these patients. Their findings are reported in Science Translational Medicine. (2020-11-11)

Rapid test can ID unknown causes of infections throughout the body
UC San Francisco scientists have developed a single clinical laboratory test capable of zeroing in on the microbial miscreant afflicting patients hospitalized with serious infections in as little as six hours -- irrespective of what body fluid is sampled, the type or species of infectious agent, or whether physicians start out with any clue as to what the culprit may be. (2020-11-10)

Electrical stimulation reduces swallowing problems in patients with neurological conditions
Using electrical stimulation in the throats of patients recovering from conditions such as strokes or head injuries will help to relieve swallowing problems, leading to a quicker recovery time, according to a new study. (2020-11-10)

Technique to regenerate optic nerve offers hope for future glaucoma treatment
Scientists have used gene therapy to regenerate damaged nerve fibres in the eye, in a discovery that could aid the development of new treatments for glaucoma, one of the leading causes of blindness worldwide. (2020-11-05)

The ebb and flow of brain ventricles
Enlarged ventricles in the brains of people with multiple sclerosis were previously considered a sign of tissue loss. But a team at the MDC and ECRC demonstrated that this expansion often recedes. A study published in JCI Insight now shows that the process observed in mice is transferable to humans. (2020-11-05)

The dangers of collecting drinking water
Fetching drinking water in low and middle income countries can cause serious injury, particularly for women. A new international study published in BMJ Global Health reveals dangers including falls, traffic accidents, animal attacks, and fights, which can result in broken bones, spinal injuries, lacerations, and other physical injuries. The work draws on a survey of 6,291 randomly selected households across 24 sites in 21 low- and middle-income countries in Asia, Africa, Latin America, and the Caribbean. (2020-11-04)

Venous origin of brain blood-vessel malformations
In the condition known as cavernoma, lesions arise in a cluster of blood vessels in the brain, spinal cord or retina. Researchers from Uppsala University can now show, at molecular level, that these changes originate in vein cells. This new knowledge of the condition creates potential for developing better therapies for patients. The study has been published in the journal eLife. (2020-11-03)

Brain effects of repetitive low-level occupational blast exposure
Military and law enforcement personnel with extensive occupational blast exposure had statistically significant differences in brain imaging measures compared to nonexposed control personnel (2020-11-03)

Biomarker combination predicts kidney injury in critically ill children
Researchers at the University of Liverpool have identified a unique method of identifying the early signs of a potentially serious condition known as Acute Kidney Injury (AKI). (2020-11-02)

Higher risk of future fecal incontinence after sphincter injuries
The risk of subsequent fecal incontinence and intestinal gas leakage is significantly higher among women who, during childbirth, have suffered a sphincter injury and consequent damage to the anal sphincter muscle, was shown in a new study from the University of Gothenburg. (2020-11-02)

Study reveals unexpected protective role for brain swelling after injury
Following a brain-injuring bump or blow to the head, brain cells and blood vessels typically swell. This can lead to a potentially life-threatening increase in pressure inside the skull, and managing swelling is critical for patients with traumatic brain injuries (TBIs). But researchers at University of Utah Health have discovered that swelling may also be important for protecting the brain. (2020-11-02)

Neurosurgeons and malpractice suits
To determine the frequency of medical malpractice suits among neurosurgeons and neurosurgeons' reactions when faced with the prospect of such lawsuits, three researchers from The Netherlands surveyed members of the Congress of Neurological Surgeons. The results of the survey can be found in this article. (2020-11-01)

Treating spinal mets with fewer, higher doses of radiation reduces pain more effectively
A new study shows using fewer and higher doses of high-precision radiation therapy is a more effective approach for treating painful spinal tumors than conventional radiation therapy. Findings from the Canadian phase II/III trial (NCT02512965) will be presented today at the American Society for Radiation Oncology (ASTRO) Annual Meeting. (2020-10-26)

Model predicts acute kidney injury requiring dialysis in patients with COVID-19
In a recent study, a new algorithm achieved good performance for predicting which hospitalized patients will develop acute kidney injury requiring dialysis. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-24)

New population of immune cells could play a role in multiple sclerosis
Researchers uncover defining features of a subset of T-cells that may drive autoimmunity in MS, and could prove to be a new target for therapy. (2020-10-23)

New algorithm predicts likelihood of acute kidney injury
In a recent study, a new algorithm outperformed the standard method for predicting which hospitalized patients will develop acute kidney injury. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-23)

Acute kidney injury among African Americans with sickle cell trait and disease
New research examines the risk of acute kidney injury in people with sickle cell trait or disease, as well as the effect of acute kidney injury on kidney function decline in these individuals. Results from the study will be presented online during ASN Kidney Week 2020 Reimagined October 19-October 25. (2020-10-23)

Multiple sclerosis as the flip side of immune fitness
About half of the people with multiple sclerosis have the HLA-DR15 gene variant. A study led by the University of Zurich has now shown how this genetic predisposition contributes to the development of the autoimmune disease multiple sclerosis in combination with environmental factors. The decisive factor is the shaping of a repertoire of immune cells which - although they are effective in fighting off pathogens such as Epstein-Barr virus - also attack brain tissue. (2020-10-22)

Exercising one arm has twice the benefits
New research from Edith Cowan University (ECU) has revealed that training one arm can improve strength and decrease muscle loss in the other arm - without even moving it. The findings could help to address the muscle wastage and loss of strength often experienced in an immobilised arm, such as after injury, by using eccentric exercise on the opposing arm. (2020-10-22)

Enzyme biofactories to enhance cord blood transplants
Stem cell trafficking to the bone marrow is improved by enzyme manufactured in silkworms and yeast. (2020-10-22)

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