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Summit charts a course to uncover the origins of genetic diseases
A team led by Ivaylo Ivanov of Georgia State University used the 200-petaflop IBM AC922 Summit system, the world's smartest and most powerful supercomputer, to develop an integrative model of the transcription preinitiation complex (PIC), a complex of proteins vital to gene expression. (2019-05-21)
Neurobiology: Doubly secured
Ludwig-Maximilians-Universitaet (LMU) in Munich researchers have used CRISPR technology to probe the mechanisms that guide the developmental trajectories of stem cells in the brain. (2019-05-20)
Structural and functional mechanisms of a new class of bacterial sigma/anti-sigma factors revealed
Prof. FENG Yingang and his colleagues from the Qingdao Institute of Bioenergy and Bioprocess Technology (QIBEBT) of the Chinese Academy of Sciences recently revealed the structural and functional mechanism of the SigI/RsgI factors from C. thermocellum. (2019-05-19)
Dead zones in circadian clocks
Circadian clocks of organisms respond to light signals during night but do not respond in daytime. (2019-05-14)
Key step in transformation of B cells to antibody-secreting cells described
Immunologist Frances Lund, Ph.D., and colleagues have detailed the role of a key controlling factor in the transformation of B cells into antibody-secreting cells, the cells that produce antibodies to fight invading pathogens like viruses. (2019-05-07)
Threatened sturgeon learns for the fitness
An international team led by IGB is providing one of the first proofs of the complex learning behavior of fish in a recent study. (2019-05-07)
Chemical modifiers tag-team to regulate essential mechanism of life
For decades, scientists thought that one modification, phosphorylation, ran the show. (2019-05-02)
Proteins stand up to nerve cell regression
Fruit fly studies reveal proteins that promote healthy nervous system development by preventing the reversal of nerve cell differentiation. (2019-04-24)
Taming the genome's 'jumping' sequences
EPFL scientists have discovered how a family of proteins that regulates the activity of transposable elements in the genome allows them to make inheritable changes to the growing fetus. (2019-04-18)
Bioengineers add cooperative molecules to their toolkit for programming signal processing
Synthetic biologists have added a new toolset powered by self-assembling molecules and predictive modeling will allow researchers to construct the complex computation and signal processing found in eukaryotic organisms, including human cells. (2019-04-18)
Bioengineers program cells as digital signal processors
Synthetic biologists have added high-precision analog-to-digital signal processing to the genetic circuitry of living cells. (2019-04-18)
Scientists crack the code to regenerate plant tissues
A group of scientists from Tokyo University of Science have discovered a new way to regenerate flowering plant tissues, opening possibilities of mitigating global food shortage problem. (2019-04-16)
Researchers explain signals of CpG 'traffic lights' in DNA
A research team featuring bioinformaticians from the Moscow Institute of Physics and Technology (MIPT) has identified reliable markers of gene activity. (2019-04-09)
uliCUT&RUN maps protein binding on chromatin in single cells and single embryos
Originally adapted in 2017, CUT&RUN has since been successfully applied to populations of more than 1,000 cells. (2019-04-08)
Scientists develop methods to validate gene regulation networks
A team of biologists and computer scientists has mapped out a network of interactions for how plant genes coordinate their response to nitrogen, a crucial nutrient and the main component of fertilizer. (2019-04-05)
Mutation stands in the way of healthy blood cell maturation
In a new study, researchers from the University of Copenhagen and EMBL in Heidelberg have learned how a specific genetic mutation affects the maturation of blood cells in mouse models. (2019-04-05)
Unjamming the genome after DNA damage
A protein complex that is involved in nearly every step in the regulatory control of gene expression in cells has now been shown also to play a key role in clearing potential traffic jams in the production of RNA. (2019-04-05)
Cell lesson: better coordinated than isolated
A new study led by Juana Díez, principal investigator of the Department of Experimental and Health Sciences (DCEXS) at UPF, has found a new system in our cells that makes them more robust against possible alterations in the expression of our genes. (2019-04-04)
HKUST scientists discover how RNA PoII maintains accurate transcription with super computer
Scientists from the Hong Kong University of Science and Technology have recently uncovered the mechanisms of how RNA polymerase II performs intrinsic cleavage reaction to proofread RNA transcriptions, shedding light on how misregulation of accurate transcription can lead to diseases including cancer and Alzheimer's disease. (2019-04-02)
A cellular protein as a 'gas pump attendant' of cancer development
Scientists at the University of Würzburg have discovered a new mechanism of gene transcription in tumor cells. (2019-04-01)
Crime scene schizophrenia -- 30 genes under suspicion
The research group led by Prof. Alex Schier, Director of the University of Basel's Biozentrum, has identified 30 genes associated with schizophrenia. (2019-03-28)
How nerve cells control misfolded proteins
Researchers have identified a protein complex that marks misfolded proteins, stops them from interacting with other proteins in the cell and directs them towards disposal. (2019-03-27)
Engineering cellular function without living cells
EPFL scientists have come up with a systematic method for studying and even predicting gene expression - without using cells. (2019-03-25)
UTSW researchers identify new mechanism to reduce inflammation
UT Southwestern researchers have identified two proteins that act as gatekeepers to dampen a potentially life-threatening immune response to chronic infection. (2019-03-22)
Artificial chemical DNA switch helps understand epigenetic mechanisms
Researchers from the Czech Academy of Sciences and Charles University constructed an artificial chemical DNA switch and made the first step towards artificial epigenetics -- targeted switching on and off of genes. (2019-03-21)
Chromatin changes rapidly in response to low oxygen, study finds
A study by the University of Liverpool reveals new insights into how cells respond to oxygen deprivation. (2019-03-20)
Androgen receptor, treatment target for prostate cancer, imports into mitochondria
Androgens stimulate prostate cancer cells to grow. Many drugs to target that cancer focus on stopping androgen biosynthesis or blocking the androgen receptor, or AR. (2019-03-19)
Scientists discover key enzyme in breast cancer proliferation, treatment resistance
UNC School of Medicine scientists uncovered a possible reason why some breast cancers are so aggressive and difficult to treat: an enzyme called USP21 promotes proliferation of basal-like breast cancer and is upregulated in a significant percentage of patient tumors. (2019-03-12)
New regulatory factor identified in bone formation
Researchers report the identification of a novel transcription factor that helps regulate the differentiation of mesenchymal stem cells into bone in mice. (2019-03-11)
Anti-inflammatory drug is the key to boosting cardiac reprogramming
University of Tsukuba researchers and colleagues developed a high-throughput screening system to identify the NSAID diclofenac as a factor responsible for enhancing cardiac reprogramming in postnatal and adult fibroblasts. (2019-03-06)
How viruses outsmart their host cells
Viruses depend on host cells for replication, but how does a virus induce its host to transcribe its own genetic information alongside that of the virus, thus producing daughter viruses? (2019-03-06)
Old drugs bring new hope to a cancer that lacks precision therapy
Two older drugs, designed for other purposes, produced promising results in the treatment of mice with triple negative breast cancer. (2019-03-06)
Transcription factor network gets to heart of wood formation
Research on high-level switches that control wood formation has applications in timber, paper and biofuels, as well as making forests healthier. (2019-03-06)
Electrical signals kick off flatworm regeneration
In a study publishing March 5 in Biophysical Journal, scientists report that electrical activity is the first known step in the tissue-regeneration process of planarian flatworms, starting before the earliest known genetic machinery kicks in and setting off the downstream activities of gene transcription needed to construct new heads or tails. (2019-03-05)
A new way to map cell regulatory networks
A new mathematical method developed by researchers at Cincinnati Children's and New York University may soon make it much easier to conduct more of the complex data analysis needed to drive advances in the exploding field of personalized medicine. (2019-03-05)
Source of citrus' sour taste is identified
A team of researchers, including two from the University of California, Riverside, has identified the genes responsible for the hallmark sour taste of many citrus fruits. (2019-03-04)
Researchers develop techniques to track the activity of a potent cancer gene
Researchers at the National Cancer Institute use novel tools to reveal that cancer gene MYC causes global changes in gene activation, with subtle differences between individual cells. (2019-03-01)
Gene transcription machinery constrains DNA movements, study suggests
Researchers in Japan have discovered that the DNA inside human cells moves around less when its genes are active. (2019-03-01)
Scientists devise strategies to counteract T cell exhaustion in CAR T cancer therapies
CAR T-cell therapies have saved lives in patients with blood cancers, but there has been a downside: T cells that enter solid tumors can stop working due to a phenomenon called T cell exhaustion. (2019-02-27)
Study sheds more light on genes' 'on/off' switches
Regulation of genes by noncoding DNA might help explain the complex interplay between our environment and genetic expression. (2019-02-26)
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