Current Synthetic biology News and Events

Current Synthetic biology News and Events, Synthetic biology News Articles.
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Taking a shine to polymers: Fluorescent molecule betrays the breakdown of polymer materials
Scientists at the Tokyo Institute of Technology (Tokyo Tech) have come up with a simple method to evaluate the strength and performance of polymer materials. They present their innovation in the latest issue of Angewandte Chemie International Edition, and hope that their work will enable scientists and engineers to better evaluate the polymers they work with, and eventually synthesize better ones. (2020-11-24)

Near-infrared probe decodes telomere dynamics
A new synthetic probe offers a safe and straightforward approach for visualizing chromosome tips in living cells. The probe was designed by scientists at the Institute for Integrated Cell-Material Science (iCeMS) and colleagues at Kyoto University, and could advance research into aging and a wide range of diseases, including cancers. The details were published in the Journal of the American Chemical Society. (2020-11-20)

Biofriendly protocells pump up blood vessels
In a new study published today in Nature Chemistry, Professor Stephen Mann and Dr Mei Li from Bristol's School of Chemistry, together with Associate Professor Jianbo Liu and colleagues at Hunan University and Central South University in China, prepared synthetic protocells coated in red blood cell fragments for use as nitric oxide generating bio-bots within blood vessels. (2020-11-20)

New process narrows the gap between natural and synthetic materials
Skin and cartilage are both strong and flexible - properties that are hard to replicate in artificial materials. But a new fabrication process, developed by scientists at EPFL, brings lifelike synthetic polymers a step closer. (2020-11-19)

Understanding lung infections in patients with cystic fibrosis
For young people with cystic fibrosis, lung infection with Staphylococcus aureus, MRSA, is common and is treated with antibiotics in the hope that this will prevent a decline in lung function. However there has recently been debate over the role S. aureus plays in CF lung disease. Researchers from the University of Warwick have used a new model of CF lungs which could be used to make better decisions about future use of antibiotics. (2020-11-19)

Gut microbiome manipulation could result from virus discovery
Scientists have discovered how a common virus in the human gut infects and takes over bacterial cells - a finding that could be used to control the composition of the gut microbiome, which is important for human health. The Rutgers co-authored research, which could aid efforts to engineer beneficial bacteria that produce medicines and fuels and clean up pollutants, is published in the journal Nature. (2020-11-18)

Killing cancer naturally: New process to produce compounds with anti-cancer properties
Scientists from the Tokyo University of Science have made a breakthrough in the development of potential drugs that can kill cancer cells. They have discovered a method of synthesizing organic compounds that are four times more fatal to cancer cells and leave non-cancerous cells unharmed. Published in the American Chemical Society Omega, their research can assist in the creation of new anticancer drugs with minimal side effects. (2020-11-17)

???New insights can foster development of natural and safer fungicides
In a recent study published in PhytoFrontiers journal, plant pathologists confirmed that 13 natural and semi-synthetic glucosinolate derivatives are efficient fungicides alone or when used in combination against widespread genetically distant species of fungal plant pathogens. Combinations of these compounds showed strong synergistic fungitoxic effects. (2020-11-13)

Researchers at Goethe University create artificial cell organelles for biotechnology
Cells of higher organisms use cell organelles to separate metabolic processes from each other. This is how cell respiration takes place in the mitochondria, the cell's power plants. They can be compared to sealed laboratory rooms in the large factory of the cell. A research team at Goethe University has now succeeded in creating artificial cell organelles and using them for their own devised biochemical reactions. (2020-11-12)

Illuminating tiny proteins in living cells using single-residue labeling tags
SciLifeLab Fellow Simon Elsässer laboratory at Karolinska Institutet reports a method, which allows fluorescent tagging of proteins with the small perturbation -- a single amino acid -- added genetically on either end of a (micro)protein of interest. The method is termed Single-residue Terminal Labeling, STELLA. (2020-11-12)

Tomosynthesis with synthetic mammography improves breast cancer detection
Digital breast tomosynthesis (DBT), in combination with synthetic mammography, improves cancer detection over digital mammography alone, according to a new study. The study results add further support to the use of DBT in population-based breast cancer screening programs. (2020-11-10)

Glioblastoma nanomedicine crosses into brain in mice, eradicates recurring brain cancer
A new synthetic protein nanoparticle capable of slipping past the nearly impermeable blood-brain barrier in mice could deliver cancer-killing drugs directly to malignant brain tumors, new research from the University of Michigan shows. (2020-11-10)

NYUAD researchers develop protocol for a more accurate COVID-19 testing technique
Researchers from NYU Abu Dhabi's Biology Program and Center for Genomics and Systems Biology (CGSB) have implemented a new three-step testing approach that promises to significantly - and cost-effectively -- improve testing accuracy. (2020-11-09)

Reducing dementia in patients with rheumatoid arthritis
The incidence of dementia in patients with rheumatoid arthritis is lower in patients receiving biologic or targeted synthetic disease modifying antirheumatic drugs (DMARDs) than in patients who receive conventional synthetic DMARDs, according to a new study. The study was presented at the virtual annual meeting of the American College of Rheumatology. (2020-11-06)

Scientists identify synthetic mini-antibody to combat COVID-19
By screening hundreds of synthetic mini-antibodies called sybodies, a group of scientists has identified one that might stop SARS-CoV-2 from infecting human cells. (2020-11-04)

New multicomponent reaction frontiers
The synthesis of complex molecules such as drugs, requires a process that sometimes involves several phases that increase its cost and harden the access to the product. Now, a team of the University of Barcelona has designed a new methodological approach that combines multicomponent reactions with domino type processes -continuous transformations on an only compound- to ease the synthesis of high structural complex molecules. (2020-11-04)

Hungry plants rely on their associated bacteria to mobilize unavailable iron
Researchers from the Max Planck Institute for Plant Breeding Research have found that, faced with limiting iron, plants direct their microbiota to mobilise this essential nutrient for optimal growth. (2020-11-02)

Researchers develop a new way to create a spectrum of natural-looking hair colors
Northwestern University researchers have developed a new way to create a spectrum of natural-looking hair colors, ranging from blond to black, by using enzymes to catalyze synthetic melanin. (2020-10-30)

Well oriented
Polypropylene (PP) is one of the most widely used plastics in the world. By controlling the spatial orientation of the propylene building blocks and additional polar components, it should be possible to create a new generation of attractive, engineered, specialty plastics, with improved wettability or enhanced degradability, based on PP. In the journal Angewandte Chemie, Japanese scientists have introduced the basis for a new class of palladium catalysts for such polymerizations. (2020-10-30)

New artificial skin functions like natural skin
Researchers at RIKEN in Japan have developed an improved human-skin equivalent that reproduces a property that controls the structure and physiological function of skin. This artificial skin will enhance in-depth analyses of physiological skin functions, provide solutions to skin problems caused by diseases or ageing, and reduce the need for animal testing. (2020-10-30)

Wistar creates a new synthetic DNA vaccine against Powassan virus
Wistar scientists have designed and tested the first-of-its-kind synthetic DNA vaccine against Powassan virus (POWV), targeting portions of the virus envelope protein. (2020-10-30)

An artificial cell on a chip
Researchers at the University of Basel have developed a precisely controllable system for mimicking biochemical reaction cascades in cells. Using microfluidic technology, they produce miniature polymeric reaction containers equipped with the desired properties. This 'cell on a chip' is useful not only for studying processes in cells, but also for the development of new synthetic pathways for chemical applications or for biological active substances in medicine. (2020-10-28)

A new RNA catalyst from the lab
On the track of evolution: a catalytically active RNA molecule that specifically attaches methyl groups to other RNAs - a research group from the University of Würzburg reports on this new discovery in Nature. (2020-10-28)

Discovery of pH-dependent 'switch' in interaction between pair of protein molecules
All biological processes are in some way pH-dependent. Our human bodies, and those of other organisms, need to maintain specific- and constant- pH regulation in order to function. Changes in pH can have serious biological consequences or, as researchers at the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT), Chinese Academy of Sciences (CAS) found, serious benefits. (2020-10-23)

SPOTlight supercharges cell studies
Researchers develop a new method to isolate specific cells, and in the process find a more robust fluorescent protein. (2020-10-23)

MonoEye: A human motion capture system using a single wearable camera
Researchers at Tokyo Institute of Technology and Carnegie Mellon University have together developed a new human motion capture system that consists of a single ultra-wide fisheye camera mounted on the user's chest. The simplicity of their system could be conducive to a wide range of applications in the sports, medical and entertainment fields. (2020-10-21)

Removal of synthetic estrogen from water
Synthetic estrogens from pharmaceuticals contaminate rivers and threaten the health of humans and fish. An effective and cost-efficient method for removing synthetic estrogen from bodies of water (2020-10-20)

Enzymatic DNA synthesis sees the light
Researchers at Harvard's Wyss Institute for Biologically Inspired Engineering and Harvard Medical School have applied photolithographic techniques from the computer chip industry to enzymatic DNA synthesis, and thus developed a new method to multiplex the superior DNA writing ability of Terminal deoxynucleotidyl Transferase TdT's. (2020-10-16)

Cartilage-Inspired, Lipid-Based and Super Slippery Synthetic Hydrogels
Drawing inspiration from the mechanisms that lubricate the cartilage in our joints over a lifetime of wear, researchers designed extremely slippery hydrogels with self-renewing, lipid-based boundary layers, which result in a near 100-fold reduction in friction and wear over other hydrogels. (2020-10-15)

Engineered developmental signals could illuminate regenerative medicine
For a tiny embryo to develop into an adult organism, its cells must develop in precise patterns and interact with their neighbors in carefully orchestrated ways. To create complex tissues and organs -- from the pattern of rods and cones in the retina to the Byzantine filtration systems of the kidney -- all these developing cells must constantly answer a fundamental but surprisingly difficult question: Where am I? (2020-10-15)

Setting a TRAP for pandemic-causing viruses
A new laboratory technique quickly sifts through trillions of synthetic proteins to find ones that can target viruses, helping healthcare authorities rapidly respond to evolving pandemics. (2020-10-08)

Scientists developed key principles for creating an artificial vessel
Researchers from St. Petersburg provided a unique experiment. They implanted a polymer scaffold as a vascular prosthesis into the rat abdominal aorta and monitored the process of its bioresobtion for 16 months. An artificial vessel was formed where the scaffold was located. It posess similar characteristics as a natural vessel. (2020-10-08)

Deep learning takes on synthetic biology
Machine learning is helping biologists solve hard problems, including designing effective synthetic biology tools. Two teams from the Wyss Institute and MIT have created a set of algorithms that can effectively predict the efficacy of thousands of RNA-based sensors called toehold switches, allowing the rapid identification and optimization of sequences that can act as biological sensors for medicine and other applications. (2020-10-07)

Igniting the synthetic transport of amino acids in living cells
Researchers from ICIQ's Ballester group and IRBBarcelona's Palacín group have published a paper in Chem showing how a synthetic carrier calix[4]pyrrole cavitand can transport amino acids across liposome and cell membranes bringing future therapies a step closer. (2020-10-06)

Facile synthesis of quinoline in water
This review summarizes an overview of the synthesis and functionalisation of quinoline scaffolds in aqueous medium. This method may encourage researchers to adopt green chemistry and to apply these environmentally safe methods in designing important heterocyclic cores. (2020-09-29)

Prototype graft, designed to replace damaged heart vessels, shows promise in cell study
North Carolina State University researchers reported promising preclinical findings for a prototype of a vascular graft designed as a replacement for a damaged or blocked coronary artery, which supplies blood to the heart. (2020-09-29)

Copycat plant booster improves on nature
A molecular mimic designed to promote plant growth and limit witchweed infestation shows promise in initial trials. (2020-09-28)

Machine learning takes on synthetic biology: algorithms can bioengineer cells for you
Scientists at Lawrence Berkeley National Laboratory have developed a new tool that adapts machine learning algorithms to the needs of synthetic biology to guide development systematically. The innovation means scientists will not have to spend years developing a meticulous understanding of each part of a cell and what it does in order to manipulate it. (2020-09-25)

Secure nano-carrier delivers medications directly to cells
Medications often have unwanted side-effects. One reason is that they reach not only the unhealthy cells for which they are intended, but also reach and have an impact on healthy cells. Researchers at the Technical University of Munich (TUM), working together with the KTH Royal Institute of Technology in Stockholm, have developed a stable nano-carrier for medications. A special mechanism makes sure the drugs are only released in diseased cells. (2020-09-25)

Bioelectronic device achieves unprecedented control of cell membrane voltage
Every living cell maintains a voltage across the cell membrane that results from differences in the concentrations of charged ions inside and outside the cell. In an impressive proof-of-concept demonstration, an interdisciplinary team of scientists has developed a bioelectronic system driven by a machine learning algorithm that can shift the membrane voltage in living cells and maintain it at a set point for 10 hours. (2020-09-24)

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