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New mechanisms regulating neural stem cells
The use of stem cells to repair organs is one of the foremost goals of modern regenerative medicine. (2019-02-21)
Study of Arctic fishes reveals the birth of a gene -- from 'junk'
Though separated by a world of ocean, and unrelated to each other, two fish groups - one in the Arctic, the other in the Antarctic - share a surprising survival strategy: They both have evolved the ability to produce the same special brand of antifreeze protein in their tissues. (2019-02-11)
New insights into radial expansion of plants can boost biomass production
Besides the obvious longitudinal growth, plants also enlarge in the radial sense. (2019-02-08)
Folliculin mutations disrupt embryo implantation
New information is unfolding on the genetic controls of an early turning point in pregnancy -- the changes in an embryo's cells that occur as it prepares to lodge in the wall of the uterus. (2019-02-07)
HIV-1 protein suppresses immune response more broadly than thought
Scientists have revealed how a protein produced by HIV-1 plays a broader role in suppressing the immune system's response to infection than previously thought. (2019-02-05)
Exercise may fight depression in older adults, study suggests
New research suggests that exercise-induced muscle changes could help boost mood in older adults. (2019-01-31)
How transcription factors explore the genome
EPFL scientists have discovered how proteins that regulate gene transcription can scan and bind the genome efficiently. (2019-01-30)
Kick-starting the genome in early development
We can think of the egg and sperm as information capsules with stored instructions for starting a new life, but post fertilisation, what kick starts the interpretation of these instructions? (2019-01-28)
Interferon regulatory factor 6 mutations implicated in neural tube defects, including spina bifida
Mutations in a gene known as interferon regulatory factor 6 that cause cleft lip and palate also are implicated in neural tube defects such as spina bifida, suggests research by an international study team published online Jan. (2019-01-25)
Helmholtz scientists identify the causes of cortisone-induced side effects
Patients undergoing long-term treatment with steroids may suffer from metabolic side effects. (2019-01-25)
Keeping chromosomes in check: a new role for heterochromatin
Large changes in the structure of chromosomes are usually fatal for the cell or can lead to genetic diseases such as cancer. (2019-01-24)
Enzyme that breaks down amino acids may promote aging
Permanently arrested cell growth is known as 'cellular senescence', and the accumulation of senescent cells may be one cause of aging in our bodies. (2019-01-24)
Noisy gene atlas to help reveal how plants 'hedge their bets' in race for survival
Plant scientists at the Sainsbury Laboratory Cambridge University have built a gene expression atlas that maps the 'noisy genes' of genetically identical plants. (2019-01-24)
Plant peptide helps roots to branch out in the right places
How do plants space out their roots? A Japanese research team has identified a peptide and its receptor that help lateral roots to grow with the right spacing. (2019-01-18)
Researchers discovered new immune response regulators
The research groups of Academy Professor Riitta Lahesmaa and Research Director Laura Elo from Turku Centre for Biotechnology have discovered new proteins that regulate T cells in the human immune system. (2019-01-15)
Predicting enhancers from multiple cell lines and tissues based on SVM method
Enhancers are short DNA regions that improve transcription efficiency by recruiting transcription factors. (2019-01-14)
Unconventional immune cells trigger disturbed cytokine production in human spondyloarthritis
Spondyloarthritis is one of the most common types of chronic joint inflammation affecting nearly 1-2 percent of the Western population. (2019-01-10)
Targeting an RNA-binding protein to fight aging
Researchers at EPFL found that the RNA-binding protein PUM2 contributes to the accumulation of defective mitochondria, a key feature of the aging process. (2019-01-10)
How trees and turnips grow fatter
Two international research teams have identified key regulatory networks controlling how plants grow 'outwards,' which could help us to grow trees to be more efficient carbon sinks and increase vegetable crop yields. (2019-01-09)
Scientists provide new insight on how gene expression is controlled
Researchers have provided new insight on the mechanism underlying the control of gene expression in all living organisms, according to a study published today in eLife. (2019-01-08)
A new hope in treating neurodegenerative disease
Korean researchers have clarified the fundamentals of coiled toxin protein which causes neurodegenerative brain disorders. (2019-01-04)
Unmuting large silent genes lets bacteria produce new molecules, potential drug candidates
By enticing away the repressors dampening unexpressed, silent genes in Streptomyces bacteria, researchers at the University of Illinois have unlocked several large gene clusters for new natural products. (2018-12-31)
Long-term memory encoding engram neurons are established by the transcriptional cycling
Long-term memory (LTM) is formed by repetitive training trials with rest intervals and LTM formation requires transcription factors, including CREB and c-Fos. (2018-12-27)
Genetic polymorphisms and zinc status
Zinc is an essential component for all living organisms, representing the second most abundant trace element, after iron. (2018-12-27)
Predicting enhancers from multiple cell lines and tissues: Different developmental stages
In this paper, we proposed a method based on support vector machines (SVMs) to investigate enhancer prediction on cell lines and tissues from EnhancerAtlas. (2018-12-21)
Elegant trick improves single-cell RNA sequencing
Researchers at Cornell -- led by Iwijn De Vlaminck, assistant professor in the Meinig School of Biomedical Engineering -- have come up with an elegant, low-cost method that solves that problem. (2018-12-20)
Scientists gain insights into traffic cop function of gene expression protein
Scientists at the UNC School of Medicine have discovered a crucial quality-control mechanism inside cells that, when it fails, might contribute to major diseases including cancers. (2018-12-18)
What prevents remyelination? New stem cell research reveals a critical culprit
New research on remyelination, the spontaneous regeneration of the brain's fatty insulator that keeps neurons communicating, could lead to a novel approach to developing treatments for multiple sclerosis (MS) and other inflammatory diseases. (2018-12-18)
Protein police keep the immune system in check
Researchers learn how a key transcription factor helps regulate the immune system and could be critical to understanding autoimmune disease and cancer immunosuppression. (2018-12-17)
Study confirms role of brain's support cells in Huntington's, points to new therapies
New research gives scientists a clearer picture of what is happening in the brains of people with Huntington's disease and lays out a potential path for treatment. (2018-12-13)
Nuclear events make a flower bloom
Researchers at the Nara Institute of Science and Technology (NAIST) report AGAMOUS and CRABS CLAW partner in a feed-forward system to terminate the floral meristem and form the gynoecium in Arabidopsis plants. (2018-12-11)
How glial cells develop in the brain from neural precursor cells
A Mainz-based research team studied how glial cells develop in the brain from neural precursor cells. (2018-12-10)
UA scientist identifies cellular gene signatures for heart muscle regeneration
A research team led by Jared Churko, PhD, director of the University of Arizona iPSC Core in the UA Sarver Heart Center, used a transcriptomic approach -- studying what genes are expressed -- to identify gene signatures of cell subpopulations identified as atrial-like or ventricular-like. (2018-11-30)
DNA Origami full of potent anticancer agents
One of the most successful techniques to combat multidrug resistance in cancer cells is the downregulation of those genes responsible for drug resistance. (2018-11-21)
Getting things under control: New mouse model aids study of immunomodulation
Mice are resistant to immunomodulatory drugs (IMiDs). As a result, studying the effects of IMiDs was not possible in existing types of mice. (2018-11-19)
Mutation that causes autism and intellectual disability makes brain less flexible
About 1 percent of patients diagnosed with autism spectrum disorder and intellectual disability have a mutation in a gene called SETD5. (2018-11-19)
Freeze-frame microscopy captures molecule's 'lock-and-load' on DNA
One of the body's largest macromolecules is the machinery that gloms onto DNA and transcribes it into mRNA, the blueprint for proteins. (2018-11-19)
'Druggable' cancer target found in pathway regulating organ size
It's known that cancer involves unchecked cell growth and that a biological pathway that regulates organ size, known at the Hippo pathway, is also involved in cancer. (2018-11-19)
HIV latency differs across tissues in the body
Mechanisms that govern HIV transcription and latency differ in the gut and blood, according to a study published Nov. (2018-11-15)
Clues for drugging the 'undruggable'
Nicolas Thomä's group at the Friedrich Miescher Institute for Biomedical Research (FMI) has joined forces with the group of Benjamin Ebert at Harvard's Broad Institute to show how thalidomide analogs mediate degradation of many more proteins than previously anticipated. (2018-11-05)
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